WO2001036011A1 - Auto-adhesive composition - Google Patents
Auto-adhesive composition Download PDFInfo
- Publication number
- WO2001036011A1 WO2001036011A1 PCT/GB2000/004396 GB0004396W WO0136011A1 WO 2001036011 A1 WO2001036011 A1 WO 2001036011A1 GB 0004396 W GB0004396 W GB 0004396W WO 0136011 A1 WO0136011 A1 WO 0136011A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- natural rubber
- weight
- rubber latex
- polymer
- adhesive
- Prior art date
Links
- 239000000853 adhesive Substances 0.000 title claims abstract description 47
- 239000000203 mixture Substances 0.000 title claims abstract description 42
- 230000001070 adhesive effect Effects 0.000 claims abstract description 38
- 229920006173 natural rubber latex Polymers 0.000 claims abstract description 36
- 229920000642 polymer Polymers 0.000 claims abstract description 29
- 239000002998 adhesive polymer Substances 0.000 claims description 4
- 102000004169 proteins and genes Human genes 0.000 abstract description 31
- 108090000623 proteins and genes Proteins 0.000 abstract description 31
- 239000007795 chemical reaction product Substances 0.000 abstract description 2
- 229920001577 copolymer Polymers 0.000 description 13
- 229920000126 latex Polymers 0.000 description 12
- 239000004816 latex Substances 0.000 description 12
- RRHGJUQNOFWUDK-UHFFFAOYSA-N Isoprene Chemical compound CC(=C)C=C RRHGJUQNOFWUDK-UHFFFAOYSA-N 0.000 description 8
- 239000000047 product Substances 0.000 description 8
- 239000006185 dispersion Substances 0.000 description 7
- 229920001971 elastomer Polymers 0.000 description 7
- PPBRXRYQALVLMV-UHFFFAOYSA-N Styrene Chemical compound C=CC1=CC=CC=C1 PPBRXRYQALVLMV-UHFFFAOYSA-N 0.000 description 6
- 238000009472 formulation Methods 0.000 description 6
- 239000007788 liquid Substances 0.000 description 6
- 239000003963 antioxidant agent Substances 0.000 description 5
- 239000000758 substrate Substances 0.000 description 5
- -1 tackifiers Substances 0.000 description 5
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 4
- 230000000172 allergic effect Effects 0.000 description 4
- 239000003906 humectant Substances 0.000 description 4
- 239000004615 ingredient Substances 0.000 description 4
- 239000003381 stabilizer Substances 0.000 description 4
- 239000004094 surface-active agent Substances 0.000 description 4
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 3
- XTXRWKRVRITETP-UHFFFAOYSA-N Vinyl acetate Chemical compound CC(=O)OC=C XTXRWKRVRITETP-UHFFFAOYSA-N 0.000 description 3
- 208000027418 Wounds and injury Diseases 0.000 description 3
- 239000002253 acid Substances 0.000 description 3
- 239000000654 additive Substances 0.000 description 3
- 208000010668 atopic eczema Diseases 0.000 description 3
- 230000000052 comparative effect Effects 0.000 description 3
- 229920001519 homopolymer Polymers 0.000 description 3
- 239000000463 material Substances 0.000 description 3
- 238000000034 method Methods 0.000 description 3
- 229940044603 styrene Drugs 0.000 description 3
- 239000000126 substance Substances 0.000 description 3
- 238000012546 transfer Methods 0.000 description 3
- 229940117958 vinyl acetate Drugs 0.000 description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 3
- KBPLFHHGFOOTCA-UHFFFAOYSA-N 1-Octanol Chemical compound CCCCCCCCO KBPLFHHGFOOTCA-UHFFFAOYSA-N 0.000 description 2
- VBICKXHEKHSIBG-UHFFFAOYSA-N 1-monostearoylglycerol Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(O)CO VBICKXHEKHSIBG-UHFFFAOYSA-N 0.000 description 2
- KAKZBPTYRLMSJV-UHFFFAOYSA-N Butadiene Chemical compound C=CC=C KAKZBPTYRLMSJV-UHFFFAOYSA-N 0.000 description 2
- VGGSQFUCUMXWEO-UHFFFAOYSA-N Ethene Chemical compound C=C VGGSQFUCUMXWEO-UHFFFAOYSA-N 0.000 description 2
- 239000005977 Ethylene Substances 0.000 description 2
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 2
- 102000035195 Peptidases Human genes 0.000 description 2
- 108091005804 Peptidases Proteins 0.000 description 2
- ZFOZVQLOBQUTQQ-UHFFFAOYSA-N Tributyl citrate Chemical compound CCCCOC(=O)CC(O)(C(=O)OCCCC)CC(=O)OCCCC ZFOZVQLOBQUTQQ-UHFFFAOYSA-N 0.000 description 2
- 206010052428 Wound Diseases 0.000 description 2
- 150000001298 alcohols Chemical class 0.000 description 2
- 230000004888 barrier function Effects 0.000 description 2
- MWKFXSUHUHTGQN-UHFFFAOYSA-N decan-1-ol Chemical compound CCCCCCCCCCO MWKFXSUHUHTGQN-UHFFFAOYSA-N 0.000 description 2
- 239000000839 emulsion Substances 0.000 description 2
- 150000002191 fatty alcohols Chemical class 0.000 description 2
- 239000012765 fibrous filler Substances 0.000 description 2
- 239000006260 foam Substances 0.000 description 2
- 125000000524 functional group Chemical group 0.000 description 2
- WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 description 2
- 239000008204 material by function Substances 0.000 description 2
- 238000002156 mixing Methods 0.000 description 2
- 239000003607 modifier Substances 0.000 description 2
- 239000000178 monomer Substances 0.000 description 2
- 229920001296 polysiloxane Chemical class 0.000 description 2
- 229920002545 silicone oil Polymers 0.000 description 2
- 239000007787 solid Substances 0.000 description 2
- 239000000243 solution Substances 0.000 description 2
- 238000005406 washing Methods 0.000 description 2
- BOXSVZNGTQTENJ-UHFFFAOYSA-L zinc dibutyldithiocarbamate Chemical compound [Zn+2].CCCCN(C([S-])=S)CCCC.CCCCN(C([S-])=S)CCCC BOXSVZNGTQTENJ-UHFFFAOYSA-L 0.000 description 2
- WGIMXKDCVCTHGW-UHFFFAOYSA-N 2-(2-hydroxyethoxy)ethyl dodecanoate Chemical compound CCCCCCCCCCCC(=O)OCCOCCO WGIMXKDCVCTHGW-UHFFFAOYSA-N 0.000 description 1
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 1
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 1
- 229920001353 Dextrin Polymers 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
- 206010016946 Food allergy Diseases 0.000 description 1
- 244000043261 Hevea brasiliensis Species 0.000 description 1
- 206010020751 Hypersensitivity Diseases 0.000 description 1
- 101000952180 Morus alba Mulatexin Proteins 0.000 description 1
- AMQJEAYHLZJPGS-UHFFFAOYSA-N N-Pentanol Chemical compound CCCCCO AMQJEAYHLZJPGS-UHFFFAOYSA-N 0.000 description 1
- 229920003171 Poly (ethylene oxide) Polymers 0.000 description 1
- 239000004952 Polyamide Substances 0.000 description 1
- 239000002202 Polyethylene glycol Substances 0.000 description 1
- 229920002472 Starch Polymers 0.000 description 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 description 1
- BZHJMEDXRYGGRV-UHFFFAOYSA-N Vinyl chloride Chemical class ClC=C BZHJMEDXRYGGRV-UHFFFAOYSA-N 0.000 description 1
- QYKIQEUNHZKYBP-UHFFFAOYSA-N Vinyl ether Chemical class C=COC=C QYKIQEUNHZKYBP-UHFFFAOYSA-N 0.000 description 1
- 229920004482 WACKER® Polymers 0.000 description 1
- 150000007513 acids Chemical class 0.000 description 1
- 150000001252 acrylic acid derivatives Chemical class 0.000 description 1
- 125000005396 acrylic acid ester group Chemical group 0.000 description 1
- NIXOWILDQLNWCW-UHFFFAOYSA-N acrylic acid group Chemical group C(C=C)(=O)O NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 description 1
- 239000012190 activator Substances 0.000 description 1
- 239000013566 allergen Substances 0.000 description 1
- 208000030961 allergic reaction Diseases 0.000 description 1
- CEGOLXSVJUTHNZ-UHFFFAOYSA-K aluminium tristearate Chemical compound [Al+3].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O CEGOLXSVJUTHNZ-UHFFFAOYSA-K 0.000 description 1
- 150000001412 amines Chemical class 0.000 description 1
- 229910021529 ammonia Inorganic materials 0.000 description 1
- 239000002518 antifoaming agent Substances 0.000 description 1
- 230000003078 antioxidant effect Effects 0.000 description 1
- 239000012736 aqueous medium Substances 0.000 description 1
- 230000000386 athletic effect Effects 0.000 description 1
- 229920001400 block copolymer Polymers 0.000 description 1
- 239000004359 castor oil Substances 0.000 description 1
- 235000019438 castor oil Nutrition 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- YACLQRRMGMJLJV-UHFFFAOYSA-N chloroprene Chemical compound ClC(=C)C=C YACLQRRMGMJLJV-UHFFFAOYSA-N 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
- 239000003086 colorant Substances 0.000 description 1
- 230000000536 complexating effect Effects 0.000 description 1
- 238000013329 compounding Methods 0.000 description 1
- 238000007906 compression Methods 0.000 description 1
- 230000006835 compression Effects 0.000 description 1
- 238000011109 contamination Methods 0.000 description 1
- 235000005687 corn oil Nutrition 0.000 description 1
- 239000002285 corn oil Substances 0.000 description 1
- 239000003431 cross linking reagent Substances 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 239000013530 defoamer Substances 0.000 description 1
- 239000002781 deodorant agent Substances 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 230000018109 developmental process Effects 0.000 description 1
- FYGDTMLNYKFZSV-MRCIVHHJSA-N dextrin Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)OC1O[C@@H]1[C@@H](CO)OC(O[C@@H]2[C@H](O[C@H](O)[C@H](O)[C@H]2O)CO)[C@H](O)[C@H]1O FYGDTMLNYKFZSV-MRCIVHHJSA-N 0.000 description 1
- VPSZKCCWOGZNLS-CFYXSCKTSA-N dibutyl (z)-but-2-enedioate;ethenyl acetate Chemical compound CC(=O)OC=C.CCCCOC(=O)\C=C/C(=O)OCCCC VPSZKCCWOGZNLS-CFYXSCKTSA-N 0.000 description 1
- 235000014113 dietary fatty acids Nutrition 0.000 description 1
- 238000010790 dilution Methods 0.000 description 1
- 239000012895 dilution Substances 0.000 description 1
- 238000007598 dipping method Methods 0.000 description 1
- 239000000806 elastomer Substances 0.000 description 1
- HDERJYVLTPVNRI-UHFFFAOYSA-N ethene;ethenyl acetate Chemical group C=C.CC(=O)OC=C HDERJYVLTPVNRI-UHFFFAOYSA-N 0.000 description 1
- UIWXSTHGICQLQT-UHFFFAOYSA-N ethenyl propanoate Chemical compound CCC(=O)OC=C UIWXSTHGICQLQT-UHFFFAOYSA-N 0.000 description 1
- 229920001038 ethylene copolymer Polymers 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 239000000194 fatty acid Substances 0.000 description 1
- 229930195729 fatty acid Natural products 0.000 description 1
- 150000004665 fatty acids Chemical class 0.000 description 1
- 239000000945 filler Substances 0.000 description 1
- 239000003205 fragrance Substances 0.000 description 1
- VZCYOOQTPOCHFL-OWOJBTEDSA-L fumarate(2-) Chemical class [O-]C(=O)\C=C\C([O-])=O VZCYOOQTPOCHFL-OWOJBTEDSA-L 0.000 description 1
- 235000011187 glycerol Nutrition 0.000 description 1
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 description 1
- 229940075507 glyceryl monostearate Drugs 0.000 description 1
- 229920000578 graft copolymer Polymers 0.000 description 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 1
- 238000011534 incubation Methods 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 239000003456 ion exchange resin Substances 0.000 description 1
- 229920003303 ion-exchange polymer Polymers 0.000 description 1
- 150000002500 ions Chemical class 0.000 description 1
- 238000002386 leaching Methods 0.000 description 1
- 230000014759 maintenance of location Effects 0.000 description 1
- 150000002688 maleic acid derivatives Chemical class 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000002609 medium Substances 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 239000002480 mineral oil Substances 0.000 description 1
- 235000010446 mineral oil Nutrition 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 239000001788 mono and diglycerides of fatty acids Substances 0.000 description 1
- 230000008450 motivation Effects 0.000 description 1
- 238000010422 painting Methods 0.000 description 1
- 239000003415 peat Substances 0.000 description 1
- 150000002989 phenols Chemical class 0.000 description 1
- OJMIONKXNSYLSR-UHFFFAOYSA-N phosphorous acid Chemical compound OP(O)O OJMIONKXNSYLSR-UHFFFAOYSA-N 0.000 description 1
- 239000010665 pine oil Substances 0.000 description 1
- 239000004014 plasticizer Substances 0.000 description 1
- 229920002647 polyamide Polymers 0.000 description 1
- 229920000728 polyester Polymers 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
- 229940113115 polyethylene glycol 200 Drugs 0.000 description 1
- 229920000098 polyolefin Polymers 0.000 description 1
- 229920003225 polyurethane elastomer Polymers 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 229920005604 random copolymer Polymers 0.000 description 1
- 239000011347 resin Substances 0.000 description 1
- 229920005989 resin Polymers 0.000 description 1
- 238000005096 rolling process Methods 0.000 description 1
- LPXPTNMVRIOKMN-UHFFFAOYSA-M sodium nitrite Substances [Na+].[O-]N=O LPXPTNMVRIOKMN-UHFFFAOYSA-M 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 239000000600 sorbitol Substances 0.000 description 1
- 238000005507 spraying Methods 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 150000003460 sulfonic acids Chemical class 0.000 description 1
- 239000011593 sulfur Substances 0.000 description 1
- 229910052717 sulfur Inorganic materials 0.000 description 1
- 230000007704 transition Effects 0.000 description 1
- STCOOQWBFONSKY-UHFFFAOYSA-N tributyl phosphate Chemical compound CCCCOP(=O)(OCCCC)OCCCC STCOOQWBFONSKY-UHFFFAOYSA-N 0.000 description 1
- 229920001567 vinyl ester resin Polymers 0.000 description 1
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08C—TREATMENT OR CHEMICAL MODIFICATION OF RUBBERS
- C08C1/00—Treatment of rubber latex
- C08C1/02—Chemical or physical treatment of rubber latex before or during concentration
- C08C1/04—Purifying; Deproteinising
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
- A61L15/58—Adhesives
- A61L15/585—Mixtures of macromolecular compounds
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09J—ADHESIVES; NON-MECHANICAL ASPECTS OF ADHESIVE PROCESSES IN GENERAL; ADHESIVE PROCESSES NOT PROVIDED FOR ELSEWHERE; USE OF MATERIALS AS ADHESIVES
- C09J107/00—Adhesives based on natural rubber
- C09J107/02—Latex
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L2666/00—Composition of polymers characterized by a further compound in the blend, being organic macromolecular compounds, natural resins, waxes or and bituminous materials, non-macromolecular organic substances, inorganic substances or characterized by their function in the composition
- C08L2666/02—Organic macromolecular compounds, natural resins, waxes or and bituminous materials
Definitions
- Natural rubber latex provides adhesive compositions with excellent auto-adhesion and non-residue properties, but the problem of allergic reaction to proteins in these natural rubber latex persists
- adhesives are made of specific blends of low protein natural rubber latex in combination with at least one polymer Proportions of these components may vary according to the requirements of the specific end products but in order to achieve the desired results of the present invention, at least 90 percent by weight of the low protein natural rubber latex and at least 1 percent by weight of the polymer are necessary in the adhesive
- the low protein natural rubber latex is preferably present from 90 to 99 percent by weight, more preferably from 90 to 97 percent by weight, and the polymer is preferably present from 1 to 10 percent by weight, more preferably from 3 to 10 percent by weight
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Polymers & Plastics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Hematology (AREA)
- General Chemical & Material Sciences (AREA)
- Materials Engineering (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Adhesives Or Adhesive Processes (AREA)
Abstract
Auto-adhesive compositions are made of specific blends of low protein natural rubber latex in combination with at least one polymer. Proportions of these components may vary according to the requirements of the specific end products but in order to achieve the desired results of the present invention, at least 90.0 percent by weight of the low protein natural rubber latex and at least 1.0 percent by weight of the polymer are necessary in the adhesive. The low protein natural rubber latex can be present from 90.0 to 97.0 percent by weight and the polymer can be present from 3.0 to 10.0 percent by weight.
Description
AUTO-ADHESIVE COMPOSITION
FIELD OF THE INVENTION
This invention relates to novel auto-adhesive compositions that are especially formulated for use on skin More particularly, the present invention relates to adhesive compositions that comprise low protein natural rubber latex and at least one polymer
"Auto-adhesive" as used herein is intended to mean an adhesive that bonds to itself or to a substrate and unwinds from itself and from the substrate without much effort
BACKGROUND OF THE INVENTION
The adhesive compositions of this invention are designed for cohesive elastic conforming bandages Such bandages adhere to themselves, but not to skin, hair or clothes Auto-adhesive bandages are used for dressing retention and are easy to apply especially on difficult parts of the body They are also used for fixation of padding material, cannulae and tubes, and for light compression and support bandages, and for application to the skin to protect wounds from contamination thereby reducing the danger of infection and guarding against further injury
Natural rubber latex provides adhesive compositions with excellent auto-adhesion and non-residue properties, but the problem of allergic reaction to proteins in these natural rubber latex persists
It is known in the prior art to reduce the protein content of natural rubber latex Several methods to remove these proteins are utilised including, for example, leaching, however the most efficient method is by enzyme treatment as it removes both water soluble and combined proteins Prior art examples of protein removal include complexing the proteins of natural rubber latex with e g ion exchange resins and thereafter separating the resulting protein-resin complex from the latex (as described
in US Pat No 5,563,241 ), or by incubating the latex with a proteolytic enzyme in the presence of a combination of surfactants and then washing with water to remove both the protein combined with rubber molecules and the water-soluble proteins (as described by Shinichi Nakade "Progress in Prevention Developments Achieved in Low-Allergen NR Products" paper presented at "Latex Protein Allergy" Conference
Amsterdam, Netherlands 19 February 1996)
Other prior art methods of reducing the allergic affect of proteins in natural rubber latex, such as that exemplified by U S Pat no 5776484, rely on forming a barrier layer to prevent or minimise contact between the skin and the latex or by bonding the protein in natural rubber latex to a material, such as a copolymer, and thereby lessening the ability of the protein to be transported to the skin
Although it is known to use low protein natural rubber latex in rubber products such as gloves to reduce the allergic affect of proteins, the use of such latex in auto-adhesives has heretofore not been considered viable due to the belief that they would impart poor auto-adhesion properties to such adhesives
The drive and motivation as described in the prior art has been towards the continued use of protein-containing natural rubber latex in adhesive compositions combined with a means of preventing or minimising the transfer of proteins from the adhesive composition to the skin by utilising physical barriers or restraints This ensures the adhesive continues to obtain the benefits of auto-adhesion and elasticity known to be provided by protein-containing natural rubber latex It is to the prior-art problem of providing adhesives containing natural rubber latex whilst retaining the desired properties of auto adhesion and peel strength that the present invention is specifically directed
SUMMARY OF THE INVENTION
It has now been discovered that auto-adhesive dressings made from specific blends of a low protein natural rubber latex and one or more polymers possess good adhesion and non-residue properties
According to the present invention, adhesives are made of specific blends of low protein natural rubber latex in combination with at least one polymer Proportions of these components may vary according to the requirements of the specific end products but in order to achieve the desired results of the present invention, at least 90 percent by weight of the low protein natural rubber latex and at least 1 percent by weight of the polymer are necessary in the adhesive The low protein natural rubber latex is preferably present from 90 to 99 percent by weight, more preferably from 90 to 97 percent by weight, and the polymer is preferably present from 1 to 10 percent by weight, more preferably from 3 to 10 percent by weight
The adhesives of this invention are useful to prepare medical adhesive articles such as surgical bandages, athletic tapes, wound dressings and the like These adhesives may be coated onto any backing suitable for medical uses including occlusive (substantially non-breathable) and non-occlustve backings (breathable) Occlusive backings are also known as low porosity backings Non limiting examples of occlusive backings include films, foams and laminates thereof Non limiting examples of non- occlusive backings include woven substrates, non woven substrates or melt blown webs, foams and thermally embossed non woven substrates
DETAILED DESCRIPTION OF THE INVENTION
The present invention provides adhesive compositions comprising low-protein natural rubber latex and at least one polymer More particularly, the low-protein natural rubber latex content of the adhesive is at least 90 percent by weight, preferably from 90 to 99 percent by weight, more preferably from 90 to 97 percent by weight and the polymer is present in at least 1 percent by weight, preferably from 1 to 10 percent by weight, more preferably from 3 to 10 percent by weight
The term "natural rubber latex" as used in this invention is the naturally occurring form of rubber, i e , cιs-1 ,4-polyιsoprene Amongst its natural sources is included the sap of the Havea brasiliensts rubber tree Natural rubber latex also comprises 1-2% proteins and it is known that some individuals are allergic to these proteins
It is known to remove proteins from natural rubber latex, for example through incubation with a proteolytic enzyme in the presence of surfactants followed by washing with water This results in the removal of rubber proteins and water-soluble proteins The colloidal properties of the deproteinised natural rubber latex are maintained by addition of appropriate surfactants However, once the proteins have been removed the intrinsic properties of natural rubber latex are modified Such modification effectively reduces auto-adhesion and elasticity
Deproteinised natural rubber latex is known and used to lessen the allergic effects of e g surgical gloves and similar rubber products However, it has not heretofore been known that such latex could be used in combination with polymers of this invention to provide adhesives having desirable properties
The adhesive composition of this invention comprises deproteinised natural rubber latex and at least one polymer The adhesive is applied to a bandage to provide good auto-adhesion, low or no residue skin adhesion after peeling, good viscosity during production and good peel coating weight This invention provides the first adhesive product comprising deproteinised natural rubber latex having the above properties
For the purpose of this invention, "polymer" refers to a homopolymer, a copolymer or an adhesive polymer as well as any mixtures or blends of one or more homopolymers, and/or one or more copolymers, and/or one or more adhesive polymers "Copolymer" refers to a polymeric material produced by the polymerisation of two or more dissimilar monomers, either with or without another functional group grafted thereto, as well as to a homopolymer with a functional group grafted thereto Thus, the term "copolymer" includes, without limitation, random copolymers, block copolymers, sequential copolymers, and graft copolymers Typical monomers include, but are not limited to, hydroxyl substituted
C1 to C12 esters of acrylic and methacry c acids, vinyl esters (vinyl acetate and vinyl propionate), vinyl ethers, fumarates, maleates, styrene, acrylonitπle
"Adhesive polymer" refers to a polymer that is inherently adhesive, or has been rendered adhesive by combining additives and/or modifiers with the polymer
Examples of suitable additives and/or modifiers include, without limitation, tackifiers, plasticisers, stabilisers, cross-linking agents, and combinations thereof Typical polymers include, without limitation, for example, polyolefins, non-elastomeπc polyesters, non-elastomeπc polyamides, cellulosic derived polymers, vinyl acetates, acrylates, vinyl chlorides and polyvmyl alcohols Examples of trade name polymers suitable for use in the present invention include without limitation Vinamul 62118 a dextrine stabilised vinyl acetate-dibutyl maleate copolymer available from Vinamul, Vinamul 6152 a vinyl acetate-dibutyl maleate available from Vinamul, Airflex 920 a carboxylated Vinyl Acetate-Ethylene copolymer available from Air Product, Duroset 78-6964 E250 a ethylene / vinyl acetate copolymer available from National Starch and Chemical Company, Vinnapas LL8647 a mixture of copolymers of vinyl-acetate, acrylic acid ester and ethylene available from Wacker, Luphen D200A a polyurethane elastomer available from BASF, Aquastick 1120 a chloroprene and methacryhc acid copolymer available from DuPont Dow Elastomers, Synthomer VL10533 a carboxylated butadiene methyl methacrylate copolymer latex from available from Synthomer, Revacryl 239 a styrene / acrylic ester copolymer dispersion available from Harlow Chemical Company
Other ingredients may be employed as desired and may include, for example, stabilisers, tackifiers, antioxidants, fibrous fillers, non-fibrous fillers, humectants, colorants, and deodorants or fragrances
A typical stabiliser that may be utilised in the mix to form the compositions of the present invention includes, for example the trade name product, Nopco S This is a highly sulphated fatty acid used in rubber industry to stabilise lattices during compounding, storage and application and is available from Henkel Other stabilisers may include Dapro DF 900 from
KRAHN CHEMIE GmbH and Byk-033 from BYK-CHEMIE GmbH
Typical antioxidants and/or metal transition ion scavengers that may be utilised in the mix to form the compositions of the present invention includes, for example hindered phenols, amines, and sulfur and phosphorous hydroxide decomposers A list of common antioxidants is given in McCutcheon's Functional Materials (1991 ), pp 13-18
A suitable antioxidant is available under the trade name product, Dispersion 2074M from Vita Liquid Polymers, this is an aqueous dispersion of Zinc Dibutyl Dithiocarbamate
The preparation according to the invention may also include a humectant Suitable humectants include glycerin, sorbitol, polyethylene glycol, propylene glycol, and other polyhydπc alcohols
A suitable humectant is available under the trade name Polyethylene glycol 200 from ICI Surfactant - this is also called polyoxyethylene glycol
Defoaming agents may be used in the mix The most common defoamers are given in McCutcheon's Functional Materials (1991), pgs 89-112 Typical defoamers include aluminium stearate, amyl alcohol, capπllic alcohol, capryl alcohol, castor oil, corn oil, decyl alcohol, diethylene glycol monolaurate, glyceryl monostearate, mineral oil, pine oil, polyalkyl glycol, silicone oils, steanc acid, sulfonic acid salts, tributyl citrate and , tributyl phosphate A suitable defoamer is available from Henkel under the trade name product Dehydran 1620 This is a blend of modified fatty alcohols and a polysiloxane
The above additives and other components such as the cure activators, pH control agents, and silicone oils employed in the latex formulations of the present invention may be present in the range of from 2 percent by weight to 9 percent by weight of the latex
The adhesive compositions of the invention may be prepared by mixing the latex and polymer, and any other desired ingredients, e g tackifiers, antioxidants, fillers etc in any convenient way (e g in a Sigma mixer) The mixing can be carried out in a liquid
medium which is a solvent for some or all of the ingredients, or which is an aqueous medium Each of the ingredients can be added to the mixture as a solid, or as a molten liquid, or as a solution, emulsion or dispersion, as appropriate The resulting liquid mixture, i e solution, emulsion or dispersion in a liquid carrier, can be applied, if desired after further dilution, to the backing in conventional fashion, e g by spraying, painting, dipping or rolling
EXAMPLES
The following adhesive composition was prepared in accordance with the present invention
KDP 150 is an highly deproteinised Natural Rubber Latex available from Kao Corporation under this trade name
Revacryl 239 is a hard styr ene/acry c ester copolymer available from Harlow Chemical Company under this trade name
Dehydran 1620 is a blend of modified fatty alcohols and a polysiloxane available from Henkel under this trade name
4 Nopco S is a highly sulphated fatty and is available from Henkel under this trade name
5 Dispersion 2074M is an aqueous dispersion of Zinc Dibutyl Dithiocarbamate available from Vita Liquid Polymers under this trade name
This adhesive composition had a density of 0 95, a solids content of 59 to 62%, a pH of 9 5 to 10 5, and a viscosity in the range 80 to 130 cps
The following Examples are based on the above formulation but with differing amounts (by Weight) of KDP 150 and/or Revacryl 239, or by replacing KDP 150 with LATZ Latex at the stated level (LATZ Latex is a low-ammonia protein-containing natural rubber latex available from Lewis and Peat under this trade name), or by replacing Revacryl 239 with another suitable polymer at the stated level
Tpeel (ASTM D1876-61 T) refers to the force required to separate the adhesive to adhesive bond using paper strips that are 1 inch wide, 12 inches long and 30μm coated with the adhesive The specimens are bonded over 9 inches They are tested on an Instron tensometer 5 mm after bonding The paper strips are peeled apart and the force to do so recorded Higher Tpeel force means higher transfer from one side of the paper strip to the other Adhesives having Tpeel values between 2 and 4 N/25mm indicate acceptable tack levels and auto-adhesive properties
The term "transfer" means auto-adhesion is higher than the adhesion between the adhesive and the paper
Adhesion to skin was measured as follows tape samples 1 inch wide by 3 inches long were placed on the skin of a human subject using a predetermined constant pressure The tape was removed and a subjective evaluation of adhesion and residual tack was made and rated as
no adhesion to skin. to 2 good adhesion; no tack. good adhesion; tack.
' = KDP 150 7 = Duroset 78-6964
2 = Revacryl 239 8 = Luphen D200A
3 = Vinamul 62118 9 = Vinamul 6152
4 = Aquastick 1120 10 = Synthomer VL10533
5 = Vinnapas LL8647 11 = LATZ Latex
6 = Airflex 920
Examples 1 to 13 were formulated according to the teachings of the present invention All of these formulations show Tpeel values between 2 and 4 N/25mm and have good skin adhesion with no residual tack
In comparative Example 14, KDP 150 (highly deproteinised natural rubber latex) was substituted by a protein-containing natural rubber latex This formulation has a high Tpeel force and shows residual tack on skin
Comparative Example 15 contains polymer and highly derproteinised latex according to the invention, but the latex is present at level less than the claimed amount This formulation has very low Tpeel force and shows no adhesion on skin
Comparative Example 16 contains latex and polymer according to this invention, but both are present at levels outside their claimed amounts This formulation shows very high Tpeel force and shows residual tack on skin
From the above Examples it is clearly seen that the key amount of low-protein natural rubber latex is 90 to 97 percent by weight and the key amount by weight of polymer is
1 to 6 percent by weight
Claims
1 An adhesive composition which comprises a) at least 90% by weight of a low-protein natural rubber latex, and b) at least 1 % by weight of a polymer
2 An adhesive composition according to claim 1 wherein the low-protein natural rubber latex is present from 90% to 99% by weight
3 An adhesive composition according to claim 1 wherein the polymer is present from 1 % to 10% by weight
4 An adhesive composition according to claim 1 wherein the low-protein natural rubber latex is present from 90% to 97% by weight
5 An adhesive composition according to claim 1 wherein the polymer is present from 3% to 10% by weight
6 An adhesive composition according to any one of the preceding claims wherein the polymer is an adhesive polymer
7 An adhesive composition according to any one of the preceding claims, which is applied to a bandage, tape or wound dressing for use in the medical or surgical field
Priority Applications (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP00976181A EP1229943A1 (en) | 1999-11-17 | 2000-11-17 | Auto-adhesive composition |
| AU14060/01A AU1406001A (en) | 1999-11-17 | 2000-11-17 | Auto-adhesive composition |
| JP2001538001A JP2003514105A (en) | 1999-11-17 | 2000-11-17 | Self-adhesive composition |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB9927195.9 | 1999-11-17 | ||
| GBGB9927195.9A GB9927195D0 (en) | 1999-11-17 | 1999-11-17 | Auto-adhesive composition |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| WO2001036011A1 true WO2001036011A1 (en) | 2001-05-25 |
Family
ID=10864681
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/GB2000/004396 WO2001036011A1 (en) | 1999-11-17 | 2000-11-17 | Auto-adhesive composition |
Country Status (5)
| Country | Link |
|---|---|
| EP (1) | EP1229943A1 (en) |
| JP (1) | JP2003514105A (en) |
| AU (1) | AU1406001A (en) |
| GB (1) | GB9927195D0 (en) |
| WO (1) | WO2001036011A1 (en) |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1283252A3 (en) * | 2001-08-03 | 2003-08-20 | Tesa AG | Adhesive tape for wrapping purposes |
| EP1695723A3 (en) * | 2005-02-25 | 2007-10-31 | Covalence Specialty Materials Corp. | Pressure sensitive adhesive for surgical drapes |
| US8034430B2 (en) * | 2005-10-27 | 2011-10-11 | Kimberly-Clark Worldwide, Inc. | Nonwoven fabric and fastening system that include an auto-adhesive material |
| CN109749662A (en) * | 2018-12-21 | 2019-05-14 | 南京斯瑞奇医疗用品有限公司 | A kind of natural emulsion adhesive of storability and preparation method thereof |
| EP3470092A4 (en) * | 2016-06-14 | 2020-02-12 | Tokuyama Corporation | PROTECTIVE MATERIAL FOR LIVESTOCK, KIT FOR FORMING A PROTECTIVE FILM FOR LIVESTOCK AND METHOD FOR PROTECTING SICK / INJURED AREAS IN LIVESTOCK |
| CN112704764A (en) * | 2020-12-28 | 2021-04-27 | 杭州高斯博医疗用品有限公司 | Hydrophilic self-adhesive suitable for cold compress self-adhesive compression bandage, preparation method and application |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2446246T3 (en) | 2006-08-04 | 2014-03-06 | Kuraray Co., Ltd. | Stretchable non-woven textile material and bands |
| CN102020950A (en) * | 2011-01-14 | 2011-04-20 | 尚盟运动用品(惠阳)有限公司 | High-strength adhesive |
| JP7140774B2 (en) | 2017-11-10 | 2022-09-21 | 株式会社クラレ | Fiber structure and manufacturing method thereof |
| CN114288088B (en) * | 2021-12-27 | 2022-08-09 | 杭州高斯博医疗用品有限公司 | Self-dissolving strong self-adhesive elastic bandage and preparation method thereof |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB853572A (en) * | 1956-06-30 | 1960-11-09 | Dunlop Rubber Co | Rubber latex adhesive compositions |
| JPH0539222A (en) * | 1991-08-02 | 1993-02-19 | Yoshitomi Pharmaceut Ind Ltd | Analgesic anti-inflammatory patch |
| EP0713697A1 (en) * | 1994-10-26 | 1996-05-29 | Tokuhon Corporation | Analgesic anti-inflammatory adhesive preparations |
| WO1997003097A1 (en) * | 1995-07-07 | 1997-01-30 | Kao Corporation | Graft natural rubber pressure-sensitive adhesive and pressure-sensitive adhesive tape using it |
| JPH09249863A (en) * | 1996-03-14 | 1997-09-22 | Sumitomo Rubber Ind Ltd | Adhesives and adhesives |
| US5962147A (en) * | 1996-11-26 | 1999-10-05 | General Latex And Chemical Corporation | Method of bonding with a natural rubber latex and laminate produced |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP3314094B2 (en) * | 1992-12-22 | 2002-08-12 | 日東電工株式会社 | Natural rubber-based pressure-sensitive adhesive composition and pressure-sensitive adhesive tape thereof |
| JPH09217048A (en) * | 1996-02-08 | 1997-08-19 | Kao Corp | Pressure-sensitive adhesive composition and sheet for information carrier |
-
1999
- 1999-11-17 GB GBGB9927195.9A patent/GB9927195D0/en not_active Ceased
-
2000
- 2000-11-17 AU AU14060/01A patent/AU1406001A/en not_active Abandoned
- 2000-11-17 EP EP00976181A patent/EP1229943A1/en not_active Withdrawn
- 2000-11-17 WO PCT/GB2000/004396 patent/WO2001036011A1/en not_active Application Discontinuation
- 2000-11-17 JP JP2001538001A patent/JP2003514105A/en not_active Ceased
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB853572A (en) * | 1956-06-30 | 1960-11-09 | Dunlop Rubber Co | Rubber latex adhesive compositions |
| JPH0539222A (en) * | 1991-08-02 | 1993-02-19 | Yoshitomi Pharmaceut Ind Ltd | Analgesic anti-inflammatory patch |
| EP0713697A1 (en) * | 1994-10-26 | 1996-05-29 | Tokuhon Corporation | Analgesic anti-inflammatory adhesive preparations |
| WO1997003097A1 (en) * | 1995-07-07 | 1997-01-30 | Kao Corporation | Graft natural rubber pressure-sensitive adhesive and pressure-sensitive adhesive tape using it |
| JPH09249863A (en) * | 1996-03-14 | 1997-09-22 | Sumitomo Rubber Ind Ltd | Adhesives and adhesives |
| US5962147A (en) * | 1996-11-26 | 1999-10-05 | General Latex And Chemical Corporation | Method of bonding with a natural rubber latex and laminate produced |
Non-Patent Citations (2)
| Title |
|---|
| DATABASE WPI Section Ch Week 199312, Derwent World Patents Index; Class A96, AN 1993-096738, XP002160507 * |
| DATABASE WPI Section Ch Week 199748, Derwent World Patents Index; Class A11, AN 1997-522075, XP002160508 * |
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1283252A3 (en) * | 2001-08-03 | 2003-08-20 | Tesa AG | Adhesive tape for wrapping purposes |
| US6908672B2 (en) | 2001-08-03 | 2005-06-21 | Tesa Ag | Adhesive tape particularly for packaging use |
| EP1695723A3 (en) * | 2005-02-25 | 2007-10-31 | Covalence Specialty Materials Corp. | Pressure sensitive adhesive for surgical drapes |
| US8034430B2 (en) * | 2005-10-27 | 2011-10-11 | Kimberly-Clark Worldwide, Inc. | Nonwoven fabric and fastening system that include an auto-adhesive material |
| US8562774B2 (en) | 2005-10-27 | 2013-10-22 | Kimberly-Clark Worldwide, Inc. | Method of forming a nonwoven fabric and fastening system that include an auto-adhesive material |
| EP3470092A4 (en) * | 2016-06-14 | 2020-02-12 | Tokuyama Corporation | PROTECTIVE MATERIAL FOR LIVESTOCK, KIT FOR FORMING A PROTECTIVE FILM FOR LIVESTOCK AND METHOD FOR PROTECTING SICK / INJURED AREAS IN LIVESTOCK |
| CN109749662A (en) * | 2018-12-21 | 2019-05-14 | 南京斯瑞奇医疗用品有限公司 | A kind of natural emulsion adhesive of storability and preparation method thereof |
| CN112704764A (en) * | 2020-12-28 | 2021-04-27 | 杭州高斯博医疗用品有限公司 | Hydrophilic self-adhesive suitable for cold compress self-adhesive compression bandage, preparation method and application |
Also Published As
| Publication number | Publication date |
|---|---|
| JP2003514105A (en) | 2003-04-15 |
| EP1229943A1 (en) | 2002-08-14 |
| GB9927195D0 (en) | 2000-01-12 |
| AU1406001A (en) | 2001-05-30 |
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