WO2001024830A3 - Incorporation of chemical substances into cells - Google Patents

Incorporation of chemical substances into cells Download PDF

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Publication number
WO2001024830A3
WO2001024830A3 PCT/US2000/027562 US0027562W WO0124830A3 WO 2001024830 A3 WO2001024830 A3 WO 2001024830A3 US 0027562 W US0027562 W US 0027562W WO 0124830 A3 WO0124830 A3 WO 0124830A3
Authority
WO
WIPO (PCT)
Prior art keywords
cells
incorporation
chemical substances
methods
compositions
Prior art date
Application number
PCT/US2000/027562
Other languages
French (fr)
Other versions
WO2001024830A2 (en
Inventor
John W Holaday
Jamshed H Shah
Original Assignee
Theramed Inc
John W Holaday
Jamshed H Shah
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Theramed Inc, John W Holaday, Jamshed H Shah filed Critical Theramed Inc
Priority to AU79956/00A priority Critical patent/AU7995600A/en
Publication of WO2001024830A2 publication Critical patent/WO2001024830A2/en
Publication of WO2001024830A3 publication Critical patent/WO2001024830A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/40—Esters thereof
    • C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/4018—Esters of cycloaliphatic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/08—Esters of oxyacids of phosphorus
    • C07F9/09—Esters of phosphoric acids
    • C07F9/117—Esters of phosphoric acids with cycloaliphatic alcohols

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The present invention relates to compositions and methods for increasing the bioavailability of chemical substances. In particular, alkylated and acetylated chemical compositions and methods for their natural incorporation into cells is provided. In one embodiment, alkylated and acetylated hemoglobin allosteric effectors are incorporated into red blood cells. These compositions and methods are useful for reducing the affinity of hemoglobin for oxygen and improving the release of oxygen from erythrocytes in tissues.
PCT/US2000/027562 1999-10-05 2000-10-05 Incorporation of chemical substances into cells WO2001024830A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU79956/00A AU7995600A (en) 1999-10-05 2000-10-05 Compositions and methods for the incorporation of chemical substances into cells

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US15773599P 1999-10-05 1999-10-05
US60/157,735 1999-10-05

Publications (2)

Publication Number Publication Date
WO2001024830A2 WO2001024830A2 (en) 2001-04-12
WO2001024830A3 true WO2001024830A3 (en) 2002-03-14

Family

ID=22565043

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2000/027562 WO2001024830A2 (en) 1999-10-05 2000-10-05 Incorporation of chemical substances into cells

Country Status (2)

Country Link
AU (1) AU7995600A (en)
WO (1) WO2001024830A2 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9546350B2 (en) 2004-05-12 2017-01-17 Maxcyte, Inc. Methods and devices related to a regulated flow electroporation chamber

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6773669B1 (en) 1995-03-10 2004-08-10 Maxcyte, Inc. Flow electroporation chamber and method
US6610702B2 (en) 2000-08-01 2003-08-26 Gmp Oxycell, Inc. Ammonium salts of inositol hexaphosphate, and uses thereof
US7029916B2 (en) 2001-02-21 2006-04-18 Maxcyte, Inc. Apparatus and method for flow electroporation of biological samples
WO2003018751A2 (en) 2001-08-22 2003-03-06 Maxcyte, Inc. Apparatus and method for electroporation of biological samples
WO2003092700A1 (en) 2002-04-29 2003-11-13 Gmp Oxycell, Inc. Inositol pyrophosphates, and methods of use thereof
US7745423B2 (en) 2004-07-06 2010-06-29 NormOxys, Inc Calcium/sodium salt of inositol tripyrophosphate as an allosteric effector of hemoglobin
WO2020157362A1 (en) * 2019-01-30 2020-08-06 Sanifit Therapeutics, S.A. Inositol phosphate compounds for use in increasing tissular perfusion

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0472772A1 (en) * 1989-08-03 1992-03-04 Krüss GmbH Process for the preparation of vital drug-laden human erythrocytes
WO1994021117A1 (en) * 1993-03-23 1994-09-29 Cbr Laboratories, Inc. Method and apparatus for encapsulation of biologically-active substances in cells
WO1996028199A1 (en) * 1995-03-10 1996-09-19 Entremed, Inc. Flow electroporation chamber and method
US20010001064A1 (en) * 1998-03-18 2001-05-10 Holaday John W. Flow electroporation chamber and methods of use thereof

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0472772A1 (en) * 1989-08-03 1992-03-04 Krüss GmbH Process for the preparation of vital drug-laden human erythrocytes
WO1994021117A1 (en) * 1993-03-23 1994-09-29 Cbr Laboratories, Inc. Method and apparatus for encapsulation of biologically-active substances in cells
WO1996028199A1 (en) * 1995-03-10 1996-09-19 Entremed, Inc. Flow electroporation chamber and method
US20010001064A1 (en) * 1998-03-18 2001-05-10 Holaday John W. Flow electroporation chamber and methods of use thereof

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
EINCK, L. ET AL: "Enhancement of tissue oxygenation by intracellular introduction of inositol hexaphosphate by flow electroporation of red blood cells", UPDATE INTENSIVE CARE EMERG. MED. (1998), 33(TISSUE OXYGENATION IN ACUTE MEDICINE), 357-374, XP001023862 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9546350B2 (en) 2004-05-12 2017-01-17 Maxcyte, Inc. Methods and devices related to a regulated flow electroporation chamber

Also Published As

Publication number Publication date
AU7995600A (en) 2001-05-10
WO2001024830A2 (en) 2001-04-12

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