WO2001046412A3 - Proteines d'interaction pour le facteur de transcription stat - Google Patents

Proteines d'interaction pour le facteur de transcription stat Download PDF

Info

Publication number
WO2001046412A3
WO2001046412A3 PCT/DE2000/004557 DE0004557W WO0146412A3 WO 2001046412 A3 WO2001046412 A3 WO 2001046412A3 DE 0004557 W DE0004557 W DE 0004557W WO 0146412 A3 WO0146412 A3 WO 0146412A3
Authority
WO
WIPO (PCT)
Prior art keywords
amino acid
transcription factor
relates
stat transcription
interaction
Prior art date
Application number
PCT/DE2000/004557
Other languages
German (de)
English (en)
Other versions
WO2001046412A2 (fr
Inventor
Renate Weber-Nordt
Angelika Gabler
Original Assignee
Univ Ruprecht Karls Heidelberg
Weber Nordt Renate
Angelika Gabler
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Ruprecht Karls Heidelberg, Weber Nordt Renate, Angelika Gabler filed Critical Univ Ruprecht Karls Heidelberg
Priority to AU33593/01A priority Critical patent/AU3359301A/en
Publication of WO2001046412A2 publication Critical patent/WO2001046412A2/fr
Publication of WO2001046412A3 publication Critical patent/WO2001046412A3/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity
    • C07K14/4705—Regulators; Modulating activity stimulating, promoting or activating activity
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

L'invention concerne des polypeptides isolés qui fonctionnent comme protéine d'interaction du facteur de transcription STAT3 et qui présentent la séquence d'aminoacides représentée dans le protocole de séquence SEQ ID NO: 2 ou bien une séquence d'aminoacides résultant d'une substitution, d'une délétion, d'une insertion ou d'une inversion d'aminoacides, en tant qu'allèle ou dérivé. L'invention concerne en outre des acides nucléiques isolés qui codent pour de telles protéines d'interaction ou au moins pour des parties de celles-ci, l'utilisation de tels polypeptides et acides nucléiques pour le dépistage, en particulier le diagnostic, le traitement et la recherche. De plus, cette invention concerne des réactifs qui sont produits au moyen d'au moins une de ces molécules, en particulier des molécules vecteurs et des anticorps de recombinaison.
PCT/DE2000/004557 1999-12-21 2000-12-19 Proteines d'interaction pour le facteur de transcription stat WO2001046412A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU33593/01A AU3359301A (en) 1999-12-21 2000-12-19 Interaction proteins for the stat transcription factor

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE1999161899 DE19961899A1 (de) 1999-12-21 1999-12-21 Interaktikonsproteine für STAT Transkriptionsfaktor
DE19961899.2 1999-12-21

Publications (2)

Publication Number Publication Date
WO2001046412A2 WO2001046412A2 (fr) 2001-06-28
WO2001046412A3 true WO2001046412A3 (fr) 2002-03-14

Family

ID=7933731

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/DE2000/004557 WO2001046412A2 (fr) 1999-12-21 2000-12-19 Proteines d'interaction pour le facteur de transcription stat

Country Status (3)

Country Link
AU (1) AU3359301A (fr)
DE (1) DE19961899A1 (fr)
WO (1) WO2001046412A2 (fr)

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998030688A1 (fr) * 1997-01-10 1998-07-16 Tadamitsu Kishimoto Nouvelle proteine de regulation de la fonction stat

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999050455A1 (fr) * 1998-03-27 1999-10-07 Temple University - Of The Commonwealth System Of Higher Education Methodes permettant de diagnostiquer un cancer et d'identifier des agents antiproliferatifs

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998030688A1 (fr) * 1997-01-10 1998-07-16 Tadamitsu Kishimoto Nouvelle proteine de regulation de la fonction stat
EP0989186A1 (fr) * 1997-01-10 2000-03-29 Kishimoto, Tadami Nouvelle proteine de regulation de la fonction stat

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
CHIEN C-T ET AL: "THE TWO-HYBRID SYSTEM: A METHOD TO IDENTIFY AND CLONE GENES FOR PROTEINS THAT INTERACT WITH A PROTEIN OF INTEREST", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA, NATIONAL ACADEMY OF SCIENCE. WASHINGTON, US, vol. 88, 1 November 1991 (1991-11-01), pages 9578 - 9582, XP000647704, ISSN: 0027-8424 *
FRANK DAVID A: "STAT signaling in the pathogenesis and treatment of cancer.", MOLECULAR MEDICINE (NEW YORK), vol. 5, no. 7, July 1999 (1999-07-01), pages 432 - 456, XP001021603, ISSN: 1076-1551 *
GABLER ANGELIKA ET AL: "C102: A novel STAT3 interacting protein.", BLOOD, vol. 96, no. 11 Part 1, 16 November 2000 (2000-11-16), 42nd Annual Meeting of the American Society of Hematology;San Francisco, California, USA; December 01-05, 2000, pages 94a, XP001025916, ISSN: 0006-4971 *
NAKA T ET AL: "NEGATIVE REGULATION OF CYTOKINE SIGNALING: STAT-INDUCED STAT INHIBITOR", TIBS TRENDS IN BIOCHEMICAL SCIENCES, ELSEVIER PUBLICATION, CAMBRIDGE, EN, vol. 24, no. 10, October 1999 (1999-10-01), pages 394 - 398, XP001019044, ISSN: 0968-0004 *
NAKA T ET AL: "Structure and function of a new STAT-induced STAT inhibitor", NATURE, MACMILLAN JOURNALS LTD. LONDON, GB, vol. 387, no. 6636, 26 June 1997 (1997-06-26), pages 924 - 929, XP002088455, ISSN: 0028-0836 *

Also Published As

Publication number Publication date
DE19961899A1 (de) 2001-07-12
AU3359301A (en) 2001-07-03
WO2001046412A2 (fr) 2001-06-28

Similar Documents

Publication Publication Date Title
WO1999066025A3 (fr) NOUVELLES MOLECULES PROTEIQUES ET NUCLEOTIDIQUES MTbx ET LEURS APPLICATIONS
BR0015137A (pt) Peptìdeos antigênicos de neisseria
WO1999055868A3 (fr) Proteines fizz
EA199800046A1 (ru) Полипептид, последовательность днк, вакцинная композиция (варианты), антитело или его фрагмент, вакцина, применения указанных полипептида, последовательности днк и антитела или его фрагмента
ATE380867T1 (de) Lactoferrinrezeptorgen von moraxella
EP1009752A4 (fr) Nouvelles molecules de la famille des proteines de type tango-77 et utilisations de ces molecules
AU3217100A (en) Methods of use of a novel lysyl oxidase-related protein
WO2000052047A3 (fr) Proteine humaine et molecules d'acide nucleique associees a dickkopf et leurs utilisations
WO2000019988A8 (fr) NOUVELLES MOLECULES SPECIFIQUES DE Th2 ET LEURS UTILISATIONS
AU6517400A (en) 15571, a novel gpcr-like molecule of the secretin-like family and uses thereof
WO2001061005A3 (fr) Nouvelles molecules de la famille de proteines du domaine pyrine, et leurs utilisations
WO2000012544A3 (fr) Nouvelles molecules d'acides nucleiques et de polypeptides irap-bp et leurs utilisations
WO1995008628A3 (fr) Acides nucleiques codant la merosine, fragments de merosine et utilisations de ceux-ci
WO2002061049A3 (fr) Nouvelles molecules de la famille des proteines pyrin/nbs/lrr et leurs utilisations
WO1999054437A3 (fr) Nouvelles molecules de la famille des proteines liees a t125 et utilisations de celles-ci
WO2000008045A3 (fr) Nouvelles molecules de la famille de proteines apparentees a tango-93 et leurs utilisations
WO2001046412A3 (fr) Proteines d'interaction pour le facteur de transcription stat
WO2003029434A3 (fr) Nouvelles molecules de la famille de proteines associee a la hkid-1 et utilisations desdites molecules
WO2000017232A3 (fr) Proteine regulatrice issue de keratinocytes humains
WO2001049714A3 (fr) Polypeptides nope, acides nucleiques les codant, et modes d'utilisation
WO2000018890A3 (fr) Nouvelles molecules de proteine phosphatase et utilisation de ces molecules
WO2003020912A3 (fr) Nouvelle proteine cark et molecules d'acides nucleiques et leurs utilisation
WO1999062943A3 (fr) Nouvelles molecules de la famille des proteines apparentees aip et leurs utilisations
WO2000018923A3 (fr) Proteine et nouvelle molecule d'acide nucleique slgp et utilisations de celles-ci
WO2000055192A3 (fr) Molecule d'acides nucleiques, comprenant une sequence d'acides nucleiques codant pour une hemocyanine

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AU CA CN IL JP US

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE TR

121 Ep: the epo has been informed by wipo that ep was designated in this application
DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
AK Designated states

Kind code of ref document: A3

Designated state(s): AU CA CN IL JP US

AL Designated countries for regional patents

Kind code of ref document: A3

Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE TR

122 Ep: pct application non-entry in european phase
NENP Non-entry into the national phase

Ref country code: JP