WO2001021795A3 - Fatty acid transport proteins - Google Patents

Fatty acid transport proteins Download PDF

Info

Publication number
WO2001021795A3
WO2001021795A3 PCT/US2000/025891 US0025891W WO0121795A3 WO 2001021795 A3 WO2001021795 A3 WO 2001021795A3 US 0025891 W US0025891 W US 0025891W WO 0121795 A3 WO0121795 A3 WO 0121795A3
Authority
WO
WIPO (PCT)
Prior art keywords
fatp
fatty acid
fatps
methods
proteins
Prior art date
Application number
PCT/US2000/025891
Other languages
French (fr)
Other versions
WO2001021795A2 (en
WO2001021795A9 (en
Inventor
Andreas Stahl
David J Hirsch
Harvey F Lodish
Ruth E Gimeno
Louis A Tartaglia
Original Assignee
Whitehead Biomedical Inst
Millennium Pharm Inc
Andreas Stahl
David J Hirsch
Harvey F Lodish
Ruth E Gimeno
Louis A Tartaglia
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US09/405,504 external-priority patent/US7033772B1/en
Application filed by Whitehead Biomedical Inst, Millennium Pharm Inc, Andreas Stahl, David J Hirsch, Harvey F Lodish, Ruth E Gimeno, Louis A Tartaglia filed Critical Whitehead Biomedical Inst
Priority to EP00965250A priority Critical patent/EP1218503A2/en
Priority to AU75994/00A priority patent/AU7599400A/en
Publication of WO2001021795A2 publication Critical patent/WO2001021795A2/en
Publication of WO2001021795A3 publication Critical patent/WO2001021795A3/en
Publication of WO2001021795A9 publication Critical patent/WO2001021795A9/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Toxicology (AREA)
  • Hematology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cell Biology (AREA)
  • Immunology (AREA)
  • Obesity (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

A family of fatty acid transport proteins (FATPs) mediate transport of long chain fatty acids (LCFAs) across cell membranes into cells. These proteins exhibit different expression patterns among the organs of mammals. Nucleic acids encoding FATPs of this family, vectors comprising these nucleic acids, as well as the production of FATP proteins in host cells are described. Also described are methods to test FATPs for fatty acid transport function, and methods to identify inhibitors or enhancers of transport function. The altering of LCFA uptake by administering to the mammal an inhibitor or enhancer of FATP transport function of a FATP in the small intestine can decrease or increase calories available as fats, and can decrease or increase circulating fatty acids. The organ specificity of FATP distribution can be exploited in methods to direct drugs, diagnostic indicators and so forth to an organ such as the heart.
PCT/US2000/025891 1999-09-23 2000-09-21 Fatty acid transport proteins WO2001021795A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
EP00965250A EP1218503A2 (en) 1999-09-23 2000-09-21 Fatty acid transport proteins
AU75994/00A AU7599400A (en) 1999-09-23 2000-09-21 Fatty acid transport proteins

Applications Claiming Priority (10)

Application Number Priority Date Filing Date Title
US40550599A 1999-09-23 1999-09-23
US09/405,504 US7033772B1 (en) 1998-01-15 1999-09-23 Methods of identifying inhibitors of fatty acid transport proteins (FATP)
US09/405,505 1999-09-23
US09/405,504 1999-09-23
US46528099A 1999-12-16 1999-12-16
US09/465,280 1999-12-16
US50625200A 2000-02-17 2000-02-17
US09/506,252 2000-02-17
US61119700A 2000-07-06 2000-07-06
US09/611,197 2000-07-06

Publications (3)

Publication Number Publication Date
WO2001021795A2 WO2001021795A2 (en) 2001-03-29
WO2001021795A3 true WO2001021795A3 (en) 2001-11-22
WO2001021795A9 WO2001021795A9 (en) 2002-05-30

Family

ID=27541483

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2000/025891 WO2001021795A2 (en) 1999-09-23 2000-09-21 Fatty acid transport proteins

Country Status (3)

Country Link
EP (1) EP1218503A2 (en)
AU (1) AU7599400A (en)
WO (1) WO2001021795A2 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7033772B1 (en) 1998-01-15 2006-04-25 Millennium Pharmaceuticals, Inc. Methods of identifying inhibitors of fatty acid transport proteins (FATP)
US20030165430A1 (en) * 2001-12-13 2003-09-04 Whitehead Institute For Biomedical Research Transgenic fatty acid transport one (FATP1) non-human knockout mammals uses thereof
CA2535969A1 (en) * 2003-08-18 2005-03-03 Millennium Pharmaceuticals, Inc. Methods and compositions comprising fatp5 for use in the diagnosis and treatment of metabolic disorders
FR2859220B1 (en) * 2003-08-27 2007-10-19 Merck Sante Sas PROMOTER OF FATP 5 HUMAN GENE AND USES THEREOF
JPWO2006090900A1 (en) * 2005-02-24 2008-07-24 武田薬品工業株式会社 Cancer preventive / therapeutic agent
CN102604958A (en) * 2011-11-01 2012-07-25 云南农业大学 Intramuscular fat deposition fatty acid transport protein-1 (FATP-1) gene

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999036537A2 (en) * 1998-01-15 1999-07-22 Whitehead Institute For Biomedical Research Fatty acid transport proteins
WO1999046281A2 (en) * 1998-03-10 1999-09-16 Genentech, Inc. Novel polypeptides and nucleic acids encoding the same

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999036537A2 (en) * 1998-01-15 1999-07-22 Whitehead Institute For Biomedical Research Fatty acid transport proteins
WO1999046281A2 (en) * 1998-03-10 1999-09-16 Genentech, Inc. Novel polypeptides and nucleic acids encoding the same

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
BANASZAK, L. ET AL.: "Lipid-binding proteins: A family of fatty acid and retinoid transport proteins.", ADVANCES IN PROTEIN CHEMISTRY, vol. 45, 1994, pages 89 - 151, XP000982080, ISBN: 0-12-034245-6 *
DATABASE EM_EST EMBL; 1 July 1998 (1998-07-01), "ov56b02.x1 Soares_testis_NHT Homo sapiens cDNA clone IMAGE:1641291 3'", XP002160454 *
DATABASE EM_EST EMBL; 23 January 1997 (1997-01-23), HILLIER, L. ET AL.: "zr40b06.r1 Soares_NhHMPu_S1 Homo sapiens cDNA clone IMAGE:665843 5'", XP002160453 *
FLOWER D: "The lipocalin protein family: structure and function", BIOCHEMICAL JOURNAL, vol. 318, 1996, pages 1 - 14, XP002095126, ISSN: 0264-6021 *
HILLIER, L. ET AL.: "Generation and expression of 280,000 human expressed sequence tags", GENOME RESEARCH, vol. 6, 1996, pages 807 - 828, XP000914615 *
HIRSCH ET AL: "A family of fatty acid transporters conserved from mycobacterium to man", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA, vol. 95, July 1998 (1998-07-01), pages 8625 - 8629, XP002107853, ISSN: 0027-8424 *

Also Published As

Publication number Publication date
WO2001021795A2 (en) 2001-03-29
EP1218503A2 (en) 2002-07-03
AU7599400A (en) 2001-04-24
WO2001021795A9 (en) 2002-05-30

Similar Documents

Publication Publication Date Title
WO1999036537A3 (en) Fatty acid transport proteins
Fernandez et al. Characterization of α-amylase activity in five species of Mediterranean sparid fishes (Sparidae, Teleostei)
Martin et al. Proteomic sensitivity to dietary manipulations in rainbow trout
Dabkowski et al. Mitochondrial dysfunction in the type 2 diabetic heart is associated with alterations in spatially distinct mitochondrial proteomes
Baur et al. Genetic polymorphism of tetrazolium oxidase in dogs
Nässl et al. Amino acid absorption and homeostasis in mice lacking the intestinal peptide transporter PEPT1
Zhou et al. Effects of replacing fishmeal protein with poultry by-product meal protein and soybean meal protein on growth, feed intake, feed utilization, gut and liver histology of hybrid grouper (Epinephelus fuscoguttatus♀× Epinephelus lanceolatus♂) juveniles
Dıaz-López et al. Characterization of fish acid proteases by substrate–gel electrophoresis
Grubbs et al. Selection for residual feed intake alters the mitochondria protein profile in pigs
Wang et al. Excessive thyroxine enhances susceptibility to apoptosis and decreases contractility of cardiomyocytes
Said et al. Intestinal uptake of retinol: enhancement by bovine milk beta-lactoglobulin
López-López et al. Characterization of digestive gland esterase–lipase activity of juvenile redclaw crayfish Cherax quadricarinatus
DE69621953D1 (en) VEHICLE FOR INSERTING NUCLEIC ACIDS IN CELLS
ATE253647T1 (en) METHOD AND COMPOSITION FOR DETECTING PATHOGENIC CONDITIONS
Koelle Cholinesterases of the tissues and sera of rabbits
Silvestre et al. A differential proteomic approach to assess the effects of chemotherapeutics and production management strategy on giant tiger shrimp Penaeus monodon
WO2001021795A3 (en) Fatty acid transport proteins
CN102329853A (en) Method for determining isolated soy protein digestibility in vitro
DK1576095T3 (en) Fat alcohol oxidase genes and proteins of Candida Troplicalis and methods related thereto
Perazzolo et al. Purification and partial characterization of the plasma clotting protein from the pink shrimp Farfantepenaeus paulensis
Song et al. Ontogenetic changes in digestive enzyme activities and the amino acid profile of starry flounder Platichthys stellatus
WO2008081447A3 (en) Compounds and methods for detection of cells
CA3137533A1 (en) Aging progression suppressing agent, and food or beverage product comprising same
Fathi et al. Influence of dietary glutamine supplementation on performance, biochemical indices and enzyme activities in broilers with cold-induced ascites
Itoi et al. Changes in mitochondrial fatty acid composition following temperature acclimation of carp and their possible effects on F o F 1-ATPase activity

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CR CU CZ DE DK DM DZ EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT TZ UA UG US US US US US UZ VN YU ZA ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
AK Designated states

Kind code of ref document: A3

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CR CU CZ DE DK DM DZ EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT TZ UA UG US US US US US UZ VN YU ZA ZW

AL Designated countries for regional patents

Kind code of ref document: A3

Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG

WWE Wipo information: entry into national phase

Ref document number: 2000965250

Country of ref document: EP

AK Designated states

Kind code of ref document: C2

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CR CU CZ DE DK DM DZ EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT TZ UA UG US US US US US UZ VN YU ZA ZW

AL Designated countries for regional patents

Kind code of ref document: C2

Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG

COP Corrected version of pamphlet

Free format text: PAGES 1/148-148/148, DRAWINGS, REPLACED BY NEW PAGES 1/202-202/202; DUE TO LATE TRANSMITTAL BY THE RECEIVING OFFICE

WWP Wipo information: published in national office

Ref document number: 2000965250

Country of ref document: EP

REG Reference to national code

Ref country code: DE

Ref legal event code: 8642

NENP Non-entry into the national phase

Ref country code: JP

WWW Wipo information: withdrawn in national office

Ref document number: 2000965250

Country of ref document: EP