WO2001025269A3 - Nouveau recepteur couple a la proteine g humaine - Google Patents
Nouveau recepteur couple a la proteine g humaine Download PDFInfo
- Publication number
- WO2001025269A3 WO2001025269A3 PCT/EP2000/009584 EP0009584W WO0125269A3 WO 2001025269 A3 WO2001025269 A3 WO 2001025269A3 EP 0009584 W EP0009584 W EP 0009584W WO 0125269 A3 WO0125269 A3 WO 0125269A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- igs4
- polynucleotides
- polypeptides
- disorders
- family
- Prior art date
Links
- 101000887490 Homo sapiens Guanine nucleotide-binding protein G(z) subunit alpha Proteins 0.000 title 1
- 102000052301 human GNAZ Human genes 0.000 title 1
- 102000005962 receptors Human genes 0.000 title 1
- 108020003175 receptors Proteins 0.000 title 1
- 108091033319 polynucleotide Proteins 0.000 abstract 4
- 102000040430 polynucleotide Human genes 0.000 abstract 4
- 239000002157 polynucleotide Substances 0.000 abstract 4
- 229920001184 polypeptide Polymers 0.000 abstract 4
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 4
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 4
- 241001465754 Metazoa Species 0.000 abstract 2
- 239000000556 agonist Substances 0.000 abstract 2
- 239000005557 antagonist Substances 0.000 abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- 208000026278 immune system disease Diseases 0.000 abstract 2
- 102000003688 G-Protein-Coupled Receptors Human genes 0.000 abstract 1
- 108090000045 G-Protein-Coupled Receptors Proteins 0.000 abstract 1
- 208000019693 Lung disease Diseases 0.000 abstract 1
- 102100038813 Neuromedin-U Human genes 0.000 abstract 1
- 108090000189 Neuropeptides Proteins 0.000 abstract 1
- 230000003213 activating effect Effects 0.000 abstract 1
- 210000000748 cardiovascular system Anatomy 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 210000005095 gastrointestinal system Anatomy 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 239000003446 ligand Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 210000000653 nervous system Anatomy 0.000 abstract 1
- 108010021512 neuromedin U Proteins 0.000 abstract 1
- 238000012216 screening Methods 0.000 abstract 1
- 210000002027 skeletal muscle Anatomy 0.000 abstract 1
- 210000001685 thyroid gland Anatomy 0.000 abstract 1
- 230000009261 transgenic effect Effects 0.000 abstract 1
- 210000002229 urogenital system Anatomy 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
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- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/582—Recycling of unreacted starting or intermediate materials
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Cardiology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Virology (AREA)
- Rheumatology (AREA)
- Urology & Nephrology (AREA)
- Physical Education & Sports Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Pulmonology (AREA)
- Immunology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Endocrinology (AREA)
- Diabetes (AREA)
- Hospice & Palliative Care (AREA)
- Molecular Biology (AREA)
- Hematology (AREA)
- Psychology (AREA)
- Otolaryngology (AREA)
- Biophysics (AREA)
- AIDS & HIV (AREA)
Abstract
Priority Applications (17)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2001528209A JP2003521894A (ja) | 1999-09-24 | 2000-09-25 | 新規のヒトg−タンパク質共役型受容体 |
AU21536/01A AU779993B2 (en) | 1999-09-24 | 2000-09-25 | Novel human G-protein coupled receptor |
CA002379462A CA2379462A1 (fr) | 1999-09-24 | 2000-09-25 | Nouveau recepteur couple a la proteine g humaine |
US10/088,744 US6998255B1 (en) | 1999-09-24 | 2000-09-25 | Human G-protein coupled receptor |
EP00984940A EP1218412A2 (fr) | 1999-09-24 | 2000-09-25 | Nouveau recepteur couple a la proteine g humaine |
IL14788900A IL147889A0 (en) | 1999-09-24 | 2000-09-25 | Novel human g-protein coupled receptor |
IL147889A IL147889A (en) | 1999-09-24 | 2002-01-29 | Human g-protein coupled receptor |
US10/770,583 US7151165B2 (en) | 1999-09-24 | 2004-02-04 | Antibodies immunospecific for a novel human G-protein coupled receptor family |
US11/170,153 US7459279B2 (en) | 1999-09-24 | 2005-06-30 | Binding assay employing IGS4, a human G-protein coupled neuromedin receptor |
US11/170,166 US20050272122A1 (en) | 1999-09-24 | 2005-06-30 | Novel human G-protein coupled receptor |
US11/170,351 US7459292B2 (en) | 1999-09-24 | 2005-06-30 | Polynucleotides and expression system of a novel human G-protein coupled receptor |
IL196053A IL196053A0 (en) | 1999-09-24 | 2008-12-18 | Novel human g-protein coupled receptor |
IL206564A IL206564A0 (en) | 1999-09-24 | 2010-06-23 | A nucleotide sequence whice is complimentary to a nucleotide encoding an igs4 polypeptide |
IL206566A IL206566A0 (en) | 1999-09-24 | 2010-06-23 | Use of an antagonist to the igs4 neuromedin receptor polypeptide for the preparation of a medicament for the treatment of a disease related to the expression or acitivity of the igs4 neuromedin receptor polypeptide |
IL206565A IL206565A0 (en) | 1999-09-24 | 2010-06-23 | An antibody immunospecific for an igs4 polypeptide |
IL206568A IL206568A0 (en) | 1999-09-24 | 2010-06-23 | A method of determining whether a substance is a potential ligand of igs4 receptor |
IL206567A IL206567A0 (en) | 1999-09-24 | 2010-06-23 | Use of an agonist to the igs4 neuromdin receptor polypeptide for the preparation of a medicament for the treatment of a disease related to the expression or activity of the igs4 neuromedin receptor ploypeptide |
Applications Claiming Priority (8)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
NL1013140 | 1999-09-24 | ||
NL1013140 | 1999-09-24 | ||
EP99203140.1 | 1999-09-24 | ||
EP99203140 | 1999-09-24 | ||
EP00202683 | 2000-07-28 | ||
EP00202683.9 | 2000-07-28 | ||
US22204700P | 2000-07-31 | 2000-07-31 | |
US60/222,047 | 2000-07-31 |
Related Parent Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US22204700P Continuation | 1999-09-24 | 2000-07-31 |
Related Child Applications (6)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US10/088,744 A-371-Of-International US6998255B1 (en) | 1999-09-24 | 2000-09-25 | Human G-protein coupled receptor |
US10088744 A-371-Of-International | 2000-09-25 | ||
US10/770,583 Division US7151165B2 (en) | 1999-09-24 | 2004-02-04 | Antibodies immunospecific for a novel human G-protein coupled receptor family |
US11/170,351 Continuation US7459292B2 (en) | 1999-09-24 | 2005-06-30 | Polynucleotides and expression system of a novel human G-protein coupled receptor |
US11/170,166 Division US20050272122A1 (en) | 1999-09-24 | 2005-06-30 | Novel human G-protein coupled receptor |
US11/170,153 Division US7459279B2 (en) | 1999-09-24 | 2005-06-30 | Binding assay employing IGS4, a human G-protein coupled neuromedin receptor |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2001025269A2 WO2001025269A2 (fr) | 2001-04-12 |
WO2001025269A3 true WO2001025269A3 (fr) | 2001-10-11 |
Family
ID=27440014
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/EP2000/009584 WO2001025269A2 (fr) | 1999-09-24 | 2000-09-25 | Nouveau recepteur couple a la proteine g humaine |
Country Status (7)
Country | Link |
---|---|
EP (2) | EP1218412A2 (fr) |
JP (1) | JP2003521894A (fr) |
CN (1) | CN1249087C (fr) |
AU (1) | AU779993B2 (fr) |
CA (1) | CA2379462A1 (fr) |
IL (8) | IL147889A0 (fr) |
WO (1) | WO2001025269A2 (fr) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6461836B1 (en) | 1999-11-05 | 2002-10-08 | Smithkline Beecham Corporation | Molecular cloning of a 7TM receptor (AxOR34) and screening methods thereof |
US7029857B1 (en) | 1999-12-17 | 2006-04-18 | H. Lundbeck A/S | Processes for obtaining compounds employing SNORF72 receptors |
WO2001081418A1 (fr) | 2000-04-27 | 2001-11-01 | Merck & Co., Inc. | Nouveau recepteur de la neuromedine u, dit nmur2, et nucleotides codant pour lui |
GB0100782D0 (en) * | 2001-01-11 | 2001-02-21 | Glaxo Group Ltd | Assay |
EP1365246A1 (fr) | 2002-05-23 | 2003-11-26 | Bayer Ag | Diagnostic et traitement des maladies associés au récepteur U2 du neuromedin |
WO2004067725A2 (fr) * | 2003-01-30 | 2004-08-12 | Regeneron Pharmaceuticals, Inc. | Procedes d'identification de modulateurs d'activite mediee par nmur2 |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1990001330A1 (fr) * | 1988-08-11 | 1990-02-22 | Terence Bennett | UTILISATION DE NEUROMEDINES U8 et U25 COMME COMPOSES THERAPEUTIQUES |
US5482835A (en) * | 1990-09-13 | 1996-01-09 | Duke University | Methods of testing in yeast cells for agonists and antagonists of mammal G-protein coupled receptors |
JPH08143597A (ja) * | 1994-11-24 | 1996-06-04 | Takeda Chem Ind Ltd | ヒト・ニューロテンシンレセプター蛋白質、その製造法および用途 |
WO1999055732A1 (fr) * | 1998-04-24 | 1999-11-04 | Astrazeneca Ab | Nouveau recepteur couple a la proteine g |
WO2000022131A2 (fr) * | 1998-10-13 | 2000-04-20 | Arena Pharmaceuticals, Inc. | Recepteurs non-endogenes de la proteine g humaine ayant une activite constitutive |
Family Cites Families (3)
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US4873191A (en) | 1981-06-12 | 1989-10-10 | Ohio University | Genetic transformation of zygotes |
AU770871B2 (en) * | 1998-10-12 | 2004-03-04 | Arena Pharmaceuticals, Inc. | Non-endogenous, constitutively activated human G protein-coupled receptors |
JP2003525018A (ja) * | 1998-10-13 | 2003-08-26 | アリーナ・フアーマシユーチカルズ・インコーポレーテツド | 非内在性の構成的に活性化されるヒトgタンパク質共役型受容体 |
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2000
- 2000-09-25 AU AU21536/01A patent/AU779993B2/en not_active Ceased
- 2000-09-25 JP JP2001528209A patent/JP2003521894A/ja active Pending
- 2000-09-25 EP EP00984940A patent/EP1218412A2/fr not_active Withdrawn
- 2000-09-25 CA CA002379462A patent/CA2379462A1/fr not_active Abandoned
- 2000-09-25 EP EP10183739A patent/EP2298803A3/fr not_active Withdrawn
- 2000-09-25 IL IL14788900A patent/IL147889A0/xx unknown
- 2000-09-25 CN CNB008122652A patent/CN1249087C/zh not_active Expired - Fee Related
- 2000-09-25 WO PCT/EP2000/009584 patent/WO2001025269A2/fr active Application Filing
-
2002
- 2002-01-29 IL IL147889A patent/IL147889A/en not_active IP Right Cessation
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2008
- 2008-12-18 IL IL196053A patent/IL196053A0/en unknown
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2010
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Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1990001330A1 (fr) * | 1988-08-11 | 1990-02-22 | Terence Bennett | UTILISATION DE NEUROMEDINES U8 et U25 COMME COMPOSES THERAPEUTIQUES |
US5482835A (en) * | 1990-09-13 | 1996-01-09 | Duke University | Methods of testing in yeast cells for agonists and antagonists of mammal G-protein coupled receptors |
JPH08143597A (ja) * | 1994-11-24 | 1996-06-04 | Takeda Chem Ind Ltd | ヒト・ニューロテンシンレセプター蛋白質、その製造法および用途 |
WO1999055732A1 (fr) * | 1998-04-24 | 1999-11-04 | Astrazeneca Ab | Nouveau recepteur couple a la proteine g |
WO2000022131A2 (fr) * | 1998-10-13 | 2000-04-20 | Arena Pharmaceuticals, Inc. | Recepteurs non-endogenes de la proteine g humaine ayant une activite constitutive |
Non-Patent Citations (15)
Title |
---|
DATABASE EMBL NUCLEOTIDE AND PROTEIN SEQUENCES, 17 February 1996 (1996-02-17), HINXTON, GB, XP002131652 * |
DATABASE EMBL NUCLEOTIDE AND PROTEIN SEQUENCES, 3 July 1995 (1995-07-03), HINXTON, GB, XP002131654 * |
DATABASE EMBL NUCLEOTIDE AND PROTEIN SEQUENCES, 4 August 1999 (1999-08-04), HINXTON, GB, XP002131651 * |
DATABASE EMBL NUCLEOTIDE AND PROTEIN SEQUENCES, 9 June 1996 (1996-06-09), HINXTON, GB, XP002131653 * |
DATABASE WPI Section Ch Week 199632, Derwent World Patents Index; Class B04, AN 1996-318958, XP002131656 * |
FUJII RYO ET AL: "Identification of neuromedin U as the cognate ligand of the orphan G protein-coupled receptor FM-3.", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 275, no. 28, 14 July 2000 (2000-07-14), pages 21068 - 21074, XP002163226, ISSN: 0021-9258 * |
HOSOYA MASAKI ET AL: "Identification and functional characterization of a novel subtype of neuromedin U receptor.", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 275, no. 38, 22 September 2000 (2000-09-22), pages 29528 - 29532, XP002163224, ISSN: 0021-9258 * |
HOWARD ANDREW D ET AL: "Identification of receptors for neuromedin U and its role in feeding.", NATURE (LONDON), vol. 406, no. 6791, 2000, pages 70 - 74, XP000926239, ISSN: 0028-0836 * |
MCKEE K.K. ET AL.,: "Cloning and characterization of two human G protein-coupled receptor genes (GPR38 and GPR39) related to the growth hormone secretagogue and neurotensin receptors", GENOMICS, vol. 46(3), 1997, pages 426-434, XP000889897 * |
RADDATZ RITA ET AL: "Identification and characterization of two neuromedin U receptors differentially expressed in peripheral tissues and the central nervous system.", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 275, no. 42, 20 October 2000 (2000-10-20), pages 32452 - 32459, XP002163227, ISSN: 0021-9258 * |
SHAN LIXIN ET AL: "Identification of a novel neuromedin U receptor subtype expressed in the central nervous system.", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 275, no. 50, 15 December 2000 (2000-12-15), pages 39482 - 39486, XP002163228, ISSN: 0021-9258 * |
SZEKERES PHILIP G ET AL: "Neuromedin U is a potent agonist at the orphan G protein-coupled receptor FM3.", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 275, no. 27, 7 July 2000 (2000-07-07), pages 20247 - 20250, XP002163225, ISSN: 0021-9258 * |
TAN C.P. ET AL.,: "Cloning and characterization of a human and murine T-cell orphan G-protein-coupled receptor similar to the growth hormone secretagogue and neurotensin receptors", GENOMICS, vol. 52(2), 1998, pages 223-229, XP000879493 * |
VITA N ET AL.,: "Neurotensin is an antagonist of the human neurotensin NT2 receptor expressed in Chinese hamster ovary cells", EUROPEAN JOURNAL OF PHARMACOLOGY, vol. 360, no. 2/3, 6 November 1998 (1998-11-06), pages 265 - 272, XP000879367 * |
VITA N ET AL: "CLONING AND EXPRESSION OF A COMPLEMENTARY DNA ENCODING A HIGH AFFINITY HUMAN NEUROTENSIN RECEPTOR", FEBS LETTERS,NL,ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, vol. 317, no. 1/02, 1 February 1993 (1993-02-01), pages 139-142, XP002048144, ISSN: 0014-5793 * |
Also Published As
Publication number | Publication date |
---|---|
WO2001025269A2 (fr) | 2001-04-12 |
EP2298803A2 (fr) | 2011-03-23 |
IL206564A0 (en) | 2011-07-31 |
CA2379462A1 (fr) | 2001-04-12 |
CN1249087C (zh) | 2006-04-05 |
EP2298803A3 (fr) | 2011-06-22 |
IL206565A0 (en) | 2011-07-31 |
EP1218412A2 (fr) | 2002-07-03 |
IL206568A0 (en) | 2011-07-31 |
IL206567A0 (en) | 2011-07-31 |
JP2003521894A (ja) | 2003-07-22 |
IL147889A (en) | 2010-11-30 |
IL147889A0 (en) | 2002-08-14 |
CN1399644A (zh) | 2003-02-26 |
IL206566A0 (en) | 2011-07-31 |
AU2153601A (en) | 2001-05-10 |
IL196053A0 (en) | 2011-08-01 |
AU779993B2 (en) | 2005-02-24 |
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