WO2001068862A1 - Polypeptide zins4 homologue de l'insuline - Google Patents

Polypeptide zins4 homologue de l'insuline Download PDF

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Publication number
WO2001068862A1
WO2001068862A1 PCT/US2001/004199 US0104199W WO0168862A1 WO 2001068862 A1 WO2001068862 A1 WO 2001068862A1 US 0104199 W US0104199 W US 0104199W WO 0168862 A1 WO0168862 A1 WO 0168862A1
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WO
WIPO (PCT)
Prior art keywords
seq
polypeptide
amino acid
residue
zins4
Prior art date
Application number
PCT/US2001/004199
Other languages
English (en)
Inventor
James L. Holloway
Si Lok
Stephen R. Jaspers
Original Assignee
Zymogenetics, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zymogenetics, Inc. filed Critical Zymogenetics, Inc.
Priority to AU2001236817A priority Critical patent/AU2001236817A1/en
Priority to CA002402614A priority patent/CA2402614A1/fr
Priority to EP01909021A priority patent/EP1294887A1/fr
Priority to JP2001567346A priority patent/JP2003526373A/ja
Publication of WO2001068862A1 publication Critical patent/WO2001068862A1/fr

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6454—Dibasic site splicing serine proteases, e.g. kexin (3.4.21.61); furin (3.4.21.75) and other proprotein convertases
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/04—Drugs for genital or sexual disorders; Contraceptives for inducing labour or abortion; Uterotonics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/64—Relaxins

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Endocrinology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Genetics & Genomics (AREA)
  • Reproductive Health (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Pregnancy & Childbirth (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Neurosurgery (AREA)
  • Cardiology (AREA)
  • Neurology (AREA)
  • Diabetes (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • General Engineering & Computer Science (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

L'invention concerne des molécules polynucléotidiques et polypeptidiques destinées au polypeptide zins4, un nouveau polypeptide présentant une homologie avec les relaxines. On peut, par exemple, utiliser les polynucléotides codant pour le polypeptide zins4 afin d'identifier une région du génome associée à des états pathologiques humains. L'invention concerne également des procédés permettant de produire cette protéine, ses utilisateurs et ses anticorps.
PCT/US2001/004199 2000-03-10 2001-02-09 Polypeptide zins4 homologue de l'insuline WO2001068862A1 (fr)

Priority Applications (4)

Application Number Priority Date Filing Date Title
AU2001236817A AU2001236817A1 (en) 2000-03-10 2001-02-09 Insulin homolog polypeptide zins4
CA002402614A CA2402614A1 (fr) 2000-03-10 2001-02-09 Polypeptide zins4 homologue de l'insuline
EP01909021A EP1294887A1 (fr) 2000-03-10 2001-02-09 Polypeptide zins4 homologue de l'insuline
JP2001567346A JP2003526373A (ja) 2000-03-10 2001-02-09 インスリン相同体ポリペプチドｚｉｎｓ４

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US52334600A 2000-03-10 2000-03-10
US09/523,346 2000-03-10

Publications (1)

Publication Number Publication Date
WO2001068862A1 true WO2001068862A1 (fr) 2001-09-20

Family

ID=24084640

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/004199 WO2001068862A1 (fr) 2000-03-10 2001-02-09 Polypeptide zins4 homologue de l'insuline

Country Status (5)

Country Link
EP (1) EP1294887A1 (fr)
JP (1) JP2003526373A (fr)
AU (1) AU2001236817A1 (fr)
CA (1) CA2402614A1 (fr)
WO (1) WO2001068862A1 (fr)

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1283260A1 (fr) * 2000-04-21 2003-02-12 Takeda Chemical Industries, Ltd. Nouveaux polypeptides appartenant a la famille insuline/igf/relaxine et adn correspondants
WO2003030930A1 (fr) * 2001-10-08 2003-04-17 Howard Florey Institute Of Experimental Physiology And Medicine Relaxine humaine 3
WO2005075641A1 (fr) 2004-02-09 2005-08-18 Eisai R & D Management Co., Ltd. Procede de test de selection
EP1636384A2 (fr) * 2003-06-20 2006-03-22 Tularik Inc. Amplification et surexpression geniques dans le cancer
EP1789452A2 (fr) * 2004-08-25 2007-05-30 Janssen Pharmaceutica N.V. Polypeptides chimères de relaxine-3 et leur préparation et leur utilisation
EP2129359A2 (fr) * 2007-01-30 2009-12-09 Janssen Pharmaceutica, N.V. Peptide chimère antagoniste du gpcr1 35 ou du gpcr1 42
US7893197B2 (en) 2004-08-25 2011-02-22 Janssen Pharmaceutica N.V. Relaxin-3 chimeric polypeptides and their preparation and use

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998005782A1 (fr) * 1996-08-02 1998-02-12 Zymogenetics, Inc. Polypeptides homologues de l'insuline, specifiques des testicules
WO1998016635A1 (fr) * 1996-10-15 1998-04-23 Zymogenetics, Inc. Homologues de l'insuline
WO1998027210A1 (fr) * 1996-12-16 1998-06-25 Zymogenetics, Inc. Compositions et methodes pour stimuler la regeneration des cellules des ilots pancreatiques

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998005782A1 (fr) * 1996-08-02 1998-02-12 Zymogenetics, Inc. Polypeptides homologues de l'insuline, specifiques des testicules
WO1998016635A1 (fr) * 1996-10-15 1998-04-23 Zymogenetics, Inc. Homologues de l'insuline
WO1998027210A1 (fr) * 1996-12-16 1998-06-25 Zymogenetics, Inc. Compositions et methodes pour stimuler la regeneration des cellules des ilots pancreatiques

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
BELL G I ET AL: "SEQUENCE OF THE HUMAN INSULIN GENE", NATURE,GB,MACMILLAN JOURNALS LTD. LONDON, vol. 284, 6 March 1980 (1980-03-06), pages 26 - 32, XP000616174, ISSN: 0028-0836 *
DATABASE EMBL/GENBANK/DDBJ 27 January 2000 (2000-01-27), DOE JOINT GENOME INSTITUTE: "Homo sapiens chromosome 19 clone CTB-5506", XP002170031 *

Cited By (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1283260A4 (fr) * 2000-04-21 2004-08-18 Takeda Chemical Industries Ltd Nouveaux polypeptides appartenant a la famille insuline/igf/relaxine et adn correspondants
EP1283260A1 (fr) * 2000-04-21 2003-02-12 Takeda Chemical Industries, Ltd. Nouveaux polypeptides appartenant a la famille insuline/igf/relaxine et adn correspondants
US7410641B2 (en) 2000-04-21 2008-08-12 Takeda Pharmaceutical Company Limited Antibodies to insulin/IGF/relaxin family polypeptides
AU2002331460B2 (en) * 2001-10-08 2008-01-24 Howard Florey Institute Of Experimental Physiology And Medicine Human 3 relaxin
WO2003030930A1 (fr) * 2001-10-08 2003-04-17 Howard Florey Institute Of Experimental Physiology And Medicine Relaxine humaine 3
US8841254B2 (en) 2001-10-08 2014-09-23 Howard Florey Institute Of Experimental Physiology And Medicine Method for treatment of anxiety
AU2008201803B2 (en) * 2001-10-08 2011-06-30 Howard Florey Institute Of Experimental Physiology And Medicine Human 3 relaxin
EP1636384A2 (fr) * 2003-06-20 2006-03-22 Tularik Inc. Amplification et surexpression geniques dans le cancer
EP1636384A4 (fr) * 2003-06-20 2007-03-07 Amgen Inc Amplification et surexpression geniques dans le cancer
AU2005210369B2 (en) * 2004-02-09 2008-11-13 Eisai R & D Management Co., Ltd. Screening method
US7638490B2 (en) 2004-02-09 2009-12-29 Eisai R&D Managment Co., Ltd. Methods of affecting feeding and weight in mammals by administration of relaxin-3
WO2005075641A1 (fr) 2004-02-09 2005-08-18 Eisai R & D Management Co., Ltd. Procede de test de selection
EP1789452A2 (fr) * 2004-08-25 2007-05-30 Janssen Pharmaceutica N.V. Polypeptides chimères de relaxine-3 et leur préparation et leur utilisation
EP1789452A4 (fr) * 2004-08-25 2008-11-05 Janssen Pharmaceutica Nv Polypeptides chimères de relaxine-3 et leur préparation et leur utilisation
US7893197B2 (en) 2004-08-25 2011-02-22 Janssen Pharmaceutica N.V. Relaxin-3 chimeric polypeptides and their preparation and use
EP2129359A2 (fr) * 2007-01-30 2009-12-09 Janssen Pharmaceutica, N.V. Peptide chimère antagoniste du gpcr1 35 ou du gpcr1 42
EP2129359A4 (fr) * 2007-01-30 2011-05-18 Janssen Pharmaceutica Nv Peptide chimère antagoniste du gpcr1 35 ou du gpcr1 42
US8299028B2 (en) 2007-01-30 2012-10-30 Janssen Pharmaceutica Nv Chimeric peptide antagonist for GPCR135 or GPCR142

Also Published As

Publication number Publication date
EP1294887A1 (fr) 2003-03-26
AU2001236817A1 (en) 2001-09-24
JP2003526373A (ja) 2003-09-09
CA2402614A1 (fr) 2001-09-20

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