WO2001040198A3 - Derives macrocycliques de l'acide hydroxamique et leur utilisation en tant qu'antimicrobiens - Google Patents

Derives macrocycliques de l'acide hydroxamique et leur utilisation en tant qu'antimicrobiens Download PDF

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Publication number
WO2001040198A3
WO2001040198A3 PCT/FR2000/003333 FR0003333W WO0140198A3 WO 2001040198 A3 WO2001040198 A3 WO 2001040198A3 FR 0003333 W FR0003333 W FR 0003333W WO 0140198 A3 WO0140198 A3 WO 0140198A3
Authority
WO
WIPO (PCT)
Prior art keywords
alkyl
optionally substituted
hydroxyalkyl
represent
antimicrobial agents
Prior art date
Application number
PCT/FR2000/003333
Other languages
English (en)
Other versions
WO2001040198A2 (fr
Inventor
Marc Capet
Arielle Genevois-Borella
Jean-Paul Martin
Vincent Mikol
Chantal Carrez
Sylvie Wentzler
Original Assignee
Aventis Pharma Sa
Marc Capet
Genevois Borella Arielle
Martin Jean Paul
Vincent Mikol
Chantal Carrez
Sylvie Wentzler
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from FR9915077A external-priority patent/FR2801591B1/fr
Application filed by Aventis Pharma Sa, Marc Capet, Genevois Borella Arielle, Martin Jean Paul, Vincent Mikol, Chantal Carrez, Sylvie Wentzler filed Critical Aventis Pharma Sa
Priority to AU21802/01A priority Critical patent/AU2180201A/en
Publication of WO2001040198A2 publication Critical patent/WO2001040198A2/fr
Publication of WO2001040198A3 publication Critical patent/WO2001040198A3/fr

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D245/00—Heterocyclic compounds containing rings of more than seven members having two nitrogen atoms as the only ring hetero atoms
    • C07D245/02—Heterocyclic compounds containing rings of more than seven members having two nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Dérivés macrocycliques de l'acide hydroxamique de formule générale (I) dans laquelle Y est -CH2-, -CH2-CH2- ou -CH=CH- et Z et Z' représentent -CH2- ou bien Y-Z ou Y-Z' représentent -CH=CH- et Z' ou Z sont définis comme ci-avant; X est -CH2-, O ou S; R1 est phényle non substitué ou substitué ou cycloalcoyle (5 ou 6 chaînons), hétérocyclyle mono ou bicyclique (5 à 10 chaînons), saturé ou insaturé (1 à 3 hétéroatomes: N, O ou S), éventuellement substitué ou N-oxydé, ou alcoyle éventuellement substitué; R2 est H, alcoyle ou hydroxyalcoyle éventuellement substitués; R3 est H, alcoyle, alcoyloxycarbonyle, carbamoyle, alcoylcarbamoyle ou dialcoylcarbamoyle, ou bien R2 et R3 forment avec les atomes auquels ils sont attachés, un hétérocycle azoté à 5 ou 6 chaînons pouvant en outre contenir un autre hétéroatome choisi parmi N, O ou S, et éventuellement substitué, par un radical alcoyle, hydroxyalcoyle ou OH; R4 et R'4 sont identiques ou différents et représentent H, OH, alcoyle, hydroxyalcoyle ou alcoyloxy; les radicaux alcoyle ou acyle (1 à 4C) sont droits ou ramifiés, ainsi que leurs sels lorsqu'ils existent et lorsque R4 et R'4 sont différents, leurs formes diastéréoisomères ou leurs mélanges. Les dérivés de formule générale (I) sont particulièrement intéressants comme antimicrobiens.
PCT/FR2000/003333 1999-11-30 2000-11-29 Derives macrocycliques de l'acide hydroxamique et leur utilisation en tant qu'antimicrobiens WO2001040198A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU21802/01A AU2180201A (en) 1999-11-30 2000-11-29 Hydroxamic acid macrocyclic derivatives, preparation method and compositions containing same

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
FR9915077A FR2801591B1 (fr) 1999-11-30 1999-11-30 Derives macrocycliques de l'acide hydroxamique, leur preparation et les compositions qui les contiennent
FR99/15077 1999-11-30
US17603000P 2000-01-14 2000-01-14
US60/176,030 2000-01-14

Publications (2)

Publication Number Publication Date
WO2001040198A2 WO2001040198A2 (fr) 2001-06-07
WO2001040198A3 true WO2001040198A3 (fr) 2001-11-29

Family

ID=26235172

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/FR2000/003333 WO2001040198A2 (fr) 1999-11-30 2000-11-29 Derives macrocycliques de l'acide hydroxamique et leur utilisation en tant qu'antimicrobiens

Country Status (2)

Country Link
AU (1) AU2180201A (fr)
WO (1) WO2001040198A2 (fr)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10358824A1 (de) 2003-12-16 2005-07-21 Bayer Healthcare Ag Antibakterielle Makrozyklen mit substituiertem Biphenyl
CN104981249B (zh) * 2012-12-18 2018-06-19 英国卫生部 抗微生物化合物、它们的合成及其应用

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4692510A (en) * 1985-08-30 1987-09-08 Bristol-Myers Company Peptide antibiotics
WO1999059568A1 (fr) * 1998-05-16 1999-11-25 British Biotech Pharmaceuticals Limited Derives de l'acide hydroxamique en tant qu'agents antibacteriens

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4692510A (en) * 1985-08-30 1987-09-08 Bristol-Myers Company Peptide antibiotics
WO1999059568A1 (fr) * 1998-05-16 1999-11-25 British Biotech Pharmaceuticals Limited Derives de l'acide hydroxamique en tant qu'agents antibacteriens

Also Published As

Publication number Publication date
AU2180201A (en) 2001-06-12
WO2001040198A2 (fr) 2001-06-07

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