WO2001030373A8 - Composition polypeptidique - Google Patents

Composition polypeptidique

Info

Publication number
WO2001030373A8
WO2001030373A8 PCT/RU2000/000427 RU0000427W WO0130373A8 WO 2001030373 A8 WO2001030373 A8 WO 2001030373A8 RU 0000427 W RU0000427 W RU 0000427W WO 0130373 A8 WO0130373 A8 WO 0130373A8
Authority
WO
WIPO (PCT)
Prior art keywords
polypeptide
inhibitor
organic acid
polypeptide composition
proteolytic ferment
Prior art date
Application number
PCT/RU2000/000427
Other languages
English (en)
Russian (ru)
Other versions
WO2001030373A1 (fr
Inventor
Nikolai Alfredovich Plate
Lev Ivanovich Valuev
Gennady Alexeevich Sytov
Mariya Viktorovna Uliyanova
Ljudmila Vitalievna Vanchugova
Ljudmila Konstan Staroseltseva
Elena Iliinichna Shakhmatova
Nataliya Pavlovna Prutskova
Jury Viktorovich Natochin
Vladimir Alexandrovic Knyazhev
Jay Henis
Original Assignee
Inst Neftechimicheskogo Sintez
Nikolai Alfredovich Plate
Lev Ivanovich Valuev
Gennady Alexeevich Sytov
Mariya Viktorovna Uliyanova
Ljudmila Vitalievna Vanchugova
Ljudmila Konstan Staroseltseva
Elena Iliinichna Shakhmatova
Nataliya Pavlovna Prutskova
Jury Viktorovich Natochin
Vladimir Alexandrovic Knyazhev
Jay Henis
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from RU99122655A external-priority patent/RU2171687C2/ru
Application filed by Inst Neftechimicheskogo Sintez, Nikolai Alfredovich Plate, Lev Ivanovich Valuev, Gennady Alexeevich Sytov, Mariya Viktorovna Uliyanova, Ljudmila Vitalievna Vanchugova, Ljudmila Konstan Staroseltseva, Elena Iliinichna Shakhmatova, Nataliya Pavlovna Prutskova, Jury Viktorovich Natochin, Vladimir Alexandrovic Knyazhev, Jay Henis filed Critical Inst Neftechimicheskogo Sintez
Priority to IL14935500A priority Critical patent/IL149355A0/xx
Priority to AU13162/01A priority patent/AU1316201A/en
Priority to DE10085144T priority patent/DE10085144T1/de
Publication of WO2001030373A1 publication Critical patent/WO2001030373A1/fr
Publication of WO2001030373A8 publication Critical patent/WO2001030373A8/fr
Priority to DK200200624A priority patent/DK200200624A/da

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/28—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/27—Growth hormone [GH], i.e. somatotropin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/55—Protease inhibitors
    • A61K38/56—Protease inhibitors from plants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/55—Protease inhibitors
    • A61K38/57—Protease inhibitors from animals; from humans

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Zoology (AREA)
  • Endocrinology (AREA)
  • Botany (AREA)
  • Diabetes (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

L'invention relève de la médecine et concerne notamment une composition polypeptidique destinée à soigner les malades par l'administration pérorale dans leur organisme de préparations médicinales polypeptidiques. La composition polypeptidique de l'invention comprend en tant que composant actif un polypeptide ayant un poids moléculaire entre 1000 et 21000, un inhibiteur de ferments protéolytiques tel qu'un inhibiteur de trypsine à base de soja, un inhibiteur pancréatique de trypsine, une aprotinine, une ovomucoïde à base du blanc d'oeuf d'oiseaux et un acide organique et une charge inerte pharmacologiquement acceptables, avec le rapport suivant des composants (en % en poids): polypeptide 1,0-95,0; inhibiteur de ferments protéolytiques 0,02 10,0; acide organique 1,0 - 94,0; charge inerte le reste. Pour augmenter l'efficacité de cette composition, on peut y inclure des substances connues qui facilitent la pénétration des polypeptides à travers la membrane des muqueuses.
PCT/RU2000/000427 1999-10-28 2000-10-27 Composition polypeptidique WO2001030373A1 (fr)

Priority Applications (4)

Application Number Priority Date Filing Date Title
IL14935500A IL149355A0 (en) 1999-10-28 2000-10-27 Polypeptide corporation
AU13162/01A AU1316201A (en) 1999-10-28 2000-10-27 Polypeptide composition
DE10085144T DE10085144T1 (de) 1999-10-28 2000-10-27 Polypeptidkomposition
DK200200624A DK200200624A (da) 1999-10-28 2002-04-25 Polypeptid-præparat

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
RU99122655 1999-10-28
RU99122655A RU2171687C2 (ru) 1999-10-28 Полипептидная композиция

Publications (2)

Publication Number Publication Date
WO2001030373A1 WO2001030373A1 (fr) 2001-05-03
WO2001030373A8 true WO2001030373A8 (fr) 2002-02-07

Family

ID=20226315

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/RU2000/000427 WO2001030373A1 (fr) 1999-10-28 2000-10-27 Composition polypeptidique

Country Status (6)

Country Link
AU (1) AU1316201A (fr)
DE (1) DE10085144T1 (fr)
DK (1) DK200200624A (fr)
IL (1) IL149355A0 (fr)
WO (1) WO2001030373A1 (fr)
YU (1) YU31902A (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6997785B2 (ja) 2017-01-27 2022-02-04 マイクロファーム・リミテッド 炎症性障害の治療療法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU225496B1 (en) * 1993-04-07 2007-01-29 Scios Inc Pharmaceutical compositions of prolonged delivery, containing peptides
RU2076733C1 (ru) * 1994-03-23 1997-04-10 Институт нефтехимического синтеза им.А.В.Топчеева РАН Способ получения производных инсулина
FR2719479B1 (fr) * 1994-05-04 1996-07-26 Sanofi Elf Formulation stable lyophilisée comprenant une protéine: kit de dosage.
US5653987A (en) * 1995-05-16 1997-08-05 Modi; Pankaj Liquid formulations for proteinic pharmaceuticals
US5780431A (en) * 1996-09-20 1998-07-14 Neurobiological Technologies, Inc. Pharmaceutical formulations of corticotropin releasing factor having improved stability in liquid form

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6997785B2 (ja) 2017-01-27 2022-02-04 マイクロファーム・リミテッド 炎症性障害の治療療法

Also Published As

Publication number Publication date
YU31902A (sh) 2004-12-31
AU1316201A (en) 2001-05-08
DK200200624A (da) 2002-06-21
IL149355A0 (en) 2002-11-10
WO2001030373A1 (fr) 2001-05-03
DE10085144T1 (de) 2003-04-24

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