WO2001017998A3 - Verfahren zur herstellung substituierter pyrimidinderivate - Google Patents

Verfahren zur herstellung substituierter pyrimidinderivate Download PDF

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Publication number
WO2001017998A3
WO2001017998A3 PCT/EP2000/008362 EP0008362W WO0117998A3 WO 2001017998 A3 WO2001017998 A3 WO 2001017998A3 EP 0008362 W EP0008362 W EP 0008362W WO 0117998 A3 WO0117998 A3 WO 0117998A3
Authority
WO
WIPO (PCT)
Prior art keywords
production
pyrimidine derivatives
substituted pyrimidine
formula
enolcarboxylates
Prior art date
Application number
PCT/EP2000/008362
Other languages
English (en)
French (fr)
Other versions
WO2001017998A2 (de
Inventor
Jan Jaenichen
Michael Preiss
Christina Alonso-Alija
Alexander Straub
Original Assignee
Bayer Ag
Jan Jaenichen
Michael Preiss
Alonso Alija Christina
Alexander Straub
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Ag, Jan Jaenichen, Michael Preiss, Alonso Alija Christina, Alexander Straub filed Critical Bayer Ag
Priority to AU74143/00A priority Critical patent/AU7414300A/en
Publication of WO2001017998A2 publication Critical patent/WO2001017998A2/de
Publication of WO2001017998A3 publication Critical patent/WO2001017998A3/de

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
    • C07C255/31—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing rings other than six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/02—Systems containing only non-condensed rings with a three-membered ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Die vorliegende Erfindung betrifft ein Verfahren zur Herstellung von 3-(5-Cycloalkyl-4-amino-1,3-pyrimidin-2-yl)-1-(2-fluorbenzyl)-1H-pyrazolo[3,4-b]pyridinderivaten der Formel (I), bei welchem Amidinderivate der Formel (II) mit Enolcarboxylaten der Formel (III), in Gegenwart einer Base umgesetzt werden.
PCT/EP2000/008362 1999-09-08 2000-08-28 Verfahren zur herstellung substituierter pyrimidinderivate WO2001017998A2 (de)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU74143/00A AU7414300A (en) 1999-09-08 2000-08-28 Method for the production of substituted pyrimidine derivatives

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19942809A DE19942809A1 (de) 1999-09-08 1999-09-08 Verfahren zur Herstellung substituierter Pyrimidinderivate
DE19942809.3 1999-09-08

Publications (2)

Publication Number Publication Date
WO2001017998A2 WO2001017998A2 (de) 2001-03-15
WO2001017998A3 true WO2001017998A3 (de) 2001-10-11

Family

ID=7921171

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2000/008362 WO2001017998A2 (de) 1999-09-08 2000-08-28 Verfahren zur herstellung substituierter pyrimidinderivate

Country Status (3)

Country Link
AU (1) AU7414300A (de)
DE (1) DE19942809A1 (de)
WO (1) WO2001017998A2 (de)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10122894A1 (de) * 2001-05-11 2002-11-14 Bayer Ag Neue Sulfonat-substituierte Pyrazolopyridinderivate
DE102007028407A1 (de) 2007-06-20 2008-12-24 Bayer Healthcare Ag Substituierte Oxazolidinone und ihre Verwendung
DE102007028320A1 (de) 2007-06-20 2008-12-24 Bayer Healthcare Ag Substituierte Oxazolidinone und ihre Verwendung
DE102007028406A1 (de) 2007-06-20 2008-12-24 Bayer Healthcare Ag Substituierte Oxazolidinone und ihre Verwendung
DE102007028319A1 (de) 2007-06-20 2008-12-24 Bayer Healthcare Ag Substituierte Oxazolidinone und ihre Verwendung
EP2138178A1 (de) 2008-06-28 2009-12-30 Bayer Schering Pharma Aktiengesellschaft Oxazolidninone zur Behandlung der chronisch obstruktiven Lungenerkrankung (COPD) und/oder Asthma
US20130178475A1 (en) 2010-03-17 2013-07-11 Ironwood Pharmaceuticals, Inc. sGC STIMULATORS
DK2588465T3 (en) 2010-06-30 2017-05-01 Ironwood Pharmaceuticals Inc SGC stimulators
CN107266433A (zh) 2010-11-09 2017-10-20 铁木医药有限公司 sGC刺激剂
CA2861804C (en) 2011-12-27 2021-10-26 Ironwood Pharmaceuticals, Inc. 2-benzyl,3(pyrimidin-2-yl)substituted pyrazoles useful as sgc stimulators
LT2847228T (lt) 2012-05-10 2018-11-12 Bayer Pharma Aktiengesellschaft Antikūnai, galintys jungtis prie koaguliacijos faktoriaus xi ir (arba) jo aktyvuotos formos faktoriaus xia, ir jų panaudojimas
WO2014047111A1 (en) 2012-09-18 2014-03-27 Ironwood Pharmaceuticals, Inc. Sgc stimulators
CA2885645A1 (en) 2012-09-19 2014-03-27 Ironwood Pharmaceuticals, Inc. Sgc stimulators
CN109369635B (zh) 2013-03-15 2023-06-30 赛克里翁治疗有限公司 化合物或其药学上可接受的盐及其应用和药物组合物
US20160311826A1 (en) 2013-12-11 2016-10-27 Ironwood Pharmaceuticals, Inc. Sgc stimulators
WO2015106268A1 (en) 2014-01-13 2015-07-16 Ironwood Pharmaceuticals, Inc. USE OF sGC STIMULATORS FOR THE TREATMENT OF NEUROMUSCULAR DISORDERS
EP3194386A2 (de) 2014-09-17 2017-07-26 Ironwood Pharmaceuticals, Inc. Sgc-stimulatoren
US20170298055A1 (en) 2014-09-17 2017-10-19 Ironwood Pharmaceuticals, Inc. sGC STIMULATORS
US20170291889A1 (en) 2014-09-17 2017-10-12 Ironwood Pharmaceuticals, Inc. Pyrazole derivatives as sgc stimulators
CN108463224A (zh) 2015-12-14 2018-08-28 铁木医药有限公司 sGC刺激剂用于胃肠功能障碍治疗的应用
CA3029374A1 (en) 2016-07-07 2018-01-11 Ironwood Pharmaceuticals, Inc. Phosphorus prodrugs of sgc stimulators
US10889577B2 (en) 2016-07-07 2021-01-12 Cyclerion Therapeutics, Inc. Solid forms of an sGC stimulator
BR112019004468A2 (pt) 2016-09-02 2019-05-28 Ironwood Pharmaceuticals Inc estimulantes de sgc
EP3538096B1 (de) 2016-11-08 2024-02-28 Tisento Therapeutics Inc. Behandlung von zns-erkrankungen mit sgc-stimulatoren
CN110267949A (zh) 2016-11-08 2019-09-20 塞科里昂医疗股份有限公司 sGC刺激剂
WO2018111795A2 (en) 2016-12-13 2018-06-21 Ironwood Pharmaceuticals, Inc. Use of sgc stimulators for the treatment of esophageal motility disorders
US11897887B2 (en) 2017-12-19 2024-02-13 Tisento Therapeutics Inc. sGC stimulators
MX2023004857A (es) 2018-03-07 2023-11-24 Cyclerion Therapeutics Inc Formas cristalinas de un estimulante de la guanilil ciclasa soluble (sgc).
EP3820476A1 (de) 2018-07-11 2021-05-19 Cyclerion Therapeutics, Inc. Verwendung von sgc-stimulatoren zur behandlung von mitochondrialen erkrankungen
BR112021009958A2 (pt) 2018-11-28 2021-08-17 Topadur Pharma Ag modo duplo de ação de ativadores de guanilato ciclase solúveis e inibidores de fosfodiesterase e seus usos
US20230130739A1 (en) 2020-03-26 2023-04-27 Cyclerion Therapeutics, Inc. DEUTERATED sGC STIMULATORS
WO2021202546A1 (en) 2020-03-31 2021-10-07 Cyclerion Therapeutics, Inc. Early drug interventions to reduce covid-19 related respiratory distress, need for ventilator assistance and death
EP4326722A1 (de) 2021-04-20 2024-02-28 Tisento Therapeutics Inc. Sgc-stimulatoren
US20240207265A1 (en) 2021-04-20 2024-06-27 Tisento Therapeutics Inc. TREATMENT OF CNS DISEASES WITH sGC STIMULATORS
WO2024086179A1 (en) 2022-10-18 2024-04-25 Tisento Therapeutics, Inc. Pyrimidine sgc stimulators
WO2024086182A1 (en) 2022-10-18 2024-04-25 Tisento Therapeutics Inc. Treatment of mitochondrial diseases with sgc stimulators

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
CHEMICAL ABSTRACTS, vol. 40, no. 14, 1946, Columbus, Ohio, US; CHELINTSEV ET AL.: "New metod for the vitamin B1 synthesis" column 4069; XP002164058 *
J. GEN. CHEM., vol. 14, 1944, pages 1142 - 1147 *

Also Published As

Publication number Publication date
DE19942809A1 (de) 2001-03-15
AU7414300A (en) 2001-04-10
WO2001017998A2 (de) 2001-03-15

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