WO2000076456A2 - Modulateurs de fibrose - Google Patents

Modulateurs de fibrose Download PDF

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Publication number
WO2000076456A2
WO2000076456A2 PCT/US2000/016366 US0016366W WO0076456A2 WO 2000076456 A2 WO2000076456 A2 WO 2000076456A2 US 0016366 W US0016366 W US 0016366W WO 0076456 A2 WO0076456 A2 WO 0076456A2
Authority
WO
WIPO (PCT)
Prior art keywords
eiiia
polypeptide
compound
sequence
domain
Prior art date
Application number
PCT/US2000/016366
Other languages
English (en)
Other versions
WO2000076456A3 (fr
Inventor
Livingston Van De Water
Kenneth G. Wieder
Yung-Feng Liao
Jeanne M. Classen
Original Assignee
The General Hospital Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by The General Hospital Corporation filed Critical The General Hospital Corporation
Priority to AU54889/00A priority Critical patent/AU5488900A/en
Publication of WO2000076456A2 publication Critical patent/WO2000076456A2/fr
Publication of WO2000076456A3 publication Critical patent/WO2000076456A3/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/78—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin, cold insoluble globulin [CIG]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)

Abstract

L'invention concerne des compositions et des méthodes permettant d'inhiber ou de stimuler une fibrose.
PCT/US2000/016366 1999-06-14 2000-06-14 Modulateurs de fibrose WO2000076456A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU54889/00A AU5488900A (en) 1999-06-14 2000-06-14 Modulators of fibrosis

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US13902099P 1999-06-14 1999-06-14
US60/139,020 1999-06-14

Publications (2)

Publication Number Publication Date
WO2000076456A2 true WO2000076456A2 (fr) 2000-12-21
WO2000076456A3 WO2000076456A3 (fr) 2001-07-12

Family

ID=22484768

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2000/016366 WO2000076456A2 (fr) 1999-06-14 2000-06-14 Modulateurs de fibrose

Country Status (2)

Country Link
AU (1) AU5488900A (fr)
WO (1) WO2000076456A2 (fr)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1913954A2 (fr) * 2005-06-13 2008-04-23 Proyecto de Biomedicina Cima, S.L. Agents et methodes fondes sur l'utilisation du domaine eda de la fibronectine
US11597769B2 (en) * 2018-01-25 2023-03-07 Massachusetts Institute Of Technology Nanobody based imaging and targeting of ECM in disease and development

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
LIAO ET AL.: 'Identification of two amino acids within the EIIIA (ED-A) segment of fibronectin constituting the epitope for two function-blocking monoclonal antibodies' J. BIOL. CHEM. vol. 274, no. 25, 18 June 1999, pages 17876 - 17884, XP002934458 *

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1913954A2 (fr) * 2005-06-13 2008-04-23 Proyecto de Biomedicina Cima, S.L. Agents et methodes fondes sur l'utilisation du domaine eda de la fibronectine
EP1913954A4 (fr) * 2005-06-13 2011-01-12 Proyecto Biomedicina Cima Sl Agents et methodes fondes sur l'utilisation du domaine eda de la fibronectine
AU2006259041B2 (en) * 2005-06-13 2012-02-02 Proyecto De Biomedicina Cima, S.L. Agents and methods based on the use of the EDA domain of fibronectin
US9155783B2 (en) 2005-06-13 2015-10-13 Proyecto De Biomedicina Cima, S.L. Agents and methods based on the use of the EDA domain of fibronectin
US11597769B2 (en) * 2018-01-25 2023-03-07 Massachusetts Institute Of Technology Nanobody based imaging and targeting of ECM in disease and development

Also Published As

Publication number Publication date
AU5488900A (en) 2001-01-02
WO2000076456A3 (fr) 2001-07-12

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