WO2000071095A3 - Release of poorly soluble agents - Google Patents

Release of poorly soluble agents Download PDF

Info

Publication number
WO2000071095A3
WO2000071095A3 PCT/GB2000/001856 GB0001856W WO0071095A3 WO 2000071095 A3 WO2000071095 A3 WO 2000071095A3 GB 0001856 W GB0001856 W GB 0001856W WO 0071095 A3 WO0071095 A3 WO 0071095A3
Authority
WO
WIPO (PCT)
Prior art keywords
poorly soluble
core
release
soluble agents
active agent
Prior art date
Application number
PCT/GB2000/001856
Other languages
French (fr)
Other versions
WO2000071095A2 (en
Inventor
Charles Tokunbo Adesuyi
Mark Alexander Livingstone
David Montieth
Gordon Findlay Dawson
Original Assignee
Cenes Drug Delivery Ltd
Charles Tokunbo Adesuyi
Mark Alexander Livingstone
David Montieth
Gordon Findlay Dawson
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cenes Drug Delivery Ltd, Charles Tokunbo Adesuyi, Mark Alexander Livingstone, David Montieth, Gordon Findlay Dawson filed Critical Cenes Drug Delivery Ltd
Priority to AU50827/00A priority Critical patent/AU5082700A/en
Priority to JP2000619403A priority patent/JP2003500347A/en
Priority to EP00935270A priority patent/EP1198228A2/en
Priority to CA002374051A priority patent/CA2374051A1/en
Publication of WO2000071095A2 publication Critical patent/WO2000071095A2/en
Publication of WO2000071095A3 publication Critical patent/WO2000071095A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5026—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
    • A61K9/5042—Cellulose; Cellulose derivatives, e.g. phthalate or acetate succinate esters of hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

A controlled release pellet for releasing a poorly soluble active agent comprises a core containing the active agent (e.g. nifedipine, glibenclamide, griseofulvin, oxaprozin, ibuprofen, diclofenac, nabumetone etc.), a polyethylene glycol and a carrier; the core having a coating comprising a water soluble cellulose and a water insoluble acrylic polymer. A disintegrating agent is preferably included in the core.
PCT/GB2000/001856 1999-05-19 2000-05-18 Release of poorly soluble agents WO2000071095A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
AU50827/00A AU5082700A (en) 1999-05-19 2000-05-18 Release of poorly soluble agents
JP2000619403A JP2003500347A (en) 1999-05-19 2000-05-18 Release of poorly soluble drugs
EP00935270A EP1198228A2 (en) 1999-05-19 2000-05-18 Release of poorly soluble agents
CA002374051A CA2374051A1 (en) 1999-05-19 2000-05-18 Release of poorly soluble agents

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB9911546.1 1999-05-19
GBGB9911546.1A GB9911546D0 (en) 1999-05-19 1999-05-19 Release of poorly soluble agents

Publications (2)

Publication Number Publication Date
WO2000071095A2 WO2000071095A2 (en) 2000-11-30
WO2000071095A3 true WO2000071095A3 (en) 2001-01-25

Family

ID=10853685

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2000/001856 WO2000071095A2 (en) 1999-05-19 2000-05-18 Release of poorly soluble agents

Country Status (6)

Country Link
EP (1) EP1198228A2 (en)
JP (1) JP2003500347A (en)
AU (1) AU5082700A (en)
CA (1) CA2374051A1 (en)
GB (1) GB9911546D0 (en)
WO (1) WO2000071095A2 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4926495B2 (en) * 2006-02-22 2012-05-09 興和株式会社 Coated granules containing ibuprofen
WO2007096902A2 (en) * 2006-02-23 2007-08-30 Lupin Limited Solid oral dosage forms of griseofulvin
US20100151035A1 (en) * 2007-03-13 2010-06-17 Sandoz Ag Pharmaceutical compositions of poorly soluble drugs
CN111481527B (en) * 2020-04-30 2022-05-06 福建太平洋制药有限公司 Method for improving yield of ibuprofen sustained-release capsule finished product

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993000093A1 (en) * 1991-06-26 1993-01-07 Galephar P.R. Inc. Extended-release form of diltiazem
EP0551820A1 (en) * 1992-01-15 1993-07-21 Bayer Ag Taste-masked pharmaceutical compositions
EP0583726A2 (en) * 1992-08-19 1994-02-23 Kali-Chemie Pharma GmbH Enteric coated pancreative micropellets

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993000093A1 (en) * 1991-06-26 1993-01-07 Galephar P.R. Inc. Extended-release form of diltiazem
EP0551820A1 (en) * 1992-01-15 1993-07-21 Bayer Ag Taste-masked pharmaceutical compositions
EP0583726A2 (en) * 1992-08-19 1994-02-23 Kali-Chemie Pharma GmbH Enteric coated pancreative micropellets

Also Published As

Publication number Publication date
WO2000071095A2 (en) 2000-11-30
JP2003500347A (en) 2003-01-07
EP1198228A2 (en) 2002-04-24
CA2374051A1 (en) 2000-11-30
GB9911546D0 (en) 1999-07-21
AU5082700A (en) 2000-12-12

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