WO2001001142A3 - Arrays of biopolymeric agents and method for their production and use - Google Patents

Arrays of biopolymeric agents and method for their production and use Download PDF

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Publication number
WO2001001142A3
WO2001001142A3 PCT/US2000/016894 US0016894W WO0101142A3 WO 2001001142 A3 WO2001001142 A3 WO 2001001142A3 US 0016894 W US0016894 W US 0016894W WO 0101142 A3 WO0101142 A3 WO 0101142A3
Authority
WO
WIPO (PCT)
Prior art keywords
arrays
production
biopolymeric
spacer layer
binding agents
Prior art date
Application number
PCT/US2000/016894
Other languages
French (fr)
Other versions
WO2001001142A2 (en
Inventor
Deborah Charych
Original Assignee
Chiron Corp
Deborah Charych
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chiron Corp, Deborah Charych filed Critical Chiron Corp
Priority to AU58794/00A priority Critical patent/AU5879400A/en
Publication of WO2001001142A2 publication Critical patent/WO2001001142A2/en
Publication of WO2001001142A3 publication Critical patent/WO2001001142A3/en

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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y30/00—Nanotechnology for materials or surface science, e.g. nanocomposites
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y15/00—Nanotechnology for interacting, sensing or actuating, e.g. quantum dots as markers in protein assays or molecular motors
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6834—Enzymatic or biochemical coupling of nucleic acids to a solid phase
    • C12Q1/6837—Enzymatic or biochemical coupling of nucleic acids to a solid phase using probe arrays or probe chips

Landscapes

  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nanotechnology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Biophysics (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Physics & Mathematics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biotechnology (AREA)
  • Condensed Matter Physics & Semiconductors (AREA)
  • Immunology (AREA)
  • Composite Materials (AREA)
  • Materials Engineering (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • General Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • Medical Informatics (AREA)
  • Genetics & Genomics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)

Abstract

Arrays of biopolymeric binding agents, as well as methods for their fabrication and use, are provided. The subject arrays are characterized having at least two non-modified biopolymeric binding agents, e.g. proteins, nucleic acids, etc., bound to the hydrophilic surface of a spacer layer present a planar surface of a solid support, where the spacer layer at least includes a self-assembled monolayer. The subject arrays find use in a variety of different binding assay applications. Also provided are kits including the subject arrays.
PCT/US2000/016894 1999-06-29 2000-06-19 Arrays of biopolymeric agents and method for their production and use WO2001001142A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU58794/00A AU5879400A (en) 1999-06-29 2000-06-19 Arrays of biopolymeric agents and method for their production and use

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US14146999P 1999-06-29 1999-06-29
US60/141,469 1999-06-29

Publications (2)

Publication Number Publication Date
WO2001001142A2 WO2001001142A2 (en) 2001-01-04
WO2001001142A3 true WO2001001142A3 (en) 2001-08-30

Family

ID=22495820

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2000/016894 WO2001001142A2 (en) 1999-06-29 2000-06-19 Arrays of biopolymeric agents and method for their production and use

Country Status (2)

Country Link
AU (1) AU5879400A (en)
WO (1) WO2001001142A2 (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020055125A1 (en) * 2000-06-05 2002-05-09 Chiron Corporation Microarrays for performing proteomic analyses
US7148058B2 (en) 2000-06-05 2006-12-12 Chiron Corporation Protein microarrays on mirrored surfaces for performing proteomic analyses
US7153682B2 (en) 2000-06-05 2006-12-26 Chiron Corporation Microarrays on mirrored substrates for performing proteomic analyses
US7678539B2 (en) 2000-08-10 2010-03-16 Corning Incorporated Arrays of biological membranes and methods and use thereof
US6977155B2 (en) 2000-08-10 2005-12-20 Corning Incorporated Arrays of biological membranes and methods and use thereof
JP2004524528A (en) * 2001-02-14 2004-08-12 ユニバーシティ オブ メリーランド，ボルチモア Radiation attenuation operation
CA2438345A1 (en) * 2001-02-16 2002-08-29 Vir A/S Method for the preparation of optical (bio)chemical sensor devices
CN1735807A (en) * 2003-12-19 2006-02-15 成都夸常医学工业有限公司 Chip detecting method and relevant apparatus

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993022680A1 (en) * 1992-04-24 1993-11-11 Affymax Technologies N.V. Spatially-addressable immobilization of oligonucleotides and other biological polymers on surfaces
WO1998031839A2 (en) * 1997-01-21 1998-07-23 President And Fellows Of Harvard College Electronic-property probing of biological molecules at surfaces
WO1998039481A1 (en) * 1997-03-05 1998-09-11 Molecular Tool, Inc. Covalent attachment of nucleic acid molecules onto solid-phases via disulfide bonds
WO1999067425A2 (en) * 1998-06-23 1999-12-29 Clinical Micro Sensors, Inc. Binding acceleration techniques for the detection of analytes
WO2000067028A1 (en) * 1999-05-04 2000-11-09 Wisconsin Alumni Research Foundation Process to create biomolecule arrays on metal surfaces

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993022680A1 (en) * 1992-04-24 1993-11-11 Affymax Technologies N.V. Spatially-addressable immobilization of oligonucleotides and other biological polymers on surfaces
WO1998031839A2 (en) * 1997-01-21 1998-07-23 President And Fellows Of Harvard College Electronic-property probing of biological molecules at surfaces
WO1998039481A1 (en) * 1997-03-05 1998-09-11 Molecular Tool, Inc. Covalent attachment of nucleic acid molecules onto solid-phases via disulfide bonds
WO1999067425A2 (en) * 1998-06-23 1999-12-29 Clinical Micro Sensors, Inc. Binding acceleration techniques for the detection of analytes
WO2000067028A1 (en) * 1999-05-04 2000-11-09 Wisconsin Alumni Research Foundation Process to create biomolecule arrays on metal surfaces

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
BONCHEVA M ET AL.: "Design of oligonucleotide arrays at interfaces", LANGMUIR, vol. 15, 1999, pages 4317 - 4320, XP000991094 *
BROCKMAN ET AL: "A Multistep Chemical Modification Procedure To Create DNA Arrays on Gold Surfaces for the Study of Protein-DNA Interactions with Surface Plasmon Resonance Imaging", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY,AMERICAN CHEMICAL SOCIETY, WASHINGTON, DC,US, vol. 121, no. 35, 1999, pages 8044 - 8051, XP002148625, ISSN: 0002-7863 *
FOLKERS J P ET AL.: "Self-assembled monolayers of alkanethiols on gold: Comparisons of monolayers containing mixtures of short- and long-chain constituents with CH3 and CH2OH terminal groups", LANGMUIR, vol. 8, 1992, pages 1330 - 1341, XP000979989 *
FRUTOS A G ET AL.: "Reversible protection and reactive patterning of amine-and hydroxyl-terminated self-assembled monolayers on gold surfaces for the fabrication of biopolymer arrays", LANGMUIR, vol. 16, 2000, pages 2192 - 2197, XP000946578 *
LEE M-T ET A.: "Air oxidation of self-assembled monolayers on polycrystalline gold: The role of the gold substrate", LANGMUIR, vol. 14, 1998, pages 6419 - 6423, XP000979882 *
THIEL A J ET AL: "IN SITU SURFACE PLASMON RESONANCE IMAGING DETECTION OF DNA HYBRIDIZATION TO OLIGONUCLEOTIDE ARRAYS ON GOLD SURFACES", ANALYTICAL CHEMISTRY,AMERICAN CHEMICAL SOCIETY. COLUMBUS,US, vol. 69, no. 24, 15 December 1997 (1997-12-15), pages 4948 - 4956, XP000733394, ISSN: 0003-2700 *

Also Published As

Publication number Publication date
AU5879400A (en) 2001-01-31
WO2001001142A2 (en) 2001-01-04

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