WO2001000783A2 - Echafaudages tridimensionnels surveillables et systemes de cultures cellulaires - Google Patents

Echafaudages tridimensionnels surveillables et systemes de cultures cellulaires Download PDF

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Publication number
WO2001000783A2
WO2001000783A2 PCT/US2000/017542 US0017542W WO0100783A2 WO 2001000783 A2 WO2001000783 A2 WO 2001000783A2 US 0017542 W US0017542 W US 0017542W WO 0100783 A2 WO0100783 A2 WO 0100783A2
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WO
WIPO (PCT)
Prior art keywords
tissue
dimensional
cells
stromal
biosensor
Prior art date
Application number
PCT/US2000/017542
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English (en)
Other versions
WO2001000783A3 (fr
Inventor
Gail K. Naughton
Jonathan N. Mansbridge
David L. Horwitz
Joan Zeltinger
David J. Cerny
Original Assignee
Advanced Tissue Sciences, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Advanced Tissue Sciences, Inc. filed Critical Advanced Tissue Sciences, Inc.
Priority to AU57679/00A priority Critical patent/AU5767900A/en
Publication of WO2001000783A2 publication Critical patent/WO2001000783A2/fr
Publication of WO2001000783A3 publication Critical patent/WO2001000783A3/fr

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M25/00—Means for supporting, enclosing or fixing the microorganisms, e.g. immunocoatings
    • C12M25/14—Scaffolds; Matrices

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  • Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Sustainable Development (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Immunology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Materials For Medical Uses (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)

Abstract

La présente invention concerne, d'une part des échafaudages tridimensionnels et des tissus stromatolithiques tridimensionnels comprenant au moins un biocapteur biocompatible, et d'autre part des procédés d'élaboration et d'utilisation s'y rapportant. Selon un mode de réalisation préféré, le tissu tridimensionnel est un tissu stromatolithique vivant préparé in vivo, comprenant des cellules stromatolithiques et des protéines tissulaires connectives sécrétées par les ces cellules stromatolithiques attachées à une charpente qu'elles enveloppent, laquelle charpente est composée d'un matériau biocompatible non vivant présentant une structure tridimensionnelle dont les espaces interstitiels sont partiellement comblés par les cellules stromatolithiques en association fonctionnelle avec une sonde chimique biocompatible. Ce biocapteur peut s'utiliser, d'une part pour surveiller la croissance des tissus, leur viabilité et intégrité, un vivo ou in vitro, mais également pour renforcer ou améliorer une fonction tissulaire après implantation chez un patient.
PCT/US2000/017542 1999-06-25 2000-06-26 Echafaudages tridimensionnels surveillables et systemes de cultures cellulaires WO2001000783A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU57679/00A AU5767900A (en) 1999-06-25 2000-06-26 Monitorable three-dimensional scaffolds and tissue culture systems

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US14102999P 1999-06-25 1999-06-25
US60/141,029 1999-06-25

Publications (2)

Publication Number Publication Date
WO2001000783A2 true WO2001000783A2 (fr) 2001-01-04
WO2001000783A3 WO2001000783A3 (fr) 2001-05-17

Family

ID=22493847

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2000/017542 WO2001000783A2 (fr) 1999-06-25 2000-06-26 Echafaudages tridimensionnels surveillables et systemes de cultures cellulaires

Country Status (2)

Country Link
AU (1) AU5767900A (fr)
WO (1) WO2001000783A2 (fr)

Cited By (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003080791A2 (fr) * 2002-03-27 2003-10-02 Innovacell Biotechnologie Gmbh Support de cellules et procede de fabrication dudit support
WO2003087292A2 (fr) * 2002-04-08 2003-10-23 Millenium Biologix Inc. Systeme automatise d'ingenierie des tissus
WO2004111209A1 (fr) * 2003-06-13 2004-12-23 Isis Innovation Limited Procede de surveillance faisant appel a des sondes a micro-membrane
WO2004101743A3 (fr) * 2003-05-06 2005-06-09 Bellbrook Labs Llc Cultures cellulaires tridimensionnelles dans un systeme de manipulation fluidique a petite echelle
WO2007008057A1 (fr) * 2005-07-14 2007-01-18 Erasmus University Medical Center Rotterdam Système et procédé de surveillance de la vitalité d'un tissu, et technique chirurgicale
US9277999B2 (en) 2009-02-27 2016-03-08 University of Pittsburgh—of the Commonwealth System of Higher Education Joint bioscaffolds
WO2019197522A1 (fr) * 2018-04-11 2019-10-17 Københavns Universitet Bioencre fonctionnalisée par un capteur
US11371018B2 (en) 2017-09-01 2022-06-28 Octane Biotech Inc. End-to-end cell therapy automation
US11597905B2 (en) 2018-12-28 2023-03-07 Octane Biotech Inc. Cell culture and tissue engineering systems with controlled environmental zones
US11608486B2 (en) 2015-07-02 2023-03-21 Terumo Bct, Inc. Cell growth with mechanical stimuli
US11613727B2 (en) 2010-10-08 2023-03-28 Terumo Bct, Inc. Configurable methods and systems of growing and harvesting cells in a hollow fiber bioreactor system
US11624046B2 (en) 2017-03-31 2023-04-11 Terumo Bct, Inc. Cell expansion
US11629332B2 (en) 2017-03-31 2023-04-18 Terumo Bct, Inc. Cell expansion
US11634677B2 (en) 2016-06-07 2023-04-25 Terumo Bct, Inc. Coating a bioreactor in a cell expansion system
US11667876B2 (en) 2013-11-16 2023-06-06 Terumo Bct, Inc. Expanding cells in a bioreactor
US11667881B2 (en) 2014-09-26 2023-06-06 Terumo Bct, Inc. Scheduled feed
US11685883B2 (en) 2016-06-07 2023-06-27 Terumo Bct, Inc. Methods and systems for coating a cell growth surface
US11714096B2 (en) 2018-12-21 2023-08-01 Octane Biotech Inc. Carousel for modular biologic production units
US11718833B2 (en) 2018-12-21 2023-08-08 Lonza Walkersville, Inc. Automated production of viral vectors
US11773365B2 (en) 2019-02-08 2023-10-03 Lonza Walkersville, Inc. Cell concentration methods and devices for use in automated bioreactors
US11795432B2 (en) 2014-03-25 2023-10-24 Terumo Bct, Inc. Passive replacement of media
US11965175B2 (en) 2016-05-25 2024-04-23 Terumo Bct, Inc. Cell expansion

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1990004645A1 (fr) * 1988-10-21 1990-05-03 Molecular Devices Corporation Procede et appareil permettant de detecter l'effet qu'ont sur des cellules vivantes des agents agissant sur les cellules
WO1999047922A2 (fr) * 1998-03-18 1999-09-23 Massachusetts Institute Of Technology Ensemble de micro-tissus et de micro-organes vascularises et perfuses

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1990004645A1 (fr) * 1988-10-21 1990-05-03 Molecular Devices Corporation Procede et appareil permettant de detecter l'effet qu'ont sur des cellules vivantes des agents agissant sur les cellules
WO1999047922A2 (fr) * 1998-03-18 1999-09-23 Massachusetts Institute Of Technology Ensemble de micro-tissus et de micro-organes vascularises et perfuses

Cited By (43)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003080791A3 (fr) * 2002-03-27 2004-03-04 Innovacell Biotechnologie Gmbh Support de cellules et procede de fabrication dudit support
WO2003080791A2 (fr) * 2002-03-27 2003-10-02 Innovacell Biotechnologie Gmbh Support de cellules et procede de fabrication dudit support
US10844338B1 (en) 2002-04-08 2020-11-24 Octane Biotech Inc. Automated tissue engineering system
US8492140B2 (en) 2002-04-08 2013-07-23 Octane Biotech Inc. Automated tissue engineering system
JP2019092515A (ja) * 2002-04-08 2019-06-20 オクテイン バイオテック インコーポレイテッド 自動的な組織工学モジュール
WO2003087292A2 (fr) * 2002-04-08 2003-10-23 Millenium Biologix Inc. Systeme automatise d'ingenierie des tissus
JP2005531300A (ja) * 2002-04-08 2005-10-20 ミレニアム・バイオロジクス，インコーポレイテッド 自動的な組織工学モジュール
AU2009202476B2 (en) * 2002-04-08 2012-06-28 Octane Biotech, Inc. Automated tissue engineering system
AU2003218572B2 (en) * 2002-04-08 2009-08-20 Octane Biotech, Inc. Automated tissue engineering system
US9701932B2 (en) 2002-04-08 2017-07-11 Octane Biotech Inc. Automated tissue engineering system
AU2009202476B8 (en) * 2002-04-08 2012-07-19 Octane Biotech, Inc. Automated tissue engineering system
AU2009202476A8 (en) * 2002-04-08 2012-07-19 Octane Biotech, Inc. Automated tissue engineering system
US10723986B2 (en) 2002-04-08 2020-07-28 Octane Biotech Inc. Automated tissue engineering system
WO2003087292A3 (fr) * 2002-04-08 2003-12-04 Millenium Biologix Inc Systeme automatise d'ingenierie des tissus
US9534195B2 (en) 2002-04-08 2017-01-03 Octane Biotech Inc. Automated tissue engineering system
WO2004101743A3 (fr) * 2003-05-06 2005-06-09 Bellbrook Labs Llc Cultures cellulaires tridimensionnelles dans un systeme de manipulation fluidique a petite echelle
WO2004111209A1 (fr) * 2003-06-13 2004-12-23 Isis Innovation Limited Procede de surveillance faisant appel a des sondes a micro-membrane
WO2007008057A1 (fr) * 2005-07-14 2007-01-18 Erasmus University Medical Center Rotterdam Système et procédé de surveillance de la vitalité d'un tissu, et technique chirurgicale
US9277999B2 (en) 2009-02-27 2016-03-08 University of Pittsburgh—of the Commonwealth System of Higher Education Joint bioscaffolds
US9848987B2 (en) 2009-02-27 2017-12-26 University of Pittsburgh — Of the Commonwealth System of Higher Education Joint bioscaffolds
US11773363B2 (en) 2010-10-08 2023-10-03 Terumo Bct, Inc. Configurable methods and systems of growing and harvesting cells in a hollow fiber bioreactor system
US11613727B2 (en) 2010-10-08 2023-03-28 Terumo Bct, Inc. Configurable methods and systems of growing and harvesting cells in a hollow fiber bioreactor system
US11746319B2 (en) 2010-10-08 2023-09-05 Terumo Bct, Inc. Customizable methods and systems of growing and harvesting cells in a hollow fiber bioreactor system
US11667876B2 (en) 2013-11-16 2023-06-06 Terumo Bct, Inc. Expanding cells in a bioreactor
US11708554B2 (en) 2013-11-16 2023-07-25 Terumo Bct, Inc. Expanding cells in a bioreactor
US11795432B2 (en) 2014-03-25 2023-10-24 Terumo Bct, Inc. Passive replacement of media
US11667881B2 (en) 2014-09-26 2023-06-06 Terumo Bct, Inc. Scheduled feed
US11608486B2 (en) 2015-07-02 2023-03-21 Terumo Bct, Inc. Cell growth with mechanical stimuli
US11965175B2 (en) 2016-05-25 2024-04-23 Terumo Bct, Inc. Cell expansion
US11685883B2 (en) 2016-06-07 2023-06-27 Terumo Bct, Inc. Methods and systems for coating a cell growth surface
US11634677B2 (en) 2016-06-07 2023-04-25 Terumo Bct, Inc. Coating a bioreactor in a cell expansion system
US11629332B2 (en) 2017-03-31 2023-04-18 Terumo Bct, Inc. Cell expansion
US11702634B2 (en) 2017-03-31 2023-07-18 Terumo Bct, Inc. Expanding cells in a bioreactor
US11624046B2 (en) 2017-03-31 2023-04-11 Terumo Bct, Inc. Cell expansion
US11781113B2 (en) 2017-09-01 2023-10-10 Lonza Walkersville, Inc. End-to-end cell therapy automation
US11371018B2 (en) 2017-09-01 2022-06-28 Octane Biotech Inc. End-to-end cell therapy automation
US11827902B2 (en) 2017-09-01 2023-11-28 Lonza Walkersville, Inc. End-to-end cell therapy automation
US11447745B2 (en) 2017-09-01 2022-09-20 Lonza Walkersville, Inc. End-to-end cell therapy automation
WO2019197522A1 (fr) * 2018-04-11 2019-10-17 Københavns Universitet Bioencre fonctionnalisée par un capteur
US11718833B2 (en) 2018-12-21 2023-08-08 Lonza Walkersville, Inc. Automated production of viral vectors
US11714096B2 (en) 2018-12-21 2023-08-01 Octane Biotech Inc. Carousel for modular biologic production units
US11597905B2 (en) 2018-12-28 2023-03-07 Octane Biotech Inc. Cell culture and tissue engineering systems with controlled environmental zones
US11773365B2 (en) 2019-02-08 2023-10-03 Lonza Walkersville, Inc. Cell concentration methods and devices for use in automated bioreactors

Also Published As

Publication number Publication date
WO2001000783A3 (fr) 2001-05-17
AU5767900A (en) 2001-01-31

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