CA2374751A1 - System, method, and device for non-invasive body fluid sampling and analysis - Google Patents

System, method, and device for non-invasive body fluid sampling and analysis Download PDF

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Publication number
CA2374751A1
CA2374751A1 CA002374751A CA2374751A CA2374751A1 CA 2374751 A1 CA2374751 A1 CA 2374751A1 CA 002374751 A CA002374751 A CA 002374751A CA 2374751 A CA2374751 A CA 2374751A CA 2374751 A1 CA2374751 A1 CA 2374751A1
Authority
CA
Canada
Prior art keywords
body fluid
area
receiver
biological membrane
membrane
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002374751A
Other languages
French (fr)
Other versions
CA2374751C (en
Inventor
Linda Custer
Tuan A. Elstrom
Scott C. Kellogg
Joseph Kost
Nicholas F. Warner
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Echo Therapeutics Inc
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2374751A1 publication Critical patent/CA2374751A1/en
Application granted granted Critical
Publication of CA2374751C publication Critical patent/CA2374751C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/14507—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue specially adapted for measuring characteristics of body fluids other than blood
    • A61B5/1451—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue specially adapted for measuring characteristics of body fluids other than blood for interstitial fluid
    • A61B5/14514—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue specially adapted for measuring characteristics of body fluids other than blood for interstitial fluid using means for aiding extraction of interstitial fluid, e.g. microneedles or suction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/14532—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue for measuring glucose, e.g. by tissue impedance measurement
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0092—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin using ultrasonic, sonic or infrasonic vibrations, e.g. phonophoresis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M2037/0007—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin having means for enhancing the permeation of substances through the epidermis, e.g. using suction or depression, electric or magnetic fields, sound waves or chemical agents

Abstract

A system, method, and device for non-in-vasive body fluid sampling is provided. According to one embodiment of the present invention, the system includes a controller that controls the generation of ultrasound; an ultrasonic applicator that applies the ultrasound to an area of biological membrane; a receiver that contacts the area of biological membrane and receives body fluid through and out of the area of biological membrane; and a meter that interacts with the receiver and detects the presence of at least one analyte in the body fluid in the receiver. The receiver may include a membrane and a medium, such as a hydrogel, a fluid, or a liquid, that is contained in the membrane. According to one embodiment of the present invention, the method includes the steps of (1) identifying an area of biological membrane having a permeability level;
(2) increasing the permeability level of the area of biological membrane; (3) contacting the area of biological membrane with a receiver; (4) extracting body fluid through and out of the area of biological membrane; (5) providing an external force to enhance the body fluid extraction; (6) collecting the body fluid in the receiver; (7) analyzing the collected body fluid for the presence of at least one analyte;
and (8) providing the results of the step of analyzing the body fluid.
CA002374751A 2000-03-17 2001-03-16 System, method, and device for non-invasive body fluid sampling and analysis Expired - Fee Related CA2374751C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US18997100P 2000-03-17 2000-03-17
US60/189,971 2000-03-17
PCT/US2001/008489 WO2001070330A2 (en) 2000-03-17 2001-03-16 Non-invasive body fluid sampling and analysis

Publications (2)

Publication Number Publication Date
CA2374751A1 true CA2374751A1 (en) 2001-09-27
CA2374751C CA2374751C (en) 2009-10-13

Family

ID=22699523

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002374751A Expired - Fee Related CA2374751C (en) 2000-03-17 2001-03-16 System, method, and device for non-invasive body fluid sampling and analysis

Country Status (5)

Country Link
EP (1) EP1225831A2 (en)
JP (2) JP2003527613A (en)
AU (1) AU781149B2 (en)
CA (1) CA2374751C (en)
WO (1) WO2001070330A2 (en)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040171980A1 (en) 1998-12-18 2004-09-02 Sontra Medical, Inc. Method and apparatus for enhancement of transdermal transport
NZ512367A (en) * 2001-06-14 2005-05-27 Horticulture & Food Res Inst Non-invasive transudate extraction
US20060094945A1 (en) 2004-10-28 2006-05-04 Sontra Medical Corporation System and method for analyte sampling and analysis
JP5502279B2 (en) * 2004-10-28 2014-05-28 エコー セラピューティクス， インコーポレイテッド System and method for analyte sampling and analysis using hydrogels
JP2006167428A (en) 2004-11-16 2006-06-29 Sysmex Corp Analyte extraction device, analyzer, analyte extraction method, and analysis method
US8343134B2 (en) 2006-06-13 2013-01-01 Ben Gurion University Of The Negev Research And Development Authority System and method for transfetal (amnion-chorion) membranes transport
WO2008109739A1 (en) 2007-03-07 2008-09-12 Echo Therapeutics, Inc. Transdermal analyte monitoring systems and methods for analyte detection
DK2152358T3 (en) 2007-04-27 2011-06-27 Echo Therapeutics Inc Skin penetration device for analyte measurement and transdermal drug delivery
JP2010266203A (en) * 2008-05-20 2010-11-25 Sony Corp Method and device for acquisition of biological information, and method and device for measurement of physiologically active substance
CN102105103B (en) 2008-07-31 2015-09-09 希森美康株式会社 The in vivo assay method of composition, for the data processing method of in vivo composition measurement, in vivo component measuring device and collecting part
EP2376059A2 (en) * 2008-11-25 2011-10-19 B.G. Negev Technologies and Applications Ltd. Pharmaceutical composition and system for permeabilizing fetal membranes
JP5406646B2 (en) * 2009-09-16 2014-02-05 シスメックス株式会社 Tissue fluid collection kit and tissue fluid collection sheet used for tissue fluid collection method
MX2014003957A (en) * 2011-10-05 2014-04-30 Koninkl Philips Nv Assays for ultrasound mediated delivery.
KR20180013518A (en) 2016-07-29 2018-02-07 삼성전자주식회사 Apparatus and method for estimating substance in bloo and, wearable device
KR102638309B1 (en) 2016-10-26 2024-02-19 삼성전자주식회사 Wearable device, and method for health monitoring
KR20180054351A (en) 2016-11-15 2018-05-24 삼성전자주식회사 Apparatus and method for measuring biological components
US10390701B2 (en) 2016-11-17 2019-08-27 Samsung Electronics Co., Ltd. Apparatus and method for estimating biometric information

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4767402A (en) 1986-07-08 1988-08-30 Massachusetts Institute Of Technology Ultrasound enhancement of transdermal drug delivery
KR970011449B1 (en) 1988-01-29 1997-07-11 더 리전트 오브 디 유니버시티 오브 캘리포니아 Device for iontophoretic non-invasive sampling or delivery of substances
US5139023A (en) * 1989-06-02 1992-08-18 Theratech Inc. Apparatus and method for noninvasive blood glucose monitoring
US5458140A (en) * 1993-11-15 1995-10-17 Non-Invasive Monitoring Company (Nimco) Enhancement of transdermal monitoring applications with ultrasound and chemical enhancers
ATE196741T1 (en) * 1994-06-24 2000-10-15 Cygnus Therapeutic Systems IONTOPHORETIC SAMPLING DEVICE
DE69630226T2 (en) * 1995-07-12 2004-08-05 Cygnus, Inc., Redwood City hydrogel
US6002961A (en) 1995-07-25 1999-12-14 Massachusetts Institute Of Technology Transdermal protein delivery using low-frequency sonophoresis
DE69624668T2 (en) * 1995-07-25 2003-08-28 Massachusetts Inst Technology IMPROVED TRANSDERMAL TRANSPORTATION USING ULTRASOUND
US5947921A (en) 1995-12-18 1999-09-07 Massachusetts Institute Of Technology Chemical and physical enhancers and ultrasound for transdermal drug delivery
US5735273A (en) * 1995-09-12 1998-04-07 Cygnus, Inc. Chemical signal-impermeable mask
US5895362A (en) * 1996-02-23 1999-04-20 Abbott Laboratories Transdermal transport using ultrasonic standing waves
US6009343A (en) 1996-02-23 1999-12-28 Abbott Laboratories Enhanced transdermal transport of fluid using vacuum
DE69719761T2 (en) * 1996-06-18 2003-12-18 Alza Corp DEVICE FOR IMPROVING THE TRANSDERMAL ADMINISTRATION OF MEDICINAL PRODUCTS OR THE DETECTION OF BODY LIQUIDS
WO1998000194A2 (en) * 1996-06-28 1998-01-08 Sontra Medical, L.P. Ultrasound enhancement of transdermal transport
AU740999B2 (en) 1998-01-08 2001-11-22 Sontra Medical, Inc. Sonophoretic enhanced transdermal transport
US7273458B2 (en) * 1998-01-12 2007-09-25 Georgia Tech Research Corporation Method of applying acoustic energy effective to alter transport or cell viability
CA2265119C (en) * 1998-03-13 2002-12-03 Cygnus, Inc. Biosensor, iontophoretic sampling system, and methods of use thereof
WO1999058190A1 (en) * 1998-05-13 1999-11-18 Cygnus, Inc. Collection assemblies for transdermal sampling system
ATE318103T1 (en) * 1998-07-21 2006-03-15 Spectrx Inc DEVICE FOR CONTINUOUS EXTRACTION AND ANALYSIS OF LIQUIDS
EP1139880A4 (en) 1998-12-18 2005-08-17 Sontra Medical Inc Method and apparatus for producing homogenous cavitation to enhance transdermal transport

Also Published As

Publication number Publication date
AU781149B2 (en) 2005-05-05
JP2012068263A (en) 2012-04-05
EP1225831A2 (en) 2002-07-31
WO2001070330A3 (en) 2002-05-23
CA2374751C (en) 2009-10-13
JP2003527613A (en) 2003-09-16
AU4580901A (en) 2001-10-03
WO2001070330A2 (en) 2001-09-27

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Effective date: 20190318