WO2001072120A3 - A strategy for maintaining pregnancy - Google Patents

A strategy for maintaining pregnancy Download PDF

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Publication number
WO2001072120A3
WO2001072120A3 PCT/US2001/009403 US0109403W WO0172120A3 WO 2001072120 A3 WO2001072120 A3 WO 2001072120A3 US 0109403 W US0109403 W US 0109403W WO 0172120 A3 WO0172120 A3 WO 0172120A3
Authority
WO
WIPO (PCT)
Prior art keywords
embryos
pregnancy
uterus
term
fertile
Prior art date
Application number
PCT/US2001/009403
Other languages
French (fr)
Other versions
WO2001072120A2 (en
Inventor
Timothy J King
Original Assignee
Geron Corp
Timothy J King
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0007297A external-priority patent/GB2360522A/en
Application filed by Geron Corp, Timothy J King filed Critical Geron Corp
Priority to AU2001247732A priority Critical patent/AU2001247732A1/en
Publication of WO2001072120A2 publication Critical patent/WO2001072120A2/en
Publication of WO2001072120A3 publication Critical patent/WO2001072120A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0603—Embryonic cells ; Embryoid bodies
    • C12N5/0604—Whole embryos; Culture medium therefor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K2035/122—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells for inducing tolerance or supression of immune responses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2510/00—Genetically modified cells

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Biotechnology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Developmental Biology & Embryology (AREA)
  • Chemical & Material Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Reproductive Health (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Cell Biology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

Pregnancy in animals such as the pig usually does not continue to term when there are only a few embryos in the uterus. Currently available technology for maintaining pregnancy involves a series of hormone injections, and the failure rate is high. It has now been discovered that pregnancy can be maintained by complementing fertile embryos in the uterus with additional embryos that aren't expected to survive the full term of the pregnancy. Particularly suitable are parthenogenetic embryos, formed by activating and diploidizing unfertilized oocytes. The carrier embryos are engrafted into the uterus of a surrogate female, and the pregnancy continues to term without further intervention - even if the number of fertile embryos is below the minimum litter size. This provides valuable biological material that can be used for transplantation, the production of pharmaceuticals, and for agricultural use.
PCT/US2001/009403 2000-03-24 2001-03-23 A strategy for maintaining pregnancy WO2001072120A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2001247732A AU2001247732A1 (en) 2000-03-24 2001-03-23 A strategy for maintaining pregnancy

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB0007297.5 2000-03-24
GB0007297A GB2360522A (en) 2000-03-24 2000-03-24 A strategy for maintaining pregnancy
US09/538,867 2000-03-29
US09/538,867 US6673987B1 (en) 2000-03-24 2000-03-29 Strategy for maintaining pregnancy

Publications (2)

Publication Number Publication Date
WO2001072120A2 WO2001072120A2 (en) 2001-10-04
WO2001072120A3 true WO2001072120A3 (en) 2002-02-14

Family

ID=26243963

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/009403 WO2001072120A2 (en) 2000-03-24 2001-03-23 A strategy for maintaining pregnancy

Country Status (2)

Country Link
AU (1) AU2001247732A1 (en)
WO (1) WO2001072120A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MXPA03006751A (en) * 2001-01-30 2005-04-08 Amy K Rebholtz Systems of transferring embryos and managing recipients.

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1991016419A1 (en) * 1990-04-17 1991-10-31 Pherin Corporation Methods of tissue implantation
US5843754A (en) * 1993-02-10 1998-12-01 Abs Global, Inc. Parthenogenic bovine oocyte activation
WO1999001164A1 (en) * 1997-07-03 1999-01-14 University Of Massachusetts, A Public Institution Of Higher Education Of The Commonwealth Of Massachusetts, Represented By Its Amherst Campus Cloning pigs using donor nuclei from differentiated cells
WO1999021415A1 (en) * 1997-10-28 1999-05-06 Stem Cell Sciences Pty. Ltd. Nuclear transfer for production of transgenic animal embryo
WO1999046982A1 (en) * 1998-03-16 1999-09-23 Relag Pty Ltd Porcine nuclear transfer

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1991016419A1 (en) * 1990-04-17 1991-10-31 Pherin Corporation Methods of tissue implantation
US5843754A (en) * 1993-02-10 1998-12-01 Abs Global, Inc. Parthenogenic bovine oocyte activation
WO1999001164A1 (en) * 1997-07-03 1999-01-14 University Of Massachusetts, A Public Institution Of Higher Education Of The Commonwealth Of Massachusetts, Represented By Its Amherst Campus Cloning pigs using donor nuclei from differentiated cells
WO1999021415A1 (en) * 1997-10-28 1999-05-06 Stem Cell Sciences Pty. Ltd. Nuclear transfer for production of transgenic animal embryo
WO1999046982A1 (en) * 1998-03-16 1999-09-23 Relag Pty Ltd Porcine nuclear transfer

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
NAGY A ET AL: "Derivation of completely cell culture-derived mice from early-passage embryonic stem cells", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA., vol. 90, no. 18, 15 September 1993 (1993-09-15), pages 8424 - 8428, XP002182191 *
PRATHER R S ET AL: "CHARACTERIZATION OF DNA SYNTHESIS DURING THE 2-CELL STAGE AND THE PRODUCTION OF TETRAPLOID CHIMERIC PIG EMBRYOS", MOLECULAR REPRODUCTION AND DEVELOPMENT, NEW YORK, NY, US, vol. 45, no. 1, 1 September 1996 (1996-09-01), pages 38 - 42, XP002049676 *

Also Published As

Publication number Publication date
AU2001247732A1 (en) 2001-10-08
WO2001072120A2 (en) 2001-10-04

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