WO2001005822A3 - Molecules derived from interleukin-1 beta - Google Patents

Molecules derived from interleukin-1 beta Download PDF

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Publication number
WO2001005822A3
WO2001005822A3 PCT/GB2000/002657 GB0002657W WO0105822A3 WO 2001005822 A3 WO2001005822 A3 WO 2001005822A3 GB 0002657 W GB0002657 W GB 0002657W WO 0105822 A3 WO0105822 A3 WO 0105822A3
Authority
WO
WIPO (PCT)
Prior art keywords
interleukin
beta
molecules derived
ice
fragment
Prior art date
Application number
PCT/GB2000/002657
Other languages
French (fr)
Other versions
WO2001005822A2 (en
Inventor
Sylvie Toulmond
Original Assignee
Univ Manchester
Sylvie Toulmond
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Manchester, Sylvie Toulmond filed Critical Univ Manchester
Priority to AU59971/00A priority Critical patent/AU5997100A/en
Publication of WO2001005822A2 publication Critical patent/WO2001005822A2/en
Publication of WO2001005822A3 publication Critical patent/WO2001005822A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/545—IL-1

Abstract

The present invention relates to an isolated C-terminal fragment of pro-interleukin 1β comprising a protein sequence having a molecular weight of 20-22 kD or an N-terminal truncation thereof, incorporating an interleukin-1β converting enzyme (ICE) cleavage site, the fragment being cleavable by ICE to produce active IL-1β, and the cleavage product thereof.
PCT/GB2000/002657 1999-07-16 2000-07-11 Molecules derived from interleukin-1 beta WO2001005822A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU59971/00A AU5997100A (en) 1999-07-16 2000-07-11 Molecules derived from interleukins

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9916630.8A GB9916630D0 (en) 1999-07-16 1999-07-16 Molecules derived from interleukins
GB9916630.8 1999-07-16

Publications (2)

Publication Number Publication Date
WO2001005822A2 WO2001005822A2 (en) 2001-01-25
WO2001005822A3 true WO2001005822A3 (en) 2001-05-25

Family

ID=10857304

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2000/002657 WO2001005822A2 (en) 1999-07-16 2000-07-11 Molecules derived from interleukin-1 beta

Country Status (3)

Country Link
AU (1) AU5997100A (en)
GB (1) GB9916630D0 (en)
WO (1) WO2001005822A2 (en)

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0187991A2 (en) * 1984-12-21 1986-07-23 Otsuka Pharmaceutical Co., Ltd. Antitumor active substance, process for preparing the same, drug containing the substance, gene coding for the substance, vector containing the gene and recombinant microorganism
EP0237967A2 (en) * 1986-03-14 1987-09-23 Otsuka Pharmaceutical Co., Ltd. IL-1 beta derivatives and drugs
JPS62248489A (en) * 1986-04-22 1987-10-29 Ajinomoto Co Inc Recombinant dna and production of polypeptide using same
WO1988010299A1 (en) * 1987-06-24 1988-12-29 Novo-Nordisk A/S A process for preparing a protein or polypeptide, a dna sequence coding for the polypeptide, a microorganism containing the dna sequence as well as the polypeptide and its use as a pharmaceutical preparation

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0187991A2 (en) * 1984-12-21 1986-07-23 Otsuka Pharmaceutical Co., Ltd. Antitumor active substance, process for preparing the same, drug containing the substance, gene coding for the substance, vector containing the gene and recombinant microorganism
EP0237967A2 (en) * 1986-03-14 1987-09-23 Otsuka Pharmaceutical Co., Ltd. IL-1 beta derivatives and drugs
JPS62248489A (en) * 1986-04-22 1987-10-29 Ajinomoto Co Inc Recombinant dna and production of polypeptide using same
WO1988010299A1 (en) * 1987-06-24 1988-12-29 Novo-Nordisk A/S A process for preparing a protein or polypeptide, a dna sequence coding for the polypeptide, a microorganism containing the dna sequence as well as the polypeptide and its use as a pharmaceutical preparation

Non-Patent Citations (7)

* Cited by examiner, † Cited by third party
Title
AURON P E ET AL: "STUDIES ON THE MOLECULAR NATURE OF HUMAN INTERLEUKIN 1", JOURNAL OF IMMUNOLOGY, vol. 138, no. 5, 1987, pages 1447 - 1456, XP002160116, ISSN: 0022-1767 *
BLACK R A ET AL: "GENERATION OF BIOLOGICALLY ACTIVE INTERLEUKIN-1-BETA BY PROTEOLYTIC CLEAVAGE OF THE INACTIVE PRECURSOR", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 263, no. 19, 1988, pages 9437 - 9442, XP002160117, ISSN: 0021-9258 *
HIGGINS GLORIA C ET AL: "Interleukin 1-beta propeptide is detected by intracellularly and extracellularly when human monocytes are stimulated with LPS in vitro.", JOURNAL OF EXPERIMENTAL MEDICINE, vol. 180, no. 2, 1994, pages 607 - 614, XP000982152, ISSN: 0022-1007 *
LUNDQVIST ELISABET NYLANDER ET AL: "Biologically active, alternatively processed interleukin-1-beta in psoriatic scales.", EUROPEAN JOURNAL OF IMMUNOLOGY, vol. 27, no. 9, 1997, pages 2165 - 2171, XP000982123, ISSN: 0014-2980 *
PATENT ABSTRACTS OF JAPAN vol. 012, no. 128 (C - 489) 20 April 1988 (1988-04-20) *
PECCEU F ET AL: "Human interleukin 1-beta fused to the human growth hormone signal peptide is N-glycosylated and secreted by Chinese hamster ovary cells", GENE,ELSEVIER BIOMEDICAL PRESS. AMSTERDAM,NL, vol. 97, 1991, pages 253 - 258, XP002131134, ISSN: 0378-1119 *
PERREGAUX DAVID G ET AL: "Human monocyte stimulus-coupled IL-1beta posttranslational processing: Modulation via monovalent cations.", AMERICAN JOURNAL OF PHYSIOLOGY, vol. 275, no. 6 PART 1, December 1998 (1998-12-01), pages C1538 - C1547, XP002160115, ISSN: 0002-9513 *

Also Published As

Publication number Publication date
AU5997100A (en) 2001-02-05
WO2001005822A2 (en) 2001-01-25
GB9916630D0 (en) 1999-09-15

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