WO2001015727A3 - Compositions de polymeres et d'adjuvants a base de saponine immunostimulants et leurs utilisations - Google Patents

Compositions de polymeres et d'adjuvants a base de saponine immunostimulants et leurs utilisations Download PDF

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Publication number
WO2001015727A3
WO2001015727A3 PCT/US2000/023688 US0023688W WO0115727A3 WO 2001015727 A3 WO2001015727 A3 WO 2001015727A3 US 0023688 W US0023688 W US 0023688W WO 0115727 A3 WO0115727 A3 WO 0115727A3
Authority
WO
WIPO (PCT)
Prior art keywords
compositions
saponin adjuvants
immunostimulatory
immunostimulatory polymers
phosphazenes
Prior art date
Application number
PCT/US2000/023688
Other languages
English (en)
Other versions
WO2001015727A2 (fr
Inventor
Charlotte A Kensil
Sharon A Jenkins
Original Assignee
Aquila Biopharm Inc
Charlotte A Kensil
Sharon A Jenkins
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aquila Biopharm Inc, Charlotte A Kensil, Sharon A Jenkins filed Critical Aquila Biopharm Inc
Priority to AU70854/00A priority Critical patent/AU7085400A/en
Publication of WO2001015727A2 publication Critical patent/WO2001015727A2/fr
Publication of WO2001015727A3 publication Critical patent/WO2001015727A3/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants

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  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Communicable Diseases (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Steroid Compounds (AREA)

Abstract

L'invention concerne des compositions de vaccin comprenant des phosphazènes, des adjuvants à base de saponine, et des antigènes immunostimulants, et leur utilisation pour stimuler une immunité. L'invention concerne également des compositions immunes d'adjuvant à base de phosphazènes et d'adjuvants à base de saponine immunostimulants. Les compositions immunes d'adjuvant peuvent s'utiliser pour améliorer une réponse immunitaire induite par une cellule, et la production d'anticorps. L'invention concerne enfin une technique de stimulation immunitaire par rapport à un antigène.
PCT/US2000/023688 1999-09-02 2000-08-29 Compositions de polymeres et d'adjuvants a base de saponine immunostimulants et leurs utilisations WO2001015727A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU70854/00A AU7085400A (en) 1999-09-02 2000-08-29 Compositions of immunostimulatory polymers and saponin adjuvants and uses thereof

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US15217499P 1999-09-02 1999-09-02
US60/152,174 1999-09-02

Publications (2)

Publication Number Publication Date
WO2001015727A2 WO2001015727A2 (fr) 2001-03-08
WO2001015727A3 true WO2001015727A3 (fr) 2001-09-07

Family

ID=22541802

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2000/023688 WO2001015727A2 (fr) 1999-09-02 2000-08-29 Compositions de polymeres et d'adjuvants a base de saponine immunostimulants et leurs utilisations

Country Status (2)

Country Link
AU (1) AU7085400A (fr)
WO (1) WO2001015727A2 (fr)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2204186B1 (fr) 1999-02-17 2016-04-06 CSL Limited Complexes immunogènes et méthodes y relatives
EP1467755A1 (fr) 2001-12-21 2004-10-20 Antigenics Inc. Compositions comprenant des reactifs immunoreactifs et des saponosides et techniques d'utilisation de ces compositions
CA2692740A1 (fr) * 2007-07-09 2009-01-15 Apogee Technology, Inc. Composes de polyphosphazene immunostimulants pour une immunisation intradermique
NZ591925A (en) 2008-10-16 2012-09-28 Internat Vaccine Inst Adjuvant composition comprising a host defense peptide, an immunostimulatory sequence and a polyanionic polymer
KR20180077180A (ko) 2015-11-06 2018-07-06 아쥬반스 테크놀로지스 인코포레이티드 트리테르펜 사포닌 유사체
SG11201909311TA (en) * 2017-04-13 2019-11-28 Adjuvance Technologies Inc Triterpene saponin synthesis, intermediates and adjuvant combinations
SG11202001826YA (en) 2017-10-16 2020-03-30 Adjuvance Technologies Inc Triterpene saponin analogues

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5494673A (en) * 1993-07-12 1996-02-27 Virus Research Institute Phosphazene polyelectrolytes as immunoadjuvants
US5583112A (en) * 1987-05-29 1996-12-10 Cambridge Biotech Corporation Saponin-antigen conjugates and the use thereof
WO1998052573A1 (fr) * 1997-05-20 1998-11-26 Galenica Pharmaceuticals, Inc. Analogues de la saponine triterpenique a activite d'adjuvant et immunostimulatoire
WO1999027959A1 (fr) * 1997-11-28 1999-06-10 Commonwealth Scientific And Industrial Research Organisation Composition a base de saponine, tenant lieu d'adjuvant

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5583112A (en) * 1987-05-29 1996-12-10 Cambridge Biotech Corporation Saponin-antigen conjugates and the use thereof
US5494673A (en) * 1993-07-12 1996-02-27 Virus Research Institute Phosphazene polyelectrolytes as immunoadjuvants
WO1998052573A1 (fr) * 1997-05-20 1998-11-26 Galenica Pharmaceuticals, Inc. Analogues de la saponine triterpenique a activite d'adjuvant et immunostimulatoire
WO1999027959A1 (fr) * 1997-11-28 1999-06-10 Commonwealth Scientific And Industrial Research Organisation Composition a base de saponine, tenant lieu d'adjuvant

Also Published As

Publication number Publication date
AU7085400A (en) 2001-03-26
WO2001015727A2 (fr) 2001-03-08

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