WO2000066174A3 - Compounds - Google Patents

Compounds Download PDF

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Publication number
WO2000066174A3
WO2000066174A3 PCT/IE2000/000041 IE0000041W WO0066174A3 WO 2000066174 A3 WO2000066174 A3 WO 2000066174A3 IE 0000041 W IE0000041 W IE 0000041W WO 0066174 A3 WO0066174 A3 WO 0066174A3
Authority
WO
WIPO (PCT)
Prior art keywords
adduct
ranitidine
clarithromycin
base
compounds
Prior art date
Application number
PCT/IE2000/000041
Other languages
French (fr)
Other versions
WO2000066174A2 (en
Inventor
Helmut Schickaneder
Aggelos Kikolopoulos
Gesine Hermann
Original Assignee
Russinsky Ltd
Helmut Schickaneder
Aggelos Kikolopoulos
Gesine Hermann
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Russinsky Ltd, Helmut Schickaneder, Aggelos Kikolopoulos, Gesine Hermann filed Critical Russinsky Ltd
Priority to AU36680/00A priority Critical patent/AU3668000A/en
Publication of WO2000066174A2 publication Critical patent/WO2000066174A2/en
Publication of WO2000066174A3 publication Critical patent/WO2000066174A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/55—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound the modifying agent being also a pharmacologically or therapeutically active agent, i.e. the entire conjugate being a codrug, i.e. a dimer, oligomer or polymer of pharmacologically or therapeutically active compounds
    • A61K47/552—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound the modifying agent being also a pharmacologically or therapeutically active agent, i.e. the entire conjugate being a codrug, i.e. a dimer, oligomer or polymer of pharmacologically or therapeutically active compounds one of the codrug's components being an antibiotic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

An adduct contains Clarithromycin and Ranitidine either in the form of a base or a base hydrate in which the molar ratio of Clarithromycin to Ranitidine in the adduct is at least 2:1. The adduct has high stability and is particularly useful in a single dose formulation for the treatment of gastrointestinal disorders.
PCT/IE2000/000041 1999-04-29 2000-04-04 Compounds WO2000066174A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU36680/00A AU3668000A (en) 1999-04-29 2000-04-04 Compounds

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
IE990357 1999-04-29
IE990357 1999-04-29
IE990993 1999-11-29
IE990993 1999-11-29

Publications (2)

Publication Number Publication Date
WO2000066174A2 WO2000066174A2 (en) 2000-11-09
WO2000066174A3 true WO2000066174A3 (en) 2001-03-15

Family

ID=26320246

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IE2000/000041 WO2000066174A2 (en) 1999-04-29 2000-04-04 Compounds

Country Status (2)

Country Link
AU (1) AU3668000A (en)
WO (1) WO2000066174A2 (en)

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0533281A1 (en) * 1991-09-20 1993-03-24 Glaxo Group Limited The use of ranitidine bismuth citrate and one or more heliocobacte pylon-inhibiting antibiotics with manufacture of a medicament for treating gastrointestinal disorders
WO1998056357A1 (en) * 1995-12-19 1998-12-17 Abbott Laboratories A controlled release formulation for poorly soluble basic drugs
WO1999065890A1 (en) * 1998-06-17 1999-12-23 Russinsky Limited Ranitidine adduct

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0533281A1 (en) * 1991-09-20 1993-03-24 Glaxo Group Limited The use of ranitidine bismuth citrate and one or more heliocobacte pylon-inhibiting antibiotics with manufacture of a medicament for treating gastrointestinal disorders
WO1998056357A1 (en) * 1995-12-19 1998-12-17 Abbott Laboratories A controlled release formulation for poorly soluble basic drugs
WO1999065890A1 (en) * 1998-06-17 1999-12-23 Russinsky Limited Ranitidine adduct

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
FROTZ H ET AL: "[ Ranitidine and clarithromycin for eradication of Helicobacter pylori in patients with duodenal ulcer]. Ranitidin und Clarithromycin zur Eradikation von Helicobacter pylori bei Patienten mit Ulcus duodeni.", ARZNEIMITTEL-FORSCHUNG, (1995 FEB) 45 (2) 184-6., XP002155014 *

Also Published As

Publication number Publication date
WO2000066174A2 (en) 2000-11-09
IE20000248A1 (en) 2000-11-29
AU3668000A (en) 2000-11-17

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WO2000066174A3 (en) Compounds

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