WO2001053344A3 - Chondromodulin-i related peptide - Google Patents

Chondromodulin-i related peptide Download PDF

Info

Publication number
WO2001053344A3
WO2001053344A3 PCT/US2001/001700 US0101700W WO0153344A3 WO 2001053344 A3 WO2001053344 A3 WO 2001053344A3 US 0101700 W US0101700 W US 0101700W WO 0153344 A3 WO0153344 A3 WO 0153344A3
Authority
WO
WIPO (PCT)
Prior art keywords
chondromodulin
polypeptide
relates
related peptide
antibodies
Prior art date
Application number
PCT/US2001/001700
Other languages
French (fr)
Other versions
WO2001053344A2 (en
Inventor
Hung Nguyen
Jeannie Jung
Kristie Clarkin
Original Assignee
Amgen Inc
Hung Nguyen
Jeannie Jung
Kristie Clarkin
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Amgen Inc, Hung Nguyen, Jeannie Jung, Kristie Clarkin filed Critical Amgen Inc
Priority to CA002398695A priority Critical patent/CA2398695A1/en
Priority to EP01908629A priority patent/EP1261639A2/en
Priority to JP2001553816A priority patent/JP2003520590A/en
Priority to AU36477/01A priority patent/AU3647701A/en
Priority to MXPA02007119A priority patent/MXPA02007119A/en
Publication of WO2001053344A2 publication Critical patent/WO2001053344A2/en
Publication of WO2001053344A3 publication Critical patent/WO2001053344A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/51—Bone morphogenetic factor; Osteogenins; Osteogenic factor; Bone-inducing factor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Rheumatology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Dermatology (AREA)
  • Peptides Or Proteins (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pain & Pain Management (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

The present invention relates to a novel polynucleotide encoding a polypeptide which is structurally related to chondromodulin-I, as well as to the purified protein itself. The invention also relates to vectors, host cells, antibodies and recombinant methods for producing the polypeptide. In addition, the invention discloses therapeutic, diagnostic and research utilities for these and related products.
PCT/US2001/001700 2000-01-19 2001-01-18 Chondromodulin-i related peptide WO2001053344A2 (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
CA002398695A CA2398695A1 (en) 2000-01-19 2001-01-18 Chondromodulin-i related peptide
EP01908629A EP1261639A2 (en) 2000-01-19 2001-01-18 Chondromodulin-i related peptide
JP2001553816A JP2003520590A (en) 2000-01-19 2001-01-18 Chondromodulin I-related peptide
AU36477/01A AU3647701A (en) 2000-01-19 2001-01-18 Chondromodulin-i related peptide
MXPA02007119A MXPA02007119A (en) 2000-01-19 2001-01-18 Chondromodulin i related peptide.

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US17689800P 2000-01-19 2000-01-19
US60/176,898 2000-01-19
US72431000A 2000-11-28 2000-11-28
US09/724,310 2000-11-28

Publications (2)

Publication Number Publication Date
WO2001053344A2 WO2001053344A2 (en) 2001-07-26
WO2001053344A3 true WO2001053344A3 (en) 2002-01-03

Family

ID=26872727

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/001700 WO2001053344A2 (en) 2000-01-19 2001-01-18 Chondromodulin-i related peptide

Country Status (7)

Country Link
EP (1) EP1261639A2 (en)
JP (1) JP2003520590A (en)
AR (1) AR027238A1 (en)
AU (1) AU3647701A (en)
CA (1) CA2398695A1 (en)
MX (1) MXPA02007119A (en)
WO (1) WO2001053344A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100934594B1 (en) 1999-09-29 2009-12-31 데이진 가부시키가이샤 New polypeptides and genes encoding them

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999053051A2 (en) * 1998-04-09 1999-10-21 Genset 5' ests and encoded human proteins
WO2000012708A2 (en) * 1998-09-01 2000-03-09 Genentech, Inc. Further pro polypeptides and sequences thereof
WO2000029579A1 (en) * 1998-11-13 2000-05-25 Zymogenetics, Inc. Mammalian chondromodulin-like protein
WO2000043495A2 (en) * 1999-01-19 2000-07-27 Human Genome Sciences, Inc. 33 human secreted proteins
WO2000078961A1 (en) * 1999-06-23 2000-12-28 Genentech, Inc. Secreted and transmembrane polypeptides and nucleic acids encoding the same
WO2001016318A2 (en) * 1999-09-01 2001-03-08 Genentech, Inc. Secreted and transmembrane polypeptides and nucleic acids encoding the same

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3585180B2 (en) * 1993-05-11 2004-11-04 三菱化学株式会社 Novel human proteins and genes encoding them
KR100934594B1 (en) * 1999-09-29 2009-12-31 데이진 가부시키가이샤 New polypeptides and genes encoding them
WO2001048203A1 (en) * 1999-12-27 2001-07-05 Takeda Chemical Industries, Ltd. Novel protein and dna thereof
JP2001299363A (en) * 1999-12-27 2001-10-30 Takeda Chem Ind Ltd New polypeptide and dna encoding the same

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999053051A2 (en) * 1998-04-09 1999-10-21 Genset 5' ests and encoded human proteins
WO2000012708A2 (en) * 1998-09-01 2000-03-09 Genentech, Inc. Further pro polypeptides and sequences thereof
WO2000029579A1 (en) * 1998-11-13 2000-05-25 Zymogenetics, Inc. Mammalian chondromodulin-like protein
WO2000043495A2 (en) * 1999-01-19 2000-07-27 Human Genome Sciences, Inc. 33 human secreted proteins
WO2000078961A1 (en) * 1999-06-23 2000-12-28 Genentech, Inc. Secreted and transmembrane polypeptides and nucleic acids encoding the same
WO2001016318A2 (en) * 1999-09-01 2001-03-08 Genentech, Inc. Secreted and transmembrane polypeptides and nucleic acids encoding the same

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
DATABASE EMBL [online] NCI-CGAP, XP002175241, retrieved from EBI Database accession no. AI123839 *
DATABASE EMBL [online] NCI-CGAP, XP002175242, retrieved from EBI Database accession no. AI039039 *
DATABASE EMBL [online] NCI-CGAP, XP002175243, retrieved from EBI Database accession no. AI147044 *
HIRAKI Y ET AL: "MOLECULAR CLONING OF A NEW CLASS OF CARTILAGE-SPECIFIC MATRIX CHONDROMODULIN I WHICH STIMULATES GROWTH OF CULTURED CHONDROCYTES", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, vol. 175, no. 3, 1991, pages 971 - 977, XP001018911, ISSN: 0006-291X *

Also Published As

Publication number Publication date
WO2001053344A2 (en) 2001-07-26
AU3647701A (en) 2001-07-31
JP2003520590A (en) 2003-07-08
AR027238A1 (en) 2003-03-19
EP1261639A2 (en) 2002-12-04
MXPA02007119A (en) 2003-04-14
CA2398695A1 (en) 2001-07-26

Similar Documents

Publication Publication Date Title
WO2001038486A3 (en) Kunitz-type protease inhibitor polynucleotides, polypeptides, and antibodies
WO1998056927A3 (en) Nucleic acids encoding polypeptide having protease activity
WO2003070760A3 (en) Anti-amyloid beta antibodies and their use
EP2258383A3 (en) Antigenic peptides derived from telomerase
WO2007002261A3 (en) IL-1β BINDING ANTIBODIES AND FRAGMENTS THEREOF
WO2000075350A3 (en) Nucleic acid sequences encoding proteins involved in fatty acid beta-oxidation and methods of use
EP1053245A4 (en) 45 human secreted proteins
EP1054958A4 (en) Human serine protease and serpin polypeptides
WO2002059315A3 (en) Human nucleic acids and polypeptides and methods of use thereof
DK0804558T3 (en) tripeptidyl aminopeptidase
WO2002008426A3 (en) Fh-binding protein of streptococcus pneumoniae
WO2002046409A3 (en) Proteins and nucleic acids encoding same
WO2000052136A3 (en) Human glycosylation enzymes
WO2000015659A3 (en) Stomach polypeptide zsig28
DE60118359D1 (en) HUMAN PELLINO POLYPEPTIDE
WO2001008635A3 (en) Calcium channel transport polynucleotides, polypeptides, and antibodies
WO2000068247A3 (en) Serine proteases
WO2001062891A3 (en) 207 human secreted proteins
WO1998027932A3 (en) Cerebellum and embryo specific protein
AU2001238064A1 (en) 18477, a human protein kinase and uses therefor
WO2000059942A3 (en) Human obesity protein binding protrein-2 homolog and uses thereof
WO2001053344A3 (en) Chondromodulin-i related peptide
WO2002090500A3 (en) Novel human proteins, polynucleotides encoding them and methods of using the same
WO2001032878A3 (en) A novel polypeptide hormone phosphatonin
WO2002046408A3 (en) Human proteins, polynucleotides encoding them and methods of using the same

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CR CU CZ DE DK DM DZ EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT TZ UA UG US UZ VN YU ZA ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE TR BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
AK Designated states

Kind code of ref document: A3

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CR CU CZ DE DK DM DZ EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT TZ UA UG US UZ VN YU ZA ZW

AL Designated countries for regional patents

Kind code of ref document: A3

Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE TR BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG

ENP Entry into the national phase

Ref document number: 2001 553816

Country of ref document: JP

Kind code of ref document: A

WWE Wipo information: entry into national phase

Country of ref document: MX

Ref document number: PA/a/2002/007119

Ref document number: 2398695

Country of ref document: CA

WWE Wipo information: entry into national phase

Ref document number: 36477/01

Country of ref document: AU

WWE Wipo information: entry into national phase

Ref document number: 2001908629

Country of ref document: EP

WWP Wipo information: published in national office

Ref document number: 2001908629

Country of ref document: EP

REG Reference to national code

Ref country code: DE

Ref legal event code: 8642