WO2001040312A3 - Naive screening method - Google Patents

Naive screening method Download PDF

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Publication number
WO2001040312A3
WO2001040312A3 PCT/GB2000/004629 GB0004629W WO0140312A3 WO 2001040312 A3 WO2001040312 A3 WO 2001040312A3 GB 0004629 W GB0004629 W GB 0004629W WO 0140312 A3 WO0140312 A3 WO 0140312A3
Authority
WO
WIPO (PCT)
Prior art keywords
polypeptide
naive
screening method
target ligand
naïve
Prior art date
Application number
PCT/GB2000/004629
Other languages
French (fr)
Other versions
WO2001040312A2 (en
Inventor
Lucy Jessica Holt
Wildt Rudolf Maria Theodora De
Ian Tomlinson
Original Assignee
Diversys Ltd
Lucy Jessica Holt
Wildt Rudolf Maria Theodora De
Ian Tomlinson
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Diversys Ltd, Lucy Jessica Holt, Wildt Rudolf Maria Theodora De, Ian Tomlinson filed Critical Diversys Ltd
Priority to JP2001541066A priority Critical patent/JP2003515331A/en
Priority to EP00979803A priority patent/EP1234179A2/en
Priority to AU17187/01A priority patent/AU1718701A/en
Priority to CA002392939A priority patent/CA2392939A1/en
Publication of WO2001040312A2 publication Critical patent/WO2001040312A2/en
Publication of WO2001040312A3 publication Critical patent/WO2001040312A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/04—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers
    • C07K1/047—Simultaneous synthesis of different peptide species; Peptide libraries

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • Cell Biology (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Analytical Chemistry (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

The invention describes a method for isolating, from a naïve polypeptide repertoire which has not been preselected with a specific target ligand, a polypeptide of interest capable of interacting with said specific target ligand, which method comprises direct screening of the naïve polypeptide repertoire with the target ligand in order to identify the polypeptide of interest.
PCT/GB2000/004629 1999-12-03 2000-12-04 Naive screening method WO2001040312A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
JP2001541066A JP2003515331A (en) 1999-12-03 2000-12-04 Naive screening method
EP00979803A EP1234179A2 (en) 1999-12-03 2000-12-04 Naive screening method
AU17187/01A AU1718701A (en) 1999-12-03 2000-12-04 Naive screening method
CA002392939A CA2392939A1 (en) 1999-12-03 2000-12-04 Naive screening method

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9928789.8A GB9928789D0 (en) 1999-12-03 1999-12-03 Naive screening method
GB9928789.8 1999-12-03

Publications (2)

Publication Number Publication Date
WO2001040312A2 WO2001040312A2 (en) 2001-06-07
WO2001040312A3 true WO2001040312A3 (en) 2002-01-17

Family

ID=10865786

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2000/004629 WO2001040312A2 (en) 1999-12-03 2000-12-04 Naive screening method

Country Status (6)

Country Link
EP (1) EP1234179A2 (en)
JP (1) JP2003515331A (en)
AU (1) AU1718701A (en)
CA (1) CA2392939A1 (en)
GB (1) GB9928789D0 (en)
WO (1) WO2001040312A2 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020115068A1 (en) * 2000-06-23 2002-08-22 Ian Tomlinson Matrix screening method
US6815078B2 (en) 2002-03-06 2004-11-09 Eastman Kodak Company Substrate for protein microarray containing functionalized polymer
US7153896B2 (en) 2003-11-14 2006-12-26 Eastman Kodak Company Element for protein microarrays
US7235641B2 (en) 2003-12-22 2007-06-26 Micromet Ag Bispecific antibodies

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1990015070A1 (en) * 1989-06-07 1990-12-13 Affymax Technologies N.V. Very large scale immobilized peptide synthesis
WO1992010092A1 (en) * 1990-12-06 1992-06-25 Affymax Technologies N.V. Very large scale immobilized polymer synthesis
WO1999020749A1 (en) * 1997-10-20 1999-04-29 Medical Research Council Method to screen phage display libraries with different ligands

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU740830B2 (en) * 1998-01-29 2001-11-15 Glaucus Proteomics B.V. High density arrays for proteome analysis and methods and compositions therefor
CA2318175A1 (en) * 1998-02-04 1999-08-12 Invitrogen Corporation Microarrays and uses therefor

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1990015070A1 (en) * 1989-06-07 1990-12-13 Affymax Technologies N.V. Very large scale immobilized peptide synthesis
WO1992010092A1 (en) * 1990-12-06 1992-06-25 Affymax Technologies N.V. Very large scale immobilized polymer synthesis
WO1999020749A1 (en) * 1997-10-20 1999-04-29 Medical Research Council Method to screen phage display libraries with different ligands

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of EP1234179A2 *

Also Published As

Publication number Publication date
AU1718701A (en) 2001-06-12
CA2392939A1 (en) 2001-06-07
GB9928789D0 (en) 2000-02-02
EP1234179A2 (en) 2002-08-28
WO2001040312A2 (en) 2001-06-07
JP2003515331A (en) 2003-05-07

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