WO2001070330A3 - Non-invasive body fluid sampling and analysis - Google Patents

Non-invasive body fluid sampling and analysis Download PDF

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Publication number
WO2001070330A3
WO2001070330A3 PCT/US2001/008489 US0108489W WO0170330A3 WO 2001070330 A3 WO2001070330 A3 WO 2001070330A3 US 0108489 W US0108489 W US 0108489W WO 0170330 A3 WO0170330 A3 WO 0170330A3
Authority
WO
WIPO (PCT)
Prior art keywords
body fluid
area
receiver
biological membrane
membrane
Prior art date
Application number
PCT/US2001/008489
Other languages
French (fr)
Other versions
WO2001070330A2 (en
Inventor
Linda Custer
Tuan A Elstrom
Scott C Kellogg
Joseph Kost
Nicholas F Warner
Original Assignee
Sontra Medical Inc
Linda Custer
Tuan A Elstrom
Scott C Kellogg
Joseph Kost
Nicholas F Warner
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sontra Medical Inc, Linda Custer, Tuan A Elstrom, Scott C Kellogg, Joseph Kost, Nicholas F Warner filed Critical Sontra Medical Inc
Priority to CA002374751A priority Critical patent/CA2374751C/en
Priority to AU45809/01A priority patent/AU781149B2/en
Priority to JP2001568521A priority patent/JP2003527613A/en
Priority to US09/979,096 priority patent/US7066884B2/en
Priority to EP01918770A priority patent/EP1225831A2/en
Publication of WO2001070330A2 publication Critical patent/WO2001070330A2/en
Publication of WO2001070330A3 publication Critical patent/WO2001070330A3/en
Priority to US11/065,278 priority patent/US20060015058A1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/14507—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue specially adapted for measuring characteristics of body fluids other than blood
    • A61B5/1451—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue specially adapted for measuring characteristics of body fluids other than blood for interstitial fluid
    • A61B5/14514—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue specially adapted for measuring characteristics of body fluids other than blood for interstitial fluid using means for aiding extraction of interstitial fluid, e.g. microneedles or suction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/14532—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue for measuring glucose, e.g. by tissue impedance measurement
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0092—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin using ultrasonic, sonic or infrasonic vibrations, e.g. phonophoresis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M2037/0007—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin having means for enhancing the permeation of substances through the epidermis, e.g. using suction or depression, electric or magnetic fields, sound waves or chemical agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biomedical Technology (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Optics & Photonics (AREA)
  • Biophysics (AREA)
  • Pathology (AREA)
  • Surgery (AREA)
  • Anesthesiology (AREA)
  • Dermatology (AREA)
  • Hematology (AREA)
  • Emergency Medicine (AREA)
  • Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
  • Sampling And Sample Adjustment (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

A system, method, and device for non-invasive body fluid sampling is provided. According to one embodiment of the present invention, the system includes a controller that controls the generation of ultrasound; an ultrasonic applicator that applies the ultrasound to an area of biological membrane; a receiver that contacts the area of biological membrane and receives body fluid through and out of the area of biological membrane; and a meter that interacts with the receiver and detects the presence of at least one analyte in the body fluid in the receiver. The receiver may include a membrane and a medium, such as a hydrogel, a fluid, or a liquid, that is contained in the membrane. According to one embodiment of the present invention, the method includes the steps of (1) identifying an area of biological membrane having a permeability level; (2) increasing the permeability level of the area of biological membrane; (3) contacting the area of biological membrane with a receiver; (4) extracting body fluid through and out of the area of biological membrane; (5) providing an external force to enhance the body fluid extraction; (6) collecting the body fluid in the receiver; (7) analyzing the collected body fluid for the presence of at least one analyte; and (8) providing the results of the step of analyzing the body fluid.
PCT/US2001/008489 1998-01-08 2001-03-16 Non-invasive body fluid sampling and analysis WO2001070330A2 (en)

Priority Applications (6)

Application Number Priority Date Filing Date Title
CA002374751A CA2374751C (en) 2000-03-17 2001-03-16 System, method, and device for non-invasive body fluid sampling and analysis
AU45809/01A AU781149B2 (en) 2000-03-17 2001-03-16 System, method, and device for non-invasive body fluid sampling and analysis
JP2001568521A JP2003527613A (en) 2000-03-17 2001-03-16 Systems, methods and devices for non-invasive sampling and analysis of body fluids
US09/979,096 US7066884B2 (en) 1998-01-08 2001-03-16 System, method, and device for non-invasive body fluid sampling and analysis
EP01918770A EP1225831A2 (en) 2000-03-17 2001-03-16 Non-invasive body fluid sampling and analysis
US11/065,278 US20060015058A1 (en) 1998-01-08 2005-02-25 Agents and methods for enhancement of transdermal transport

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US18997100P 2000-03-17 2000-03-17
US60/189,971 2000-03-17

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US11/065,278 Continuation-In-Part US20060015058A1 (en) 1998-01-08 2005-02-25 Agents and methods for enhancement of transdermal transport

Publications (2)

Publication Number Publication Date
WO2001070330A2 WO2001070330A2 (en) 2001-09-27
WO2001070330A3 true WO2001070330A3 (en) 2002-05-23

Family

ID=22699523

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/008489 WO2001070330A2 (en) 1998-01-08 2001-03-16 Non-invasive body fluid sampling and analysis

Country Status (5)

Country Link
EP (1) EP1225831A2 (en)
JP (2) JP2003527613A (en)
AU (1) AU781149B2 (en)
CA (1) CA2374751C (en)
WO (1) WO2001070330A2 (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8870810B2 (en) 1998-12-18 2014-10-28 Echo Therapeutics, Inc. Method and apparatus for enhancement of transdermal transport
US9572527B2 (en) 2007-04-27 2017-02-21 Echo Therapeutics, Inc. Skin permeation device for analyte sensing or transdermal drug delivery

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ512367A (en) * 2001-06-14 2005-05-27 Horticulture & Food Res Inst Non-invasive transudate extraction
US8224414B2 (en) * 2004-10-28 2012-07-17 Echo Therapeutics, Inc. System and method for analyte sampling and analysis with hydrogel
JP5502279B2 (en) * 2004-10-28 2014-05-28 エコー セラピューティクス， インコーポレイテッド System and method for analyte sampling and analysis using hydrogels
JP2006167428A (en) * 2004-11-16 2006-06-29 Sysmex Corp Analyte extraction device, analyzer, analyte extraction method, and analysis method
US8343134B2 (en) 2006-06-13 2013-01-01 Ben Gurion University Of The Negev Research And Development Authority System and method for transfetal (amnion-chorion) membranes transport
RU2444980C2 (en) 2007-03-07 2012-03-20 Эко Терапьютикс, Инк. Transdermal system of analite monitoring and methods of analite detection
JP2010266203A (en) * 2008-05-20 2010-11-25 Sony Corp Method and device for acquisition of biological information, and method and device for measurement of physiologically active substance
JP5350382B2 (en) * 2008-07-31 2013-11-27 シスメックス株式会社 In vivo component measuring method, in vivo component measuring data processing method, and in vivo component measuring device
EP2376059A2 (en) * 2008-11-25 2011-10-19 B.G. Negev Technologies and Applications Ltd. Pharmaceutical composition and system for permeabilizing fetal membranes
JP5406646B2 (en) * 2009-09-16 2014-02-05 シスメックス株式会社 Tissue fluid collection kit and tissue fluid collection sheet used for tissue fluid collection method
US20140243737A1 (en) * 2011-10-05 2014-08-28 Koninklijke Philips N.V. Assays for ultrasound mediated delivery
KR102673720B1 (en) 2016-07-29 2024-06-07 삼성전자주식회사 Apparatus and method for estimating substance in blood
KR102638309B1 (en) 2016-10-26 2024-02-19 삼성전자주식회사 Wearable device, and method for health monitoring
KR20180054351A (en) 2016-11-15 2018-05-24 삼성전자주식회사 Apparatus and method for measuring biological components
KR102658240B1 (en) 2016-11-17 2024-04-16 삼성전자주식회사 Apparatus and method for estimating biological information

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997004832A1 (en) * 1995-07-25 1997-02-13 Massachusetts Institute Of Technology Enhanced transdermal transport using ultrasound
WO1997030628A1 (en) * 1996-02-23 1997-08-28 Abbott Laboratories Enhanced transdermal transport of fluid using vacuum
WO1998000194A2 (en) * 1996-06-28 1998-01-08 Sontra Medical, L.P. Ultrasound enhancement of transdermal transport
US5722397A (en) * 1993-11-15 1998-03-03 Altea Technologies, Inc. Enhancement of transdermal monitoring applications with ultrasound and chemical enhancers
WO1999034858A1 (en) * 1998-01-12 1999-07-15 Georgia Tech Research Corporation Assessment and control of acoustic tissue effects
WO2000004821A1 (en) * 1998-07-21 2000-02-03 Spectrx, Inc. Fluid management in a continuous fluid collection and sensor device

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US4767402A (en) 1986-07-08 1988-08-30 Massachusetts Institute Of Technology Ultrasound enhancement of transdermal drug delivery
WO1989006989A1 (en) 1988-01-29 1989-08-10 The Regents Of The University Of California Iontophoretic non-invasive sampling or delivery device
US5139023A (en) * 1989-06-02 1992-08-18 Theratech Inc. Apparatus and method for noninvasive blood glucose monitoring
EP1016433A1 (en) * 1994-06-24 2000-07-05 Cygnus, Inc. Iontophoteric sampling device and method
DE69630226T2 (en) * 1995-07-12 2004-08-05 Cygnus, Inc., Redwood City hydrogel
US6002961A (en) 1995-07-25 1999-12-14 Massachusetts Institute Of Technology Transdermal protein delivery using low-frequency sonophoresis
US5947921A (en) 1995-12-18 1999-09-07 Massachusetts Institute Of Technology Chemical and physical enhancers and ultrasound for transdermal drug delivery
US5735273A (en) * 1995-09-12 1998-04-07 Cygnus, Inc. Chemical signal-impermeable mask
US5895362A (en) * 1996-02-23 1999-04-20 Abbott Laboratories Transdermal transport using ultrasonic standing waves
DK0914178T3 (en) * 1996-06-18 2003-04-22 Alza Corp Device for enhancing transdermal delivery or sampling of an agent
AU740999B2 (en) 1998-01-08 2001-11-22 Sontra Medical, Inc. Sonophoretic enhanced transdermal transport
CA2265119C (en) * 1998-03-13 2002-12-03 Cygnus, Inc. Biosensor, iontophoretic sampling system, and methods of use thereof
ATE220936T1 (en) * 1998-05-13 2002-08-15 Cygnus Therapeutic Systems COLLECTION DEVICES FOR TRANSDERMAL SAMPLING SYSTEMS
JP2002542841A (en) 1998-12-18 2002-12-17 ソントラ・メディカル・インコーポレーテッド Method and apparatus for producing a homogeneous cavity that facilitates transdermal movement

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5722397A (en) * 1993-11-15 1998-03-03 Altea Technologies, Inc. Enhancement of transdermal monitoring applications with ultrasound and chemical enhancers
WO1997004832A1 (en) * 1995-07-25 1997-02-13 Massachusetts Institute Of Technology Enhanced transdermal transport using ultrasound
WO1997030628A1 (en) * 1996-02-23 1997-08-28 Abbott Laboratories Enhanced transdermal transport of fluid using vacuum
WO1998000194A2 (en) * 1996-06-28 1998-01-08 Sontra Medical, L.P. Ultrasound enhancement of transdermal transport
WO1999034858A1 (en) * 1998-01-12 1999-07-15 Georgia Tech Research Corporation Assessment and control of acoustic tissue effects
WO2000004821A1 (en) * 1998-07-21 2000-02-03 Spectrx, Inc. Fluid management in a continuous fluid collection and sensor device

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8870810B2 (en) 1998-12-18 2014-10-28 Echo Therapeutics, Inc. Method and apparatus for enhancement of transdermal transport
US9572527B2 (en) 2007-04-27 2017-02-21 Echo Therapeutics, Inc. Skin permeation device for analyte sensing or transdermal drug delivery

Also Published As

Publication number Publication date
JP2003527613A (en) 2003-09-16
AU781149B2 (en) 2005-05-05
EP1225831A2 (en) 2002-07-31
CA2374751C (en) 2009-10-13
AU4580901A (en) 2001-10-03
WO2001070330A2 (en) 2001-09-27
JP2012068263A (en) 2012-04-05
CA2374751A1 (en) 2001-09-27

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