WO2001028464A1 - Procede de reconstruction de l'annulus du disque intervertebral et stent d'annulus de disque intervertebral - Google Patents
Procede de reconstruction de l'annulus du disque intervertebral et stent d'annulus de disque intervertebral Download PDFInfo
- Publication number
- WO2001028464A1 WO2001028464A1 PCT/US2000/028756 US0028756W WO0128464A1 WO 2001028464 A1 WO2001028464 A1 WO 2001028464A1 US 0028756 W US0028756 W US 0028756W WO 0128464 A1 WO0128464 A1 WO 0128464A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- annulus
- annulus stent
- disc
- intervertebral disc
- stent
- Prior art date
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2210/00—Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2210/0004—Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof bioabsorbable
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2210/00—Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2210/0014—Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof using shape memory or superelastic materials, e.g. nitinol
- A61F2210/0019—Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof using shape memory or superelastic materials, e.g. nitinol operated at only one temperature whilst inside or touching the human body, e.g. constrained in a non-operative shape during surgery, another temperature only occurring before the operation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2230/00—Geometry of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2230/0002—Two-dimensional shapes, e.g. cross-sections
- A61F2230/0017—Angular shapes
- A61F2230/0026—Angular shapes trapezoidal
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2230/00—Geometry of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2230/0063—Three-dimensional shapes
- A61F2230/0093—Umbrella-shaped, e.g. mushroom-shaped
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2310/00—Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
- A61F2310/00005—The prosthesis being constructed from a particular material
- A61F2310/00011—Metals or alloys
Definitions
- the invention generally relates to a surgical method of intervertebral disc wall reconstruction with a related annulus stent augmenting the repair.
- the effects of said reconstruction are restoration of disc wall integrity and reduction of the failure rate (3-21%) of a common surgical procedure (disc fragment removal or discectomy). This surgical procedure is performed about 390,000 times annually in the United States.
- the spinal column is formed from a number of vertebrae, which in their normal state are separated from each other by cartilaginous intervertebral discs.
- the intervertebral disc acts in the spine as a crucial stabilizer, and as a mechanism for force distribution between the vertebral bodies. Without the disc, collapse of the intervertebral space occurs in conjunction with abnormal joint mechanics and premature development of arthritic changes.
- the normal intervertebral disc has an outer ligamentous ring called the annulus surrounding the nucleus pulposus.
- the annulus binds the adjacent vertebrae together and is constituted of collagen fibers that are attached to the vertebrae and cross each other so that half of the individual fibers will tighten as the vertebrae are rotated in either direction, thus resisting twisting or torsional motion.
- the nucleus pulposus is constituted of loose tissue, having about
- the annulus tends to thicken, desicate, and become more rigid.
- the nucleus pulposus in turn, becomes more viscous and less fluid and sometimes even dehydrates and contracts.
- the annulus also becomes susceptibleto fracturing or fissuring. These fractures tend to occur all around the circumference of the annulus and can extend from both the outside of the annulus inwards, and the interior outward. Occasionally, a fissure from the outside of the annulus meets a fissure from the inside and results in a complete rent or tear through the annulus fibrosis.
- the nucleus pulposus may extrude out through the annulus wall. The extruded material, in turn, can impinge on the spinal cord or on the spinal nerve rootlet as it exits through the intervertebral disc foramen, resulting in a condition termed ruptured disc or herniated disc
- the inner-nucleus component migrates along the path of least resistance forcing the fissure to open further, allowing migration of the nucleus pulposus through the wall of the disc, with resultant nerve compression and leakage of chemicals of inflammation into the space around the adjacent nerve roots supplying the extremities, bladder, bowel and genitalia.
- the usual effect of nerve compression and inflammation is intolerable back or neck pain, radiating into the extremities, with accompanying numbness, weakness, and in late stages, paralysis and muscle atrophy, and/or bladder and bowel incontinence.
- injury, disease or other degenerative disorders may cause one or more of the intervertebral discs to shrink, collapse, deteriorate or become displaced, herniated, or otherwise damaged.
- thermal annuloplasty involving the heating of sub-annular zones in the non-herniated painful disc, seeking pain relief, but making no claim of reconstruction of the ruptured, discontinuous annulus wall.
- the present invention provides methods and related materials for reconstruction of the disk wall in cases of displaced, herniated, ruptured, or otherwise damaged intervertebral discs.
- one or more mild biodegradable surgical sutures are placed at about equal distances along the sides of a pathologic aperture in the ruptured disc wall (annulus) or along the sides of a surgical incision in the weakened, thinned disc annulus.
- Sutures are then tied in such fashion as to draw together the sides of the aperture, effecting reapproximation or closure of the opening, to enhance natural healing and subsequent reconstruction by natural tissue (fibroblasts) crossing the now surgically narrowed gap in the disc annulus.
- the method can be augmented by placement of a patch of human muscle fascia (the membrane covering the muscle) or any other autograft or allograft acting as a bridge in and across the aperture, providing a platform for traverse of fibroblasts or other normal cells of repair existing in and around the various layers of the disc annulus, prior to closure of the aperture.
- a 30-50%) reduction in the rate of recurrence of disc herniation has been achieved using the aforementioned fascial augmentation with this embodiment.
- biocompatible membranes can be employed as a bridge, stent, patch or barrier to subsequent migration of the disc nucleus through the aperture.
- biocompatible materials may be, for example, a medical grade biocompatible fabric, biodegradable polymeric sheets, or form fitting or non-form fitting fillers for the cavity created by removal of a portion of the disc nucleus in the course of the disc fragment removal or discectomy.
- the prosthetic material can be placed in and around the intervertebral space, created by removal of the degenerated disc fragments.
- Figure 1 shows a perspective view of the annulus stent.
- Figure 2 shows a front view of the annulus stent.
- Figure 3 shows a side view of the annulus stent.
- Figure 4A-4C show a front view of various alternative embodiments of the annulus stent.
- Figure 5A-5B shows the alternative embodiment of a pyramid shaped annulus stent.
- Figure 6A-6B shows the alternative embodiment of a coned shaped annulus stent.
- Figure 7 shows the primary closure of the opening in the disc annulus, without an intervertebral or subannular stent.
- Figure 8A-8B shows the primary closure with a stent in generic form.
- Figure 9 shows a method of suturing the annulus stent into the disc annulus, utilizing sub-annular fixation points.
- Figure 10A-10B show the annulus stent with flexible bladder being expanded into the disc annulus.
- Figure 11A-11D show the annulus stent being inserted into the disc annulus.
- Figure 12A-12B show the annulus stent with the flexible bladder being expanded by injection.
- the present invention provides methods and related materials for reconstruction of the disk wall in cases of displaced, herniated, ruptured, or otherwise damaged intervertebral discs.
- a damaged annulus as shown in Figure 7, as shown in Figure 7, a damaged annulus
- surgical sutures 40 are placed at about equal distances along the sides of a pathologic aperture 44 in the ruptured annulus 42. Reapproximation or closure of the aperture 44 is accomplished by tying the sutures 40 in such a fashion that the sides of the aperture 44 are drawn together. The reapproximation or closure of the aperture 44 enhances the natural healing and subsequent reconstruction by the natural tissue crossing the now surgically narrowed gap in the annulus 42.
- the surgical sutures 40 are biodegradable, but permanent non-biodegradable may be utilized.
- a surgical incision is made along the weakened or thinned region of the annulus 42 and one or more surgical sutures 40 are placed at about equal distances along the sides of the incision.
- Reapproximation or closure of the incision is accomplished by tying the sutures 40 in such a fashion that the sides of the incision are drawn together.
- the reapproximation or closure of the incision enhances the natural healing and subsequent reconstruction by the natural tissue crossing the now surgically narrowed gap in the annulus 42.
- the surgical sutures 40 are biodegradable, but permanent non-biodegradable materials may be utilized.
- the method can be augmented by the placementof a patch of human muscle fascia or any other autograft, allograft or xenograft in and across the aperture 44.
- the patch acts as a bridge in and across the aperture, providing a platform for traverse of fibroblasts or other normal cells of repair existing in and around the various layers of the disc annulus, prior to closure of the aperture.
- a biocompatible membrane can be employed as an annulus stent 10, being placed in and across the aperture 44.
- the annulus stent 10 acts as a bridge in and across the aperture 44, providing a platform for a traverse of fibroblasts or other normal cells of repair existing in and around the various layers of the disc annulus, prior to closure of the aperture 44.
- the annulus stent 10 comprises a centralized vertical extension 12, with an upper section 14 and a lower section 16.
- the centralized vertical extension 12 can be trapezoid in shape through the width and may be from about 8mm -12mm in length.
- the upper section 14 of the centralized vertical extension 12 may be any number of different shapes, as shown in Figures 4A and 4B, with the sides of the upper section
- annulus stent 10 may contain a recess between the upper section 14 and the lower section 16, enabling the annulus stent 10 to form a compatible fit with the edges of the aperture 44.
- the upper section 14 of the centralized vertical extension 12 can comprise a slot 18, where the slot 18 forms an orifice through the upper section 14.
- the slot 18 is positioned within the upper section such that 14 it traverses the upper section's 14 longitudinal axis.
- the slot 18 is of such a size and shape that sutures, tension bands, staples or any other type of fixation device known in the art may be passed through, to affix the annulus stent 10 to the disc annulus 44.
- the perforated upper section 14 contains a plurality of holes which traverse the upper section's 14 longitudinal axis.
- the perforations are of such a size and shape that sutures, tension bands, staples or any other type of fixation device known in the art may be passed through, to affix the annulus stent 10 to the disc annulus 44.
- the lower section 16 can comprise a pair of lateral extensions, a left lateral extension 20 and a right lateral extension 22.
- the lateral extensions 20 and 22 comprise an inside edge 24, an outside edge 26, an upper surface 28, and a lower surface 30.
- the lateral extensions 20 and 22 can have an essentially constant thickness throughout.
- the inside edge 24 is attached to the lower section 16 and is about the same length as the lower section 16.
- the outside edge 26 can be about 8mm - 16mm in length.
- the inside edge 24 and the lower section 16 meet to form a horizontal plane, essentially perpendicular to the centralized vertical extension 12.
- the upper surface 28 of the lateral extensions 20 and 22 can form an angle of about 0°-60° below the horizontal plane.
- the width of the annulus stent 10 may be from about 3mm-5mm.
- the upper surface 28 of the lateral extensions 20 and 22 may be barbed for fixation to the inside surface of the disc annulus 40 and to resist expulsion through the aperture 44.
- the lateral extensions 20 and 22 have a greater thickness at the inside edge 24 than at the outside edge 26.
- the annulus stent 10 is a solid unit, formed from one or more of the flexible resilient biocompatible or bioresorbable materials well know in the art.
- the annulus stent may be made from: a porous matrix or mesh of biocompatible and bioresorbable fibers acting as a scaffold to regenerate disc tissue and replace annulus fibrosus as disclosed in, for example, U.S.
- the annulus stent 10 may contain hygroscopic material for a controlled limited expansion of the annulus stent 10 to fill the evacuated disc space cavity.
- annulus stent 10 may comprise materials to facilitate regeneration of disc tissue, such as bioactive silica-based materials which assist in regeneration of disc tissue as disclosed in U.S. Patent No. 5,849,331 (Ducheyne, et al.), or other tissue growth factors well known in the art.
- the left and right lateral extensions 20 and 22 join to form a solid pyramid or cone. Additionally, the left and right lateral extensions 20 and 22 may form a solid trapezoid, wedge, or bullet shape.
- the solid formation may be a solid biocompatible or bioresorbable flexible material, allowing the lateral extensions20 and 22 to be compressed for insertion into aperture 44, then to expand conforming to the shape of the annulus' 42 inner wall.
- a compressible core may be attached to the lower surface 30 of the lateral extensions 20 and 22, forming a pyramid , cone, trapezoid, wedge, or bullet shape.
- the compressible core may be made from one of the biocompatible or bioresorbable resilient foams well known in the art.
- the compressible core allows the lateral extensions 20 and 22 to be compressed for insertion into aperture 44, then to expand conforming to the shape of the annulus' 42 inner wall and to the cavity created by pathologic extrusion or surgical removal of the disc fragment.
- the lateral extensions 20 and 22 are compressed together for insertion into the aperture 44 of the disc annulus 40.
- the annulus stent 10 is then inserted into the aperture 44, where the lateral extensions 20 and 22 expand, with the upper surface 28 contouring to the inside surface of the disc annulus 40.
- the upper section 14 is positioned within the aperture 44 so that the annulus stent 10 may be secured to the disc annulus 40, using means well known in the art.
- the annulus stent 10 In an alternative method, where the length of the aperture 44 is less than the length of the outside edge 26 of the annulus stent 10, the annulus stent 10 must be inserted laterally into the aperture 44.
- the lateral extensions 20 and 22 are compressed, and the annulus stent 10 is laterally inserted into the aperture 44.
- the annulus stent 10 is then rotated inside the disc annulus 40, such that the upper section 14 is pulled back through the aperture 44.
- the lateral extensions 20 and 22 are then allowed to expand, with the upper surface 28 contouring to the inside surface of the disc annulus 40.
- the upper section 14 is positioned within the aperture 44 such that the annulus stent 10 may be secured to the disc annulus, using means well known in the art.
- a first surgical screw 50 and second surgical screw 52 with eye holes 53 located at the top of the screws 50 and 52, are opposingly inserted into the adjacent vertebrae 54 and 56 below the annulus stent 10.
- a suture is passed down though the disc annulus 40, adjacent to the aperture 44, through the eye hole 53 on the first screw 50 then back up through the disc annulus 40 and through the orifice 18 on the annulus stent 10. This is repeated for the second screw 52, after which the suture is secured.
- One or more surgical sutures 40 are placed at about equal distances along the sides of the aperture 44 in the disc annulus 42.
- Reapproximation or closure of the aperture 44 is accomplished by tying the sutures 40 in such a fashion that the sides of the aperture 44 are drawn together.
- the reapproximation or closure of the aperture 44 enhances the natural healing and subsequent reconstruction by the natural tissue crossing the now surgically narrowed gap in the annulus 42.
- the surgical sutures 40 are biodegradable but permanent nonbiodegradable forms may be utilized. This method should decrease the strain on the disc annulus 40 adjacent to the aperture 44, precluding the tearing of the sutures through the disc annulus 40. It is anticipated that fibroblasts will engage the fibers of the polymer or fabric of the intervertebral disc stent, forming a strong wall duplicating the currently existing condition of healing seen in the normal reparative process.
- a flexible bladder 60 is attached to the lower surface 30 of the annulus stent 10.
- the flexible bladder 60 comprises an internal cavity 62 surrounded by a membrane 64, where the membrane 64 is made from a thin flexible biocompatible material.
- the flexible bladder 60 is attached to the lower surface 28 of the annulus stent 10 in an unexpanded condition.
- the flexible bladder 60 is expanded by injecting a biocompatible fluid or expansive foam, as known in the art, into the internal cavity 62.
- the exact size of the flexible bladder 60 can be varied for different individuals. The typical size of an adult nucleus is 2 cm in the semi-minor axis, 4 cm in the semi-major axis and 1.2 cm in thickness.
- the membrane 64 is made of a semi-permeable biocompatible material.
- a hydrogel is injected into the internal cavity of the flexible bladder 28.
- a hydrogel is a substance formed when an organic polymer (natural or synthetic) is cross- linked via covalent, ionic, or hydrogen bonds to create a three-dimensional open-lattice structure which entraps water molecules to form a gel.
- the hydrogel may be used in either the hydrated or dehydrated form.
- an injection instrument as known in the art, such as a syringe, is used to inject the biocompatible fluid or expansive foam into the internal cavity 62 of the flexible bladder 60.
- the biocompatible fluid or expansive foam is injected through the annulus stent 10 into the internal cavity of the flexible bladder 28.
- Sufficient material is injected into the internal cavity 62 to expand the flexible bladder 60 to fill the void in the intervertebral disc cavity.
- the use of the flexible bladder 60 is particularly useful when it is required to remove all or part of the intervertebral disc nucleus.
- the surgical repair of an intervertebral disc may require the removal of the entire disc nucleus, being replaced with an implant, or the removal of a portion of the disc nucleus thereby leaving a void in the intervertebral disc cavity.
- the flexible bladder 60 allows for the removal of only the damaged section of the disc nucleus, with the expanded flexible bladder 60 filling the resultant void in the intervertebral disc cavity.
- a major advantage of the annulus stent 10 with the flexible bladder 60 is that the incision area in the annulus can be reduced in size as there is no need for the insertion of an implant into the intervertebral disc cavity.
- a dehydrated hydrogel is injected into the internal cavity 28 of the flexible bladder 60. Fluid, from the disc nucleus, passes through the semi-permeable membrane 64 hydratingthe dehydrated hydrogel. As the hydrogel absorbs the fluid the flexible bladder expands 60, filling the void in the intervertebral disc cavity.
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- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Transplantation (AREA)
- Neurology (AREA)
- Heart & Thoracic Surgery (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Cardiology (AREA)
- Vascular Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Dispersion Chemistry (AREA)
- Physical Education & Sports Medicine (AREA)
- Prostheses (AREA)
Abstract
Priority Applications (7)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CA002388382A CA2388382C (fr) | 1999-10-20 | 2000-10-17 | Procede de reconstruction de l'annulus du disque intervertebral et stent d'annulus de disque intervertebral |
DE60039618T DE60039618D1 (de) | 1999-10-20 | 2000-10-17 | Stent für einen bandscheibenannulus |
DE10085121T DE10085121T1 (de) | 1999-10-20 | 2000-10-17 | Verfahren zur Wiederherstellung eines Wirbelsäulen Bandscheibenannulus und Wirbelsäulen Bandscheibenannulus Stent |
AU12114/01A AU775881B2 (en) | 1999-10-20 | 2000-10-17 | Spinal disc annulus reconstruction method and spinal disc annulus stent |
IL14916200A IL149162A0 (en) | 1999-10-20 | 2000-10-17 | Spinal disc annulus reconstruction method and spinal disc annulus stent |
JP2001531061A JP2003511199A (ja) | 1999-10-20 | 2000-10-17 | 椎間板線維輪の再生方法及び同線維輪用のステント |
EP00973619A EP1221913B1 (fr) | 1999-10-20 | 2000-10-17 | Stent d'annulus de disque intervertebral |
Applications Claiming Priority (7)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US16071099P | 1999-10-20 | 1999-10-20 | |
US60/160,710 | 1999-10-20 | ||
US48470600A | 2000-01-18 | 2000-01-18 | |
US09/484,706 | 2000-01-18 | ||
US30910501P | 2001-07-31 | 2001-07-31 | |
US09/947,078 US6592625B2 (en) | 1999-10-20 | 2001-09-05 | Spinal disc annulus reconstruction method and spinal disc annulus stent |
US10/075,615 US20020123807A1 (en) | 1999-10-20 | 2002-02-15 | Spinal disc annulus reconstruction method and spinal disc annulus stent |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2001028464A1 true WO2001028464A1 (fr) | 2001-04-26 |
Family
ID=46149893
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2000/028756 WO2001028464A1 (fr) | 1999-10-20 | 2000-10-17 | Procede de reconstruction de l'annulus du disque intervertebral et stent d'annulus de disque intervertebral |
Country Status (1)
Country | Link |
---|---|
WO (1) | WO2001028464A1 (fr) |
Cited By (47)
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US6425919B1 (en) | 1999-08-18 | 2002-07-30 | Intrinsic Orthopedics, Inc. | Devices and methods of vertebral disc augmentation |
WO2002080821A1 (fr) * | 2001-04-06 | 2002-10-17 | Core Medical, Inc. | Appareil et procedes de fermeture d'ouvertures dans les disques intervertebraux |
WO2003020169A2 (fr) * | 2001-08-30 | 2003-03-13 | Sdgi Holdings, Inc. | Implants de noyau de disque intervertebral et procedes associes |
WO2003055396A2 (fr) * | 2001-09-06 | 2003-07-10 | Core Medical, Inc. | Dispositif et techniques de traitement des disques vertebraux |
EP1328221A2 (fr) * | 1999-08-18 | 2003-07-23 | Intrinsic Therapeutics, Inc. | Dispositifs et procede permettant d'augmenter ou de conserver un noyau gelatineux |
WO2003099171A1 (fr) * | 2002-05-25 | 2003-12-04 | Efmt Entwicklungs- Und Forschungszentrum Für Mikrotherapie Gmbh | Implant de type ballon gonflable |
WO2004002374A1 (fr) * | 2002-06-27 | 2004-01-08 | Raymedica, Inc. | Dispositif d'occlusion d'anneau discal vertebral a transition autonome |
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US6835205B2 (en) | 2000-04-04 | 2004-12-28 | Spinalabs, Llc | Devices and methods for the treatment of spinal disorders |
EP1495725A1 (fr) * | 2003-07-08 | 2005-01-12 | A- Spine Holding Group Corp. | Ancrage pour suture et système d'ancrage d'un tissue à un os |
EP1496819A1 (fr) * | 2002-04-25 | 2005-01-19 | Blackstone Medical, Inc. | Disque intervertebral artificiel |
WO2005020859A1 (fr) | 2003-08-26 | 2005-03-10 | Aesculap Ag & Co. Kg | Implant destiné à fermer une ouverture dans l'anneau fibreux |
EP1594422A2 (fr) * | 2003-01-29 | 2005-11-16 | Anulex Technologies, Inc. | Methode de reconstruction d'annulus de disque vertebral et stent pour annulus de disque vertebral |
US7144397B2 (en) | 2000-08-18 | 2006-12-05 | Intrinsic Therapeutics, Inc. | Minimally invasive system for manipulating intervertebral disc tissue |
US7223289B2 (en) | 2002-04-16 | 2007-05-29 | Warsaw Orthopedic, Inc. | Annulus repair systems and techniques |
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CN102395333A (zh) * | 2009-04-16 | 2012-03-28 | 华沙整形外科股份有限公司 | 侵害性最小的可膨大椎骨植入物和方法 |
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US8852229B2 (en) | 2003-10-17 | 2014-10-07 | Cordis Corporation | Locator and closure device and method of use |
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