WO2001007469A3 - Polypeptide dendrimers as unimolecular carriers of diagnostic imaging contrast agents, bioactive substances and drugs - Google Patents

Polypeptide dendrimers as unimolecular carriers of diagnostic imaging contrast agents, bioactive substances and drugs Download PDF

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Publication number
WO2001007469A3
WO2001007469A3 PCT/EP2000/007022 EP0007022W WO0107469A3 WO 2001007469 A3 WO2001007469 A3 WO 2001007469A3 EP 0007022 W EP0007022 W EP 0007022W WO 0107469 A3 WO0107469 A3 WO 0107469A3
Authority
WO
WIPO (PCT)
Prior art keywords
bioactive substances
carriers
polypeptide
contrast agents
diagnostic imaging
Prior art date
Application number
PCT/EP2000/007022
Other languages
French (fr)
Other versions
WO2001007469A2 (en
Inventor
Antonio Verdini
Original Assignee
Antonio Verdini
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Antonio Verdini filed Critical Antonio Verdini
Priority to CA002380178A priority Critical patent/CA2380178A1/en
Priority to AU62766/00A priority patent/AU772167B2/en
Priority to PL00353273A priority patent/PL353273A1/en
Priority to NZ517231A priority patent/NZ517231A/en
Priority to JP2001512552A priority patent/JP2003506326A/en
Priority to EP00949393A priority patent/EP1200461A2/en
Publication of WO2001007469A2 publication Critical patent/WO2001007469A2/en
Publication of WO2001007469A3 publication Critical patent/WO2001007469A3/en
Priority to NO20020333A priority patent/NO20020333D0/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/001—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof by chemical synthesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A61K47/641—Branched, dendritic or hypercomb peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Epidemiology (AREA)
  • Virology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

The invention describes new polypeptide dendrimers and processes for the synthesis of the same. The polypeptide dendrimers of the invention have a structure which consists of a multifunctional core moiety from which highly branched polypeptide chains, formed by short peptide branching units, extend radially outwards. The outermost branches surround a lower density space with hollows and channels into which bioactive substances employed in diagnosis and therapy can be entrapped or covalently linked. For these properties the said polypeptide dendrimers are particularly useful in a number of areas in biology and medicine as carriers for the delivery of bioactive substances, including drugs, or as carriers of bacterial, viral and parasite antigens, gene-therapy compounds and diagnostic imaging contrast agents.
PCT/EP2000/007022 1999-07-23 2000-07-21 Polypeptide dendrimers as unimolecular carriers of diagnostic imaging contrast agents, bioactive substances and drugs WO2001007469A2 (en)

Priority Applications (7)

Application Number Priority Date Filing Date Title
CA002380178A CA2380178A1 (en) 1999-07-23 2000-07-21 Polypeptide dendrimers as unimolecular carriers of diagnostic imaging contrast agents, bioactive substances and drugs
AU62766/00A AU772167B2 (en) 1999-07-23 2000-07-21 Polypeptide dendrimers as unimolecular carriers of diagnostic imaging contrast agents, bioactive substances and drugs
PL00353273A PL353273A1 (en) 1999-07-23 2000-07-21 Polypeptide dendrimers as unimolecular carriers of diagnostic imaging contrast agents, bioactive substances and drugs
NZ517231A NZ517231A (en) 1999-07-23 2000-07-21 Polypeptide dendrimers as unimolecular carriers of diagnostic imaging contrast agents, bioactive substances and drugs
JP2001512552A JP2003506326A (en) 1999-07-23 2000-07-21 Polypeptide dendrimers as monomolecular carriers for diagnostic imaging contrast agents, bioactive agents, and drugs
EP00949393A EP1200461A2 (en) 1999-07-23 2000-07-21 Polypeptide dendrimers as unimolecular carriers of diagnostic imaging contrast agents, bioactive substances and drugs
NO20020333A NO20020333D0 (en) 1999-07-23 2002-01-22 Polypeptide dendrimers as unimolecular carriers of diagnostic, imaging contrast agents, bioactive substances and drugs

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT1999FO000015A ITFO990015A1 (en) 1999-07-23 1999-07-23 "POLYPEPTIDE DENDRIMERS AS UNIMOLECULAR CARRIERS OF DRUGS AND BIOLOGICALLY ACTIVE SUBSTANCES".
ITFO99A000015 1999-07-23

Publications (2)

Publication Number Publication Date
WO2001007469A2 WO2001007469A2 (en) 2001-02-01
WO2001007469A3 true WO2001007469A3 (en) 2001-05-10

Family

ID=11353680

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2000/007022 WO2001007469A2 (en) 1999-07-23 2000-07-21 Polypeptide dendrimers as unimolecular carriers of diagnostic imaging contrast agents, bioactive substances and drugs

Country Status (12)

Country Link
EP (1) EP1200461A2 (en)
JP (1) JP2003506326A (en)
CN (1) CN1364171A (en)
AU (1) AU772167B2 (en)
CA (1) CA2380178A1 (en)
HU (1) HUP0201975A3 (en)
IT (1) ITFO990015A1 (en)
NO (1) NO20020333D0 (en)
NZ (1) NZ517231A (en)
PL (1) PL353273A1 (en)
WO (1) WO2001007469A2 (en)
ZA (1) ZA200201089B (en)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR032930A1 (en) 2001-03-05 2003-12-03 Shell Int Research PROCEDURE TO PREPARE AN OIL BASED OIL AND GAS OIL
AR032941A1 (en) 2001-03-05 2003-12-03 Shell Int Research A PROCEDURE TO PREPARE A LUBRICATING BASE OIL AND BASE OIL OBTAINED, WITH ITS VARIOUS USES
MY137259A (en) 2001-03-05 2009-01-30 Shell Int Research Process to prepare a lubricating base oil and a gas oil.
CN1558777A (en) * 2001-10-29 2004-12-29 �Ϻ���ͨ��ѧ An antineoplastic dendritic polymer drug delivery system
ES2254973T3 (en) 2002-07-18 2006-06-16 Shell Internationale Research Maatschappij B.V. PROCEDURE FOR PREPARATION OF A MICROCRYSTAL WAX AND A MEDIUM DISTILLATE FUEL.
EP1525890A1 (en) 2003-10-02 2005-04-27 Complex Biosystems GmbH Protein-Proteophore complexes
ES2437581T3 (en) 2005-11-17 2014-01-13 Zogenix, Inc. Supply of viscous formulations by needleless injection
HUP0700782A3 (en) * 2007-12-05 2009-11-30 Biostatin Gyogyszerkutato Fejl Novel peptides and amino acid derivatives, pharmaceutical compositions containing the same and use of the compounds
EP2756756B1 (en) 2008-04-28 2016-01-06 Zogenix, Inc. Novel formulations for treatment of migraine
US20110274713A1 (en) * 2008-08-05 2011-11-10 The University Of Queensland Antigen-presenting scaffolds

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995000540A1 (en) * 1993-06-18 1995-01-05 Robert Webber Synthetic carrier and immunogen
WO1998032469A2 (en) * 1997-01-29 1998-07-30 Nycomed Imaging As Polymers

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995000540A1 (en) * 1993-06-18 1995-01-05 Robert Webber Synthetic carrier and immunogen
WO1998032469A2 (en) * 1997-01-29 1998-07-30 Nycomed Imaging As Polymers

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
CHOW H -F ET AL: "The Synthesis and Properties of Novel Functional Dendritic Molecules", TETRAHEDRON,NL,ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, vol. 54, no. 30, 23 July 1998 (1998-07-23), pages 8543 - 8660, XP004124033, ISSN: 0040-4020 *
HUANG E.A.: "Lipophilic multiple antigen peptide system for peptide immungen and synthetic vaccin", MOL.IMMUNOL., vol. 31, no. 15, 1994, pages 1191 - 1199, XP002160052 *
JANSEN J F G A ET AL: "ENCAPSULATION OF GUEST MOLECULES INTO A DENDRITIC BOX", SCIENCE,US,AMERICAN ASSOCIATION FOR THE ADVANCEMENT OF SCIENCE,, vol. 266, no. 5188, 18 November 1994 (1994-11-18), pages 1226 - 1229, XP000500113, ISSN: 0036-8075 *

Also Published As

Publication number Publication date
AU6276600A (en) 2001-02-13
CA2380178A1 (en) 2001-02-01
ZA200201089B (en) 2003-07-30
CN1364171A (en) 2002-08-14
ITFO990015A1 (en) 2001-01-23
HUP0201975A2 (en) 2002-10-28
EP1200461A2 (en) 2002-05-02
NO20020333L (en) 2002-01-22
AU772167B2 (en) 2004-04-08
NZ517231A (en) 2003-05-30
HUP0201975A3 (en) 2002-11-28
WO2001007469A2 (en) 2001-02-01
JP2003506326A (en) 2003-02-18
NO20020333D0 (en) 2002-01-22
PL353273A1 (en) 2003-11-03

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