WO2001040791A3 - Method and device for electrospray ionisation - Google Patents

Method and device for electrospray ionisation Download PDF

Info

Publication number
WO2001040791A3
WO2001040791A3 PCT/EP2000/011859 EP0011859W WO0140791A3 WO 2001040791 A3 WO2001040791 A3 WO 2001040791A3 EP 0011859 W EP0011859 W EP 0011859W WO 0140791 A3 WO0140791 A3 WO 0140791A3
Authority
WO
WIPO (PCT)
Prior art keywords
liquid
heating
inlet
electrospray ionisation
mass analyser
Prior art date
Application number
PCT/EP2000/011859
Other languages
French (fr)
Other versions
WO2001040791A2 (en
Inventor
Johan Eriksson
Original Assignee
Amersham Biosciences Ab
Johan Eriksson
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Amersham Biosciences Ab, Johan Eriksson filed Critical Amersham Biosciences Ab
Priority to JP2001542202A priority Critical patent/JP2003515902A/en
Priority to US10/148,717 priority patent/US6683302B1/en
Priority to EP00981314A priority patent/EP1243018A2/en
Priority to AU18605/01A priority patent/AU1860501A/en
Priority to CA002392750A priority patent/CA2392750A1/en
Publication of WO2001040791A2 publication Critical patent/WO2001040791A2/en
Publication of WO2001040791A3 publication Critical patent/WO2001040791A3/en

Links

Classifications

    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/02—Details
    • H01J49/10—Ion sources; Ion guns
    • H01J49/16—Ion sources; Ion guns using surface ionisation, e.g. field-, thermionic- or photo-emission
    • H01J49/165—Electrospray ionisation
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/02—Details
    • H01J49/04—Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components
    • H01J49/0468—Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components with means for heating or cooling the sample
    • H—ELECTRICITY
    • H05—ELECTRIC TECHNIQUES NOT OTHERWISE PROVIDED FOR
    • H05B—ELECTRIC HEATING; ELECTRIC LIGHT SOURCES NOT OTHERWISE PROVIDED FOR; CIRCUIT ARRANGEMENTS FOR ELECTRIC LIGHT SOURCES, IN GENERAL
    • H05B6/00—Heating by electric, magnetic or electromagnetic fields
    • H05B6/64—Heating using microwaves
    • H05B6/80—Apparatus for specific applications
    • H05B6/802—Apparatus for specific applications for heating fluids
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/62—Detectors specially adapted therefor
    • G01N30/72—Mass spectrometers
    • G01N30/7233—Mass spectrometers interfaced to liquid or supercritical fluid chromatograph
    • G01N30/724—Nebulising, aerosol formation or ionisation
    • G01N30/7266—Nebulising, aerosol formation or ionisation by electric field, e.g. electrospray

Landscapes

  • Physics & Mathematics (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Plasma & Fusion (AREA)
  • Electromagnetism (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Electron Tubes For Measurement (AREA)
  • Constitution Of High-Frequency Heating (AREA)

Abstract

The present invention relates to electrospray device and a method for heating a liquid in said electrospray device. The device comprising a liquid source (3), a mass analyser (5), an inlet plate (17) with an inlet orifice (19), liquid inlet means such as a capillary tube (9) having a spray tip (11) for emitting liquid from said liquid source (3) and it further comprises microwave energy emitting means (21) between said spray tip (11) and said mass analyser (5) for heating said liquid.
PCT/EP2000/011859 1999-11-29 2000-11-28 Method and device for electrospray ionisation WO2001040791A2 (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
JP2001542202A JP2003515902A (en) 1999-11-29 2000-11-28 Electrospray ionization method and apparatus
US10/148,717 US6683302B1 (en) 1999-11-29 2000-11-28 Method and device for electrospray ionization
EP00981314A EP1243018A2 (en) 1999-11-29 2000-11-28 Method and device for electrospray ionisation
AU18605/01A AU1860501A (en) 1999-11-29 2000-11-28 Method and device for electrospray ionisation
CA002392750A CA2392750A1 (en) 1999-11-29 2000-11-28 Method and device for electrospray ionisation

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE9904318-4 1999-11-29
SE9904318A SE9904318D0 (en) 1999-11-29 1999-11-29 Method and device for electrospray ionization

Publications (2)

Publication Number Publication Date
WO2001040791A2 WO2001040791A2 (en) 2001-06-07
WO2001040791A3 true WO2001040791A3 (en) 2002-07-18

Family

ID=20417891

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2000/011859 WO2001040791A2 (en) 1999-11-29 2000-11-28 Method and device for electrospray ionisation

Country Status (7)

Country Link
US (1) US6683302B1 (en)
EP (1) EP1243018A2 (en)
JP (1) JP2003515902A (en)
AU (1) AU1860501A (en)
CA (1) CA2392750A1 (en)
SE (1) SE9904318D0 (en)
WO (1) WO2001040791A2 (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10392706B8 (en) * 2002-05-31 2017-02-16 Waters Technologies Corp. (N.D.Ges.D. Staates Delaware) Fast combination multi-mode ionization source for mass spectrometers
CN1301854C (en) * 2002-06-14 2007-02-28 电气化学工业株式会社 Sheet and electronic component packaging container
US6646257B1 (en) * 2002-09-18 2003-11-11 Agilent Technologies, Inc. Multimode ionization source
US6967326B2 (en) * 2004-02-27 2005-11-22 Lucent Technologies Inc. Mass spectrometers on wafer-substrates
US20070023677A1 (en) * 2005-06-29 2007-02-01 Perkins Patrick D Multimode ionization source and method for screening molecules
ES2319837B2 (en) * 2006-08-02 2009-12-04 Universidad De Alicante INTEGRATED AND FLEXIBLE SYSTEM FOR THE INTRODUCTION OF SAMPLES IN ATOMIC SPECTROMETRY BASED ON MICROWAVE RADIATION.
US20090211522A1 (en) * 2008-02-21 2009-08-27 Gm Global Technology Operations, Inc. Use of Variable Frequency Microwaves to Control the Teflon Profile of Gas Diffusion Media
KR100971057B1 (en) 2008-03-10 2010-07-20 김미화 Spray tip for electro-spray ionization furnished with metal wire therein

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4935624A (en) * 1987-09-30 1990-06-19 Cornell Research Foundation, Inc. Thermal-assisted electrospray interface (TAESI) for LC/MS

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5935347A (en) * 1982-08-20 1984-02-27 Masahiko Tsuchiya Ion generator
US4842701A (en) * 1987-04-06 1989-06-27 Battelle Memorial Institute Combined electrophoretic-separation and electrospray method and system
JP3160050B2 (en) * 1992-03-13 2001-04-23 株式会社日立製作所 Mass spectrometer
JP3367719B2 (en) * 1993-09-20 2003-01-20 株式会社日立製作所 Mass spectrometer and electrostatic lens
US6586731B1 (en) * 1999-04-12 2003-07-01 Mds Inc. High intensity ion source apparatus for mass spectrometry

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4935624A (en) * 1987-09-30 1990-06-19 Cornell Research Foundation, Inc. Thermal-assisted electrospray interface (TAESI) for LC/MS

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
MEHDI M ET AL: "Atmospheric Pressure Microwave Induced Plasma Ionization Source for Molecular Mass Spectrometry", JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY, ELSEVIER SCIENCE INC, US, vol. 9, no. 1, 1998, pages 42 - 49, XP004102846, ISSN: 1044-0305 *

Also Published As

Publication number Publication date
CA2392750A1 (en) 2001-06-07
AU1860501A (en) 2001-06-12
WO2001040791A2 (en) 2001-06-07
EP1243018A2 (en) 2002-09-25
JP2003515902A (en) 2003-05-07
SE9904318D0 (en) 1999-11-29
US6683302B1 (en) 2004-01-27

Similar Documents

Publication Publication Date Title
WO2002082073A3 (en) A method of and apparatus for ionizing an analyte and ion source probe for use therewith
CA2359954A1 (en) Capillary tube assembly with replaceable capillary tube
HK1059499A1 (en) Process for increasing the field emission , emitter, triode, display device and light device
AU3909100A (en) Direct flow injection analysis nebulization electrospray and apci mass spectrometry
WO2002095362A3 (en) Method and apparatus for feedback controlled electrospray
TR200400076T4 (en) Method and apparatus for forming a sheath
SE9804299L (en) Device for increasing heat emission
WO2003102537A3 (en) A high speed combination multi-mode ionization source for mass spectrometers
GB0103516D0 (en) Apparatus for dispensing a sample
WO2007125297A3 (en) Mass spectrometer
WO2003036700A1 (en) Device and method for microwave plasma processing, and microwave power supply device
WO2002016927A3 (en) Sample introduction interface for analytical processing
GB2428391A (en) A capillary emitter for electrospray mass spectrometry
MX2007009668A (en) Ehd aerosol dispensing device and spraying method.
WO2004097369A3 (en) Fragmentation-based methods and systems for de novo sequencing
WO2007102087A3 (en) Capillary tube aerosol generator
DE69818633D1 (en) ELECTRON EMITTING DEVICE, FIELD EMISSION DISPLAY DEVICE AND MANUFACTURING METHOD THEREOF
WO2001044795A3 (en) Parallel sample introduction electrospray mass spectrometer with electronic indexing through multiple ion entrance orifices
WO2001040791A3 (en) Method and device for electrospray ionisation
SE0004233D0 (en) Electrospray emitter
WO2004079364A8 (en) Electrospray emitter coated with material of low surface energy
ITBO980668A0 (en) GASEOUS FUEL DISPENSING GUN.
CA2479872A1 (en) Ionization apparatus and method for mass spectrometer system
TW553472U (en) Plasma display device
WO2004101214A3 (en) Laser micromachining systems

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CR CU CZ DE DK DM DZ EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT TZ UA UG US UZ VN YU ZA ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE TR BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
WWE Wipo information: entry into national phase

Ref document number: 2000981314

Country of ref document: EP

ENP Entry into the national phase

Ref country code: JP

Ref document number: 2001 542202

Kind code of ref document: A

Format of ref document f/p: F

WWE Wipo information: entry into national phase

Ref document number: 2392750

Country of ref document: CA

AK Designated states

Kind code of ref document: A3

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CR CU CZ DE DK DM DZ EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT TZ UA UG US UZ VN YU ZA ZW

AL Designated countries for regional patents

Kind code of ref document: A3

Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE TR BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG

WWE Wipo information: entry into national phase

Ref document number: 10148717

Country of ref document: US

WWP Wipo information: published in national office

Ref document number: 2000981314

Country of ref document: EP

REG Reference to national code

Ref country code: DE

Ref legal event code: 8642

WWW Wipo information: withdrawn in national office

Ref document number: 2000981314

Country of ref document: EP