WO2000078933A3 - Novel calpains and their use - Google Patents

Novel calpains and their use Download PDF

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Publication number
WO2000078933A3
WO2000078933A3 PCT/EP2000/005261 EP0005261W WO0078933A3 WO 2000078933 A3 WO2000078933 A3 WO 2000078933A3 EP 0005261 W EP0005261 W EP 0005261W WO 0078933 A3 WO0078933 A3 WO 0078933A3
Authority
WO
WIPO (PCT)
Prior art keywords
novel
calpains
capn11
synthesis
relates
Prior art date
Application number
PCT/EP2000/005261
Other languages
German (de)
French (fr)
Other versions
WO2000078933A2 (en
Inventor
Neil T Dear
Thomas Boehm
Achim Moeller
Original Assignee
Basf Ag
Neil T Dear
Thomas Boehm
Achim Moeller
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to JP2001505676A priority Critical patent/JP2003503023A/en
Application filed by Basf Ag, Neil T Dear, Thomas Boehm, Achim Moeller filed Critical Basf Ag
Priority to MXPA01012937A priority patent/MXPA01012937A/en
Priority to IL14694000A priority patent/IL146940A0/en
Priority to SK1826-2001A priority patent/SK18262001A3/en
Priority to CA002375477A priority patent/CA2375477A1/en
Priority to AU59706/00A priority patent/AU5970600A/en
Priority to BR0011721-8A priority patent/BR0011721A/en
Priority to KR1020017016244A priority patent/KR20020011140A/en
Priority to EP00945716A priority patent/EP1185673A2/en
Publication of WO2000078933A2 publication Critical patent/WO2000078933A2/en
Publication of WO2000078933A3 publication Critical patent/WO2000078933A3/en
Priority to NO20015922A priority patent/NO20015922L/en
Priority to BG106186A priority patent/BG106186A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6472—Cysteine endopeptidases (3.4.22)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/55—Protease inhibitors
    • A61K38/57—Protease inhibitors from animals; from humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Reproductive Health (AREA)
  • Biomedical Technology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Endocrinology (AREA)
  • Microbiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pregnancy & Childbirth (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

The invention relates to a novel mammalian calpain CAPN11, to the synthesis and to the use thereof.
PCT/EP2000/005261 1999-06-18 2000-06-07 Novel calpains and their use WO2000078933A2 (en)

Priority Applications (11)

Application Number Priority Date Filing Date Title
AU59706/00A AU5970600A (en) 1999-06-18 2000-06-07 Novel calpains and their use
MXPA01012937A MXPA01012937A (en) 1999-06-18 2000-06-07 Novel calpains and their use.
IL14694000A IL146940A0 (en) 1999-06-18 2000-06-07 Novel calpains and their use
SK1826-2001A SK18262001A3 (en) 1999-06-18 2000-06-07 Novel calpains and their use
CA002375477A CA2375477A1 (en) 1999-06-18 2000-06-07 Novel calpains and their use
JP2001505676A JP2003503023A (en) 1999-06-18 2000-06-07 New calpain and its use
BR0011721-8A BR0011721A (en) 1999-06-18 2000-06-07 Polypeptide, polynucleotide sequence, use of a polypeptide, process to identify compounds that inhibit the enzymatic activity of a polypeptide, and use of compounds
KR1020017016244A KR20020011140A (en) 1999-06-18 2000-06-07 Novel Calpains and Their Use
EP00945716A EP1185673A2 (en) 1999-06-18 2000-06-07 Novel calpains and their use
NO20015922A NO20015922L (en) 1999-06-18 2001-12-04 New calpains and their use
BG106186A BG106186A (en) 1999-06-18 2001-12-06 Novel calpains and their use

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19928021A DE19928021A1 (en) 1999-06-18 1999-06-18 New nucleic acid encoding testis-specific calpain-11, useful for identifying specific inhibitors for treatment of fertility disorders
DE19928021.5 1999-06-18

Publications (2)

Publication Number Publication Date
WO2000078933A2 WO2000078933A2 (en) 2000-12-28
WO2000078933A3 true WO2000078933A3 (en) 2001-07-26

Family

ID=7911777

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2000/005261 WO2000078933A2 (en) 1999-06-18 2000-06-07 Novel calpains and their use

Country Status (18)

Country Link
EP (1) EP1185673A2 (en)
JP (1) JP2003503023A (en)
KR (1) KR20020011140A (en)
CN (1) CN1373808A (en)
AR (1) AR024573A1 (en)
AU (1) AU5970600A (en)
BG (1) BG106186A (en)
BR (1) BR0011721A (en)
CA (1) CA2375477A1 (en)
DE (1) DE19928021A1 (en)
HU (1) HUP0201800A2 (en)
IL (1) IL146940A0 (en)
MX (1) MXPA01012937A (en)
NO (1) NO20015922L (en)
PL (1) PL353004A1 (en)
SK (1) SK18262001A3 (en)
TR (1) TR200103662T2 (en)
WO (1) WO2000078933A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6433153B1 (en) 1999-09-02 2002-08-13 Lexicon Genetics Incorporated Human calcium dependent proteases and polynucleotides encoding the same
GB2505572B (en) 2010-04-30 2014-08-06 Abbott Cardiovascular Systems Catheter system providing step reduction for postconditioning

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19737105A1 (en) * 1997-08-26 1999-03-04 Basf Ag New tissue-specific calpains, their production and use
WO2000058473A2 (en) * 1999-03-31 2000-10-05 Curagen Corporation Nucleic acids including open reading frames encoding polypeptides; 'orfx'

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19737105A1 (en) * 1997-08-26 1999-03-04 Basf Ag New tissue-specific calpains, their production and use
WO2000058473A2 (en) * 1999-03-31 2000-10-05 Curagen Corporation Nucleic acids including open reading frames encoding polypeptides; 'orfx'

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
DEAR T NEIL ET AL: "CAPN11: A calpain with high mRNA levels in testis and located on chromosome 6.", GENOMICS, vol. 59, no. 2, 15 July 1999 (1999-07-15), pages 243 - 247, XP002159274, ISSN: 0888-7543 *
ZHANG WENLI ET AL: "The major calpain isozymes are long-lived proteins. Design of an antisense strategy for calpain depletion in cultured cells.", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 271, no. 31, 1996, pages 18825 - 18830, XP002159273, ISSN: 0021-9258 *

Also Published As

Publication number Publication date
MXPA01012937A (en) 2002-07-30
IL146940A0 (en) 2002-08-14
EP1185673A2 (en) 2002-03-13
NO20015922D0 (en) 2001-12-04
TR200103662T2 (en) 2002-05-21
HUP0201800A2 (en) 2002-09-28
PL353004A1 (en) 2003-09-22
SK18262001A3 (en) 2002-09-10
DE19928021A1 (en) 2000-12-21
JP2003503023A (en) 2003-01-28
AR024573A1 (en) 2002-10-16
WO2000078933A2 (en) 2000-12-28
KR20020011140A (en) 2002-02-07
NO20015922L (en) 2002-02-12
CN1373808A (en) 2002-10-09
CA2375477A1 (en) 2000-12-28
BG106186A (en) 2002-12-29
AU5970600A (en) 2001-01-09
BR0011721A (en) 2002-03-05

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