WO2000070528A3 - Procede et appareil de bioinformatique cellulaire previsionnelle - Google Patents

Procede et appareil de bioinformatique cellulaire previsionnelle Download PDF

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Publication number
WO2000070528A3
WO2000070528A3 PCT/US2000/013154 US0013154W WO0070528A3 WO 2000070528 A3 WO2000070528 A3 WO 2000070528A3 US 0013154 W US0013154 W US 0013154W WO 0070528 A3 WO0070528 A3 WO 0070528A3
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WO
WIPO (PCT)
Prior art keywords
database
dbms
descriptor
information
features
Prior art date
Application number
PCT/US2000/013154
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English (en)
Other versions
WO2000070528A9 (fr
WO2000070528A2 (fr
Inventor
James H Sabry
Cynthia L Adams
Eugeni A Vaisberg
Anne M Crompton
Robert I Blum
Donald R Oestreicher
Nolan H Sigal
Original Assignee
Cytokinetics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US09/311,890 external-priority patent/US6743576B1/en
Application filed by Cytokinetics Inc filed Critical Cytokinetics Inc
Priority to EP00930696A priority Critical patent/EP1188139A2/fr
Priority to AU48471/00A priority patent/AU4847100A/en
Publication of WO2000070528A2 publication Critical patent/WO2000070528A2/fr
Publication of WO2000070528A3 publication Critical patent/WO2000070528A3/fr
Publication of WO2000070528A9 publication Critical patent/WO2000070528A9/fr

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    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
    • G—PHYSICS
    • G06—COMPUTING; CALCULATING OR COUNTING
    • G06V—IMAGE OR VIDEO RECOGNITION OR UNDERSTANDING
    • G06V20/00—Scenes; Scene-specific elements
    • G06V20/60—Type of objects
    • G06V20/69—Microscopic objects, e.g. biological cells or cellular parts
    • G06V20/695—Preprocessing, e.g. image segmentation
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B50/00—ICT programming tools or database systems specially adapted for bioinformatics

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  • Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Theoretical Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Medical Informatics (AREA)
  • Evolutionary Biology (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Analytical Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioethics (AREA)
  • Databases & Information Systems (AREA)
  • Biomedical Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Multimedia (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

L'invention concerne des techniques d'utilisation des technologies de l'information dans les méthodes thérapeutiques ou la découverte de médicaments. Dans un mode de réalisation servant d'exemple, l'invention a trait à des techniques de détermination d'informations sur les propriétés de substances sur la base d'informations sur la structure de cellules vivantes ou non vivantes mises en contact avec ces substances. Un procédé selon la présente invention permet à des chercheurs et/ou scientifiques de repérer des candidats prometteurs lors de la recherche de médicaments ou de traitements nouveaux et améliorés, grâce, par exemple, à une base de données informatique cellulaire. La présente invention concerne en outre un système d'acquisition de connaissances à partir d'informations cellulaires. Le système comprend une base de données (1012) comportant un module de gestion de base de données (« SGBD »). Le système comprend également plusieurs modules, y compris un module de population couplé au SGBD et destiné à classer par catégories et à mémoriser plusieurs caractéristiques (par exemple la taille des cellules, la distance entre les cellules, la population cellulaire, le type de cellules) relevées par un dispositif d'acquisition d'images, dans la base de données. Le système comprend un module de translation couplé au SGBD et destiné à définir un descripteur à partir d'un ensemble de caractéristiques sélectionnées parmi les multiples caractéristiques. Dans un mode de réalisation particulier, le descripteur provient d'un composé connu ou inconnu, tel qu'un médicament. Un module de prédiction couplé au SGBD est destiné à sélectionner plusieurs descripteurs provenant de composés connus ou inconnus dans la base de données sur la base d'un descripteur sélectionné provenant d'un composé sélectionné. Le composé sélectionné peut être un composé s'utilisant pour le traitement d'êtres humains ou d'autres êtres vivants.
PCT/US2000/013154 1999-05-14 2000-05-12 Procede et appareil de bioinformatique cellulaire previsionnelle WO2000070528A2 (fr)

Priority Applications (2)

Application Number Priority Date Filing Date Title
EP00930696A EP1188139A2 (fr) 1999-05-14 2000-05-12 Procede et appareil de bioinformatique cellulaire previsionnelle
AU48471/00A AU4847100A (en) 1999-05-14 2000-05-12 Method and apparatus for predictive cellular bioinformatics

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
US31199699A 1999-05-14 1999-05-14
US31087999A 1999-05-14 1999-05-14
US13410499P 1999-05-14 1999-05-14
US09/311,890 US6743576B1 (en) 1999-05-14 1999-05-14 Database system for predictive cellular bioinformatics
US09/311,996 1999-05-14
US60/134,104 1999-05-14
US09/310,879 1999-05-14
US09/311,890 1999-05-14

Publications (3)

Publication Number Publication Date
WO2000070528A2 WO2000070528A2 (fr) 2000-11-23
WO2000070528A3 true WO2000070528A3 (fr) 2001-03-08
WO2000070528A9 WO2000070528A9 (fr) 2001-11-29

Family

ID=27495080

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2000/013154 WO2000070528A2 (fr) 1999-05-14 2000-05-12 Procede et appareil de bioinformatique cellulaire previsionnelle

Country Status (2)

Country Link
AU (1) AU4847100A (fr)
WO (1) WO2000070528A2 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8114615B2 (en) 2006-05-17 2012-02-14 Cernostics, Inc. Method for automated tissue analysis

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6743576B1 (en) 1999-05-14 2004-06-01 Cytokinetics, Inc. Database system for predictive cellular bioinformatics
US20030228565A1 (en) * 2000-04-26 2003-12-11 Cytokinetics, Inc. Method and apparatus for predictive cellular bioinformatics
US7151847B2 (en) * 2001-02-20 2006-12-19 Cytokinetics, Inc. Image analysis of the golgi complex
US6651008B1 (en) 1999-05-14 2003-11-18 Cytokinetics, Inc. Database system including computer code for predictive cellular bioinformatics
US6876760B1 (en) 2000-12-04 2005-04-05 Cytokinetics, Inc. Classifying cells based on information contained in cell images
EP2363828A1 (fr) * 2000-10-24 2011-09-07 Cyntellect, Inc. Appareil pour le ciblage sélectif de cellules au sein d'un échantillon à trois dimensions
US7218764B2 (en) 2000-12-04 2007-05-15 Cytokinetics, Inc. Ploidy classification method
US6956961B2 (en) 2001-02-20 2005-10-18 Cytokinetics, Inc. Extracting shape information contained in cell images
EP1379855A1 (fr) 2001-02-20 2004-01-14 Cytokinetics Procede et appareil utilises dans le domaine de la bio-informatique cellulaire automatisee
US7016787B2 (en) * 2001-02-20 2006-03-21 Cytokinetics, Inc. Characterizing biological stimuli by response curves
US7396645B1 (en) 2002-12-17 2008-07-08 Entelos, Inc. Cholestasis signature
US7778782B1 (en) 2002-12-17 2010-08-17 Entelos, Inc. Peroxisome proliferation activated receptor alpha (PPARα) signatures
US7519519B1 (en) 2002-12-20 2009-04-14 Entelos, Inc. Signature projection score
US7422854B1 (en) 2002-12-20 2008-09-09 Entelos, Inc. Cholesterol reduction signature
EP1646926A2 (fr) 2003-07-18 2006-04-19 Cytokinetics, Inc. Caracterisation de stimuli biologiques par courbes de reponse
US20050014217A1 (en) 2003-07-18 2005-01-20 Cytokinetics, Inc. Predicting hepatotoxicity using cell based assays
US7235353B2 (en) 2003-07-18 2007-06-26 Cytokinetics, Inc. Predicting hepatotoxicity using cell based assays
US7323318B2 (en) 2004-07-15 2008-01-29 Cytokinetics, Inc. Assay for distinguishing live and dead cells
EP2686688B1 (fr) 2011-03-17 2019-05-08 Cernostics, Inc. Systèmes et compositions pour le diagnostic de l' oesophage de barrett et leurs procédés d'utilisation
GB2527755B (en) * 2014-06-28 2019-03-27 Siemens Medical Solutions Usa Inc System and method for retrieval of similar findings from a hybrid image dataset
WO2017091658A1 (fr) 2015-11-25 2017-06-01 Cernostics, Inc. Procédés de prédiction de la progression de l'endobrachyoesophage
US20240029403A1 (en) * 2022-06-27 2024-01-25 Viqi, Inc. Auto high content screening using artificial intelligence for drug compound development

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WO1997040055A1 (fr) * 1996-04-19 1997-10-30 The Dow Chemical Company Chelates fluorescents utilises en tant qu'agents visuels destines a l'imagerie et specifiques de certains tissus
WO1998038490A1 (fr) * 1997-02-27 1998-09-03 Cellomics, Inc. Systeme de criblage de cellules
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Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997040055A1 (fr) * 1996-04-19 1997-10-30 The Dow Chemical Company Chelates fluorescents utilises en tant qu'agents visuels destines a l'imagerie et specifiques de certains tissus
WO1998038490A1 (fr) * 1997-02-27 1998-09-03 Cellomics, Inc. Systeme de criblage de cellules
WO1998045704A2 (fr) * 1997-04-07 1998-10-15 Bioimage A/S Procede permettant d'extraire des informations quantitatives ayant trait a une influence exercee sur une reponse cellulaire
WO1999039184A1 (fr) * 1998-01-29 1999-08-05 Ribozyme Pharmaceuticals, Inc. Acquisition et analyse d'image d'une materiau biologique
WO2000017643A2 (fr) * 1998-09-18 2000-03-30 Cellomics, Inc. Systeme de criblage cellulaire
WO2000050872A2 (fr) * 1999-02-26 2000-08-31 Cellomics, Inc. Systeme de criblage cellulaire

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8114615B2 (en) 2006-05-17 2012-02-14 Cernostics, Inc. Method for automated tissue analysis
US8597899B2 (en) 2006-05-17 2013-12-03 Cernostics, Inc. Method for automated tissue analysis

Also Published As

Publication number Publication date
WO2000070528A9 (fr) 2001-11-29
WO2000070528A2 (fr) 2000-11-23
AU4847100A (en) 2000-12-05

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