WO2001021799B1 - Proteines du cycle cellulaire associees a la traf4, compositions et modalites d'utilisation - Google Patents

Proteines du cycle cellulaire associees a la traf4, compositions et modalites d'utilisation

Info

Publication number
WO2001021799B1
WO2001021799B1 PCT/US2000/040987 US0040987W WO0121799B1 WO 2001021799 B1 WO2001021799 B1 WO 2001021799B1 US 0040987 W US0040987 W US 0040987W WO 0121799 B1 WO0121799 B1 WO 0121799B1
Authority
WO
WIPO (PCT)
Prior art keywords
cell cycle
cycle protein
protein
bioactive agent
traf4
Prior art date
Application number
PCT/US2000/040987
Other languages
English (en)
Other versions
WO2001021799A1 (fr
WO2001021799A9 (fr
Inventor
Ying Luo
Betty Huang
Xiang Xu
Original Assignee
Rigel Pharmaceuticals Inc
Ying Luo
Betty Huang
Xiang Xu
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rigel Pharmaceuticals Inc, Ying Luo, Betty Huang, Xiang Xu filed Critical Rigel Pharmaceuticals Inc
Priority to EP00975649A priority Critical patent/EP1218506A1/fr
Priority to CA002385879A priority patent/CA2385879A1/fr
Priority to JP2001525357A priority patent/JP2003510049A/ja
Priority to AU13669/01A priority patent/AU1366901A/en
Publication of WO2001021799A1 publication Critical patent/WO2001021799A1/fr
Publication of WO2001021799B1 publication Critical patent/WO2001021799B1/fr
Publication of WO2001021799A9 publication Critical patent/WO2001021799A9/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4738—Cell cycle regulated proteins, e.g. cyclin, CDC, INK-CCR
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Toxicology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cell Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

La présente invention concerne des polypeptides, des acides nucléiques et des molécules s'y rapportant et agissant sur le cycle cellulaire ou s'y rapportant. L'invention concerne également des vecteurs et cellules hôtes comprenant ces séquences d'acides nucléiques, des séquences de polypeptides chimériques comprenant les polypeptides de l'invention fusionnés avec des séquences de polypeptides hétérologues, des anticorps qui se lient aux polypeptides de l'invention, et des procédés permettant la production des polypeptides de l'invention. L'invention concerne enfin des procédés d'identification de compositions de l'invention médiatrices de la bioactivité du cycle cellulaire, et l'utilisation de ces compositions pour le diagnostic et le traitement de maladies.
PCT/US2000/040987 1999-09-23 2000-09-25 Proteines du cycle cellulaire associees a la traf4, compositions et modalites d'utilisation WO2001021799A1 (fr)

Priority Applications (4)

Application Number Priority Date Filing Date Title
EP00975649A EP1218506A1 (fr) 1999-09-23 2000-09-25 Proteines du cycle cellulaire associees a la traf4, compositions et modalites d'utilisation
CA002385879A CA2385879A1 (fr) 1999-09-23 2000-09-25 Proteines du cycle cellulaire associees a la traf4, compositions et modalites d'utilisation
JP2001525357A JP2003510049A (ja) 1999-09-23 2000-09-25 Ｔｒａｆ４関連細胞周期タンパク質、組成物および使用法
AU13669/01A AU1366901A (en) 1999-09-23 2000-09-25 Traf4 associated cell cycle proteins, compositions and methods of use

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US40401099A 1999-09-23 1999-09-23
US09/404,010 1999-09-23

Publications (3)

Publication Number Publication Date
WO2001021799A1 WO2001021799A1 (fr) 2001-03-29
WO2001021799B1 true WO2001021799B1 (fr) 2001-10-11
WO2001021799A9 WO2001021799A9 (fr) 2002-08-08

Family

ID=23597764

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2000/040987 WO2001021799A1 (fr) 1999-09-23 2000-09-25 Proteines du cycle cellulaire associees a la traf4, compositions et modalites d'utilisation

Country Status (5)

Country Link
EP (1) EP1218506A1 (fr)
JP (1) JP2003510049A (fr)
AU (1) AU1366901A (fr)
CA (1) CA2385879A1 (fr)
WO (1) WO2001021799A1 (fr)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6562591B1 (en) 1999-10-21 2003-05-13 Rigel Pharmaceuticals, Inc. Germinal center kinase cell cycle proteins, compositions and methods of use
KR101542301B1 (ko) 2013-06-21 2015-08-06 영남대학교 산학협력단 Ｔｒａｆ４ ｔｒａｆ 도메인의 ３차 구조
CN111214647B (zh) * 2020-01-08 2023-02-14 中山大学附属第八医院（深圳福田） 一种治疗强直性脊柱炎的药物

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH07502164A (ja) * 1991-09-20 1995-03-09 フレッド ハッチンソン キャンサー リサーチ センター ヒトサイクリンｅ
ZA966663B (en) * 1995-08-17 1998-02-06 Genentech Inc Traf Inhibitors.
US6689359B1 (en) * 1997-07-21 2004-02-10 Arpi Matossian-Rogers Ligands, including antibodies, showing reactivity against endocrine cells
US6143507A (en) * 1998-10-29 2000-11-07 Boehringer Ingelheim Pharmaceuticals, Inc. High throughput compatible assay for receptor-TRAF interactions

Also Published As

Publication number Publication date
JP2003510049A (ja) 2003-03-18
CA2385879A1 (fr) 2001-03-29
WO2001021799A1 (fr) 2001-03-29
AU1366901A (en) 2001-04-24
EP1218506A1 (fr) 2002-07-03
WO2001021799A9 (fr) 2002-08-08

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