WO2001040307A8 - Antikörper gegen signal-regulator-proteine - Google Patents

Antikörper gegen signal-regulator-proteine

Info

Publication number
WO2001040307A8
WO2001040307A8 PCT/EP2000/011322 EP0011322W WO0140307A8 WO 2001040307 A8 WO2001040307 A8 WO 2001040307A8 EP 0011322 W EP0011322 W EP 0011322W WO 0140307 A8 WO0140307 A8 WO 0140307A8
Authority
WO
WIPO (PCT)
Prior art keywords
antibodies against
signal regulator
against signal
regulator proteins
sirp
Prior art date
Application number
PCT/EP2000/011322
Other languages
English (en)
French (fr)
Other versions
WO2001040307A1 (de
Inventor
Hans-Joerg Buehring
Axel Ullrich
Zhengjun Chen
Charles Cant
Original Assignee
Univ Eberhard Karls
Max Planck Gesellschaft
Buehring Hans Joerg
Axel Ullrich
Zhengjun Chen
Charles Cant
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE10010616A external-priority patent/DE10010616A1/de
Application filed by Univ Eberhard Karls, Max Planck Gesellschaft, Buehring Hans Joerg, Axel Ullrich, Zhengjun Chen, Charles Cant filed Critical Univ Eberhard Karls
Priority to EP00979567A priority Critical patent/EP1244707A1/de
Priority to AU17010/01A priority patent/AU1701001A/en
Publication of WO2001040307A1 publication Critical patent/WO2001040307A1/de
Publication of WO2001040307A8 publication Critical patent/WO2001040307A8/de
Priority to US10/158,415 priority patent/US6913894B2/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

Beschrieben werden monoklonale Antikörper, die spezifisch an die extrazelluläre Domäne der Zelloberflächenglykoproteine SIRP binden und in einigen Fällen die Interaktion von SIRP mit dem Oberflächen-Molekül CD47 blockieren.
PCT/EP2000/011322 1999-11-30 2000-11-16 Antikörper gegen signal-regulator-proteine WO2001040307A1 (de)

Priority Applications (3)

Application Number Priority Date Filing Date Title
EP00979567A EP1244707A1 (de) 1999-11-30 2000-11-16 Antikörper gegen signal-regulator-proteine
AU17010/01A AU1701001A (en) 1999-11-30 2000-11-16 Antibodies against signal regulator proteins
US10/158,415 US6913894B2 (en) 1999-11-30 2002-05-29 Antibodies directed against signal regulator proteins

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
DE19957665.3 1999-11-30
DE19957665 1999-11-30
DE10010616A DE10010616A1 (de) 1999-11-30 2000-03-03 Anitkörper gegen Signal-Regulator-Proteine
DE10010616.1 2000-03-03

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US10/158,415 Continuation US6913894B2 (en) 1999-11-30 2002-05-29 Antibodies directed against signal regulator proteins

Publications (2)

Publication Number Publication Date
WO2001040307A1 WO2001040307A1 (de) 2001-06-07
WO2001040307A8 true WO2001040307A8 (de) 2002-01-10

Family

ID=26004690

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2000/011322 WO2001040307A1 (de) 1999-11-30 2000-11-16 Antikörper gegen signal-regulator-proteine

Country Status (4)

Country Link
US (1) US6913894B2 (de)
EP (1) EP1244707A1 (de)
AU (1) AU1701001A (de)
WO (1) WO2001040307A1 (de)

Families Citing this family (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2428240A (en) * 2005-07-14 2007-01-24 Univ Gen Ve Diagnostic method for brain damage-related disorders
CA2702217A1 (en) 2007-10-11 2009-04-16 Jayne Danska Modulation of sirp.alpha. - cd47 interaction for increasing human hematopoietic stem cell engraftment and compounds therefor
EP2111869A1 (de) 2008-04-23 2009-10-28 Stichting Sanquin Bloedvoorziening Zusammensetzungen und Verfahren zur Stärkung des Immunsystems
WO2010130053A1 (en) 2009-05-15 2010-11-18 University Health Network COMPOSITIONS AND METHODS FOR TREATING HEMATOLOGIC CANCERS TARGETING THE SIRPα - CD47 INTERACTION
DK2931752T3 (da) 2012-12-17 2019-11-18 Trillium Therapeutics Inc Behandling af cd47+ sygdomsceller med sirp-alpha-fc-fusioner
CN109475603B (zh) 2016-06-20 2023-06-13 科马布有限公司 抗pd-l1抗体
JOP20190009A1 (ar) 2016-09-21 2019-01-27 Alx Oncology Inc أجسام مضادة ضد بروتين ألفا منظم للإشارات وطرق استخدامها
US11779631B2 (en) 2016-11-03 2023-10-10 Pfizer Inc. CD47 blockade therapy by HDAC inhibitors
CA3042581A1 (en) * 2016-11-03 2018-05-11 Trillium Therapeutics Inc. Enhancement of cd47 blockade therapy by proteasome inhibitors
SG10201912879YA (en) 2016-12-09 2020-02-27 Alector Llc Anti-sirp-alpha antibodies and methods of use thereof
EP3609922A2 (de) * 2017-04-13 2020-02-19 Aduro Biotech Holdings, Europe B.V. Anti-sirp-alpha-antikörper
AU2018268304A1 (en) * 2017-05-16 2019-11-14 Byondis B.V. Anti-SIRPα antibodies
PL3658589T3 (pl) 2017-07-26 2024-03-18 Forty Seven, Inc. Przeciwciała anty-sirp-alfa i powiązane sposoby
US11771764B2 (en) 2017-11-06 2023-10-03 Pfizer Inc. CD47 blockade with radiation therapy
BR112020018927A2 (pt) 2018-03-21 2021-01-05 ALX Oncology Inc. Anticorpos contra proteína alfa reguladora de sinal e métodos de uso
EP3802602A1 (de) 2018-05-25 2021-04-14 Alector LLC Anti-sirpa-antikörper und verfahren zu ihrer verwendung
WO2020047651A1 (en) 2018-09-04 2020-03-12 Trillium Therapeutics Inc. Cd47 blockade with parp inhibition for disease treatment
MX2021015452A (es) 2019-06-25 2022-02-11 Gilead Sciences Inc Proteinas de fusion flt3l-fc y metodos de uso.
JP7371243B2 (ja) 2019-10-18 2023-10-30 フォーティ セブン， インコーポレイテッド 骨髄異形成症候群及び急性骨髄性白血病を治療するための併用療法
CN110734897A (zh) * 2019-10-31 2020-01-31 浙江蓝盾药业有限公司 杂交瘤细胞株12g6、抗体及其应用
CN114599392A (zh) 2019-10-31 2022-06-07 四十七公司 基于抗cd47和抗cd20的血癌治疗
MX2022007930A (es) 2019-12-24 2022-08-08 Carna Biosciences Inc Compuestos moduladores de diacilglicerol quinasa.
WO2021163064A2 (en) 2020-02-14 2021-08-19 Jounce Therapeutics, Inc. Antibodies and fusion proteins that bind to ccr8 and uses thereof
TW202302145A (zh) 2021-04-14 2023-01-16 美商基利科學股份有限公司 ＣＤ４７／ＳＩＲＰα結合及ＮＥＤＤ８活化酶Ｅ１調節次單元之共抑制以用於治療癌症
JP2024515211A (ja) 2021-04-27 2024-04-05 ファイザー・インク Ｄｈｆｒ阻害剤を用いたｃｄ４７遮断療法の増強
US20220389394A1 (en) 2021-05-18 2022-12-08 Gilead Sciences, Inc. METHODS OF USING FLT3L-Fc FUSION PROTEINS
AU2022299051A1 (en) 2021-06-23 2023-12-07 Gilead Sciences, Inc. Diacylglyercol kinase modulating compounds
CA3222439A1 (en) 2021-06-23 2022-12-29 Gilead Sciences, Inc. Diacylglyercol kinase modulating compounds
WO2022271677A1 (en) 2021-06-23 2022-12-29 Gilead Sciences, Inc. Diacylglyercol kinase modulating compounds
EP4359413A1 (de) 2021-06-23 2024-05-01 Gilead Sciences, Inc. Diacylglyercolkinase modulierende verbindungen
US20240165229A1 (en) 2021-06-29 2024-05-23 Seagen Inc. Methods of treating cancer with a combination of a nonfucosylated anti-cd70 antibody and a cd47 antagonist
AU2022375782A1 (en) 2021-10-28 2024-05-02 Gilead Sciences, Inc. Pyridizin-3(2h)-one derivatives
WO2023073580A1 (en) 2021-10-29 2023-05-04 Pfizer Inc. Enhancement of cd47 blockade with taxanes for cd47+ cancer therapy
AU2022376954A1 (en) 2021-10-29 2024-05-02 Gilead Sciences, Inc. Cd73 compounds
AU2022417491A1 (en) 2021-12-22 2024-05-23 Gilead Sciences, Inc. Ikaros zinc finger family degraders and uses thereof
WO2023122581A2 (en) 2021-12-22 2023-06-29 Gilead Sciences, Inc. Ikaros zinc finger family degraders and uses thereof
TW202340168A (zh) 2022-01-28 2023-10-16 美商基利科學股份有限公司 Ｐａｒｐ７抑制劑
WO2023178181A1 (en) 2022-03-17 2023-09-21 Gilead Sciences, Inc. Ikaros zinc finger family degraders and uses thereof
US20230355796A1 (en) 2022-03-24 2023-11-09 Gilead Sciences, Inc. Combination therapy for treating trop-2 expressing cancers
TW202345901A (zh) 2022-04-05 2023-12-01 美商基利科學股份有限公司 用於治療結腸直腸癌之組合療法
TW202400138A (zh) 2022-04-21 2024-01-01 美商基利科學股份有限公司 Ｋｒａｓ ｇ１２ｄ調節化合物
WO2024006929A1 (en) 2022-07-01 2024-01-04 Gilead Sciences, Inc. Cd73 compounds
WO2024064668A1 (en) 2022-09-21 2024-03-28 Gilead Sciences, Inc. FOCAL IONIZING RADIATION AND CD47/SIRPα DISRUPTION ANTICANCER COMBINATION THERAPY
WO2024105180A1 (en) 2022-11-16 2024-05-23 Boehringer Ingelheim International Gmbh Predictive efficacy biomarkers for anti-sirpa antibodies

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2259122A1 (en) * 1996-06-17 1997-12-24 Max Planck Gesellschaft Zur Forderung Der Wissenschaften E.V. Novel ptp-20, pcp-2, bdp1, clk and sirp proteins and related products and methods
CA2226962A1 (en) * 1998-02-16 1999-08-16 Marie Sarfati Use of binding agents to cd47 and its ligands in the treatment or the prophylaxis of various inflammatory, autoimmune and allergic diseases and in the treatment of graft rejection
EP1048299A1 (de) * 1999-04-28 2000-11-02 Faculteit der Geneeskunde van de Vrije Universiteit Verfahren zur Hemmung der Zellfunktionierung zur Anwendung in der Therapie gegen Entzündungen und Krebs

Also Published As

Publication number Publication date
AU1701001A (en) 2001-06-12
US20030054415A1 (en) 2003-03-20
EP1244707A1 (de) 2002-10-02
WO2001040307A1 (de) 2001-06-07
US6913894B2 (en) 2005-07-05

Similar Documents

Publication Publication Date Title
WO2001040307A8 (de) Antikörper gegen signal-regulator-proteine
WO2004020404A3 (en) Modified transferin-antibody fusion proteins
WO1995023859A3 (en) Novel forms of t cells costimulatory molecules and uses therefor
WO1998050433A3 (en) Human monoclonal antibodies to epidermal growth factor receptor
ES2171705T3 (es) Complejos de polipeptido-dendrimero.
EP0930366A3 (de) Bindungsdomänen des Serrate-proteins
WO2002032925A3 (en) Protein scaffolds for antibody mimics and other binding proteins
HK1077592A1 (zh) 改進型fc融合蛋白質
EP2305715A3 (de) Monoklonaler Antikörper gegen das Osteoprotegerin-bindenden Protein
WO2001049728A3 (en) HUMAN PROTEINS HAVING HYDROPHOBIC DOMAINS AND DNAs ENCODING THESE PROTEINS
WO2005051998A3 (en) Antibodies binding to a c-terminal fragment of apolipoprotein e
EP3300739A3 (de) An 161p2f10b-proteine bindende antikörper und zugehörige moleküle
EP1112085A4 (de) Anti-thrombotisches agens und humanisierter monoklonaler antikörper gegen von-willebrand faktor
WO2002094853A3 (en) Antibodies specific for poly(ethylene glycol)
AU3587599A (en) Single chain monoclonal antibody fusion reagents that regulate transcript ion in vivo
WO2001012660A3 (en) HUMAN PROTEINS HAVING HYDROPHOBIC DOMAINS AND DNAs ENCODING THESE PROTEINS
HUP0103152A3 (en) Monoclonal antibodies directed against the g3bp protein, and uses
NO963608D0 (no) Glasstråder for armering, lim for glasstrådene samt komposittmaterialer inneholdende disse
WO2001002563A3 (en) HUMAN PROTEINS HAVING HYDROPHOBIC DOMAINS AND DNAs ENCODING THESE PROTEINS
ATE285474T1 (de) Haemophilus adhäsionsproteinen
WO2000012710A8 (en) Nucleic acids encoding ataxin-2 binding proteins, products related thereto and methods of using same
EP1434799A4 (de) Dna-moleküle und rekombinante dna-moleküle zur herstellung humanisierter monoklonaler antikörper gegen s. mutans
WO2000018909A3 (en) NUCLEIC ACIDS AND PROTEINS FROM $i(CENARCHAEUM SYMBIOSUM)
DE60023933D1 (en) Hybrid-toxine von bacillus thuringiensis
WO2000018803A3 (en) Antibodies to mammalian langerhans cell antigen and their uses

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A1

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CR CU CZ DE DK DM DZ EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT TZ UA UG US UZ VN YU ZA ZW

AL Designated countries for regional patents

Kind code of ref document: A1

Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE TR BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG

DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
121 Ep: the epo has been informed by wipo that ep was designated in this application
AK Designated states

Kind code of ref document: C1

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CR CU CZ DE DK DM DZ EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT TZ UA UG US UZ VN YU ZA ZW

AL Designated countries for regional patents

Kind code of ref document: C1

Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE TR BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG

CFP Corrected version of a pamphlet front page
CR1 Correction of entry in section i
WWE Wipo information: entry into national phase

Ref document number: 10158415

Country of ref document: US

WWE Wipo information: entry into national phase

Ref document number: 2000979567

Country of ref document: EP

WWP Wipo information: published in national office

Ref document number: 2000979567

Country of ref document: EP

REG Reference to national code

Ref country code: DE

Ref legal event code: 8642

WWW Wipo information: withdrawn in national office

Ref document number: 2000979567

Country of ref document: EP