WO2001021791A3 - Stargazin-like neuronal ca2+-channel gamma subunit polypeptides - Google Patents

Stargazin-like neuronal ca2+-channel gamma subunit polypeptides Download PDF

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Publication number
WO2001021791A3
WO2001021791A3 PCT/GB2000/003685 GB0003685W WO0121791A3 WO 2001021791 A3 WO2001021791 A3 WO 2001021791A3 GB 0003685 W GB0003685 W GB 0003685W WO 0121791 A3 WO0121791 A3 WO 0121791A3
Authority
WO
WIPO (PCT)
Prior art keywords
stargazin
neuronal
gamma subunit
subunit polypeptides
channel gamma
Prior art date
Application number
PCT/GB2000/003685
Other languages
French (fr)
Other versions
WO2001021791A2 (en
Inventor
Jeffrey John Clare
Mary Plumpton
Fraser John Moss
Philippe Sanseau
Original Assignee
Glaxo Group Ltd
Jeffrey John Clare
Mary Plumpton
Fraser John Moss
Philippe Sanseau
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Group Ltd, Jeffrey John Clare, Mary Plumpton, Fraser John Moss, Philippe Sanseau filed Critical Glaxo Group Ltd
Priority to GB0112374A priority Critical patent/GB2361923A/en
Priority to AU73046/00A priority patent/AU7304600A/en
Publication of WO2001021791A2 publication Critical patent/WO2001021791A2/en
Publication of WO2001021791A3 publication Critical patent/WO2001021791A3/en

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6872—Intracellular protein regulatory factors and their receptors, e.g. including ion channels
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value

Abstract

A stargazin-like polypeptide comprises: (i) the amino acid sequence of SEQ ID NO: 4, 6 or 2; or (ii) a variant thereof capable of modulating the steady state inactivation of an α1 pore-forming subunit of a voltage-gated calcium channel.
PCT/GB2000/003685 1999-09-23 2000-09-25 Stargazin-like neuronal ca2+-channel gamma subunit polypeptides WO2001021791A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
GB0112374A GB2361923A (en) 1999-09-23 2000-09-25 Novel protein
AU73046/00A AU7304600A (en) 1999-09-23 2000-09-25 Novel protein

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB9922571.6 1999-09-23
GBGB9922571.6A GB9922571D0 (en) 1999-09-23 1999-09-23 Novel protein

Publications (2)

Publication Number Publication Date
WO2001021791A2 WO2001021791A2 (en) 2001-03-29
WO2001021791A3 true WO2001021791A3 (en) 2001-11-01

Family

ID=10861499

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2000/003685 WO2001021791A2 (en) 1999-09-23 2000-09-25 Stargazin-like neuronal ca2+-channel gamma subunit polypeptides

Country Status (3)

Country Link
AU (1) AU7304600A (en)
GB (2) GB9922571D0 (en)
WO (1) WO2001021791A2 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2011211347B2 (en) * 2001-05-07 2015-02-19 Agriculture Victoria Services Pty Ltd Modification of plant and seed development and plant responses to stresses and stimuli (3)
GB0517916D0 (en) * 2005-09-02 2005-10-12 Paradigm Therapeutics Ltd Ion channel
WO2009101619A2 (en) * 2008-02-11 2009-08-20 Ramot At Tel-Aviv University Ltd. Methods for predicting a patient's response to lithium treatment

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5726035A (en) * 1990-02-20 1998-03-10 Sibia Neurosciences, Inc. Recombinant production of mammalian calcium channel gamma subunits
WO2000014224A1 (en) * 1998-09-08 2000-03-16 Smithkline Beecham P.L.C. Putative genes encoding skeletal muscle voltage-gated calcium channel gamma subunits

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5726035A (en) * 1990-02-20 1998-03-10 Sibia Neurosciences, Inc. Recombinant production of mammalian calcium channel gamma subunits
WO2000014224A1 (en) * 1998-09-08 2000-03-16 Smithkline Beecham P.L.C. Putative genes encoding skeletal muscle voltage-gated calcium channel gamma subunits

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
DATABASE EMBL [online] 3 September 1998 (1998-09-03), BIRREN B. ET AL.: "Homo sapiens chromosome 17, clone hRPK.349_A_8, complete sequence.", XP002162057, retrieved from EBI Database accession no. AC005544 *
DATABASE SWISSPROT [online] BOSSE E. ET A.: "VOLTAGE-DEPENDENT CALCIUM CHANNEL GAMMA-1 SUBUNIT (DIHYDROPYRIDINE-SENSITIVE L-TYPE, SKELETAL MUSCLE CALCIUM CHANNEL GAMMA SUBUNIT).", XP002162058, retrieved from EBI Database accession no. P19518 *
LETTS VERITY A ET AL: "The mouse stargazer gene encodes a neuronal Ca2+-channel gamma subunit.", NATURE GENETICS, vol. 19, no. 4, August 1998 (1998-08-01), pages 340 - 347, XP000982769, ISSN: 1061-4036 *

Also Published As

Publication number Publication date
AU7304600A (en) 2001-04-24
WO2001021791A2 (en) 2001-03-29
GB9922571D0 (en) 1999-11-24
GB2361923A (en) 2001-11-07
GB0112374D0 (en) 2001-07-11

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