WO2001066771A3 - Human serine protease - Google Patents

Human serine protease Download PDF

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Publication number
WO2001066771A3
WO2001066771A3 PCT/US2001/006432 US0106432W WO0166771A3 WO 2001066771 A3 WO2001066771 A3 WO 2001066771A3 US 0106432 W US0106432 W US 0106432W WO 0166771 A3 WO0166771 A3 WO 0166771A3
Authority
WO
WIPO (PCT)
Prior art keywords
serine protease
human serine
protease family
ztryp3
fibrinolysis
Prior art date
Application number
PCT/US2001/006432
Other languages
French (fr)
Other versions
WO2001066771A2 (en
Inventor
Darrell C Conklin
Original Assignee
Zymogenetics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zymogenetics Inc filed Critical Zymogenetics Inc
Priority to AU2001238721A priority Critical patent/AU2001238721A1/en
Publication of WO2001066771A2 publication Critical patent/WO2001066771A2/en
Publication of WO2001066771A3 publication Critical patent/WO2001066771A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

Members of the serine protease family play a role in carefully controlled processes, such as blood coagulation, fibrinolysis, complement activation, fertilization, and hormone production. These enzymes are also used in a variety of diagnostic, therapeutic, and industrial contexts. Ztryp3 is a new member of the serine protease family.
PCT/US2001/006432 2000-03-03 2001-02-28 Human serine protease WO2001066771A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2001238721A AU2001238721A1 (en) 2000-03-03 2001-02-28 Human serine protease

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US51838700A 2000-03-03 2000-03-03
US09/518,387 2000-03-03

Publications (2)

Publication Number Publication Date
WO2001066771A2 WO2001066771A2 (en) 2001-09-13
WO2001066771A3 true WO2001066771A3 (en) 2002-03-21

Family

ID=24063716

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/006432 WO2001066771A2 (en) 2000-03-03 2001-02-28 Human serine protease

Country Status (2)

Country Link
AU (1) AU2001238721A1 (en)
WO (1) WO2001066771A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030083244A1 (en) * 2000-04-26 2003-05-01 Vernet Corine A.M. Novel proteins and nucleic acids encoding same
AU2002222937A1 (en) * 2000-07-18 2002-01-30 Millennium Pharmaceuticals, Inc. 14087, a serine protease molecule and uses therefor

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1990010649A1 (en) * 1989-03-06 1990-09-20 The Board Of Regents Of The University Of Texas System Serpin resistant chymotrypsin superfamily proteases, particularly pai-1 resistant +-pa, complementary inhibitor mutants; compositions; genes; expression
WO1999010503A1 (en) * 1997-08-22 1999-03-04 Roche Diagnostics Gmbh Zymogenic protease precursors that can be autocatalytically activated and their use

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1990010649A1 (en) * 1989-03-06 1990-09-20 The Board Of Regents Of The University Of Texas System Serpin resistant chymotrypsin superfamily proteases, particularly pai-1 resistant +-pa, complementary inhibitor mutants; compositions; genes; expression
WO1999010503A1 (en) * 1997-08-22 1999-03-04 Roche Diagnostics Gmbh Zymogenic protease precursors that can be autocatalytically activated and their use

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
DATABASE EM_EST EMBL; 13 June 1997 (1997-06-13), HILLIER L ET AL.: "zx51b11.r1 Soares_testis_NHT Homo sapiens cDNA clone IMAGE:795741 5' similar to SW:TRY1_RAT P00762 TRYPSINOGEN I, ANIONIC PRECURSOR ;, mRNA sequence", XP002185786 *
DATABASE EM_EST EMBL; 22 May 1997 (1997-05-22), HILLIER L ET AL.: "zv58d08.s1 Soares_testis_NHT Homo sapiens cDNA clone IMAGE:757839 3' similar to TR:G603903 G603903 TRYPSINOGEN PRECURSOR. [1] ;, mRNA sequence", XP002185785 *
DATABASE EM_EST EMBL; 8 July 1999 (1999-07-08), NCI-CGAP: "te52d10.x1 Soares_NFL_T_GBC_S1 Homo sapiens cDNA clone IMAGE:2090323 3' similar to SW:TRY1_RAT P00762 TRYPSINOGEN I, ANIONIC PRECURSOR ;, mRNA sequence", XP002185787 *
HOOPEN J D ET AL.: "Testisin, a new human serine protease expressed by premeiotic testicular germ cells and lost in testicular germ cell tumors", CANCER RESEARCH, vol. 59, 1 July 1999 (1999-07-01), pages 3199 - 3205, XP002924343, ISSN: 0008-5472 *
WESTON G S ET AL.: "Granzymes as potential targets for rational drug design", CURRENT MEDICINAL CHEMISTRY, vol. 3, no. 1, 1996, pages 37 - 46, XP002913206, ISSN: 0929-8673 *

Also Published As

Publication number Publication date
AU2001238721A1 (en) 2001-09-17
WO2001066771A2 (en) 2001-09-13

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