WO2000073509A3 - Molecules for diagnostics and therapeutics - Google Patents

Molecules for diagnostics and therapeutics Download PDF

Info

Publication number
WO2000073509A3
WO2000073509A3 PCT/US2000/015404 US0015404W WO0073509A3 WO 2000073509 A3 WO2000073509 A3 WO 2000073509A3 US 0015404 W US0015404 W US 0015404W WO 0073509 A3 WO0073509 A3 WO 0073509A3
Authority
WO
WIPO (PCT)
Prior art keywords
dithp
provides
therapeutics
diagnostics
diagnostic assays
Prior art date
Application number
PCT/US2000/015404
Other languages
French (fr)
Other versions
WO2000073509A2 (en
Inventor
David M Hodgson
Stephen E Lincoln
Frank D Russo
Peter A Spiro
Steven C Banville
Shawn R Bratcher
Gerard E Dufour
Howard J Cohen
Bruce H Rosen
Michael S Chalup
Jennifer L Hillman
Anissa L Jones
Jimmy Y Yu
Lila B Greenawalt
Scott R Panzer
Ann M Roseberry
Rachel J Wright
Susan E Daniels
Original Assignee
Incyte Genomics Inc
David M Hodgson
Stephen E Lincoln
Frank D Russo
Peter A Spiro
Steven C Banville
Shawn R Bratcher
Gerard E Dufour
Howard J Cohen
Bruce H Rosen
Michael S Chalup
Jennifer L Hillman
Anissa L Jones
Jimmy Y Yu
Lila B Greenawalt
Scott R Panzer
Ann M Roseberry
Rachel J Wright
Susan E Daniels
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Incyte Genomics Inc, David M Hodgson, Stephen E Lincoln, Frank D Russo, Peter A Spiro, Steven C Banville, Shawn R Bratcher, Gerard E Dufour, Howard J Cohen, Bruce H Rosen, Michael S Chalup, Jennifer L Hillman, Anissa L Jones, Jimmy Y Yu, Lila B Greenawalt, Scott R Panzer, Ann M Roseberry, Rachel J Wright, Susan E Daniels filed Critical Incyte Genomics Inc
Priority to CA002381319A priority Critical patent/CA2381319A1/en
Priority to AU53209/00A priority patent/AU5320900A/en
Priority to EP00938123A priority patent/EP1268758A2/en
Publication of WO2000073509A2 publication Critical patent/WO2000073509A2/en
Publication of WO2000073509A3 publication Critical patent/WO2000073509A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6834—Enzymatic or biochemical coupling of nucleic acids to a solid phase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Organic Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

The present invention provides purified human polynucleotides for diagnostics and therapeutics (dithp). Also encompassed are the polypeptides (DITHP) encoded by dithp. The invention also provides for the use of dithp, or complements, oligonucleotides, or fragments thereof in diagnostic assays. The invention further provides for vectors and host cells containing dithp for the expression of DITHP. The invention additionally provides for the use of isolated and purified DITHP to induce antibodies and to screen libraries of compounds and the use of anti-DITHP antibodies in diagnostic assays. Also provided are microarrays containing dithp and methods of use.
PCT/US2000/015404 1999-06-01 2000-05-31 Molecules for diagnostics and therapeutics WO2000073509A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
CA002381319A CA2381319A1 (en) 1999-06-01 2000-05-31 Molecules for diagnostics and therapeutics
AU53209/00A AU5320900A (en) 1999-06-01 2000-05-31 Molecules for diagnostics and therapeutics
EP00938123A EP1268758A2 (en) 1999-06-01 2000-05-31 Molecules for diagnostics and therapeutics

Applications Claiming Priority (48)

Application Number Priority Date Filing Date Title
US13716199P 1999-06-01 1999-06-01
US60/137,161 1999-06-01
US13710999P 1999-06-02 1999-06-02
US13717399P 1999-06-02 1999-06-02
US13725899P 1999-06-02 1999-06-02
US13726099P 1999-06-02 1999-06-02
US13711399P 1999-06-02 1999-06-02
US13725999P 1999-06-02 1999-06-02
US13711499P 1999-06-02 1999-06-02
US60/137,260 1999-06-02
US60/137,109 1999-06-02
US60/137,113 1999-06-02
US60/137,259 1999-06-02
US60/137,258 1999-06-02
US60/137,173 1999-06-02
US60/137,114 1999-06-02
US13739699P 1999-06-03 1999-06-03
US13741799P 1999-06-03 1999-06-03
US13733799P 1999-06-03 1999-06-03
US13741199P 1999-06-03 1999-06-03
US60/137,396 1999-06-03
US60/137,411 1999-06-03
US60/137,337 1999-06-03
US60/137,417 1999-06-03
US14743699P 1999-08-04 1999-08-04
US14737799P 1999-08-04 1999-08-04
US60/147,436 1999-08-04
US60/147,377 1999-08-04
US14752099P 1999-08-05 1999-08-05
US14753699P 1999-08-05 1999-08-05
US14754299P 1999-08-05 1999-08-05
US14754199P 1999-08-05 1999-08-05
US14754999P 1999-08-05 1999-08-05
US14750099P 1999-08-05 1999-08-05
US14754799P 1999-08-05 1999-08-05
US14753099P 1999-08-05 1999-08-05
US14752799P 1999-08-05 1999-08-05
US14782499P 1999-08-05 1999-08-05
US60/147,541 1999-08-05
US60/147,530 1999-08-05
US60/147,547 1999-08-05
US60/147,527 1999-08-05
US60/147,824 1999-08-05
US60/147,520 1999-08-05
US60/147,542 1999-08-05
US60/147,536 1999-08-05
US60/147,500 1999-08-05
US60/147,549 1999-08-05

Related Child Applications (2)

Application Number Title Priority Date Filing Date
US09980285 A-371-Of-International 2001-11-30
US10/378,029 Continuation-In-Part US20040014087A1 (en) 1999-06-01 2003-02-28 Molecules for diagnostics and therapeutics

Publications (2)

Publication Number Publication Date
WO2000073509A2 WO2000073509A2 (en) 2000-12-07
WO2000073509A3 true WO2000073509A3 (en) 2001-04-26

Family

ID=27586737

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2000/015404 WO2000073509A2 (en) 1999-06-01 2000-05-31 Molecules for diagnostics and therapeutics

Country Status (3)

Country Link
EP (1) EP1268758A2 (en)
CA (1) CA2381319A1 (en)
WO (1) WO2000073509A2 (en)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6025191A (en) * 1995-06-07 2000-02-15 Ludwig Institute For Cancer Research Isolated nucleic acid molecules which encode a melanoma specific antigen and uses thereof
AU2001236519A1 (en) * 2000-01-24 2001-07-31 Millennium Pharmaceuitcals, Inc. Identification, assessment, prevention, and therapy of prostate cancer
AU2001243283A1 (en) * 2000-02-25 2001-09-03 Millennium Pharmaceuticals, Inc. 44576, a novel g-protein coupled receptor and uses therefor
WO2001066765A2 (en) * 2000-03-07 2001-09-13 Millennium Pharmaceuticals, Inc. 26583, a serine/threonine phosphatase and uses thereof
US7611892B2 (en) 2000-03-24 2009-11-03 President And Fellows Of Harvard College Prostate-specific or testis-specific nucleic acid molecules, polypeptides, and diagnostic and therapeutic methods
US7189565B2 (en) 2001-03-23 2007-03-13 Fahri Saatcioglu Prostate-specific or testis-specific nucleic acid molecules, polypeptides, and diagnostic and therapeutic methods
AU4941101A (en) * 2000-03-24 2001-10-08 Fahri Saatcioglu Novel prostate-specific or testis-specific nucleic acid molecules, polypeptides,and diagnostic and therapeutic methods
WO2001077339A1 (en) * 2000-04-07 2001-10-18 Merck Patent Gmbh Human pyruvate dehydrogenese phosphatase
WO2002064792A2 (en) * 2001-01-05 2002-08-22 Incyte Genomics, Inc. Molecules for disease detection and treatment
WO2002055738A2 (en) * 2001-01-12 2002-07-18 Incyte Genomics Inc Molecules for disease detection and treatment
WO2004016733A2 (en) 2002-08-16 2004-02-26 Agensys, Inc. Nucleic acid and corresponding protein entitled 251p5g2 useful in treatment and detection of cancer
AU2003287424A1 (en) * 2002-11-01 2004-06-07 Case Western Reserve University Methods of inhibiting glial scar formation
EP1652923B1 (en) 2003-08-08 2011-10-12 Perseus Proteomics Inc. Gene overexpressed in cancer
CN111269944A (en) * 2020-02-05 2020-06-12 青岛大学 Mouse cataract animal model and application thereof
CN115725733B (en) * 2022-08-10 2023-11-14 人和未来生物科技（长沙）有限公司 ZNF135 gene methylation detection reagent and application thereof

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995020681A1 (en) * 1994-01-27 1995-08-03 Incyte Pharmaceuticals, Inc. Comparative gene transcript analysis
WO1997033551A2 (en) * 1996-03-15 1997-09-18 Millennium Pharmaceuticals Compositions and methods for the diagnosis, prevention, and treatment of neoplastic cell growth and proliferation
WO1998025959A2 (en) * 1996-12-11 1998-06-18 Chiron Corporation Secreted human proteins
WO1998056951A1 (en) * 1997-06-11 1998-12-17 Abbott Laboratories Reagents and methods useful for detecting diseases of the lung
WO1999002724A2 (en) * 1997-07-11 1999-01-21 Mount Sinai Hospital Corporation Methods for identifying genes expressed in selected lineages, and a novel genes identified using the methods
JPH1169983A (en) * 1997-06-19 1999-03-16 Seikagaku Kogyo Co Ltd Polypeptide of heparan sulfate 6-o-sulfotransferase and dma capable of encoding the same

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995020681A1 (en) * 1994-01-27 1995-08-03 Incyte Pharmaceuticals, Inc. Comparative gene transcript analysis
WO1997033551A2 (en) * 1996-03-15 1997-09-18 Millennium Pharmaceuticals Compositions and methods for the diagnosis, prevention, and treatment of neoplastic cell growth and proliferation
WO1998025959A2 (en) * 1996-12-11 1998-06-18 Chiron Corporation Secreted human proteins
WO1998056951A1 (en) * 1997-06-11 1998-12-17 Abbott Laboratories Reagents and methods useful for detecting diseases of the lung
JPH1169983A (en) * 1997-06-19 1999-03-16 Seikagaku Kogyo Co Ltd Polypeptide of heparan sulfate 6-o-sulfotransferase and dma capable of encoding the same
WO1999002724A2 (en) * 1997-07-11 1999-01-21 Mount Sinai Hospital Corporation Methods for identifying genes expressed in selected lineages, and a novel genes identified using the methods

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
DATABASE EMHUM3 21 April 1999 (1999-04-21), RHODES: "HUMAN GENE FROM PAC 97K10, CHROMOSOME X, SIMILAR TO HEPARAN-SULPHATE 6-SULFOTRANSFERASE", XP002148155 *
DATABASE EMHUM3 31 October 1996 (1996-10-31), WRAY: "HUMAN DNA SEQUENCE FROM COSMID 97K10", XP002148156 *
HABUCHI HIROKO ET AL: "The occurrence of three isoforms of heparan sulfate 6-O-sulfotransferase having different specificities for hexuronic acid adjacent to the targeted N-sulfoglucosamine.", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 275, no. 4, 28 January 2000 (2000-01-28), pages 2859 - 2868, XP002148154, ISSN: 0021-9258 *
HIROKO HABUCHI ET AL: "PURIFICATION AND CHARACTERIZATION OF HEPARAN SULFATE 6-SULFOTRANSFERASE FROM THE CULTURE MEDIUM OF CHINESE HAMSTER OVARY CELLS", JOURNAL OF BIOLOGICAL CHEMISTRY,US,AMERICAN SOCIETY OF BIOLOGICAL CHEMISTS, BALTIMORE, MD, vol. 270, no. 8, 24 February 1995 (1995-02-24), pages 4172 - 4179, XP000605350, ISSN: 0021-9258 *
PATENT ABSTRACTS OF JAPAN vol. 1999, no. 08 30 June 1999 (1999-06-30) *

Also Published As

Publication number Publication date
EP1268758A2 (en) 2003-01-02
CA2381319A1 (en) 2000-12-07
WO2000073509A2 (en) 2000-12-07

Similar Documents

Publication Publication Date Title
WO2002097031A3 (en) Molecules for diagnostics and therapeutics
WO2004023973A3 (en) Molecules for diagnostics and therapeutics
WO2000073509A3 (en) Molecules for diagnostics and therapeutics
WO1998050554A3 (en) Enterococcus faecalis polynucleotides and polypeptides
WO2004037999A3 (en) A34 and a33-like 3 dna, proteins, antibodies thereto and methods of treatment using same
PL399351A1 (en) Antibody molecule, a compound containing it, DNA sequence, cloning and expression vector, host cell, method for preparing an antibody molecule, therapeutic or diagnostic composition, the use of a molecule or a compound
WO1997033909A3 (en) Compounds and methods for immunotherapy and immunodiagnosis of prostate cancer
WO2001004264A3 (en) Atherosclerosis-associated genes
EP1005540A4 (en) Ikk-beta proteins, nucleic acids and methods
WO2002083876A3 (en) Secretory molecules
WO2000020587A3 (en) Cancer associated antigens and uses therefor
WO2002046228A3 (en) Receptor for b. anthracis toxin
WO2003062376A3 (en) Molecules for diagnostics and therapeutics
WO2002040715A3 (en) Molecules for disease detection and treatment
WO2002020756A3 (en) Secretory molecules
WO2002012338A3 (en) Screening method
WO1998006841A3 (en) Two human nsp-like proteins
CA2127117A1 (en) DNA Encoding a Human Serotonin Receptor (5-HT4B) and Uses Thereof
WO2001062927A3 (en) Polypeptides and corresponding polynucleotides for diagnostics and therapeutics
WO2001062922A3 (en) Polypeptides and corresponding molecules for disease detection and treatment
WO2002020754A3 (en) Molecules for diagnostics and therapeutics
WO2003062385A3 (en) Secretory molecules
WO2002055738A3 (en) Molecules for disease detection and treatment
WO2001062918A3 (en) Secretory polypeptides and corresponding polynucleotides
WO2001021836A3 (en) Molecules for diagnostics and therapeutics

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AE AL AM AT AU AZ BA BB BG BR BY CA CH CN CU CZ DE DK EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MD MG MK MN MW MX NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT UA UG US US US US US US US US US US US US US US US US US US US US US US US US UZ VN YU ZA ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG

AK Designated states

Kind code of ref document: A3

Designated state(s): AE AL AM AT AU AZ BA BB BG BR BY CA CH CN CU CZ DE DK EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MD MG MK MN MW MX NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT UA UG US US US US US US US US US US US US US US US US US US US US US US US US UZ VN YU ZA ZW

AL Designated countries for regional patents

Kind code of ref document: A3

Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG

DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
WWE Wipo information: entry into national phase

Ref document number: 2381319

Country of ref document: CA

WWE Wipo information: entry into national phase

Ref document number: 09980285

Country of ref document: US

WWE Wipo information: entry into national phase

Ref document number: 2000938123

Country of ref document: EP

REG Reference to national code

Ref country code: DE

Ref legal event code: 8642

WWP Wipo information: published in national office

Ref document number: 2000938123

Country of ref document: EP

NENP Non-entry into the national phase

Ref country code: JP

WWW Wipo information: withdrawn in national office

Ref document number: 2000938123

Country of ref document: EP