WO2001074296A3 - Treatment of non-solid mammalian tumors with vascular endothelial growth factor receptor antagonists - Google Patents

Treatment of non-solid mammalian tumors with vascular endothelial growth factor receptor antagonists Download PDF

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Publication number
WO2001074296A3
WO2001074296A3 PCT/US2001/010504 US0110504W WO0174296A3 WO 2001074296 A3 WO2001074296 A3 WO 2001074296A3 US 0110504 W US0110504 W US 0110504W WO 0174296 A3 WO0174296 A3 WO 0174296A3
Authority
WO
WIPO (PCT)
Prior art keywords
growth factor
vascular endothelial
endothelial growth
factor receptor
treatment
Prior art date
Application number
PCT/US2001/010504
Other languages
French (fr)
Other versions
WO2001074296A2 (en
Inventor
Larry Witte
Shahin Rafii
Original Assignee
Imclone Systems Inc
Cornell Res Foundation Inc
Larry Witte
Shahin Rafii
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Imclone Systems Inc, Cornell Res Foundation Inc, Larry Witte, Shahin Rafii filed Critical Imclone Systems Inc
Priority to AU2001249736A priority Critical patent/AU2001249736A1/en
Priority to EP01922996A priority patent/EP1436000A2/en
Priority to SK1530-2002A priority patent/SK15302002A3/en
Priority to KR1020027013022A priority patent/KR20020087453A/en
Priority to IL15199201A priority patent/IL151992A0/en
Priority to JP2001572042A priority patent/JP2004501070A/en
Priority to CA002404040A priority patent/CA2404040A1/en
Publication of WO2001074296A2 publication Critical patent/WO2001074296A2/en
Publication of WO2001074296A3 publication Critical patent/WO2001074296A3/en

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Oncology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Hematology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)

Abstract

A method of inhibiting the growth of non-solid tumor cells that are stimulated by a ligand of vascular endothelial growth factor in human patients, comprising treating the human patients with an effective amount of a vascular endothelial growth factor receptor antagonist.
PCT/US2001/010504 2000-03-31 2001-03-30 Treatment of non-solid mammalian tumors with vascular endothelial growth factor receptor antagonists WO2001074296A2 (en)

Priority Applications (7)

Application Number Priority Date Filing Date Title
AU2001249736A AU2001249736A1 (en) 2000-03-31 2001-03-30 Treatment of non-solid mammalian tumors with vascular endothelial growth factor receptor antagonists
EP01922996A EP1436000A2 (en) 2000-03-31 2001-03-30 Treatment of non-solid mammalian tumors with vascular endothelial growth factor receptor antagonists
SK1530-2002A SK15302002A3 (en) 2000-03-31 2001-03-30 Treatment of non-solid mammalian tumors with vascular endothelial growth factor receptor antagonists
KR1020027013022A KR20020087453A (en) 2000-03-31 2001-03-30 Treatment of Non-Solid Mammalian Tumors with Vascular Endothelial Growth Factor Receptor Antagonists
IL15199201A IL151992A0 (en) 2000-03-31 2001-03-30 Treatment of non-solid mammalian tumors with vascular endothelial growth factor receptor antagonists
JP2001572042A JP2004501070A (en) 2000-03-31 2001-03-30 Treatment of non-solid mammalian tumors with vascular endothelial growth factor receptor antagonist
CA002404040A CA2404040A1 (en) 2000-03-31 2001-03-30 Treatment of non-solid mammalian tumors with vascular endothelial growth factor receptor antagonists

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US54077000A 2000-03-31 2000-03-31
US09/540,770 2000-03-31

Publications (2)

Publication Number Publication Date
WO2001074296A2 WO2001074296A2 (en) 2001-10-11
WO2001074296A3 true WO2001074296A3 (en) 2004-05-06

Family

ID=24156859

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/010504 WO2001074296A2 (en) 2000-03-31 2001-03-30 Treatment of non-solid mammalian tumors with vascular endothelial growth factor receptor antagonists

Country Status (10)

Country Link
EP (1) EP1436000A2 (en)
JP (1) JP2004501070A (en)
KR (1) KR20020087453A (en)
AU (1) AU2001249736A1 (en)
CA (1) CA2404040A1 (en)
CZ (1) CZ20023518A3 (en)
IL (1) IL151992A0 (en)
RU (1) RU2002129574A (en)
SK (1) SK15302002A3 (en)
WO (1) WO2001074296A2 (en)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BRPI0113757B1 (en) 2000-09-11 2017-05-23 Chiron Corp quinolinone derivatives as tyrosine kinase inhibitors
KR100847169B1 (en) 2000-12-21 2008-07-17 글락소 그룹 리미티드 Pyrimidineamines as angiogenesis modulators
EP1416960A4 (en) * 2001-07-13 2006-02-22 Imclone Systems Inc Vegfr-1 antibodies to treat breast cancer
DK1487856T3 (en) 2002-03-04 2010-10-18 Imclone Llc KDR-specific human antibodies and their use
EP2573079A3 (en) 2002-08-23 2015-03-11 Novartis AG Benzimidazole quinolinones and uses thereof
US7825132B2 (en) * 2002-08-23 2010-11-02 Novartis Vaccines And Diagnostics, Inc. Inhibition of FGFR3 and treatment of multiple myeloma
JP2007504122A (en) 2003-08-29 2007-03-01 ファイザー・インク Thienopyridine-phenylacetamide and its derivatives useful as novel anti-angiogenic agents
AP2006003619A0 (en) 2003-12-23 2006-06-30 Pfizer Novel quinoline derivatives
MX356412B (en) 2011-11-02 2018-05-29 Apexigen Inc Anti-kdr antibodies and methods of use.

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
DEDOUSSIS GEORGE V Z ET AL: "Endogenous interleukin 6 conveys resistance to cis-diamminedichloroplatinum-mediated apoptosis of the K562 human leukemic cell line", EXPERIMENTAL CELL RESEARCH, vol. 249, no. 2, 15 June 1999 (1999-06-15), pages 269 - 278, XP002267631, ISSN: 0014-4827 *
DIAS S ET AL: "NEUTRALIZING MOAB TO VERGF RECEPTORS INHIBIT PROFIFERATION AND MIGRATION OF A SUDSET OF HUMAN LEUKEMIAS THROUGH INTERACTION WITH VERGFR-2(KDR) AND VEGFR-1(FLT-1)", BLOOD, W.B.SAUNDERS COMPAGNY, ORLANDO, FL, US, vol. 94, no. 10,SUPPL01PT01, 15 November 1999 (1999-11-15), pages 620A, XP001021704, ISSN: 0006-4971 *
KATOH O ET AL: "EXPRESSION OF THE VASCULAR ENDOTHELIAL GROWTH FACTOR (VEGF) RECEPTOR GENE, KDR, IN HEMATOPOIETIC CELLS AND INHIBITORY EFFECT OF VEGF ON APOPTOTIC CELL DEATH CAUSED BY IONIZING RADIATION", CANCER RESEARCH, AMERICAN ASSOCIATION FOR CANCER RESEARCH, BALTIMORE, MD, US, vol. 55, 1 December 1995 (1995-12-01), pages 5687 - 5692, XP002915174, ISSN: 0008-5472 *
PREWETT MARIE ET AL: "Antivascular endothelial growth factor receptor (fetal liver kinase 1) monoclonal antibody inhibits tumor angiogenesis and growth of several mouse and human tumors", CANCER RESEARCH, vol. 59, no. 20, 15 October 1999 (1999-10-15), pages 5209 - 5218, XP002248647, ISSN: 0008-5472 *

Also Published As

Publication number Publication date
JP2004501070A (en) 2004-01-15
AU2001249736A1 (en) 2001-10-15
EP1436000A2 (en) 2004-07-14
KR20020087453A (en) 2002-11-22
CA2404040A1 (en) 2001-10-11
CZ20023518A3 (en) 2004-04-14
WO2001074296A2 (en) 2001-10-11
SK15302002A3 (en) 2004-06-08
RU2002129574A (en) 2004-04-20
IL151992A0 (en) 2003-04-10

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