WO2001055350A8 - Nucleic acids, proteins, and antibodies - Google Patents
Nucleic acids, proteins, and antibodiesInfo
- Publication number
- WO2001055350A8 WO2001055350A8 PCT/US2001/001350 US0101350W WO0155350A8 WO 2001055350 A8 WO2001055350 A8 WO 2001055350A8 US 0101350 W US0101350 W US 0101350W WO 0155350 A8 WO0155350 A8 WO 0155350A8
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- colorectal cancer
- polypeptides
- polynucleotides
- methods
- further relates
- Prior art date
Links
- 102000039446 nucleic acids Human genes 0.000 title abstract 2
- 108020004707 nucleic acids Proteins 0.000 title abstract 2
- 150000007523 nucleic acids Chemical class 0.000 title abstract 2
- 108091005461 Nucleic proteins Proteins 0.000 title 1
- 102000004169 proteins and genes Human genes 0.000 title 1
- 206010009944 Colon cancer Diseases 0.000 abstract 10
- 208000001333 Colorectal Neoplasms Diseases 0.000 abstract 10
- 229920001184 polypeptide Polymers 0.000 abstract 7
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 7
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 7
- 102000040430 polynucleotide Human genes 0.000 abstract 4
- 108091033319 polynucleotide Proteins 0.000 abstract 4
- 239000002157 polynucleotide Substances 0.000 abstract 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 3
- 239000000427 antigen Substances 0.000 abstract 2
- 102000036639 antigens Human genes 0.000 abstract 2
- 108091007433 antigens Proteins 0.000 abstract 2
- 210000001072 colon Anatomy 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 210000000664 rectum Anatomy 0.000 abstract 2
- 238000002560 therapeutic procedure Methods 0.000 abstract 2
- 206010027476 Metastases Diseases 0.000 abstract 1
- 239000000556 agonist Substances 0.000 abstract 1
- 239000005557 antagonist Substances 0.000 abstract 1
- 238000002405 diagnostic procedure Methods 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 238000010188 recombinant method Methods 0.000 abstract 1
- 238000012216 screening Methods 0.000 abstract 1
- 238000010189 synthetic method Methods 0.000 abstract 1
- 239000013598 vector Substances 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6424—Serine endopeptidases (3.4.21)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6489—Metalloendopeptidases (3.4.24)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2500/00—Screening for compounds of potential therapeutic value
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Biophysics (AREA)
- General Engineering & Computer Science (AREA)
- Immunology (AREA)
- Analytical Chemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Toxicology (AREA)
- Cell Biology (AREA)
- Pathology (AREA)
- Physics & Mathematics (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
The present invention relates to novel colorectal cancer related polynucleotides and the polypeptides encoded by these polynucleotides herein collectively known as 'colorectal cancer antigens', and the use of such colorectal cancer antigens for detecting disorders of the colon and/or rectum particularly the presence of colorectal cancer and colorectal cancer metastases. More specifically, isolated colorectal cancer associated nucleic acid molecules are provided encoding novel colorectal cancer associated polypeptides. Novel colorectal cancer polypeptides and antibodies that bind to these polypeptides are provided. Also provided are vectors, host cells, and recombinant and synthetic methods for producing human colorectal cancer associated polynucleotides and/or polypeptides. The invention further relates to diagnostic and therapeutic methods useful for diagnosing, treating, preventing and/or prognosing disorders related to the colon and/or rectum including colorectal cancer, and therapeutic methods for treating such disorders. The invention further relates to screening methods for identifying agonists and antagonists of polynucleotides and polypeptides of the invention. The present invention further relates to methods and/or compositions for inhibiting the production and function of the polypeptides of the present invention.
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AU3972601A AU3972601A (en) | 2000-01-31 | 2001-01-08 | Nucleic acids, proteins, and antibodies |
| EP01914330A EP1252297A1 (en) | 2000-01-31 | 2001-01-17 | Nucleic acids, proteins, and antibodies |
Applications Claiming Priority (235)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US17906500P | 2000-01-31 | 2000-01-31 | |
| US60/179,065 | 2000-01-31 | ||
| US18062800P | 2000-02-04 | 2000-02-04 | |
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| US18466400P | 2000-02-24 | 2000-02-24 | |
| US60/184,664 | 2000-02-24 | ||
| US18635000P | 2000-03-02 | 2000-03-02 | |
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| US18987400P | 2000-03-16 | 2000-03-16 | |
| US60/189,874 | 2000-03-16 | ||
| US19007600P | 2000-03-17 | 2000-03-17 | |
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| US19812300P | 2000-04-18 | 2000-04-18 | |
| US60/198,123 | 2000-04-18 | ||
| US20551500P | 2000-05-19 | 2000-05-19 | |
| US60/205,515 | 2000-05-19 | ||
| US20946700P | 2000-06-07 | 2000-06-07 | |
| US60/209,467 | 2000-06-07 | ||
| US21488600P | 2000-06-28 | 2000-06-28 | |
| US60/214,886 | 2000-06-28 | ||
| US21513500P | 2000-06-30 | 2000-06-30 | |
| US60/215,135 | 2000-06-30 | ||
| US21664700P | 2000-07-07 | 2000-07-07 | |
| US21688000P | 2000-07-07 | 2000-07-07 | |
| US60/216,647 | 2000-07-07 | ||
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| US21748700P | 2000-07-11 | 2000-07-11 | |
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| US21829000P | 2000-07-14 | 2000-07-14 | |
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| US22096400P | 2000-07-26 | 2000-07-26 | |
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| US60/249,265 | 2000-11-17 | ||
| US60/249,208 | 2000-11-17 | ||
| US60/249,299 | 2000-11-17 | ||
| US60/250,391 | 2000-12-01 | ||
| US60/250,160 | 2000-12-01 | ||
| US60/256,719 | 2000-12-05 | ||
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| US60/251,479 | 2000-12-06 | ||
| US60/251,989 | 2000-12-08 | ||
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| PCT/US2001/001315 WO2001055311A2 (en) | 2000-01-31 | 2001-01-17 | Nucleic acids, proteins, and antibodies |
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| PCT/US2001/001310 WO2001055387A1 (en) | 2000-01-31 | 2001-01-17 | Nucleic acids, proteins, and antibodies |
| PCT/US2001/001342 WO2001059064A2 (en) | 2000-01-31 | 2001-01-17 | Nucleic acids, proteins, and antibodies |
| PCT/US2001/001356 WO2001055173A2 (en) | 2000-01-31 | 2001-01-17 | Nucleic acids, proteins, and antibodies |
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| PCT/US2001/001322 WO2001055343A1 (en) | 2000-01-31 | 2001-01-17 | Nucleic acids, proteins, and antibodies |
| PCT/US2001/001350 WO2001055350A1 (en) | 2000-01-31 | 2001-01-17 | Nucleic acids, proteins, and antibodies |
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| PCT/US2001/001326 WO2001055315A2 (en) | 2000-01-31 | 2001-01-17 | Nucleic acids, proteins, and antibodies |
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| PCT/US2001/001328 WO2001055316A2 (en) | 2000-01-31 | 2001-01-17 | Nucleic acids, proteins, and antibodies |
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| PCT/US2001/001333 WO2001055448A1 (en) | 2000-01-31 | 2001-01-17 | Nucleic acids, proteins, and antibodies |
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| PCT/US2001/001358 WO2001055163A1 (en) | 2000-01-31 | 2001-01-17 | Nucleic acids, proteins, and antibodies |
| PCT/US2001/001339 WO2001055320A2 (en) | 2000-01-31 | 2001-01-17 | Nucleic acids, proteins, and antibodies |
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| PCT/US2001/001348 WO2001055368A1 (en) | 2000-01-31 | 2001-01-17 | Nucleic acids, proteins, and antibodies |
| PCT/US2001/001239 WO2001055301A2 (en) | 2000-01-31 | 2001-01-17 | Nucleic acids, proteins, and antibodies |
| PCT/US2001/001338 WO2001055367A1 (en) | 2000-01-31 | 2001-01-17 | Nucleic acids, proteins, and antibodies |
| PCT/US2001/001351 WO2001055355A1 (en) | 2000-01-31 | 2001-01-17 | Nucleic acids, proteins, and antibodies |
| PCT/US2001/001336 WO2001055204A1 (en) | 2000-01-31 | 2001-01-17 | Nucleic acids, proteins, and antibodies |
| PCT/US2001/001344 WO2001055324A2 (en) | 2000-01-31 | 2001-01-17 | Nucleic acids, proteins, and antibodies |
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| PCT/US2001/001352 WO2001055327A2 (en) | 2000-01-31 | 2001-01-17 | Nucleic acids, proteins, and antibodies |
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| PCT/US2001/001343 WO2001055323A2 (en) | 2000-01-31 | 2001-01-17 | Nucleic acids, proteins, and antibodies |
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| PCT/US2001/001341 WO2001055322A2 (en) | 2000-01-31 | 2001-01-17 | Nucleic acids, proteins, and antibodies |
| PCT/US2001/001328 WO2001055316A2 (en) | 2000-01-31 | 2001-01-17 | Nucleic acids, proteins, and antibodies |
| PCT/US2001/001324 WO2001055314A2 (en) | 2000-01-31 | 2001-01-17 | Digestive system related nucleic acids, proteins and antibodies |
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| PCT/US2001/001357 WO2001055208A1 (en) | 2000-01-31 | 2001-01-17 | Nucleic acids, proteins, and antibodies |
| PCT/US2001/001353 WO2001055206A1 (en) | 2000-01-31 | 2001-01-17 | Nucleic acids, proteins, and antibodies |
| PCT/US2001/001337 WO2001055205A1 (en) | 2000-01-31 | 2001-01-17 | Nucleic acids, proteins, and antibodies |
| PCT/US2001/001345 WO2001055325A2 (en) | 2000-01-31 | 2001-01-17 | Nucleic acids, proteins, and antibodies |
| PCT/US2001/001359 WO2001055328A2 (en) | 2000-01-31 | 2001-01-17 | Nucleic acids, proteins, and antibodies |
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| PCT/US2001/001306 WO2001055307A2 (en) | 2000-01-31 | 2001-01-17 | Nucleic acids, proteins, and antibodies |
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| PCT/US2001/001358 WO2001055163A1 (en) | 2000-01-31 | 2001-01-17 | Nucleic acids, proteins, and antibodies |
| PCT/US2001/001339 WO2001055320A2 (en) | 2000-01-31 | 2001-01-17 | Nucleic acids, proteins, and antibodies |
| PCT/US2001/001340 WO2001055321A2 (en) | 2000-01-31 | 2001-01-17 | Nucleic acids, proteins, and antibodies |
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| PCT/US2001/001349 WO2001054474A2 (en) | 2000-01-31 | 2001-01-17 | Nucleic acids, proteins, and antibodies |
| PCT/US2001/001321 WO2001055312A2 (en) | 2000-01-31 | 2001-01-17 | Nucleic acids, proteins, and antibodies |
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| PCT/US2001/001355 WO2001055207A1 (en) | 2000-01-31 | 2001-01-17 | Nucleic acids, proteins, and antibodies |
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| CA (37) | CA2395666A1 (en) |
| WO (48) | WO2001055447A1 (en) |
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2001
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