WO2001055356A3 - Nouvelles proteines kinases humaines et enzymes semblables aux proteines kinases - Google Patents

Nouvelles proteines kinases humaines et enzymes semblables aux proteines kinases Download PDF

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Publication number
WO2001055356A3
WO2001055356A3 PCT/US2001/002337 US0102337W WO0155356A3 WO 2001055356 A3 WO2001055356 A3 WO 2001055356A3 US 0102337 W US0102337 W US 0102337W WO 0155356 A3 WO0155356 A3 WO 0155356A3
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Prior art keywords
kinase
enzymes
protein
human
kinases
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PCT/US2001/002337
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English (en)
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WO2001055356A2 (fr
Inventor
Gregory Plowman
David Whyte
Gerard Manning
Sucha Sudarsanam
Ricardo Martinez
Original Assignee
Sugen Inc
Gregory Plowman
David Whyte
Gerard Manning
Sucha Sudarsanam
Ricardo Martinez
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Sugen Inc, Gregory Plowman, David Whyte, Gerard Manning, Sucha Sudarsanam, Ricardo Martinez filed Critical Sugen Inc
Priority to US10/182,243 priority Critical patent/US20040048310A1/en
Priority to AU2001234544A priority patent/AU2001234544A1/en
Priority to EP01906658A priority patent/EP1254214A2/fr
Priority to CA002398430A priority patent/CA2398430A1/fr
Priority to JP2001554387A priority patent/JP2003520602A/ja
Publication of WO2001055356A2 publication Critical patent/WO2001055356A2/fr
Publication of WO2001055356A3 publication Critical patent/WO2001055356A3/fr
Priority to US11/375,615 priority patent/US20060188974A1/en

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    • C07—ORGANIC CHEMISTRY
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    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • A61P25/00—Drugs for disorders of the nervous system
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/48—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase
    • C12Q1/485—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase involving kinase
    • G—PHYSICS
    • G01—MEASURING; TESTING
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Abstract

La présente invention concerne des polypeptides kinases, des séquences nucléotidiques codant pour les polypeptides kinases, ainsi que divers produits et méthodes utilisés dans le diagnostic et le traitement de diverses maladies et états pathologiques associés aux kinases. Grâce à l'utilisation d'une stratégie bioinformatique, des membres mammaliens des PTKs et des STKs ont été identifiés et leur structure protéique définie.
PCT/US2001/002337 2000-01-25 2001-01-25 Nouvelles proteines kinases humaines et enzymes semblables aux proteines kinases WO2001055356A2 (fr)

Priority Applications (6)

Application Number Priority Date Filing Date Title
US10/182,243 US20040048310A1 (en) 2001-01-25 2001-01-25 Novel human protein kinases and protein kinase-like enzymes
AU2001234544A AU2001234544A1 (en) 2000-01-25 2001-01-25 Novel human protein kinases and protein kinase-like enzymes
EP01906658A EP1254214A2 (fr) 2000-01-25 2001-01-25 Nouvelles proteines kinases humaines et enzymes semblables aux proteines kinases
CA002398430A CA2398430A1 (fr) 2000-01-25 2001-01-25 Nouvelles proteines kinases humaines et enzymes semblables aux proteines kinases
JP2001554387A JP2003520602A (ja) 2000-01-25 2001-01-25 新規ヒト蛋白質キナーゼおよび蛋白質キナーゼ様酵素
US11/375,615 US20060188974A1 (en) 2000-01-25 2006-03-15 Human protein kinases and protein kinase-like enzymes

Applications Claiming Priority (12)

Application Number Priority Date Filing Date Title
US17807800P 2000-01-25 2000-01-25
US60/178,078 2000-01-25
US17936400P 2000-01-31 2000-01-31
US60/179,364 2000-01-31
US18317300P 2000-02-17 2000-02-17
US60/183,173 2000-02-17
US19016200P 2000-03-17 2000-03-17
US60/190,162 2000-03-17
US19340400P 2000-03-29 2000-03-29
US60/193,404 2000-03-29
US24701300P 2000-11-13 2000-11-13
US60/247,013 2000-11-13

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US11/375,615 Division US20060188974A1 (en) 2000-01-25 2006-03-15 Human protein kinases and protein kinase-like enzymes

Publications (2)

Publication Number Publication Date
WO2001055356A2 WO2001055356A2 (fr) 2001-08-02
WO2001055356A3 true WO2001055356A3 (fr) 2002-03-28

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PCT/US2001/002337 WO2001055356A2 (fr) 2000-01-25 2001-01-25 Nouvelles proteines kinases humaines et enzymes semblables aux proteines kinases

Country Status (5)

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EP (1) EP1254214A2 (fr)
JP (1) JP2003520602A (fr)
AU (1) AU2001234544A1 (fr)
CA (1) CA2398430A1 (fr)
WO (1) WO2001055356A2 (fr)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2266195T3 (es) * 2000-04-25 2007-03-01 Bayer Healthcare Ag Nuevas moleculas de proteina quinasa 14911 y usos de las mismas.
JP2004517622A (ja) 2000-12-11 2004-06-17 レキシコン・ジェネティクス・インコーポレーテッド 新規ヒトキナーゼ及び該キナーゼをコードするポリヌクレオチド
AU2002250911A1 (en) * 2001-02-12 2002-08-28 Bayer Aktiengesellschaft Isolated polynucleotides encoding putative tyrosine kinase
US7001753B2 (en) 2001-02-15 2006-02-21 Millennium Pharmaceuticals, Inc. 59079 and 12599, protein kinase family members and uses therefor
WO2002095017A1 (fr) * 2001-05-24 2002-11-28 Cephalon, Inc. Nouveau polypeptide de kinase 7 de lignee melangee (mlk7), polynucleotides les codant, et leurs methodes d'utilisation
AU2002330672A1 (en) * 2001-07-25 2003-02-17 Genset S.A. Gmg-1 polynucleotides and polypeptides and uses thereof
JP2005508168A (ja) * 2001-10-24 2005-03-31 ミレニアム・ファーマシューティカルズ・インコーポレイテッド ６９５８３および８５９２４、新規なヒトプロテインキナーゼファミリーメンバーおよびそれらの使用
US20030199462A1 (en) * 2002-04-23 2003-10-23 Gabriel Nunez Methods and compositions for regulating cellular signaling
AU2003240688A1 (en) * 2002-05-24 2003-12-12 Bayer Aktiengesellschaft Regulation of human kinase
WO2005095637A1 (fr) * 2004-03-02 2005-10-13 Bayer Healthcare Ag Diagnostics et produits therapeutiques relatifs a des maladies associes a kinase 4 beta de lignee melangee (mlk4 beta)

Citations (5)

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Publication number Priority date Publication date Assignee Title
US5856463A (en) * 1995-09-18 1999-01-05 Prydz; Hans Peter Blankenborg PSKH-1 ribozymes
WO1999049062A1 (fr) * 1998-03-26 1999-09-30 Gene Logic, Inc. IDENTIFICATION D'UN ADNc ASSOCIE A L'ISCHEMIE DANS UN TISSU CARDIAQUE HUMAIN
WO1999053036A2 (fr) * 1998-04-14 1999-10-21 Sugen, Inc. Proteines kinases apparentees a la famille de ste20
WO1999058558A2 (fr) * 1998-05-13 1999-11-18 Incyte Pharmaceuticals, Inc. Proteines de signalisation cellulaire
WO2000063381A1 (fr) * 1999-04-16 2000-10-26 Scios, Inc. Proteine mammalienne a fonction presumee de transduction de signaux

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5856463A (en) * 1995-09-18 1999-01-05 Prydz; Hans Peter Blankenborg PSKH-1 ribozymes
WO1999049062A1 (fr) * 1998-03-26 1999-09-30 Gene Logic, Inc. IDENTIFICATION D'UN ADNc ASSOCIE A L'ISCHEMIE DANS UN TISSU CARDIAQUE HUMAIN
WO1999053036A2 (fr) * 1998-04-14 1999-10-21 Sugen, Inc. Proteines kinases apparentees a la famille de ste20
WO1999058558A2 (fr) * 1998-05-13 1999-11-18 Incyte Pharmaceuticals, Inc. Proteines de signalisation cellulaire
WO2000063381A1 (fr) * 1999-04-16 2000-10-26 Scios, Inc. Proteine mammalienne a fonction presumee de transduction de signaux

Non-Patent Citations (20)

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Title
DATABASE EMBL 1 February 1994 (1994-02-01), DOROW DS ET AL: "Mitogen-activated protein kinase kinase kinase", XP002183488 *
DATABASE EMBL 1 November 1999 (1999-11-01), BRAZAO, R ET AL: "Putative mitogen-activated protein kinase kinase kinase (fragment)", XP002183486 *
DATABASE EMBL 1 October 1996 (1996-10-01), HANES, JJ ET AL: "Protein Kinase CLK2", XP002183481 *
DATABASE EMBL 1 October 1996 (1996-10-01), TASSAN J-P ET AL: "Cell division protein kinase 7", XP002183480 *
DATABASE EMBL 10 May 1994 (1994-05-10), TASSAN JP ET AL: "H. sapiens CAK mRNA for CDK-activating kinase", XP002183479 *
DATABASE EMBL 12 October 1989 (1989-10-12), BREDE G ET AL: "Serine/threonine-protein kinase-H1", XP002183477 *
DATABASE EMBL 16 December 1999 (1999-12-16), KOEHRER K ET AL: "Homo sapiens mRNA", XP002183476 *
DATABASE EMBL 2 November 1998 (1998-11-02), HAUGE XY ET AL: "Homo sapiens dopamine D2 receptor gene", XP002183490 *
DATABASE EMBL 22 January 1997 (1997-01-22), PEARCE A: "Human DNA sequence from clone 390O13 on chromosome Xp11", XP002183485 *
DATABASE EMBL 22 November 1999 (1999-11-22), BIRREN B ET AL: "Homo sapiens chromosome 11 clone RP11-329B24 map 11", XP002183489 *
DATABASE EMBL 23 November 1998 (1998-11-23), SULSTON JE ET AL: "Homo sapiens BAC clone GS1-96J14 from 7p11.2-p21, complete sequence", XP002183482 *
DATABASE EMBL 26 April 1999 (1999-04-26), MARRA M ET AL: "vm45d02.y1 Stratagene mouse diaphragm Mus musculus cDNA clone", XP002183478 *
DATABASE EMBL 28 May 1999 (1999-05-28), NCI-CGAP: "tx08c09.x1 NCI_CGAP_Ut4 Homo sapiens cDNA clone", XP002183484 *
DATABASE EMBL 30 January 1995 (1995-01-30), HANES JJ ET AL: "Homo sapiens clk2 mRNA, complete cds", XP002183483 *
DATABASE EMBL 7 February 1996 (1996-02-07), SAKANE F ET AL: "Homo sapiens mRNA for diacylglycerol kinase delta, compete cds.", XP002183491 *
DATABASE EMBL 7 October 1999 (1999-10-07), DOE JOINT GENOME INSTITUTE: "Homo sapiens chroosome 5 clone CTC-255N20", XP002173240 *
DATABASE EMBL 8 December 1999 (1999-12-08), HALL R: "Human DNA sequence from clone RP5-862P8 on chromosome 1q42.2-43", XP002183487 *
HANES J ET AL: "CHARACTERIZATION BY CDNA CLONING OF TWO NEW HUMAN PROTEIN KINASES. EVIDENCE BY SEQUENCE COMPARISON OF A NEW FAMILY OF MAMMALIAN PROTEIN KINASES", JOURNAL OF MOLECULAR BIOLOGY,GB,LONDON, vol. 244, 1994, pages 665 - 672, XP002064038, ISSN: 0022-2836 *
MEYERSON M ET AL: "A family of human cdc2-related protein kinases", EMBO JOURNAL,GB,OXFORD UNIVERSITY PRESS, SURREY, vol. 11, no. 8, 1992, pages 2909 - 2917, XP002128265, ISSN: 0261-4189 *
SCHULTZ S J ET AL: "IDENTIFICATION OF 21 NOVEL HUMAN PROTEIN KINASES, INCLUDING 3 MEMBERS OF A FAMILY RELATED TO THE CELL CYCLE REGULATOR NIMA OF ASPERGILLUS NIDULANS", CELL GROWTH AND DIFFERENTIATION,XX,XX, vol. 4, 1 October 1993 (1993-10-01), pages 821 - 830, XP000564042 *

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CA2398430A1 (fr) 2001-08-02
WO2001055356A2 (fr) 2001-08-02
AU2001234544A1 (en) 2001-08-07
EP1254214A2 (fr) 2002-11-06
JP2003520602A (ja) 2003-07-08

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