WO2000018890A3 - Nouvelles molecules de proteine phosphatase et utilisation de ces molecules - Google Patents

Nouvelles molecules de proteine phosphatase et utilisation de ces molecules Download PDF

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Publication number
WO2000018890A3
WO2000018890A3 PCT/US1999/022924 US9922924W WO0018890A3 WO 2000018890 A3 WO2000018890 A3 WO 2000018890A3 US 9922924 W US9922924 W US 9922924W WO 0018890 A3 WO0018890 A3 WO 0018890A3
Authority
WO
WIPO (PCT)
Prior art keywords
csaptp
nucleic acid
proteins
expression vectors
acid molecules
Prior art date
Application number
PCT/US1999/022924
Other languages
English (en)
Other versions
WO2000018890A2 (fr
WO2000018890A9 (fr
Inventor
Susan Acton
Original Assignee
Millennium Pharm Inc
Susan Acton
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US09/163,833 external-priority patent/US6268135B1/en
Priority claimed from US09/164,193 external-priority patent/US6258582B1/en
Application filed by Millennium Pharm Inc, Susan Acton filed Critical Millennium Pharm Inc
Priority to AU64105/99A priority Critical patent/AU6410599A/en
Publication of WO2000018890A2 publication Critical patent/WO2000018890A2/fr
Publication of WO2000018890A3 publication Critical patent/WO2000018890A3/fr
Publication of WO2000018890A9 publication Critical patent/WO2000018890A9/fr

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y301/00—Hydrolases acting on ester bonds (3.1)
    • C12Y301/03—Phosphoric monoester hydrolases (3.1.3)
    • C12Y301/03048—Protein-tyrosine-phosphatase (3.1.3.48)

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

L'invention concerne de nouveaux polypeptides et de nouvelles protéines et molécules d'acide nucléique de CSAPTP (Cardiovascular System Associated Protein Tyrosine Phosphatase : protéine thyrosine phosphatase associée au système cardio-vasculaire). Outre des protéines CSAPTP isolées complètes, l'invention concerne des protéines de fusion et des peptides antigéniques CSAPTP ainsi que des anticorps anti-CSAPTP. L'invention concerne également des molécules d'acide nucléique CSAPTP, des vecteurs d'expression recombinants contenant une telle molécule d'acide nucléique, des cellules hôtes dans lesquelles les vecteurs d'expression ont été introduits et des animaux transgéniques dans lesquels un gène CSAPTP a été introduit ou disloqué. L'invention concerne en outre des méthodes de diagnostic, de criblage et de traitement comprenant l'utilisation de ces compositions.
PCT/US1999/022924 1998-09-30 1999-09-30 Nouvelles molecules de proteine phosphatase et utilisation de ces molecules WO2000018890A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU64105/99A AU6410599A (en) 1998-09-30 1999-09-30 Novel protein phosphatase molecules and uses therefor

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US09/163,833 US6268135B1 (en) 1998-09-30 1998-09-30 Phospholipase molecule and uses therefor
US09/164,193 1998-09-30
US09/163,833 1998-09-30
US09/164,193 US6258582B1 (en) 1998-09-30 1998-09-30 CSAPTP nucleic acid molecules and uses therefor

Publications (3)

Publication Number Publication Date
WO2000018890A2 WO2000018890A2 (fr) 2000-04-06
WO2000018890A3 true WO2000018890A3 (fr) 2000-09-28
WO2000018890A9 WO2000018890A9 (fr) 2001-02-01

Family

ID=26859984

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1999/022924 WO2000018890A2 (fr) 1998-09-30 1999-09-30 Nouvelles molecules de proteine phosphatase et utilisation de ces molecules

Country Status (2)

Country Link
AU (1) AU6410599A (fr)
WO (1) WO2000018890A2 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110283803B (zh) * 2016-06-02 2021-08-03 天津科技大学 一种磷脂酶d及其制备磷脂酸、磷脂酰丝氨酸的方法

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6492157B1 (en) 1999-04-07 2002-12-10 Ceptyr, Inc. DSP-9 dual-specificity phosphatase
AU4210100A (en) * 1999-04-07 2000-10-23 Ceptyr, Inc. Dsp-7 dual-specificity map kinase phosphatase
EP1212433A2 (fr) * 1999-08-13 2002-06-12 Sugen, Inc. Nouvelles phosphatases de proteines et diagnostic et traitement des troubles lies a la phosphatase
WO2002031132A2 (fr) * 2000-10-11 2002-04-18 Millennium Pharmaceuticals, Inc. Nouvel element de la famille des phosphatases humaines a double specificite, appele 8843, et utilisation de ce dernier

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994003611A2 (fr) * 1992-08-05 1994-02-17 MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. Sous famille ptp-d de tyrosine phosphatases de proteines
WO1998014596A2 (fr) * 1996-10-03 1998-04-09 Incyte Pharmaceuticals, Inc. Tyrosine phosphatases proteiques associees a des maladies

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994003611A2 (fr) * 1992-08-05 1994-02-17 MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. Sous famille ptp-d de tyrosine phosphatases de proteines
WO1998014596A2 (fr) * 1996-10-03 1998-04-09 Incyte Pharmaceuticals, Inc. Tyrosine phosphatases proteiques associees a des maladies

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
ZENG ET AL.: "Homo sapiens potentially prenylated protein tyrosine phosphatase", EMBL SEQUENCE DATABASE, 10 August 1998 (1998-08-10), HEIDELBERG DE, XP002132488 *
ZENG ET AL.: "HPRL-3", EMBL SEQUENCE DATABASE, 1 November 1998 (1998-11-01), HEIDELBERG DE, XP002132489 *
ZENG ET AL.: "Mouse PRL-2 and PRL-3, two potentially prenylated protein tyrosine phosphatases homologous to PRL-1", BIOCHEM BIOPHYS RES COMMUN, vol. 244, 1998, pages 421 - 427 *
ZENG ET AL.: "Mus musculus potentially prenylated protein tyrosine phosphatase mPRL-3 (Prl3) mRNA, complet compound", EMBL SEQUENCE DATABASE, 30 March 1998 (1998-03-30), HEIDELBERG DE, XP002132491 *
ZENG ET AL.: "Protein tyrosine phosphatase 4A3 (MPRL-3)", EMBL SEQUENCE DATABASE, 1 August 1998 (1998-08-01), HEIDELBERG DE, XP002132490 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110283803B (zh) * 2016-06-02 2021-08-03 天津科技大学 一种磷脂酶d及其制备磷脂酸、磷脂酰丝氨酸的方法

Also Published As

Publication number Publication date
AU6410599A (en) 2000-04-17
WO2000018890A2 (fr) 2000-04-06
WO2000018890A9 (fr) 2001-02-01

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