WO2001046213A3 - Compound comprising a peptide moiety and an organo-silane moiety. - Google Patents

Compound comprising a peptide moiety and an organo-silane moiety. Download PDF

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Publication number
WO2001046213A3
WO2001046213A3 PCT/EP2000/013099 EP0013099W WO0146213A3 WO 2001046213 A3 WO2001046213 A3 WO 2001046213A3 EP 0013099 W EP0013099 W EP 0013099W WO 0146213 A3 WO0146213 A3 WO 0146213A3
Authority
WO
WIPO (PCT)
Prior art keywords
moiety
organo
silane
compound
biomolecule
Prior art date
Application number
PCT/EP2000/013099
Other languages
French (fr)
Other versions
WO2001046213A2 (en
Inventor
Martin Huber
Wolfgang Schmidt
Manfred Mueller
Reinhard Hiller
Original Assignee
Lion Bioscience Ag
Martin Huber
Wolfgang Schmidt
Manfred Mueller
Reinhard Hiller
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from EP99125485A external-priority patent/EP1110967A1/en
Priority claimed from EP99125484A external-priority patent/EP1111068A1/en
Application filed by Lion Bioscience Ag, Martin Huber, Wolfgang Schmidt, Manfred Mueller, Reinhard Hiller filed Critical Lion Bioscience Ag
Priority to EP00993511A priority Critical patent/EP1252172A2/en
Priority to AU28432/01A priority patent/AU2843201A/en
Publication of WO2001046213A2 publication Critical patent/WO2001046213A2/en
Publication of WO2001046213A3 publication Critical patent/WO2001046213A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6834—Enzymatic or biochemical coupling of nucleic acids to a solid phase
    • C12Q1/6837—Enzymatic or biochemical coupling of nucleic acids to a solid phase using probe arrays or probe chips
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
    • C07K1/1072—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups
    • C07K1/1077—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups by covalent attachment of residues other than amino acids or peptide residues, e.g. sugars, polyols, fatty acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/001—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof by chemical synthesis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K17/00—Carrier-bound or immobilised peptides; Preparation thereof
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6834—Enzymatic or biochemical coupling of nucleic acids to a solid phase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844—Nucleic acid amplification reactions
    • C12Q1/686—Polymerase chain reaction [PCR]
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B50/00—Methods of creating libraries, e.g. combinatorial synthesis
    • C40B50/14—Solid phase synthesis, i.e. wherein one or more library building blocks are bound to a solid support during library creation; Particular methods of cleavage from the solid support
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/11—Compounds covalently bound to a solid support

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biophysics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Immunology (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Structural Engineering (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

The present invention concerns a compound comprising a biomolecule moiety and an organo-silane moiety, as well as a process for the synthesis thereof. The invention also concerns a support comprising the biomolecule moiety with the organo-silane moiety, wherein the biomolecule moiety is attached to the support through the organo-silane moiety. The invention also concerns a process for a nucleic acid synthesis reaction making use of the biomolecule moiety with the organo-silane moiety as well as uses of the novel compound. The invention in addition concerns a kit comprising the compound comprising a biomolecule moiety and an organo-silane moiety.
PCT/EP2000/013099 1999-12-21 2000-12-21 Compound comprising a peptide moiety and an organo-silane moiety. WO2001046213A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
EP00993511A EP1252172A2 (en) 1999-12-21 2000-12-21 Compound comprising a peptide moiety and an organo-silane moiety
AU28432/01A AU2843201A (en) 1999-12-21 2000-12-21 Compound comprising a peptide moiety and an organo-silane moiety.

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
EP99125485A EP1110967A1 (en) 1999-12-21 1999-12-21 Compound comprising a biomolecule moiety and an organo-silane moiety
EP99125484.8 1999-12-21
EP99125485.5 1999-12-21
EP99125484A EP1111068A1 (en) 1999-12-21 1999-12-21 Branched compound for use in nucleic acid detection and analysis reactions
US21120900P 2000-06-13 2000-06-13
US21121700P 2000-06-13 2000-06-13
US60/211,209 2000-06-13
US60/211,217 2000-06-13

Publications (2)

Publication Number Publication Date
WO2001046213A2 WO2001046213A2 (en) 2001-06-28
WO2001046213A3 true WO2001046213A3 (en) 2002-05-10

Family

ID=56290094

Family Applications (3)

Application Number Title Priority Date Filing Date
PCT/EP2000/013099 WO2001046213A2 (en) 1999-12-21 2000-12-21 Compound comprising a peptide moiety and an organo-silane moiety.
PCT/EP2000/013098 WO2001046464A1 (en) 1999-12-21 2000-12-21 Branched compound for use in nucleic acid detection and analysis reactions
PCT/EP2000/013100 WO2001046214A2 (en) 1999-12-21 2000-12-21 Compound comprising a nucleic acid moiety and an organo-silane moiety

Family Applications After (2)

Application Number Title Priority Date Filing Date
PCT/EP2000/013098 WO2001046464A1 (en) 1999-12-21 2000-12-21 Branched compound for use in nucleic acid detection and analysis reactions
PCT/EP2000/013100 WO2001046214A2 (en) 1999-12-21 2000-12-21 Compound comprising a nucleic acid moiety and an organo-silane moiety

Country Status (3)

Country Link
EP (3) EP1250344A2 (en)
AU (3) AU2170901A (en)
WO (3) WO2001046213A2 (en)

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CA2563510A1 (en) * 2001-07-13 2005-11-17 Nanosphere, Inc. Method for preparing substrates having immobilized molecules and substrates
AU2003233595A1 (en) 2002-05-20 2003-12-12 Dow Corning Corporation Peptide derivatives, and their use for the synthesis of silicon-based composite materials
ATE495826T1 (en) 2002-05-20 2011-02-15 Danisco Us Inc SYNTHESIS OF INORGANIC STRUCTURES USING TEMPLATES AND CATALYSIS BY SELF-ASSEMBLED REPEAT PROTEIN POLYMERS
US7534621B2 (en) 2003-02-07 2009-05-19 Canon Kabuhsiki Kashia Method of producing probe medium and method of immobilizing probe using probe medium
US7297678B2 (en) 2003-03-12 2007-11-20 Genencor International, Inc. Use of repeat sequence protein polymers in personal care compositions
US20050142094A1 (en) 2003-03-12 2005-06-30 Manoj Kumar Use of repeat sequence protein polymers in personal care compositions
JP4629046B2 (en) 2003-05-14 2011-02-09 ダニスコ・ユーエス・インコーポレーテッド Repeat sequence protein polymer active agent conjugates, methods and uses
JP4850709B2 (en) 2003-05-14 2012-01-11 ダニスコ・ユーエス・インコーポレーテッド Controlled release of active agent using repetitive sequence protein polymer
AU2004311882A1 (en) 2003-12-29 2005-07-21 Nugen Technologies, Inc. Methods for analysis of nucleic acid methylation status and methods for fragmentation, labeling and immobilization of nucleic acids
US7940746B2 (en) 2004-08-24 2011-05-10 Comcast Cable Holdings, Llc Method and system for locating a voice over internet protocol (VoIP) device connected to a network
CA2852949A1 (en) 2011-10-19 2013-04-25 Nugen Technologies, Inc. Compositions and methods for directional nucleic acid amplification and sequencing
WO2013072408A1 (en) * 2011-11-15 2013-05-23 Swetree Technologies Ab Surface-functionalized cellulosic fibres, method of manufacture thereof and uses thereof
EP2807292B1 (en) 2012-01-26 2019-05-22 Tecan Genomics, Inc. Compositions and methods for targeted nucleic acid sequence enrichment and high efficiency library generation
GB2518078B (en) 2012-06-18 2015-04-29 Nugen Technologies Inc Compositions and methods for negative selection of non-desired nucleic acid sequences
US20150011396A1 (en) 2012-07-09 2015-01-08 Benjamin G. Schroeder Methods for creating directional bisulfite-converted nucleic acid libraries for next generation sequencing
US9822408B2 (en) 2013-03-15 2017-11-21 Nugen Technologies, Inc. Sequential sequencing
EP3068883B1 (en) 2013-11-13 2020-04-29 Nugen Technologies, Inc. Compositions and methods for identification of a duplicate sequencing read
US9745614B2 (en) 2014-02-28 2017-08-29 Nugen Technologies, Inc. Reduced representation bisulfite sequencing with diversity adaptors
US10102337B2 (en) 2014-08-06 2018-10-16 Nugen Technologies, Inc. Digital measurements from targeted sequencing
US11099202B2 (en) 2017-10-20 2021-08-24 Tecan Genomics, Inc. Reagent delivery system
US12059674B2 (en) 2020-02-03 2024-08-13 Tecan Genomics, Inc. Reagent storage system

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DE2905657A1 (en) * 1978-02-14 1979-08-16 Sanyo Chemical Ind Ltd CONJUGATES OF IMMUNOLOGICALLY ACTIVE SUBSTANCE AND GLASS, PROCESS FOR THEIR PRODUCTION AND USE OF THE SAME
US4284553A (en) * 1980-06-20 1981-08-18 North Carolina State University At Raleigh Reversible method for covalent immobilization of biochemicals
US4894468A (en) * 1986-04-27 1990-01-16 Yeda Research And Development Co., Ltd. Substituted silica
WO1992015674A2 (en) * 1991-03-02 1992-09-17 Tepnel Medical Limited Dna -or rna- modifying enzymes immobilized to supports
WO1994000408A1 (en) * 1992-06-23 1994-01-06 Research Corporation Technologies, Inc. High performance chiral selector
WO1999005315A2 (en) * 1997-07-28 1999-02-04 Medical Biosystems Ltd. Nucleic acid sequence analysis

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US4284553A (en) * 1980-06-20 1981-08-18 North Carolina State University At Raleigh Reversible method for covalent immobilization of biochemicals
US4894468A (en) * 1986-04-27 1990-01-16 Yeda Research And Development Co., Ltd. Substituted silica
WO1992015674A2 (en) * 1991-03-02 1992-09-17 Tepnel Medical Limited Dna -or rna- modifying enzymes immobilized to supports
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Also Published As

Publication number Publication date
EP1252172A2 (en) 2002-10-30
WO2001046213A2 (en) 2001-06-28
EP1250344A2 (en) 2002-10-23
AU3163101A (en) 2001-07-03
AU2843201A (en) 2001-07-03
WO2001046214A2 (en) 2001-06-28
WO2001046464A1 (en) 2001-06-28
AU2170901A (en) 2001-07-03
WO2001046214A3 (en) 2001-12-27
EP1244812A1 (en) 2002-10-02

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