WO2000071090A1 - Oral compositions for controlling mouth and breath odors containing a zinc salt - Google Patents
Oral compositions for controlling mouth and breath odors containing a zinc salt Download PDFInfo
- Publication number
- WO2000071090A1 WO2000071090A1 PCT/US2000/014100 US0014100W WO0071090A1 WO 2000071090 A1 WO2000071090 A1 WO 2000071090A1 US 0014100 W US0014100 W US 0014100W WO 0071090 A1 WO0071090 A1 WO 0071090A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- percent
- weight
- zmc
- oral
- oral composition
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/27—Zinc; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/46—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur
- A61K8/463—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur containing sulfuric acid derivatives, e.g. sodium lauryl sulfate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q15/00—Anti-perspirants or body deodorants
Definitions
- the present invention relates to oral compositions for the control of volatile compounds associated with oral malodor.
- Oral composition means a composition for topical applications to the oral cavity to clean and care for the teeth as well as the oral cavity surfaces.
- Representatives of such compositions are oral hygiene products and dentifrices such as mouthwashes or rmses, toothpaste, dental gels, tooth powder, chewing gum, lozenges, and similar products.
- oral hygiene preparations In addition to cleaning teeth to remove dental plaque, the function of oral hygiene preparations is to stop the formation of dental calculus, to prevent dental disorders such as canes, pe ⁇ odontitis and gingivitis, and also to eliminate halitosis.
- Dental plaque is a deposit which forms on teeth and consists of inorganic and organic components de ⁇ ved from saliva, food and bacteria which are present in the oral cavity.
- HAP hydroxyapatite
- Oral malodor, or halitosis is caused by the putrefactive activity of microorganisms on appropriate substrate components of dental plaque, deb ⁇ s adhering to mucous membranes and salivary cellular elements to produce volatile sulfur compounds
- sulfur volatiles primarily consist of hydrogen sulfide (H,S), methyl mercaptan (CH-SH) and traces of dimethyl sulfide (CH 3 )-S.
- Volatile sulfur compounds, aromatic ammes, ammonia and urea have also been shown to increase m the mouth of patients suffering from pe ⁇ odontal disease
- Methods of inhibiting volatile sulfur compounds to reduce the production of mouth odor have included the use of dentifrices containing antimicrobials, such as, chlorhexidine.
- antimicrobials such as, chlorhexidine.
- side effects associated with chlorhexidme such as a bitter taste and staining of the teeth, tongue, gums and oral mucosa, precludes the use of chlorhexidme in oral compositions.
- the pnor art also shows oral compositions containing zmc salts such as zmc chlo ⁇ de, zmc iodide, zmc fluonde, zmc phenol sulfonate and the like as antiseptic agents, and correctives of oral conditions such as pyorrhea.
- Zmc chlo ⁇ de has commonly been used in oral formulations for its ast ⁇ ngency properties.
- Zmc phenol sulfonate has been utilized m the p ⁇ or art dentifrice compositions as an anti-plaque and anti-calculus agent as well as an odor inhibitor of fermentation and putrefaction which occurs in the oral cavity.
- Compositions m which these soluble zmc salts have been used have had the disadvantages such as leaving an unpleasant ast ⁇ ngent taste in the mouth and/or having short-lived efficacy against plaque, and as an odor inhibitor.
- a breath freshening toothpaste includes at least one solvent, a surfactant, a thickener and an amount of a zmc compound, preferably zinc chloride.
- a breath freshening ⁇ nse includes water and alcohol or other solvents, and an amount of a zinc component, preferably zmc chlo ⁇ de.
- the present invention includes zmc components contained in an solvent.
- the zmc component is a zinc salt which includes any that are physiologically acceptable m oral compositions.
- a preferred zmc salt is zinc chloride.
- the compositions according to the present invention also include a solvent such as water, alcohol, glyce ⁇ n or the like. Preferred solvents include sorbitol, glyce ⁇ n, polyethylene glycol, water or any similar physiologically acceptable solvent.
- solvents such as polyethylene glycol
- a surface-active agent or surfactant in the compositions.
- any physiologically acceptable surfactant, such as sodium lauryl sulfate is useful in the present invention.
- compositions according to the present invention may also be included in the compositions according to the present invention, such as for example abrasivesn (such as Zeodent), thickeners (again including for example, Zeodent), emulsifiers, sweeteners, dyes and the like, may also be included in the present compositions.
- abrasivesn such as Zeodent
- thickeners such as Zeodent
- emulsifiers such as sweeteners, dyes and the like
- a toothpaste according to the present invention may include the following: TABLE 1
- An oral ⁇ nse composition according the present invention has the following components.
- Flavor (Cmnamic Aldehyde) UJJ ⁇ T TJJjtJ " Sodium Sacchann (JT Baker) U ⁇ W
- polysorbate 80 is a surfactant, namely, a polyoxyethylene fatty acid ester.
- Poloximer 237 emulsifier a polyethylene polypropylene glycol are useful. It should be evident therefore, that the oral compositions according to the present invention and as descnbed above, carry out the objects of the invention as set forth. The present invention has been exemplified without attempting to show all of the va ⁇ ations which fall withm the scope of the invention. One skilled in the art will readily understand how to vary the composition components, amounts, and the like without departing from the scope of the invention.
Abstract
Description
Claims
Priority Applications (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP00939324A EP1180009A1 (en) | 1999-05-26 | 2000-05-23 | Oral compositions for controlling mouth and breath odors containing a zinc salt |
CA002371918A CA2371918A1 (en) | 1999-05-26 | 2000-05-23 | Oral compositions for controlling mouth and breath odors containing a zinc salt |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US13607099P | 1999-05-26 | 1999-05-26 | |
US60/136,070 | 1999-05-26 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2000071090A1 true WO2000071090A1 (en) | 2000-11-30 |
Family
ID=22471144
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2000/014100 WO2000071090A1 (en) | 1999-05-26 | 2000-05-23 | Oral compositions for controlling mouth and breath odors containing a zinc salt |
Country Status (3)
Country | Link |
---|---|
EP (1) | EP1180009A1 (en) |
CA (1) | CA2371918A1 (en) |
WO (1) | WO2000071090A1 (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP3085416A1 (en) * | 2015-04-23 | 2016-10-26 | Laboratoires Chemineau | Liquid or semi-liquid composition made of plants from the ericaceae family for oral application |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4082841A (en) * | 1975-10-10 | 1978-04-04 | Lever Brothers Company | Dentifrice |
EP0396232A2 (en) * | 1989-03-13 | 1990-11-07 | Vipont Pharmaceutical, Inc. | Oral rinse compositions |
EP0436284A1 (en) * | 1990-01-03 | 1991-07-10 | JOHNSON & JOHNSON CONSUMER PRODUCTS, INC. | Stable oral composition of zinc |
WO1997040812A1 (en) * | 1996-04-26 | 1997-11-06 | Warner-Lambert Company | Enhanced zinc containing oral composition |
US5948390A (en) * | 1997-08-25 | 1999-09-07 | Pfizer Inc. | Stable zinc/citrate/CPC oral rinse formulations |
-
2000
- 2000-05-23 CA CA002371918A patent/CA2371918A1/en not_active Abandoned
- 2000-05-23 EP EP00939324A patent/EP1180009A1/en not_active Withdrawn
- 2000-05-23 WO PCT/US2000/014100 patent/WO2000071090A1/en not_active Application Discontinuation
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4082841A (en) * | 1975-10-10 | 1978-04-04 | Lever Brothers Company | Dentifrice |
EP0396232A2 (en) * | 1989-03-13 | 1990-11-07 | Vipont Pharmaceutical, Inc. | Oral rinse compositions |
EP0436284A1 (en) * | 1990-01-03 | 1991-07-10 | JOHNSON & JOHNSON CONSUMER PRODUCTS, INC. | Stable oral composition of zinc |
WO1997040812A1 (en) * | 1996-04-26 | 1997-11-06 | Warner-Lambert Company | Enhanced zinc containing oral composition |
US5948390A (en) * | 1997-08-25 | 1999-09-07 | Pfizer Inc. | Stable zinc/citrate/CPC oral rinse formulations |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP3085416A1 (en) * | 2015-04-23 | 2016-10-26 | Laboratoires Chemineau | Liquid or semi-liquid composition made of plants from the ericaceae family for oral application |
Also Published As
Publication number | Publication date |
---|---|
EP1180009A1 (en) | 2002-02-20 |
CA2371918A1 (en) | 2000-11-30 |
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