WO2001009373A3 - NATIVE Cdc25 SUBSTRATES, COMPOSITIONS AND USES RELATED THERETO - Google Patents

NATIVE Cdc25 SUBSTRATES, COMPOSITIONS AND USES RELATED THERETO Download PDF

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Publication number
WO2001009373A3
WO2001009373A3 PCT/US2000/020936 US0020936W WO0109373A3 WO 2001009373 A3 WO2001009373 A3 WO 2001009373A3 US 0020936 W US0020936 W US 0020936W WO 0109373 A3 WO0109373 A3 WO 0109373A3
Authority
WO
WIPO (PCT)
Prior art keywords
cdc25
native
substrates
compositions
uses related
Prior art date
Application number
PCT/US2000/020936
Other languages
French (fr)
Other versions
WO2001009373A2 (en
Inventor
Jens Eckstein
David Epstein
Johannes Rudolph
Original Assignee
Basf Biores Corp
Gpc Biotech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Basf Biores Corp, Gpc Biotech Inc filed Critical Basf Biores Corp
Priority to AU63945/00A priority Critical patent/AU6394500A/en
Publication of WO2001009373A2 publication Critical patent/WO2001009373A2/en
Publication of WO2001009373A3 publication Critical patent/WO2001009373A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/48—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase
    • C12Q1/485—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase involving kinase
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5011—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing antineoplastic activity
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value

Abstract

The present invention relates to the preparation and use of a natural substrate for human Cdc25 which is useful for the direct measurement of Cdc25 activity in a quantifiable and reproducible manner.
PCT/US2000/020936 1999-07-30 2000-07-31 Native cdc25 substrates, compositions and uses related thereto WO2001009373A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU63945/00A AU6394500A (en) 1999-07-30 2000-07-31 Native cdc25 substrates, compositions and uses related thereto

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US36471599A 1999-07-30 1999-07-30
US09/364,715 1999-07-30

Publications (2)

Publication Number Publication Date
WO2001009373A2 WO2001009373A2 (en) 2001-02-08
WO2001009373A3 true WO2001009373A3 (en) 2001-10-11

Family

ID=23435750

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2000/020936 WO2001009373A2 (en) 1999-07-30 2000-07-31 Native cdc25 substrates, compositions and uses related thereto

Country Status (2)

Country Link
AU (1) AU6394500A (en)
WO (1) WO2001009373A2 (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2002239578A1 (en) * 2000-11-07 2002-05-21 THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as repreesented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES Enhanced efficacy and safety of genotoxic therapy by p38 mapk modulation
AU2003223926A1 (en) * 2002-05-15 2003-12-02 Lukas, Jiri Modulation of mitosis by enhancing the interaction of cdc24a and cyclinb/cdk1
US7057052B2 (en) 2002-09-26 2006-06-06 Duke University Heterocyclic quinones as pharmaceutical agents
EP2255192A1 (en) * 2008-03-26 2010-12-01 Merck Patent GmbH Method of long term storage of substrate-coupled beads
CN102998450B (en) * 2012-11-22 2014-10-15 北京正旦国际科技有限责任公司 Immuno-mass spectrometric detection kit for esophagus cancer
CA2937104A1 (en) * 2014-01-16 2015-07-23 Rowan University Modulation of cellular localization of cyclin c
CN110327463B (en) * 2019-06-10 2021-11-16 西南民族大学 Nano material containing gadolinium polytungstate and preparation method thereof
CN110959851A (en) * 2019-11-18 2020-04-07 青海晨菲制药有限公司 Application of agaricus bisporus gallic acid in functional food

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993010242A1 (en) * 1991-11-18 1993-05-27 Cold Spring Harbor Laboratory NOVEL HUMAN cdc25 GENES, ENCODED PRODUCTS AND USES THEREFOR
US5443962A (en) * 1993-06-04 1995-08-22 Mitotix, Inc. Methods of identifying inhibitors of cdc25 phosphatase

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993010242A1 (en) * 1991-11-18 1993-05-27 Cold Spring Harbor Laboratory NOVEL HUMAN cdc25 GENES, ENCODED PRODUCTS AND USES THEREFOR
US5443962A (en) * 1993-06-04 1995-08-22 Mitotix, Inc. Methods of identifying inhibitors of cdc25 phosphatase

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
BARATTE B ET AL: "SCREENING FOR ANTIMITOTIC COMPOUNDS USING THE CDC25 TYROSINE PHOSPHATASE, AN ACTIVATOR OF THE MITOSIS-INDUCING P34CDC2/CYCLIN BCDC13 PROTEIN KINASE", ANTICANCER RESEARCH,GR,HELENIC ANTICANCER INSTITUTE, ATHENS,, vol. 12, 1992, pages 873 - 880, XP002069498, ISSN: 0250-7005 *
BORGNE A. & MEIJER L.: "Sequential dephosphorylation of p34cdc2 on Thr-14 and Tyr-15 at the prohase/metaphase transition", J. BIOLOG. CHEMISTRY, vol. 271, no. 44, - 1996, pages 27847 - 27854, XP002162637 *
CLARK J.M. & GABRIELLI B.G.: "Production of a soluble cyclin B/cdc2 substrate for cdc25 phosphatase", ANALYT. CHEMISTRY, vol. 254, - 1997, pages 231 - 235, XP002162636 *
MUELLER P R ET AL: "MYT1: A MEMBRANE-ASSOCIATED INHIBITORY KINASE THAT PHOSPHORYLATES CDC2 ON BOTH THREONINE-14 AND TYROSINE-15", SCIENCE,US,AMERICAN ASSOCIATION FOR THE ADVANCEMENT OF SCIENCE,, vol. 270, 6 October 1995 (1995-10-06), pages 86 - 90, XP002057980, ISSN: 0036-8075 *
STRAUSFELD U. ET AL.,: "Dephosphorylation and activation of a p34cdc2/cyclin B complex in vitro by human CDC25 protein", NATURE, vol. 351, - 16 May 1991 (1991-05-16), pages 242 - 245, XP000942238 *

Also Published As

Publication number Publication date
WO2001009373A2 (en) 2001-02-08
AU6394500A (en) 2001-02-19

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