WO2000077207A3 - Nucleic acid encoding proteins involved in protein degradation, products and methods related thereto - Google Patents

Nucleic acid encoding proteins involved in protein degradation, products and methods related thereto Download PDF

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Publication number
WO2000077207A3
WO2000077207A3 PCT/US2000/015873 US0015873W WO0077207A3 WO 2000077207 A3 WO2000077207 A3 WO 2000077207A3 US 0015873 W US0015873 W US 0015873W WO 0077207 A3 WO0077207 A3 WO 0077207A3
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WO
WIPO (PCT)
Prior art keywords
proteins
nucleic acid
products
acid encoding
proteins involved
Prior art date
Application number
PCT/US2000/015873
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French (fr)
Other versions
WO2000077207A2 (en
Inventor
John C Reed
Shu-Ichi Matsuzawa
Original Assignee
Burnham Inst
John C Reed
Matsuzawa Shu Ichi
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Burnham Inst, John C Reed, Matsuzawa Shu Ichi filed Critical Burnham Inst
Priority to JP2001503651A priority Critical patent/JP2003502042A/en
Priority to EP00942718A priority patent/EP1185652A2/en
Priority to AU57303/00A priority patent/AU5730300A/en
Publication of WO2000077207A2 publication Critical patent/WO2000077207A2/en
Publication of WO2000077207A3 publication Critical patent/WO2000077207A3/en

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Rheumatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pain & Pain Management (AREA)
  • Engineering & Computer Science (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Enzymes And Modification Thereof (AREA)

Abstract

In accordance with the present invention, there are provided novel Siah-Mediated-Degradation-Proteins (SMDPs) and/or SCF-Complex Proteins (SCPs). Nucleic acid sequences encoding such proteins and assays employing same are also disclosed. The invention SMDPs and/or SCPs can be employed in a variety of ways, for example, for the production of anti-SMDP and/or SCP antibodies thereto, in therapeutic compositions, and methods employing such proteins and/or antibodies for drug screening, functional genomics and other applications. Also provided are transgenic non-human mammals that express the invention protein.
PCT/US2000/015873 1999-06-11 2000-06-09 Nucleic acid encoding proteins involved in protein degradation, products and methods related thereto WO2000077207A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
JP2001503651A JP2003502042A (en) 1999-06-11 2000-06-09 Nucleic acids encoding proteins involved in proteolysis, related products and methods
EP00942718A EP1185652A2 (en) 1999-06-11 2000-06-09 Nucleic acid encoding proteins involved in protein degradation, products and methods related thereto
AU57303/00A AU5730300A (en) 1999-06-11 2000-06-09 Nucleic acid encoding proteins involved in protein degradation, products and methods related thereto

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US33051799A 1999-06-11 1999-06-11
US09/330,517 1999-06-11

Publications (2)

Publication Number Publication Date
WO2000077207A2 WO2000077207A2 (en) 2000-12-21
WO2000077207A3 true WO2000077207A3 (en) 2001-05-10

Family

ID=23290119

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2000/015873 WO2000077207A2 (en) 1999-06-11 2000-06-09 Nucleic acid encoding proteins involved in protein degradation, products and methods related thereto

Country Status (4)

Country Link
EP (1) EP1185652A2 (en)
JP (1) JP2003502042A (en)
AU (1) AU5730300A (en)
WO (1) WO2000077207A2 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2431834T3 (en) 2000-03-07 2013-11-28 The Johns Hopkins University Sialoadhesin factor-2 antibodies
US20040175770A1 (en) * 2000-06-30 2004-09-09 Nori Matsunami Method of screening for chemotherapeutic treatments for cancer
AUPR290801A0 (en) * 2001-02-06 2001-03-01 Peter Maccallum Cancer Institute, The Substrate binding domain
GB0309116D0 (en) * 2003-04-22 2003-05-28 Univ London Target for cancer therapy and drug discovery

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997022695A2 (en) * 1995-12-20 1997-06-26 Fondation Jean Dausset-Ceph Nucleotide sequences, proteins, drugs and diagnostic agents for treating cancer
WO1998041624A1 (en) * 1997-03-19 1998-09-24 Yeda Research And Development Co. Ltd. Modulators of the function of receptors of the tnf/ngf receptor family
WO1998042741A2 (en) * 1997-03-25 1998-10-01 Genetics Institute, Inc. Secreted proteins and polynucleotides encoding them
WO1999018989A1 (en) * 1997-10-16 1999-04-22 Baylor College Of Medicine F-box proteins and genes
WO1999046374A2 (en) * 1998-03-10 1999-09-16 Metagen Gesellschaft Für Genomforschung Mbh Human nucleic acid sequences from prostate tumour tissue
WO1999047540A1 (en) * 1998-03-19 1999-09-23 Human Genome Sciences, Inc. 95 human secreted proteins

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997022695A2 (en) * 1995-12-20 1997-06-26 Fondation Jean Dausset-Ceph Nucleotide sequences, proteins, drugs and diagnostic agents for treating cancer
WO1998041624A1 (en) * 1997-03-19 1998-09-24 Yeda Research And Development Co. Ltd. Modulators of the function of receptors of the tnf/ngf receptor family
WO1998042741A2 (en) * 1997-03-25 1998-10-01 Genetics Institute, Inc. Secreted proteins and polynucleotides encoding them
WO1999018989A1 (en) * 1997-10-16 1999-04-22 Baylor College Of Medicine F-box proteins and genes
WO1999046374A2 (en) * 1998-03-10 1999-09-16 Metagen Gesellschaft Für Genomforschung Mbh Human nucleic acid sequences from prostate tumour tissue
WO1999047540A1 (en) * 1998-03-19 1999-09-23 Human Genome Sciences, Inc. 95 human secreted proteins

Non-Patent Citations (14)

* Cited by examiner, † Cited by third party
Title
CENCIARELLI C ET AL: "Identification of a family of human F-box proteins.", CURRENT BIOLOGY, vol. 9, no. 20, 21 October 1999 (1999-10-21), pages 1177 - 1179, XP000982510, ISSN: 0960-9822 *
DATABASE EMBL 1 January 1900 (1900-01-01), CENCIARELLI C., ET AL.: "IDENTIFICATION OF A FAMILY OF HUMAN F-BOX PROTEINS", XP002160991, Database accession no. Q9UKT4 *
DATABASE EMBL 1 January 1900 (1900-01-01), CENRIARELLI C., ET AL: "F-BOX PROTEIN FBX7", XP002160984, Database accession no. Q9UKT2 *
DATABASE EMBL 1 January 1900 (1900-01-01), ILYIN G. P.: "CDNA CLONING AND EXPRESSION ANALYSIS OF NEW MEMBERS OF THE MAMMALIAN F-BOX PROTEIN FAMILY", XP002160986, Database accession no. Q9Y3I1 *
DATABASE EMBL 1 January 1900 (1900-01-01), RHODES S.: "H.SAPIENS GENE FROM PAC 102G20", XP002160981, Database accession no. AL035305 *
DATABASE EMBL 1 January 1900 (1900-01-01), RHODES S.: "HYPOTHETICAL 26.2 KDA PROTEIN", XP002160982, Database accession no. O60666 *
DATABASE EMBL 1 January 1900 (1900-01-01), SCANLAN M. J., ET AL: "ANTIGENS RECOGNIZED BY AUTOLOGOUS ANTIBODY IN PATIENTS WITH RENAL-CELL CARCINOMA", XP002160987, Database accession no. Q9Y593 *
DATABASE EMBL 1 January 1900 (1900-01-01), TUBBY B.: "HYPOTHETICAL 38.7 KDA PROTEIN", XP002160985, Database accession no. O75986 *
DATABASE EMBL 1 January 1900 (1900-01-01), WINSTON J. T., ET AL.: "A FAMILY OF MAMMALIAN F-BOX PROTEINS", XP002160988, Database accession no. Q9UK97 *
FILIPEK ANNA ET AL: "Molecular cloning and expression of a mouse brain cDNA encoding a novel protein target of calcylin.", JOURNAL OF NEUROCHEMISTRY, vol. 70, no. 5, May 1998 (1998-05-01), pages 1793 - 1798, XP000982427, ISSN: 0022-3042 *
HU GANG ET AL: "Characterization of human homologs of the Drosophila seven in absentia (sina) gene.", GENOMICS, vol. 46, no. 1, 15 November 1997 (1997-11-15), pages 103 - 111, XP002153979, ISSN: 0888-7543 *
HU GANG ET AL: "Siah-1 N-terminal RING domain is required for proteolysis function, and C-terminal sequences regulate oligomerization and binding to target proteins.", MOLECULAR AND CELLULAR BIOLOGY, vol. 19, no. 1, January 1999 (1999-01-01), pages 724 - 732, XP002153980, ISSN: 0270-7306 *
KINZLER KENNETH W ET AL: "Lessons from hereditary colorectal cancer.", CELL, vol. 87, no. 2, 1996, pages 159 - 170, XP002153982, ISSN: 0092-8674 *
MATSUZAWA SHU-ICHI ET AL: "p53-inducible human homologue of Drosophila seven in absentia (Siah) inhibits cell growth: Suppression by BAG-1.", EMBO (EUROPEAN MOLECULAR BIOLOGY ORGANIZATION) JOURNAL, vol. 17, no. 10, 15 May 1998 (1998-05-15), pages 2736 - 2747, XP002153981, ISSN: 0261-4189 *

Also Published As

Publication number Publication date
EP1185652A2 (en) 2002-03-13
WO2000077207A2 (en) 2000-12-21
AU5730300A (en) 2001-01-02
JP2003502042A (en) 2003-01-21

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