WO2001068681A3 - Altered ion channel proteins - Google Patents

Altered ion channel proteins Download PDF

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Publication number
WO2001068681A3
WO2001068681A3 PCT/GB2001/001108 GB0101108W WO0168681A3 WO 2001068681 A3 WO2001068681 A3 WO 2001068681A3 GB 0101108 W GB0101108 W GB 0101108W WO 0168681 A3 WO0168681 A3 WO 0168681A3
Authority
WO
WIPO (PCT)
Prior art keywords
ion channel
channel proteins
altered
altered ion
disclosed
Prior art date
Application number
PCT/GB2001/001108
Other languages
French (fr)
Other versions
WO2001068681A2 (en
Inventor
Alan John Aitken
Mao Xing Chen
Zoe Marie Gladwell
Andrew Jonathan Powell
Simon Nicholas Tate
Original Assignee
Glaxo Group Ltd
Alan John Aitken
Mao Xing Chen
Zoe Marie Gladwell
Andrew Jonathan Powell
Simon Nicholas Tate
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Group Ltd, Alan John Aitken, Mao Xing Chen, Zoe Marie Gladwell, Andrew Jonathan Powell, Simon Nicholas Tate filed Critical Glaxo Group Ltd
Priority to AU40822/01A priority Critical patent/AU4082201A/en
Publication of WO2001068681A2 publication Critical patent/WO2001068681A2/en
Publication of WO2001068681A3 publication Critical patent/WO2001068681A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Immunology (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cell Biology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

Altered ion channel proteins having acquired sensitivity to gating agents are disclosed. The invention is directed towards those ion channels that are refractory to gating agents. The altered ion channel proteins are of use in identifying modulators of the unaltered ion channel. Host cells, vectors and screening assays are also disclosed.
PCT/GB2001/001108 2000-03-14 2001-03-14 Altered ion channel proteins WO2001068681A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU40822/01A AU4082201A (en) 2000-03-14 2001-03-14 Altered ion channel proteins

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB0006024.4 2000-03-14
GB0006024A GB0006024D0 (en) 2000-03-14 2000-03-14 Altered ion channel proteins

Publications (2)

Publication Number Publication Date
WO2001068681A2 WO2001068681A2 (en) 2001-09-20
WO2001068681A3 true WO2001068681A3 (en) 2002-01-24

Family

ID=9887523

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2001/001108 WO2001068681A2 (en) 2000-03-14 2001-03-14 Altered ion channel proteins

Country Status (3)

Country Link
AU (1) AU4082201A (en)
GB (1) GB0006024D0 (en)
WO (1) WO2001068681A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2400103A (en) * 2003-04-02 2004-10-06 Ionix Pharmaceuticals Ltd Cell lines expressing VGSC, Nav1.8

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997001577A1 (en) * 1995-06-28 1997-01-16 University College London Ion channel
WO1999047670A1 (en) * 1998-03-18 1999-09-23 Glaxo Group Limited Mammalian sodium channel proteins

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997001577A1 (en) * 1995-06-28 1997-01-16 University College London Ion channel
WO1999047670A1 (en) * 1998-03-18 1999-09-23 Glaxo Group Limited Mammalian sodium channel proteins

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
BENZINGER G RICHARD ET AL: "A specific interaction between the cardiac sodium channel and site-3 toxin anthopleurin B.", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 273, no. 1, 2 January 1998 (1998-01-02), pages 80 - 84, XP002175839, ISSN: 0021-9258 *

Also Published As

Publication number Publication date
WO2001068681A2 (en) 2001-09-20
AU4082201A (en) 2001-09-24
GB0006024D0 (en) 2000-05-03

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