WO2001068655A3 - Caprolactam derivatives and uses thereof - Google Patents
Caprolactam derivatives and uses thereof Download PDFInfo
- Publication number
- WO2001068655A3 WO2001068655A3 PCT/US2001/007935 US0107935W WO0168655A3 WO 2001068655 A3 WO2001068655 A3 WO 2001068655A3 US 0107935 W US0107935 W US 0107935W WO 0168655 A3 WO0168655 A3 WO 0168655A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- compounds
- caprolactam
- caprolactam derivatives
- derivatives
- src
- Prior art date
Links
- JBKVHLHDHHXQEQ-UHFFFAOYSA-N epsilon-caprolactam Chemical class O=C1CCCCCN1 JBKVHLHDHHXQEQ-UHFFFAOYSA-N 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 3
- 208000006386 Bone Resorption Diseases 0.000 abstract 1
- 102000014400 SH2 domains Human genes 0.000 abstract 1
- 108050003452 SH2 domains Proteins 0.000 abstract 1
- 239000005557 antagonist Substances 0.000 abstract 1
- 230000024279 bone resorption Effects 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 229940002612 prodrug Drugs 0.000 abstract 1
- 239000000651 prodrug Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/06—Phosphorus compounds without P—C bonds
- C07F9/08—Esters of oxyacids of phosphorus
- C07F9/09—Esters of phosphoric acids
- C07F9/12—Esters of phosphoric acids with hydroxyaryl compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/40—Esters thereof
- C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
- C07F9/4056—Esters of arylalkanephosphonic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
- C07F9/5532—Seven-(or more) membered rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Biochemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AU2001243601A AU2001243601A1 (en) | 2000-03-10 | 2001-03-12 | Caprolactam derivatives and uses thereof |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US52324300A | 2000-03-10 | 2000-03-10 | |
US09/523,243 | 2000-03-10 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2001068655A2 WO2001068655A2 (en) | 2001-09-20 |
WO2001068655A3 true WO2001068655A3 (en) | 2002-08-01 |
Family
ID=24084232
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2001/007935 WO2001068655A2 (en) | 2000-03-10 | 2001-03-12 | Caprolactam derivatives and uses thereof |
Country Status (2)
Country | Link |
---|---|
AU (1) | AU2001243601A1 (en) |
WO (1) | WO2001068655A2 (en) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
TW200502221A (en) | 2002-10-03 | 2005-01-16 | Astrazeneca Ab | Novel lactams and uses thereof |
EP1636196A1 (en) | 2003-03-14 | 2006-03-22 | AstraZeneca AB | Novel lactams and uses thereof |
CA2547651C (en) * | 2003-12-01 | 2015-06-23 | Cambridge University Technical Services Limited | Anti-inflammatory agents |
GB2418427A (en) | 2004-09-02 | 2006-03-29 | Univ Cambridge Tech | Ligands for G-protein coupled receptors |
GB2452696B (en) | 2007-08-02 | 2009-09-23 | Cambridge Entpr Ltd | 3-(2',2'-dimethylpropanoylamino)-tetrahydropyridin-2-one and its use in pharmaceutical compositions |
US7662967B2 (en) | 2007-08-02 | 2010-02-16 | Cambridge Enterprise Limited | Anti-inflammatory compounds and compositions |
EP2994143A4 (en) * | 2013-05-08 | 2017-02-01 | Board of Regents, The University of Texas System | Stat6 inhibitors |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1997024339A1 (en) * | 1995-12-27 | 1997-07-10 | Ono Pharmaceutical Co., Ltd. | Tetrazole derivatives and drugs containing the same as the active ingredient |
WO1999031066A1 (en) * | 1997-12-18 | 1999-06-24 | Boehringer Ingelheim Pharmaceuticals, Inc. | Pyridones as src family sh2 domain inhibitors |
FR2781483A1 (en) * | 1998-07-21 | 2000-01-28 | Hoechst Marion Roussel Inc | Thioazepinone derivatives having Src domain SH2 inhibiting and osteoclast-mediated calcium resorption from bone inhibiting activity, for treatment of osteoporosis |
-
2001
- 2001-03-12 WO PCT/US2001/007935 patent/WO2001068655A2/en active Application Filing
- 2001-03-12 AU AU2001243601A patent/AU2001243601A1/en not_active Abandoned
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1997024339A1 (en) * | 1995-12-27 | 1997-07-10 | Ono Pharmaceutical Co., Ltd. | Tetrazole derivatives and drugs containing the same as the active ingredient |
WO1999031066A1 (en) * | 1997-12-18 | 1999-06-24 | Boehringer Ingelheim Pharmaceuticals, Inc. | Pyridones as src family sh2 domain inhibitors |
FR2781483A1 (en) * | 1998-07-21 | 2000-01-28 | Hoechst Marion Roussel Inc | Thioazepinone derivatives having Src domain SH2 inhibiting and osteoclast-mediated calcium resorption from bone inhibiting activity, for treatment of osteoporosis |
Non-Patent Citations (5)
Title |
---|
BEAULIEU P L ET AL: "Ligands for the tyrosine kinase p56lck SH2 domain;discovery of potent dipeptide derivatives with monocharge, nonhydrolyzable phosphate replacement", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY. WASHINGTON, US, vol. 42, no. 10, 20 May 1999 (1999-05-20), pages 1757 - 1766, XP002148488, ISSN: 0022-2623 * |
CARLSTROM A-S ET AL: "PALLADIUM-CATALYZED SYNTHESIS OF DIDEHYDROAMINO ACID DERIVATIVES", SYNTHESIS, GEORG THIEME VERLAG. STUTTGART, DE, no. 6, 1 June 1989 (1989-06-01), pages 414 - 418, XP000026631, ISSN: 0039-7881 * |
NATCHUS M G ET AL: "Design and synthesis of conformationally-constrained MMP inhibitors", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, OXFORD, GB, vol. 8, no. 16, 18 August 1998 (1998-08-18), pages 2077 - 2080, XP004137222, ISSN: 0960-894X * |
ROBL J A ET AL: "DUAL METALLOPROTEASE INHIBITORS. 6. INCORPORATION OF BICYCLIC AND SUBSTITUTED MONOCYCLIC AZEPINONES AS DIPEPTIDE SURROGATES IN ANGIOTENSIN-CONVERTING ENZYME/NEUTRAL ENDOPEPTIDASE INHIBITORS", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY. WASHINGTON, US, vol. 39, no. 2, 19 January 1996 (1996-01-19), pages 494 - 502, XP000749701, ISSN: 0022-2623 * |
TONG ET AL: "Carboxymethyl-phenylalanine as a replacement for phosphotyrosine in SH2 domain binding", JOURNAL OF BIOLOGICAL CHEMISTRY, AMERICAN SOCIETY OF BIOLOGICAL CHEMISTS, BALTIMORE, MD, US, vol. 273, no. 32, 7 August 1998 (1998-08-07), pages 20238 - 20242, XP002143951, ISSN: 0021-9258 * |
Also Published As
Publication number | Publication date |
---|---|
AU2001243601A1 (en) | 2001-09-24 |
WO2001068655A2 (en) | 2001-09-20 |
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