WO2001038534A3 - Human serpin - Google Patents

Human serpin Download PDF

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Publication number
WO2001038534A3
WO2001038534A3 PCT/US2000/032100 US0032100W WO0138534A3 WO 2001038534 A3 WO2001038534 A3 WO 2001038534A3 US 0032100 W US0032100 W US 0032100W WO 0138534 A3 WO0138534 A3 WO 0138534A3
Authority
WO
WIPO (PCT)
Prior art keywords
serine protease
serpin
serine
family
disorders
Prior art date
Application number
PCT/US2000/032100
Other languages
French (fr)
Other versions
WO2001038534A2 (en
Inventor
James L Holloway
Original Assignee
Zymogenetics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zymogenetics Inc filed Critical Zymogenetics Inc
Priority to AU22504/01A priority Critical patent/AU2250401A/en
Publication of WO2001038534A2 publication Critical patent/WO2001038534A2/en
Publication of WO2001038534A3 publication Critical patent/WO2001038534A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
    • C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
    • C07K14/8121—Serpins

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Members of the serine protease family play a role in carefully controlled processes, such as blood coagulation, fibrinolysis, complement activation, fertilization, and hormone production. The enzymatic activity of the serine proteases is regulated in part by serpins, serine protease inhibitors. Serpin dysfunction is associated with various disorders, including emphysema, blood clotting disorders, cirrhosis, Alzheimer disease, and Parkinson disease. Zserp 11 is a new member of the serine protease inhibitor family.
PCT/US2000/032100 1999-11-29 2000-11-20 Human serpin WO2001038534A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU22504/01A AU2250401A (en) 1999-11-29 2000-11-20 Human serpin

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US45024499A 1999-11-29 1999-11-29
US09/450,244 1999-11-29

Publications (2)

Publication Number Publication Date
WO2001038534A2 WO2001038534A2 (en) 2001-05-31
WO2001038534A3 true WO2001038534A3 (en) 2002-01-03

Family

ID=23787321

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2000/032100 WO2001038534A2 (en) 1999-11-29 2000-11-20 Human serpin

Country Status (2)

Country Link
AU (1) AU2250401A (en)
WO (1) WO2001038534A2 (en)

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996034957A1 (en) * 1995-05-02 1996-11-07 Incyte Pharmaceuticals, Inc. Pancreas-derived serpin
WO1996040922A1 (en) * 1995-06-07 1996-12-19 Incyte Pharmaceuticals, Inc. Novel serpin derived from human hypothalamus

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996034957A1 (en) * 1995-05-02 1996-11-07 Incyte Pharmaceuticals, Inc. Pancreas-derived serpin
WO1996040922A1 (en) * 1995-06-07 1996-12-19 Incyte Pharmaceuticals, Inc. Novel serpin derived from human hypothalamus

Also Published As

Publication number Publication date
AU2250401A (en) 2001-06-04
WO2001038534A2 (en) 2001-05-31

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