WO2001011371A3 - Diagnosis of inflammation measuring il-8 in urine - Google Patents

Diagnosis of inflammation measuring il-8 in urine Download PDF

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Publication number
WO2001011371A3
WO2001011371A3 PCT/GB2000/002971 GB0002971W WO0111371A3 WO 2001011371 A3 WO2001011371 A3 WO 2001011371A3 GB 0002971 W GB0002971 W GB 0002971W WO 0111371 A3 WO0111371 A3 WO 0111371A3
Authority
WO
WIPO (PCT)
Prior art keywords
diagnosis
mammal
level
urine
interleukin
Prior art date
Application number
PCT/GB2000/002971
Other languages
French (fr)
Other versions
WO2001011371A2 (en
Inventor
Ali Said Assad Taha
Original Assignee
Ali Said Assad Taha
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9918589.4A external-priority patent/GB9918589D0/en
Application filed by Ali Said Assad Taha filed Critical Ali Said Assad Taha
Priority to AU64550/00A priority Critical patent/AU6455000A/en
Publication of WO2001011371A2 publication Critical patent/WO2001011371A2/en
Publication of WO2001011371A3 publication Critical patent/WO2001011371A3/en

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6863—Cytokines, i.e. immune system proteins modifying a biological response such as cell growth proliferation or differentiation, e.g. TNF, CNF, GM-CSF, lymphotoxin, MIF or their receptors
    • G01N33/6869—Interleukin
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/52—Assays involving cytokines
    • G01N2333/54—Interleukins [IL]

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Cell Biology (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

A method of diagnosis of a medical condition of a mammal comprising detection of the level of Interleukin-8 (IL-8) in excreted urine of the mammal is described. The use of a detected level of Interleukin-8 in excreted urine of a mammal in the diagnosis of a medical condition of the mammal is also described. The method and use are particularly applicable in the diagnosis of inflammatory conditions such as ulcerative colitis, Crohn's disease, arthritis, cholecystitis, appendicitis, and urinary tract infections. The present invention provides a simple and non-invasive method and apparatus for detecting the level of IL-8 in a mammal, and using the detected level to diagnose, or in the diagnosis of, various medical conditions, particularly but not exclusively inflammatory conditions.
PCT/GB2000/002971 1999-08-07 2000-08-07 Diagnosis of inflammation measuring il-8 in urine WO2001011371A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU64550/00A AU6455000A (en) 1999-08-07 2000-08-07 Method and apparatus for diagnosis

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GBGB9918589.4A GB9918589D0 (en) 1999-08-07 1999-08-07 Method and apparatus for diagnosis
GB9918589.4 1999-08-07
GB9925246.2 1999-10-27
GBGB9925246.2A GB9925246D0 (en) 1999-08-07 1999-10-27 Method and apparatus for diagnosis

Publications (2)

Publication Number Publication Date
WO2001011371A2 WO2001011371A2 (en) 2001-02-15
WO2001011371A3 true WO2001011371A3 (en) 2001-09-07

Family

ID=26315830

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2000/002971 WO2001011371A2 (en) 1999-08-07 2000-08-07 Diagnosis of inflammation measuring il-8 in urine

Country Status (2)

Country Link
AU (1) AU6455000A (en)
WO (1) WO2001011371A2 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2386862A1 (en) 2002-10-09 2011-11-16 DMI Biosciences, Inc. Methods and kits for diagnosing appendicitis
US7560244B2 (en) 2003-06-04 2009-07-14 Joslin Diabetes Center, Inc. Method of evaluating a subject for risk or predisposition of reduced renal function over time
WO2010078403A2 (en) * 2008-12-30 2010-07-08 Lipella Pharmaceuticals Inc. Methods and compositions for diagnosing urological disorders
RU2615353C1 (en) * 2016-02-24 2017-04-04 федеральное государственное бюджетное образовательное учреждение высшего образования "Северо-Западный государственный медицинский университет имени И.И. Мечникова" Министерства здравоохранения Российской Федерации Method for determination of degree of activity of exacerbation of chronic obstructive pyelonephritis

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996041194A1 (en) * 1995-06-07 1996-12-19 The Children's Medical Center Corporation Diagnosis, prognosis and monitoring of angiogenesis dependent diseases

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996041194A1 (en) * 1995-06-07 1996-12-19 The Children's Medical Center Corporation Diagnosis, prognosis and monitoring of angiogenesis dependent diseases

Non-Patent Citations (10)

* Cited by examiner, † Cited by third party
Title
BENSON MIKAEL ET AL: "Interleukin (IL)-6 and IL-8 in children with febrile urinary tract infection and asymptomatic bacteriuria.", JOURNAL OF INFECTIOUS DISEASES, vol. 174, no. 5, 1996, pages 1080 - 1084, XP000992537, ISSN: 0022-1899 *
FLORENT C H: "Inflammatory bowel disease (IBD): Therapeutic actualities.", ACTA ENDOSCOPICA, vol. 25, no. 5 SUPPL., 1995, pages 571 - 574, XP000992520, ISSN: 0240-642X *
GENDREL D: "Urinary infection and biological markers.", ARCHIVES DE PEDIATRIE, vol. 5, no. SUPPL. 3, 1998, pages 269S - 273S, XP000992530, ISSN: 0929-693X *
JACOBSON, S. ET AL.: "Interleukin-6 and Interleukin-8 in Serum and Urine in Patients with Acute Pyelonephritis in Relation to Bacterial-Virulence-Associated Traits and Renal Function", NEPHRON, vol. 67, no. 2, 1994, pages 172 - 179, XP000992531 *
MOUTABARRIK ABDELHAKIM ET AL: "Interleukin-8 in patients with glomerulonephritis.", JN JOURNAL OF NEPHROLOGY, vol. 8, no. 6, 1995, pages 325 - 330, XP000992536, ISSN: 1121-8428 *
STIEMER BEATE ET AL: "Interleukin-8 in urine: A new diagnostic parameter for intra-amniotic infection after premature rupture of the membranes.", BRITISH JOURNAL OF OBSTETRICS AND GYNAECOLOGY, vol. 104, no. 4, 1997, pages 499 - 502, XP000992558, ISSN: 0306-5456 *
TAKAYAMA FUMIO ET AL: "Involvement of interleukin-8 in dialysis-related arthritis.", KIDNEY INTERNATIONAL, vol. 53, no. 4, April 1998 (1998-04-01), pages 1007 - 1013, XP000992528, ISSN: 0085-2538 *
TESAR VLADIMIR ET AL: "Cytokines and adhesion molecules in renal vasculitis and lupus nephritis.", NEPHROLOGY DIALYSIS TRANSPLANTATION, vol. 13, no. 7, July 1998 (1998-07-01), pages 1662 - 1667, XP000992542, ISSN: 0931-0509 *
TIKHONOV I ET AL: "A study of interleukin-8 and defensins in urine and plasma of patients with pyelonephritis and glomerulonephritis.", NEPHROLOGY DIALYSIS TRANSPLANTATION, vol. 12, no. 12, December 1997 (1997-12-01), pages 2557 - 2561, XP000992540, ISSN: 0931-0509 *
YASUMOTO RYOJI ET AL: "Urinary interleukin-6 and interleukin-8 in females with urethral syndrome.", ACTA UROLOGICA JAPONICA, vol. 43, no. 4, 1997, pages 267 - 270, XP000992534, ISSN: 0018-1994 *

Also Published As

Publication number Publication date
WO2001011371A2 (en) 2001-02-15
AU6455000A (en) 2001-03-05

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