WO2001072798A3 - Regulation of human oatp2-related protein - Google Patents

Regulation of human oatp2-related protein Download PDF

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Publication number
WO2001072798A3
WO2001072798A3 PCT/EP2001/003433 EP0103433W WO0172798A3 WO 2001072798 A3 WO2001072798 A3 WO 2001072798A3 EP 0103433 W EP0103433 W EP 0103433W WO 0172798 A3 WO0172798 A3 WO 0172798A3
Authority
WO
WIPO (PCT)
Prior art keywords
related protein
regulation
oatp2
human
human oatp2
Prior art date
Application number
PCT/EP2001/003433
Other languages
French (fr)
Other versions
WO2001072798A2 (en
Inventor
Jiing-Ren Liou
Original Assignee
Bayer Ag
Jiing-Ren Liou
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Ag, Jiing-Ren Liou filed Critical Bayer Ag
Priority to EP01938051A priority Critical patent/EP1272521A2/en
Priority to AU2001263814A priority patent/AU2001263814A1/en
Publication of WO2001072798A2 publication Critical patent/WO2001072798A2/en
Publication of WO2001072798A3 publication Critical patent/WO2001072798A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Toxicology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cell Biology (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

Human organic anion transporting polypeptide 2 OATP2-related protein can be regulated to facilitate clearance of drugs or other endogenous compounds in the liver.
PCT/EP2001/003433 2000-03-27 2001-03-27 Regulation of human oatp2-related protein WO2001072798A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
EP01938051A EP1272521A2 (en) 2000-03-27 2001-03-27 Regulation of human oatp2-related protein
AU2001263814A AU2001263814A1 (en) 2000-03-27 2001-03-27 Regulation of human oatp2-related protein

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US19231400P 2000-03-27 2000-03-27
US60/192,314 2000-03-27

Publications (2)

Publication Number Publication Date
WO2001072798A2 WO2001072798A2 (en) 2001-10-04
WO2001072798A3 true WO2001072798A3 (en) 2002-07-25

Family

ID=22709140

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2001/003433 WO2001072798A2 (en) 2000-03-27 2001-03-27 Regulation of human oatp2-related protein

Country Status (3)

Country Link
EP (1) EP1272521A2 (en)
AU (1) AU2001263814A1 (en)
WO (1) WO2001072798A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102373231A (en) * 2010-08-13 2012-03-14 中南大学 Recombinant plasmid containing OATP1B1 promoter and reporter gene and method for screening OATP1B1 inducer

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000008157A2 (en) * 1998-08-07 2000-02-17 Axys Pharmaceuticals, Inc. Human anion transporter genes atnov
WO2000012702A2 (en) * 1998-08-31 2000-03-09 Bayer Corporation Human genes differentially expressed in colorectal cancer
WO2000071566A2 (en) * 1999-05-20 2000-11-30 Bristol-Myers Squibb Co. Novel organic anion transport proteins
WO2000075315A1 (en) * 1999-06-03 2000-12-14 Sankyo Company, Limited Novel transporter gene expressed in liver
WO2001074897A2 (en) * 2000-04-03 2001-10-11 Curagen Corporation Protein amf-1 to amf-10 and nucleic acids encoding the same

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000008157A2 (en) * 1998-08-07 2000-02-17 Axys Pharmaceuticals, Inc. Human anion transporter genes atnov
WO2000012702A2 (en) * 1998-08-31 2000-03-09 Bayer Corporation Human genes differentially expressed in colorectal cancer
WO2000071566A2 (en) * 1999-05-20 2000-11-30 Bristol-Myers Squibb Co. Novel organic anion transport proteins
WO2000075315A1 (en) * 1999-06-03 2000-12-14 Sankyo Company, Limited Novel transporter gene expressed in liver
WO2001074897A2 (en) * 2000-04-03 2001-10-11 Curagen Corporation Protein amf-1 to amf-10 and nucleic acids encoding the same

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
HSIANG B ET AL: "A NOVEL HUMAN HEPATIC ORGANIC ANION TRANSPORTING POLYPEPTIDE (OATP2)", JOURNAL OF BIOLOGICAL CHEMISTRY, AMERICAN SOCIETY OF BIOLOGICAL CHEMISTS, BALTIMORE, MD, US, vol. 274, no. 52, 1999, pages 37161 - 37168, XP000877290, ISSN: 0021-9258 *
J. KÖNIG ET AL.,: "A novel human organic anion transporting polypeptide localized to the basolateral hepatocyte membrane", AM. J. PHYSIOL GASTROINTEST. LIVER PHYSIOL., vol. 278, no. 1, January 2000 (2000-01-01), pages G156 - G164, XP002191047 *
T. ABE ET AL.,: "Identification of a novel gene family encoding human liver-specific organic anion transporter LST-1", J BIOL CHEM, vol. 274, no. 24, 11 June 1999 (1999-06-11), pages 17159 - 17163, XP002191048 *

Also Published As

Publication number Publication date
AU2001263814A1 (en) 2001-10-08
EP1272521A2 (en) 2003-01-08
WO2001072798A2 (en) 2001-10-04

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