WO2000076585A1 - Method of coating a metal substrate with a radioactive layer - Google Patents

Method of coating a metal substrate with a radioactive layer Download PDF

Info

Publication number
WO2000076585A1
WO2000076585A1 PCT/US2000/014389 US0014389W WO0076585A1 WO 2000076585 A1 WO2000076585 A1 WO 2000076585A1 US 0014389 W US0014389 W US 0014389W WO 0076585 A1 WO0076585 A1 WO 0076585A1
Authority
WO
WIPO (PCT)
Prior art keywords
radioactive
silver
metal
iodide
substrate
Prior art date
Application number
PCT/US2000/014389
Other languages
English (en)
French (fr)
Inventor
Robert A. Snow
Gregory L. Mcintire
Edward R. Bacon
Evan Gustow
Original Assignee
Nycomed Amersham Plc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nycomed Amersham Plc filed Critical Nycomed Amersham Plc
Priority to AU54440/00A priority Critical patent/AU5444000A/en
Priority to DE60012927T priority patent/DE60012927T2/de
Priority to JP2001502914A priority patent/JP4700870B2/ja
Priority to DK00939344T priority patent/DK1187660T3/da
Priority to EP00939344A priority patent/EP1187660B1/en
Priority to AT00939344T priority patent/ATE273050T1/de
Publication of WO2000076585A1 publication Critical patent/WO2000076585A1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
    • A61N5/1001—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy using radiation sources introduced into or applied onto the body; brachytherapy
    • C—CHEMISTRY; METALLURGY
    • C23—COATING METALLIC MATERIAL; COATING MATERIAL WITH METALLIC MATERIAL; CHEMICAL SURFACE TREATMENT; DIFFUSION TREATMENT OF METALLIC MATERIAL; COATING BY VACUUM EVAPORATION, BY SPUTTERING, BY ION IMPLANTATION OR BY CHEMICAL VAPOUR DEPOSITION, IN GENERAL; INHIBITING CORROSION OF METALLIC MATERIAL OR INCRUSTATION IN GENERAL
    • C23C—COATING METALLIC MATERIAL; COATING MATERIAL WITH METALLIC MATERIAL; SURFACE TREATMENT OF METALLIC MATERIAL BY DIFFUSION INTO THE SURFACE, BY CHEMICAL CONVERSION OR SUBSTITUTION; COATING BY VACUUM EVAPORATION, BY SPUTTERING, BY ION IMPLANTATION OR BY CHEMICAL VAPOUR DEPOSITION, IN GENERAL
    • C23C22/00—Chemical surface treatment of metallic material by reaction of the surface with a reactive liquid, leaving reaction products of surface material in the coating, e.g. conversion coatings, passivation of metals
    • C23C22/05—Chemical surface treatment of metallic material by reaction of the surface with a reactive liquid, leaving reaction products of surface material in the coating, e.g. conversion coatings, passivation of metals using aqueous solutions
    • C23C22/68—Chemical surface treatment of metallic material by reaction of the surface with a reactive liquid, leaving reaction products of surface material in the coating, e.g. conversion coatings, passivation of metals using aqueous solutions using aqueous solutions with pH between 6 and 8
    • G—PHYSICS
    • G21—NUCLEAR PHYSICS; NUCLEAR ENGINEERING
    • G21G—CONVERSION OF CHEMICAL ELEMENTS; RADIOACTIVE SOURCES
    • G21G4/00—Radioactive sources
    • G21G4/04—Radioactive sources other than neutron sources
    • G21G4/06—Radioactive sources other than neutron sources characterised by constructional features
    • G—PHYSICS
    • G21—NUCLEAR PHYSICS; NUCLEAR ENGINEERING
    • G21G—CONVERSION OF CHEMICAL ELEMENTS; RADIOACTIVE SOURCES
    • G21G4/00—Radioactive sources
    • G21G4/04—Radioactive sources other than neutron sources
    • G21G4/06—Radioactive sources other than neutron sources characterised by constructional features
    • G21G4/08—Radioactive sources other than neutron sources characterised by constructional features specially adapted for medical application
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
    • A61N5/1001—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy using radiation sources introduced into or applied onto the body; brachytherapy
    • A61N2005/1019—Sources therefor

Definitions

  • 1-125 ions are present as a dispersion of Ag 125 I, some of the Ag 125 I will gradually dissolve as the immobilisation reaction progresses thus generating 1-125 iodide ions in solution.
  • 1-125 ions m solution may react directly with the oxidised silver (i.e. the Ag + cation) to form Ag 125 I.
  • the oxidised silver may react first with bromide ions to form AgBr, followed by ion-exchange of 1-125 iodide for bromide to give Ag 125 I.
  • both oxidation of the silver and formation of AgBr will result m removal of 1-125 from the solution phase.
  • Some metal halides for example silver halides, are light-sensitive .
  • silver halides silver bromide is most light-sensitive, followed by silver chloride and silver iodide respectively.
  • One disadvantage of the prior art process of US-A 4323055 for forming silver iodide-coated silver wires was that the light-sensitivity of the silver iodide meant that the process could not be carried out under natural light, but had to be carried out under red light.
  • a further significant advantage of the method of the present invention is that it need not be carried out under safe lights but can be carried out under normal room (fluorescent) lights.

Landscapes

  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • General Engineering & Computer Science (AREA)
  • High Energy & Nuclear Physics (AREA)
  • Biomedical Technology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Mechanical Engineering (AREA)
  • Radiology & Medical Imaging (AREA)
  • Pathology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Materials Engineering (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Metallurgy (AREA)
  • Organic Chemistry (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Laminated Bodies (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
  • Radiation-Therapy Devices (AREA)
  • Manufacture And Refinement Of Metals (AREA)
PCT/US2000/014389 1999-06-11 2000-05-24 Method of coating a metal substrate with a radioactive layer WO2000076585A1 (en)

Priority Applications (6)

Application Number Priority Date Filing Date Title
AU54440/00A AU5444000A (en) 1999-06-11 2000-05-24 Method of coating a metal substrate with a radioactive layer
DE60012927T DE60012927T2 (de) 1999-06-11 2000-05-24 Verfahren zur beschichtung eines metallsubstrates mit einer radioaktiven schicht
JP2001502914A JP4700870B2 (ja) 1999-06-11 2000-05-24 金属基体を放射活性層でコーティングする方法並びにブラキテラピー用の放射活性源
DK00939344T DK1187660T3 (da) 1999-06-11 2000-05-24 Metode til at overtrække et metalsubstrat med et radioaktivt lag
EP00939344A EP1187660B1 (en) 1999-06-11 2000-05-24 Method of coating a metal substrate with a radioactive layer
AT00939344T ATE273050T1 (de) 1999-06-11 2000-05-24 Verfahren zur beschichtung eines metallsubstrates mit einer radioaktiven schicht

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US13893199P 1999-06-11 1999-06-11
US60/138,931 1999-06-11
GB9915714.1 1999-07-05
GBGB9915714.1A GB9915714D0 (en) 1999-07-05 1999-07-05 Products and methods

Publications (1)

Publication Number Publication Date
WO2000076585A1 true WO2000076585A1 (en) 2000-12-21

Family

ID=10856671

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2000/014389 WO2000076585A1 (en) 1999-06-11 2000-05-24 Method of coating a metal substrate with a radioactive layer

Country Status (10)

Country Link
US (2) US6596097B1 (ja)
EP (1) EP1187660B1 (ja)
JP (1) JP4700870B2 (ja)
AT (1) ATE273050T1 (ja)
AU (1) AU5444000A (ja)
DE (1) DE60012927T2 (ja)
DK (1) DK1187660T3 (ja)
ES (1) ES2226858T3 (ja)
GB (1) GB9915714D0 (ja)
WO (1) WO2000076585A1 (ja)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102626605A (zh) * 2012-04-13 2012-08-08 天津位一新材料科技有限公司 去除水中放射性元素的材料及制备和使用方法

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102011120A (zh) * 2009-09-08 2011-04-13 郝迈琦 一种银基镀碘-125源棒的制备工艺

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3351049A (en) 1965-04-12 1967-11-07 Hazleton Nuclear Science Corp Therapeutic metal seed containing within a radioactive isotope disposed on a carrier and method of manufacture
US4323055A (en) 1980-04-08 1982-04-06 Minnesota Mining And Manufacturing Company Radioactive iodine seed
WO1997019706A1 (en) 1995-11-27 1997-06-05 International Brachytherapy S.A. Radioisotope dispersed in a matrix for brachytherapy
WO1997049335A1 (en) 1996-06-24 1997-12-31 The Dupont Merck Pharmaceutical Company Novel radiopharmaceutical compositions and matrices and uses thereof
WO2000009212A2 (en) * 1998-08-13 2000-02-24 Nycomed Amersham Plc Apparatus and methods for radiotherapy

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS58137371U (ja) * 1982-03-11 1983-09-16 浦上　英明 寝具
US4654170A (en) * 1984-06-05 1987-03-31 Westinghouse Electric Corp. Hypohalite oxidation in decontaminating nuclear reactors
US5137709A (en) * 1991-02-15 1992-08-11 The Dow Chemical Company Layered mixed metal hydroxides for the stabilization of radioactive colloids
CA2320986A1 (en) * 1998-02-19 1999-08-26 Brett A. Trauthen Thin film radiation source
DE19850203C1 (de) 1998-10-23 2000-05-31 Eurotope Entwicklungsgesellsch Radioaktive Jod-125-Seeds basierend auf Keramikträgern und Verfahren zur Herstellung dieser Seeds

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3351049A (en) 1965-04-12 1967-11-07 Hazleton Nuclear Science Corp Therapeutic metal seed containing within a radioactive isotope disposed on a carrier and method of manufacture
US4323055A (en) 1980-04-08 1982-04-06 Minnesota Mining And Manufacturing Company Radioactive iodine seed
WO1997019706A1 (en) 1995-11-27 1997-06-05 International Brachytherapy S.A. Radioisotope dispersed in a matrix for brachytherapy
WO1997049335A1 (en) 1996-06-24 1997-12-31 The Dupont Merck Pharmaceutical Company Novel radiopharmaceutical compositions and matrices and uses thereof
WO2000009212A2 (en) * 1998-08-13 2000-02-24 Nycomed Amersham Plc Apparatus and methods for radiotherapy

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102626605A (zh) * 2012-04-13 2012-08-08 天津位一新材料科技有限公司 去除水中放射性元素的材料及制备和使用方法

Also Published As

Publication number Publication date
JP4700870B2 (ja) 2011-06-15
EP1187660B1 (en) 2004-08-11
GB9915714D0 (en) 1999-09-08
DE60012927D1 (de) 2004-09-16
DK1187660T3 (da) 2004-12-06
ATE273050T1 (de) 2004-08-15
DE60012927T2 (de) 2005-08-18
US20030209291A1 (en) 2003-11-13
ES2226858T3 (es) 2005-04-01
AU5444000A (en) 2001-01-02
US6596097B1 (en) 2003-07-22
EP1187660A1 (en) 2002-03-20
JP2003501672A (ja) 2003-01-14

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