WO2000071555A3 - 509rr - Google Patents

509rr Download PDF

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Publication number
WO2000071555A3
WO2000071555A3 PCT/US2000/011918 US0011918W WO0071555A3 WO 2000071555 A3 WO2000071555 A3 WO 2000071555A3 US 0011918 W US0011918 W US 0011918W WO 0071555 A3 WO0071555 A3 WO 0071555A3
Authority
WO
WIPO (PCT)
Prior art keywords
polypeptides
methods
utilizing
screen
producing
Prior art date
Application number
PCT/US2000/011918
Other languages
French (fr)
Other versions
WO2000071555A2 (en
Inventor
Weonhye Bae
Horn Stephanie Van
Richard L Warren
Sanjoy Biswas
John P Throup
Martin K R Burnham
Original Assignee
Smithkline Beecham Corp
Smithkline Beecham Plc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beecham Corp, Smithkline Beecham Plc filed Critical Smithkline Beecham Corp
Publication of WO2000071555A2 publication Critical patent/WO2000071555A2/en
Publication of WO2000071555A3 publication Critical patent/WO2000071555A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1223—Phosphotransferases with a nitrogenous group as acceptor (2.7.3)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/305—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Micrococcaceae (F)
    • C07K14/31—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Micrococcaceae (F) from Staphylococcus (G)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Communicable Diseases (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Microbiology (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

The invention provides 509RR polypeptides and polynucleotides encoding 509RR polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing 509RR polypeptides to screen for antibacterial compounds.
PCT/US2000/011918 1999-05-06 2000-05-03 509rr WO2000071555A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US13293599P 1999-05-06 1999-05-06
US60/132,935 1999-05-06

Publications (2)

Publication Number Publication Date
WO2000071555A2 WO2000071555A2 (en) 2000-11-30
WO2000071555A3 true WO2000071555A3 (en) 2001-05-31

Family

ID=22456248

Family Applications (2)

Application Number Title Priority Date Filing Date
PCT/US2000/011918 WO2000071555A2 (en) 1999-05-06 2000-05-03 509rr
PCT/US2000/011917 WO2000067783A1 (en) 1999-05-06 2000-05-03 509hk

Family Applications After (1)

Application Number Title Priority Date Filing Date
PCT/US2000/011917 WO2000067783A1 (en) 1999-05-06 2000-05-03 509hk

Country Status (1)

Country Link
WO (2) WO2000071555A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3342854A1 (en) 2015-08-26 2018-07-04 Universidad Pública De Navarra Mutant strains of staphylococcus aureus with multiple inactivated tcs systems

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5744338A (en) * 1996-01-19 1998-04-28 Smithkline Beecham P.L.C. DNA encoding seryl tRNA synthetase from Staphylococcus aureus
US5846772A (en) * 1995-12-22 1998-12-08 Smithkline Beecham P.L.C. Two component signal transduction system response regulator polynucleotides of Staphylococcus aureus

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5846772A (en) * 1995-12-22 1998-12-08 Smithkline Beecham P.L.C. Two component signal transduction system response regulator polynucleotides of Staphylococcus aureus
US5744338A (en) * 1996-01-19 1998-04-28 Smithkline Beecham P.L.C. DNA encoding seryl tRNA synthetase from Staphylococcus aureus

Also Published As

Publication number Publication date
WO2000071555A2 (en) 2000-11-30
WO2000067783A1 (en) 2000-11-16

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