WO2001055440A8 - Acides nucleiques, proteines et anticorps - Google Patents

Acides nucleiques, proteines et anticorps

Info

Publication number
WO2001055440A8
WO2001055440A8 PCT/US2001/001318 US0101318W WO0155440A8 WO 2001055440 A8 WO2001055440 A8 WO 2001055440A8 US 0101318 W US0101318 W US 0101318W WO 0155440 A8 WO0155440 A8 WO 0155440A8
Authority
WO
WIPO (PCT)
Prior art keywords
polypeptides
antibodies
further relates
present
novel
Prior art date
Application number
PCT/US2001/001318
Other languages
English (en)
Other versions
WO2001055440A1 (fr
Inventor
Craig A Rosen
Steven C Barash
Steven M Ruben
Original Assignee
Human Genome Sciences Inc
Craig A Rosen
Steven C Barash
Steven M Ruben
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Human Genome Sciences Inc, Craig A Rosen, Steven C Barash, Steven M Ruben filed Critical Human Genome Sciences Inc
Priority to EP01908614A priority Critical patent/EP1252326A1/fr
Priority to AU2001236462A priority patent/AU2001236462A1/en
Publication of WO2001055440A1 publication Critical patent/WO2001055440A1/fr
Publication of WO2001055440A8 publication Critical patent/WO2001055440A8/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/66—General methods for inserting a gene into a vector to form a recombinant vector using cleavage and ligation; Use of non-functional linkers or adaptors, e.g. linkers containing the sequence for a restriction endonuclease
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/10—Cells modified by introduction of foreign genetic material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P15/00—Preparation of compounds containing at least three condensed carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/06—Preparation of peptides or proteins produced by the hydrolysis of a peptide bond, e.g. hydrolysate products
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/566—Immunoassay; Biospecific binding assay; Materials therefor using specific carrier or receptor proteins as ligand binding reagents where possible specific carrier or receptor proteins are classified with their target compounds

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Veterinary Medicine (AREA)
  • Hematology (AREA)
  • Cell Biology (AREA)
  • Urology & Nephrology (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Physics & Mathematics (AREA)
  • Toxicology (AREA)
  • Epidemiology (AREA)
  • Plant Pathology (AREA)
  • Pathology (AREA)
  • Food Science & Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Peptides Or Proteins (AREA)

Abstract

L'invention concerne de protéines, plus précisément, des molécules isolées d'acide nucléique codant de nouveaux polypeptides. Elle concerne de nouveaux polypeptides et des anticorps qui lient ces polypeptides, ainsi que des vecteurs, des cellules hôtes, et des procédés de recombinaison et de synthèse destinés à produire des polynucléotides humains et/ou des polypeptides et des anticorps. L'invention concerne également des procédés de diagnostic et thérapeutiques servant à diagnostiquer, à traiter, à prévenir et/ou à pronostiquer des troubles relatifs à ces nouveaux polypeptides. Elle concerne en outre des procédés de criblage destinés à identifier des agonistes et antagonistes desdits polynucléotides et polypeptides. Elle concerne enfin des procédés et/ou des compositions conçus pour inhiber ou renforcer la production et la fonction desdits polypeptides.
PCT/US2001/001318 2000-01-31 2001-01-17 Acides nucleiques, proteines et anticorps WO2001055440A1 (fr)

Priority Applications (2)

Application Number Priority Date Filing Date Title
EP01908614A EP1252326A1 (fr) 2000-01-31 2001-01-17 Acides nucleiques, proteines et anticorps
AU2001236462A AU2001236462A1 (en) 2000-01-31 2001-01-17 Nucleic acids, proteins, and antibodies

Applications Claiming Priority (235)

Application Number Priority Date Filing Date Title
US17906500P 2000-01-31 2000-01-31
US60/179,065 2000-01-31
US18062800P 2000-02-04 2000-02-04
US60/180,628 2000-02-04
US18466400P 2000-02-24 2000-02-24
US60/184,664 2000-02-24
US18635000P 2000-03-02 2000-03-02
US60/186,350 2000-03-02
US18987400P 2000-03-16 2000-03-16
US60/189,874 2000-03-16
US19007600P 2000-03-17 2000-03-17
US60/190,076 2000-03-17
US19812300P 2000-04-18 2000-04-18
US60/198,123 2000-04-18
US20551500P 2000-05-19 2000-05-19
US60/205,515 2000-05-19
US20946700P 2000-06-07 2000-06-07
US60/209,467 2000-06-07
US21488600P 2000-06-28 2000-06-28
US60/214,886 2000-06-28
US21513500P 2000-06-30 2000-06-30
US60/215,135 2000-06-30
US21664700P 2000-07-07 2000-07-07
US21688000P 2000-07-07 2000-07-07
US60/216,880 2000-07-07
US60/216,647 2000-07-07
US21748700P 2000-07-11 2000-07-11
US21749600P 2000-07-11 2000-07-11
US60/217,496 2000-07-11
US60/217,487 2000-07-11
US21829000P 2000-07-14 2000-07-14
US60/218,290 2000-07-14
US22096400P 2000-07-26 2000-07-26
US22096300P 2000-07-26 2000-07-26
US60/220,963 2000-07-26
US60/220,964 2000-07-26
US22575900P 2000-08-14 2000-08-14
US22526600P 2000-08-14 2000-08-14
US22526700P 2000-08-14 2000-08-14
US22521300P 2000-08-14 2000-08-14
US22575800P 2000-08-14 2000-08-14
US22544700P 2000-08-14 2000-08-14
US22451900P 2000-08-14 2000-08-14
US22451800P 2000-08-14 2000-08-14
US22527000P 2000-08-14 2000-08-14
US22575700P 2000-08-14 2000-08-14
US22526800P 2000-08-14 2000-08-14
US22521400P 2000-08-14 2000-08-14
US60/225,757 2000-08-14
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US60/225,758 2000-08-14
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US60/225,447 2000-08-14
US60/225,267 2000-08-14
US60/224,268 2000-08-14
US60/224,518 2000-08-14
US60/225,266 2000-08-14
US60/224,519 2000-08-14
US60/225,214 2000-08-14
US22627900P 2000-08-18 2000-08-18
US60/226,279 2000-08-18
US22668100P 2000-08-22 2000-08-22
US22686800P 2000-08-22 2000-08-22
US22718200P 2000-08-22 2000-08-22
US60/226,868 2000-08-22
US60/227,182 2000-08-22
US60/226,681 2000-08-22
US22700900P 2000-08-23 2000-08-23
US60/227,009 2000-08-23
US22892400P 2000-08-30 2000-08-30
US60/228,924 2000-08-30
US22934500P 2000-09-01 2000-09-01
US22934300P 2000-09-01 2000-09-01
US22928700P 2000-09-01 2000-09-01
US22934400P 2000-09-01 2000-09-01
US60/229,343 2000-09-01
US60/229,344 2000-09-01
US60/229,345 2000-09-01
US60/229,287 2000-09-01
US22951300P 2000-09-05 2000-09-05
US22950900P 2000-09-05 2000-09-05
US60/229,509 2000-09-05
US60/229,513 2000-09-05
US23043800P 2000-09-06 2000-09-06
US23043700P 2000-09-06 2000-09-06
US60/230,437 2000-09-06
US60/230,438 2000-09-06
US23141300P 2000-09-08 2000-09-08
US23208100P 2000-09-08 2000-09-08
US23141400P 2000-09-08 2000-09-08
US23108000P 2000-09-08 2000-09-08
US23124200P 2000-09-08 2000-09-08
US23124400P 2000-09-08 2000-09-08
US23124300P 2000-09-08 2000-09-08
US60/231,080 2000-09-08
US60/231,244 2000-09-08
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US23704000P 2000-10-02 2000-10-02
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US23680200P 2000-10-02 2000-10-02
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US60/237,039 2000-10-02
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US60/236,802 2000-10-02
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US23993500P 2000-10-13 2000-10-13
US60/239,937 2000-10-13
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US24182600P 2000-10-20 2000-10-20
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US24096000P 2000-10-20 2000-10-20
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US24178500P 2000-10-20 2000-10-20
US60/241,221 2000-10-20
US60/240,960 2000-10-20
US60/241,785 2000-10-20
US60/241,786 2000-10-20
US60/241,809 2000-10-20
US60/241,826 2000-10-20
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US24461700P 2000-11-01 2000-11-01
US60/244,617 2000-11-01
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US24647600P 2000-11-08 2000-11-08
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US24661100P 2000-11-08 2000-11-08
US24647500P 2000-11-08 2000-11-08
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US24652500P 2000-11-08 2000-11-08
US24661000P 2000-11-08 2000-11-08
US24652700P 2000-11-08 2000-11-08
US24647700P 2000-11-08 2000-11-08
US60/246,528 2000-11-08
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US60/246,609 2000-11-08
US60/246,610 2000-11-08
US60/246,476 2000-11-08
US60/246,527 2000-11-08
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US60/249,216 2000-11-17
US60/249,214 2000-11-17
US60/249,212 2000-11-17
US60/249,299 2000-11-17
US60/249,213 2000-11-17
US60/249,265 2000-11-17
US60/249,207 2000-11-17
US60/249,217 2000-11-17
US60/249,210 2000-11-17
US60/249,297 2000-11-17
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US60/249,211 2000-11-17
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US60/249,264 2000-11-17
US60/249,244 2000-11-17
US60/249,208 2000-11-17
US60/249,245 2000-11-17
US60/249,215 2000-11-17
US60/249,218 2000-11-17
US60/250,391 2000-12-01
US60/250,160 2000-12-01
US60/251,988 2000-12-05
US60/251,030 2000-12-05
US60/256,719 2000-12-05
US60/251,479 2000-12-06
US60/251,990 2000-12-08
US60/251,868 2000-12-08
US60/251,856 2000-12-08
US60/251,989 2000-12-08
US60/251,869 2000-12-08
US60/254,097 2000-12-11
US60/259,678 2001-01-05

Publications (2)

Publication Number Publication Date
WO2001055440A1 WO2001055440A1 (fr) 2001-08-02
WO2001055440A8 true WO2001055440A8 (fr) 2001-09-07

Family

ID=33425967

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/001318 WO2001055440A1 (fr) 2000-01-31 2001-01-17 Acides nucleiques, proteines et anticorps

Country Status (2)

Country Link
CA (1) CA2395676A1 (fr)
WO (1) WO2001055440A1 (fr)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1690872A3 (fr) * 1999-12-01 2006-08-23 Genentech, Inc. Composition et procédés de diagnostic de tumeurs
EP1313761A4 (fr) * 2000-08-28 2005-01-26 Human Genome Sciences Inc 18 proteines humaines secretees
CA2420192A1 (fr) * 2000-09-20 2002-03-28 Human Genome Sciences, Inc. 21 proteines humaines secretees
PL1745069T3 (pl) * 2004-03-30 2009-10-30 Nsgene As Zastosowanie terapeutyczne czynnika wzrostu NSG33
DE102004059781A1 (de) * 2004-12-10 2006-06-22 Sanofi-Aventis Deutschland Gmbh Verwendung der Serum-/Glucocorticoid regulierten Kinase
DK2195013T3 (da) 2008-07-24 2012-02-06 Nsgene As Terapeutisk anvendelse af en vækstfaktor, METRNL
ES2584068T3 (es) 2010-10-01 2016-09-23 Nsgene A/S Uso de meteorina para el tratamiento de alodinia, hiperalgesia, dolor espontáneo y dolor fantasma
KR102075881B1 (ko) 2011-09-05 2020-02-11 호바 세라퓨틱스 에이피에스 이질통, 통각과민증, 자발통 및 환상통의 치료

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999035290A1 (fr) * 1998-01-08 1999-07-15 Millennium Pharmaceuticals, Inc. Procedes et compositions permettant de diagnostiquer et de traiter des troubles neuropsychiatriques
SE9801424D0 (sv) * 1998-04-22 1998-04-22 Astra Ab Expression methods

Also Published As

Publication number Publication date
CA2395676A1 (fr) 2001-08-02
WO2001055440A1 (fr) 2001-08-02

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