WO2000064407A1 - Absorbent tissues providing skin barrier enhancement - Google Patents

Absorbent tissues providing skin barrier enhancement Download PDF

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Publication number
WO2000064407A1
WO2000064407A1 PCT/US2000/011089 US0011089W WO0064407A1 WO 2000064407 A1 WO2000064407 A1 WO 2000064407A1 US 0011089 W US0011089 W US 0011089W WO 0064407 A1 WO0064407 A1 WO 0064407A1
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Prior art keywords
oil
composition
weight percent
product
sterol
Prior art date
Application number
PCT/US2000/011089
Other languages
French (fr)
Inventor
Duane Gerard Krzysik
Brenda Marie Nelson
Beth Anne Lange
David Roland Otts
Original Assignee
Kimberly-Clark Worldwide, Inc.
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Publication date
Priority to US13090099P priority Critical
Priority to US60/130,900 priority
Priority to US37977799A priority
Priority to US09/379,777 priority
Application filed by Kimberly-Clark Worldwide, Inc. filed Critical Kimberly-Clark Worldwide, Inc.
Publication of WO2000064407A1 publication Critical patent/WO2000064407A1/en

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K8/00Cosmetics or similar toilet preparations
    • A61K8/18Cosmetics or similar toilet preparations characterised by the composition
    • A61K8/30Cosmetics or similar toilet preparations characterised by the composition containing organic compounds
    • A61K8/33Cosmetics or similar toilet preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/34Alcohols
    • A61K8/342Alcohols having more than seven atoms in an unbroken chain
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K8/00Cosmetics or similar toilet preparations
    • A61K8/02Cosmetics or similar toilet preparations characterised by special physical form
    • A61K8/0208Tissues; Wipes; Patches
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K8/00Cosmetics or similar toilet preparations
    • A61K8/18Cosmetics or similar toilet preparations characterised by the composition
    • A61K8/30Cosmetics or similar toilet preparations characterised by the composition containing organic compounds
    • A61K8/31Hydrocarbons
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K8/00Cosmetics or similar toilet preparations
    • A61K8/18Cosmetics or similar toilet preparations characterised by the composition
    • A61K8/30Cosmetics or similar toilet preparations characterised by the composition containing organic compounds
    • A61K8/33Cosmetics or similar toilet preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/34Alcohols
    • A61K8/345Alcohols containing more than one hydroxy group
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K8/00Cosmetics or similar toilet preparations
    • A61K8/18Cosmetics or similar toilet preparations characterised by the composition
    • A61K8/30Cosmetics or similar toilet preparations characterised by the composition containing organic compounds
    • A61K8/33Cosmetics or similar toilet preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/37Esters of carboxylic acids
    • A61K8/375Esters of carboxylic acids the alcohol moiety containing more than one hydroxy group
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K8/00Cosmetics or similar toilet preparations
    • A61K8/18Cosmetics or similar toilet preparations characterised by the composition
    • A61K8/30Cosmetics or similar toilet preparations characterised by the composition containing organic compounds
    • A61K8/49Cosmetics or similar toilet preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/4973Cosmetics or similar toilet preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K8/00Cosmetics or similar toilet preparations
    • A61K8/18Cosmetics or similar toilet preparations characterised by the composition
    • A61K8/30Cosmetics or similar toilet preparations characterised by the composition containing organic compounds
    • A61K8/60Sugars; Derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K8/00Cosmetics or similar toilet preparations
    • A61K8/18Cosmetics or similar toilet preparations characterised by the composition
    • A61K8/30Cosmetics or similar toilet preparations characterised by the composition containing organic compounds
    • A61K8/63Steroids; Derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K8/00Cosmetics or similar toilet preparations
    • A61K8/18Cosmetics or similar toilet preparations characterised by the composition
    • A61K8/72Cosmetics or similar toilet preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73Polysaccharides
    • A61K8/732Starch; Amylose; Amylopectin; Derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K8/00Cosmetics or similar toilet preparations
    • A61K8/18Cosmetics or similar toilet preparations characterised by the composition
    • A61K8/72Cosmetics or similar toilet preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/81Cosmetics or similar toilet preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
    • A61K8/8105Compositions of homopolymers or copolymers of unsaturated aliphatic hydrocarbons having only one carbon-to-carbon double bond; Compositions of derivatives of such polymers
    • A61K8/8111Homopolymers or copolymers of aliphatic olefines, e.g. polyethylene, polyisobutene; Compositions of derivatives of such polymers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K8/00Cosmetics or similar toilet preparations
    • A61K8/18Cosmetics or similar toilet preparations characterised by the composition
    • A61K8/72Cosmetics or similar toilet preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/81Cosmetics or similar toilet preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
    • A61K8/8135Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by an acyloxy radical of a saturated carboxylic acid, of carbonic acid or of a haloformic acid; Compositions of derivatives of such polymers, e.g. vinyl esters (polyvinylacetate)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K8/00Cosmetics or similar toilet preparations
    • A61K8/18Cosmetics or similar toilet preparations characterised by the composition
    • A61K8/92Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
    • A61K8/922Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILET PREPARATIONS
    • A61Q19/00Preparations for care of the skin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILET PREPARATIONS
    • A61Q19/00Preparations for care of the skin
    • A61Q19/007Preparations for dry skin

Abstract

A skin barrier-enhancing tissue product, such as facial tissue, bath tissue or paper towels and the like, can be made by applying, on the surface(s) of the tissue, a lipid-enriched melted oil based-hydrophobic composition comprising a natural fat or oil, a sterol or sterol derivative, an emulsifying surfactant having an HLB range from about 3 to about 6, a humectant, an emollient, a wax, and a viscosity enhancer, and thereafter resolidifying the composition to form a distribution of solid composition on the surface(s) of the tissue.

Description

Absorbent Tissues Providing Skin Barrier Enhancement

Field of the Invention

The present invention relates to the inclusion of a lipid-enriched hydrophobic lotion on absorbent tissue products, such as facial tissue, bath tissue, paper towels, and the like. More particularly, the present invention relates to the enhancement of skin barrier function by the delivery of oil based-hydrophobic compositions from the absorbent tissue products to the skin.

Background of the Invention

The stratum corneum is the outer-most layer of the skin and is responsible for regulating skin water levels and functioning as a barrier against chemicals and other stressors found in the environment. The complex arrangement of lipids in the intercellular space of the stratum corneum is responsible for the establishment of normal barrier function. Multi-layered structures of cholesterol, ceramides, and fatty acids, as well as some other minor lipids, provide the major barrier to the transport of hydrophillic substances into the or through the skin. The link between the barrier function and skin health is apparent from the skin inflammation caused by lipid extraction from the skin.

Skin barrier can be damaged due to a number of mechanisms. Physical abrasion, for example caused by the repeated rubbing of absorbent tissue products on the skin, strips away layers of the skin and thus damages skin barrier. Biological fluids, such as urine, feces, nasal and vaginal secretions, may contain a variety of components that can damage skin barrier. Examples of these components include proteases, lipases, bile acids, and fatty acids. Once the skin barrier is compromised, these components, in addition to other constituents of biological fluids, can initiate or exacerbate skin inflammation.

Excessive hydration also has a negative impact on skin barrier. Frequent contact of the skin with fluids such as nasal secretion can contribute to increased skin hydration. Increased skin hydration disrupts skin lipid organization in the stratum corneum. This disruption may increase the skin permeability of irritants, thus increasing the risk of skin inflammation.

Absorbent tissue products such as facial tissue and bath tissue have been used to absorb body fluids and leave the skin dry. Absorbent tissue, in addition to absorbing fluids, however, also abrade the skin during use and frequently do not leave the skin completely dry and free of the body fluid the tissue is trying to absorb. During frequent nose-blowing or perianal wiping, for example, the skin can become so abraded as to appear red and be sore to the touch. To reduce skin abrasion, tissue additive formulations can be applied to the tissue such that, in use, the additive formulation either provides lubricity causing the tissue to glide across the surface of the skin, or leaves the tissue and is deposited on the skin.

Once deposited on the skin, these additive formulations provide a skin benefit by occluding the skin. Thus, these formulations provide a short-term benefit by providing an artificial barrier, even though the underlying stratum corneum is still damaged.

Thus, what is needed in the art is formulation chemistry that, when applied from an absorbent tissue, enhances the skin's barrier function by delivering lipid chemistry while minimizing the physical damage caused by the rubbing of the said absorbent tissue on the skin surface.

Summary of the Invention

It has now been discovered that a skin barrier-enhancing aborbent tissue product can be made applying, on the tissue.an oil based-hydrophobic composition comprising a natural fat or oil, a sterol or sterol derivative, a humectant, an emulsifying surfactant having an HLB range from about 3 to about 6, an emollient, a wax, and optionally a viscosity enhancer, and thereafter resolidifying the composition to form a distribution, preferably a uniform distribution, of solid deposits on the surface(s) of the tissue. Because the composition is a solid at room temperature and rapidly solidifies after deposition, it has less tendency to penetrate and migrate into the sheet. Compared to tissues treated with liquid formulations, this leaves a greater percentage of the added anhydrous solid lotion composition on the surface of the tissue where it can contact and transfer to the user's skin to provide enhanced skin health benefits. Furthermore, a lower add-on amount can be used to deliver the same benefit at a lower cost because of the efficient placement of the composition substantially at the surface of the product.

Hence, in one aspect, the present invention is an oil based-hydrophobic composition comprising from about 0.1 to about 95 weight percent natural fats or oils, from about 0.1 to about 10 weight percent sterols or sterol derivatives, from about 0.5 to about 20 weight percent of humectant, from about 1 to about 20 weight percent of water-in-oil emulsifying surfactant having an HLB range from about 3 to about 6, from about 5 to about 95 weight percent emollient, from about 5 to about 95 weight percent wax, and optionally from about 0 to about 25 weight percent viscosity enhancer. The composition may have a melting point from about 30 °C. to about 100 °C. and a process viscosity of greater than about 50 centipoise. Also, the composition may have a penetration hardness of from about 5 millimeters to 360 millimeters.

In another aspect, the invention resides in a tissue or towel product wherein one or both of the outer surfaces of the product have solidified deposits of an oil based-hydrophobic composition comprising from about 0.1 to about 95 weight percent natural fats or oils, from about 0.1 to about 10 weight percent sterol or sterol derivative, from about 0.5 to about 20 weight percent of humectant, from about 1 to about 20 weight percent of water-in-oil emulsifying surfactant having an HLB range from about 3 to about 6, from about 5 to about 95 weight percent emollient, from about 5 to about 95 weight percent wax, and optionally from about 0 to about 25 weight percent viscosity enhancer. The composition may have a melting/freezing point of from about 30 °C. to about 100 °C. and a process viscosity of greater than about 50 centipoise. Also, the composition may have a penetration hardness from about 5 millimeters of penetration to 360 millimeters of penetration.

In another aspect, the invention resides in a method of making a tissue or towel product comprising: (a) heating a composition that enhances skin barrier comprising a natural fat or oil, a sterol or sterol derivative, humectant, a water-in-oil emulsifying surfactant having an HBL range from about 3 to about 6, an emollient, a wax, and optionally a viscosity enhancer, to a temperature above the melting point of the composition, causing the composition to melt; (b) uniformly applying the melted composition to one or both surfaces of the tissue or towel web in spaced-apart deposits; and (c) resolidifying the deposits of the melted composition. The composition may have a melting point ranging from about 30 °C. to 100 about 100 °C.

Detailed Description of the Invention

105 One embodiment of the present invention is a tissue or towel product having two outer surfaces. One or both outer surfaces of the product have solidified deposits of a composition that enhances skin barrier. The composition may comprise from about 0.1 to about 95 weight percent of natural fats or oils, from about 0.1 to about 10 weight percent of sterols or sterol derivatives, from about 1 to about 20 weight percent of water-in-oil emulsifying surfactant

110 having an HLB range from about 3 to about 6, from about 0.5 to about 20 weight percent of humectant, from about 5 to about 95 weight percent of emollient, from about 5 to aboutftδ weight percent of wax, and from about 0 to about 25 weight percent of viscosity enhancer.

The composition may have a melting point from about 30 °C to about 100 °C. The 115 composition may have a penetration hardness of from about 5 millimeters to about 360 millimeters. The add-on amount of the composition is from about 0.5 to about 30 weight percent based on the weight of said product. The add-on amount of the composition may also be expressed as from about 0.1 grams per meter squared (g/m2) to about 30 g/m2 of the tissue or towel product, and more preferably from about 0.5 g/m2 to about 25 g/m2. 120

The natural fat or oil used in the composition may include sunflower oil, borage oil, or avocado oil. The sterol or sterol derivative used in the composition may include soy sterol, cholesterol, or lanasterol. The humectant used in the composition may include glycerin, sorbitol, or starch hydrolysate. The emulsifying surfactant used in the composition may 125 include sorbitan oleate, sorbitan trioleate or sorbitan stearate. The emollient used in the composition may include petrolatum, mineral oil, or stearyl alcohol. The wax used in the composition may include cerasin, ozokerite, or microcrystalline wax. The viscosity enhancer used in the composition may include ethylene/vinyl acetate copolymer or polyethylene. Another embodiment of the present invention is a method of making a tissue or towel 130 product having two outer surfaces comprising: (a) heating a composition that enhances skin barrier comprising a natural fat or oil, sterol or sterol derivative, a humectant, an emulsifying surfactant having an HLB range from about 3 to about 6, an emollient, a wax, and viscosity enhancer, to a temperature above the melting point of the composition, causing the composition to melt; (b) applying the melted composition to one or both surfaces of a tissue 135 or towel web in spaced-apart deposits; and, (c) resolidifying said deposits of the melted composition.

The composition may have a melting point of from about 30 °C to about 100 °C. The resolidified composition may have a penetration hardness of from about 5 to about 360 140 millimeters. The melted composition may be applied by printing.

Another embodiment of the present invention is a skin barrier enhancing composition comprising from about 0.1 to about 95 weight percent of natural fats or oils, from about 0.1 to about 10 weight percent of sterol or sterol derivative, from about 1 to about 20 weight percent 145 of water-in-oil emulsifying surfactant having an HLB range from about 3 to about 6, from about 0.5 to about 20 weight percent of humectant, from about 5 to about 95 weight percent of emollient, from about 5 to about 95 weight percent of wax, and from about 0 to about 25 weight percent of viscosity enhancer.

150 The composition may have a melting point from about 30 °C. to about 100 °C. The resolidified composition may have a penetration hardness of from about 5 millimeters to about 360 millimeters.

The natural fat or oil of the composition may be selected from the group consisting of: 155 avocado oil, apricot oil, babassu oil, borage oil, camellia oil, canola oil, castor oil, chamomile, coconut oil, corn oil, cottonseed oil, evening primrose oil, hemp seed, hydrogenated cottonseed oil, hydrogenated palm kernal oil, maleated soybean oil, meadowfoam oil, palm kernal oil, phospholipids, rapeseed oil, palmitic acid, stearic acid, linoleic acid, rose hip oil, rose hip oil, safflower, sunflower oil, soybean oil, sweet almond, PROLIPID 141 (proprietary 160 blend of glyceryl stearate, fatty acids, fatty alcohols, and phospholipids), or derivatives of natural fats or oils (such as stearyl alcohol, lauryl alcohol, myristyl alcohol, and benenyl alcohol, and the like), as well as mixtures thereof. (PROLIPID is commercially available from International Specialty Products located in Wayne, New Jersey. PROLIPID is generally described in U.S. Patent No. 5,849,315 to Rerek et al. which issued December 15, 1998; 165 which is herein incorporated by reference to the extent it is consistent herewith.)

The sterol or sterol derivative of the composition may be selected from the group consisting of: cholesterol, sitosterol, stigmasterol, ergosterol, lanasterol, soy sterol, avocado sterols, sterol esters, and the like, as well as mixtures thereof. The emulsifying surfactant of 170 the composition may be selected from the group consisting of: sorbitan oleate, sorbitan sesquioleate, sorbitan stearate, sorbitan tristerate, sorbitan trioleate, and the like, as well as mixtures thereof.

The humectant of the composition may be selected from the group consisting of: 175 glycerin, hydrogenated starch hydrolysate, propylene glycol, sodium PCA, sodium lactate, sorbitol, and the like, as well as mixtures thereof. The emollient of the composition may be selected from the group consisting of: mineral oil, petrolatum, stearyl alcohol, cetearyl alcohol, cetyl alcohol, behenyl alcohol, octyldodecanol, cosmetic esters, and the like, as well as mixtures thereof.

180 The wax of the composition may be selected from the group consisting of: carnuba, cerasin, cetyl esters, microcrystalline wax, montan wax, ozokerite, synthetic wax, and the like, as well as mixtures thereof. The viscosity enhancer of the composition may be selected from the group consisting of: polyolefms resins, polyolefin polymers, ethylene/vinyl acetate copolymers, polyethylene, and the like, as well as mixtures

185 thereof.

The amount of the natural fats or oils used in the composition may be from about 0.1 to about 95 weight percent. The amount of the sterol or sterol derivative used in the composition may be from about 0.1 to about 10 percent. The amount of the emulsifying 190 surfactant used in the composition may be from about 1 to about 20 weight percent. The amount of the humectant used in the composition may be from about 0.5 to about 20 weight percent. The amount of the emollient used in the composition may be from about 5 to about 95 weight percent. The amount of the wax used in the composition may be from about 5 to about 95 weight percent. The amount of the viscosity enhancer used in the composition may 195 be from about 0 to about 25 weight percent.

One embodiment of the composition comprises about 10 weight percent sunflower oil, about 0.8 weight percent soy sterol, about 1 weight percent sorbitan oleate, about 5 weight percent glycerin, about 43.2 weight percent petrolatum, about 20 weight percent stearyl 200 alcohol, and about 20 weight percent cerasin.

Another embodiment of the composition comprises about 10 weight percent borage oil, about 0.8 weight percent soy sterol, about 1 weight percent sorbitan oleate, about 5 weight percent glycerin, about 43.2 weight percent petrolatum, about 20 weight percent 205 stearyl alcohol, and about 20 weight percent cerasin.

Another embodiment of the composition comprises about 10 weight percent avocado oil, about 0.8 weight percent soy sterol, about 1 weight percent sorbitan oleate, about 5 weight percent glycerin, about 43.2 weight percent petrolatum, about 20 weight percent 210 stearyl alcohol, and about 20 weight percent cerasin.

Another embodiment of the composition comprises about 2 weight percent PROLIPID 141 (International Specialty Products, Wayne, New Jersey), about 10 weight percent sunflower oil, about 1 weight percent soy sterol, about 1 weight percent sorbitan oleate, about 215 5 weight percent glycerin, about 32 weight percent petrolatum, about 15 weight percent behenyl alcohol, about 32 weight percent cerasin, and about 2 weight percent viscosity polyethylene.

Another embodiment of the composition comprises about 2 weight percent PROLIPID 220 141 (International Specialty Products, Wayne, New Jersey), about 30 weight percent sunflower oil, about 3 weight percent soy sterol, about 5 weight percent sorbitan oleate, about 5 weight percent sorbitol, about 10 weight percent petrolatum, about 10 weight percent behenyl alcohol, about 30 weight percent ozokerite, and about 5 weight percent polyethylene. 225 Another embodiment of the composition comprises about 5 weight percent lanolin, about 20 weight percent sunflower oil, about 3 weight percent cholesterol, about 5 weight percent sorbitan stearate, about 5 weight percent hydrogenated starch hydrolysate, about 2 weight percent petrolatum, about 5 weight percent octyldodecanol , about 15 weight percent stearyl alcohol, about 30 weight percent microcrystalline wax, and about 5 weight percent

230 ethylene/vinyl acetate copolymer.

Another embodiment of the composition comprises about 27 weight percent avocado oil, about 3 weight percent avocadin or avocado sterols, about 2 weight percent sorbitan trioleate, about 15 weight percent glycerin, about 17 weight percent petrolatum, about 18 235 weight percent cetyl alcohol, and about 18 weight percent cerasin.

Another embodiment of the composition comprises about 15 weight percent avocado oil, about 5 weight percent sterol esters, about 10 weight percent sorbitan trioleate, about 8 weight percent glycerin, about 2 weight percent petrolatum, about 55 weight percent of a 240 blend of ozokerite and cetyl esters, and about 5 weight percent polyethylene. The blend of ozokerite and cetyl esters comprises about 90 weight percent ozokerite and about 10 weight percent cetyl esters.

Another embodiment of the composition comprises about 25 weight percent borage 245 oil, about 10 weight percent avocadin or avocado sterols, about 5 weight percent sorbitan trioleate, about 1 weight percent glycerin, about 11 weight percent petrolatum, about 10 weight percent stearyl alcohol, about 36 weight percent cerasin, and about 2 weight percent polyethylene.

250 Another embodiment of the composition comprises about 25 weight percent sunflower oil, about 3 weight percent lanasterol, about 2 weight percent sorbitan trioleate, about 5 weight percent glycerin, about 15 weight percent petrolatum, about 10 weight percent stearyl alcohol, about 10 weight percent behenyl alcohol, about 45 weight percent microcrystallin wax, and about 5 weight percent polyethylene.

255

Another embodiment of the composition comprises about 35 weight percent avocado oil, about 3 weight percent sitosterol about 5 weight percent sorbitan trioleate, about 5 weight percent glycerin, about 1 weight percent petrolatum, about 10 weight percent stearyl alcohol, about 21 weight percent ozokerite, and about 10 weight percent polyethylene.

260

Another embodiment of the present invention is a method for enhancing/restoring/maintaining the skin barrier function of a user. The method comprises the steps of: a) contacting a tissue or towel product on the skin of said user wherein said

265 material comprises a skin barrier enhancing/restoring/maintaining composition that provides a skin barrier enhancing/restoring/maintaining benefit upon transfer of the composition to the user's skin; b) transferring at least a portion of the composition during use of the tissue or towel product;

270 c) repeating steps a) and b) with one or more additional tissue or towel product with sufficient frequency to enhance/restore/maintain the skin barrier in an area of skin contacted by the tissue or towel product, relative to skin contacted by an equivalent tissue or towel product that does not comprise the skin barrier enhancing/restoring/maintaining composition. 275 The skin barrier enhancing/restoring/maintaining composition of the method comprises from about 0.1 to about 95 weight percent of natural fats or oils, from about 0.1 to about 10 weight percent of sterols and sterol derivatives, from about 1 to about 20 weight percent of water-in- oil emulsifying surfactant having an HLB range from about 3 to about 6, from about 0.5 to about 20 weight percent of humectant, from about 5 to about 95 weight percent of emollient, 280 from about 5 to about 95 weight percent of wax, and from about 0 to about 25 weight percent of viscosity enhancer.

The composition may have a melting point from about 30 °C. to about 100 °C. The resolidified composition may have a process viscosity greater than about 50 centipoise. The

285 resolidified composition may have a penetration hardness of from about 5 to about 360 millimeters. The method may further comprise using a tissue or towel product having a skin- barrier enhancing/restoring/maintaining composition by the user on each use occasion. The method may further comprise using a tissue or towel product which does not comprise a skin- barrier enhancing/restoring/maintaining composition by the user intermittently. The method

290 may further comprise using the tissue or towel product comprising a skin-barrier enhancing/restoring/maintaining composition by a user whose skin is compromised and with sufficient frequency to improve skin-barrier function.

The amount of a natural fat or oil or a mixture of natural fats or oils in the oil based- 295 hydrophobic composition can be from about 0.1 to about 95 weight percent, more specifically from about 5 to about 75 weight percent, more specifically from about 10 to about 50 weight percent. As used herein, the phrase natural fats or oils is understood to include fats, oils, essential oils, fatty acids, fatty alcohols, phospholipids, and mixtures thereof. As used herein, suitable natural fats or oils include, but are not limited to, the following materials classified 300 according to CTFA designations:

Fats and Oils: Apricot Kernel Oil, Avocado Oil, Babassu Oil, Borage Seed Oil, Butter, C12-C18 Acid Triglyceride, Camellia Oil, Canola Oil, Caprylic/Capric/Lauric Triglyceride, Caprylic/Capric/Linoleic Triglyceride, Caprylic/Capric/Stearic Triglyceride, Caprylic/Capric

305 Triglyceride, Carrot Oil, Cashew Nut Oil, Castor Oil, Cherry Pit Oil, Chia Oil, Cocoa Butter, Coconut Oil, Cod Liver Oil, Corn Germ Oil, Corn Oil, Cottonseed Oil, C10-C18 Triglycerides, Egg Oil, Epoxidized Soybean Oil, Evening Primrose Oil, Glyceryl Triacetyl Hydroxystearate, Glyceryl Triacetyl Ricinoleate, Glycosphingolipids, Grape Seed Oil, Hazelnut Oil, Human Placental Lipids, Hybrid Safflower Oil, Hybrid Sunflower Seed Oil, Hydrogenated Castor Oil,

310 Hydrogenated Castor Oil Laurate, Hydrogenated Coconut Oil, Hydrogenated Cottonseed Oil, Hydrogenated C12-C18 Triglycerides, Hydrogenated Fish Oil, Hydrogenated Lard, Hydrogenated Menhaden Oil, Hydrogenated Mink Oil, Hydrogenated Orange Roughy Oil, Hydrogenated Palm Kernel Oil, Hydrogenated Palm Oil, Hydrogenated Peanut Oil, Hydrogenated Shark Liver Oil, Hydrogenated Soybean Oil, Hydrogenated Tallow,

315 Hydrogenated Vegetable Oil, Lard, Lauric/Palmitic/Oleic Triglyceride, Lanolin and Lanolin derivatives, Lesquerella Oil, Linseed Oil, Macadamia Nut Oil, Maleated Soybean Oil, Meadowfoam Seed Oil, Menhaden Oil, Mink Oil, Moringa Oil, Mortierella Oil, Neatsfoot Oil, Oleic/Linoleic Triglyceride, Oleic/Palmitic/Lauric/Myristic/Linoleic Triglyceride, Oleostearine, Olive Husk Oil, Olive Oil, Omental Lipids, Orange Roughy Oil, Palm Kernel Oil, Palm Oil,

320 Peach Kernel Oil, Peanut Oil, Pengawar Djambi Oil, Pentadesma Butter, Phospholipids,

Pistachio Nut Oil, Placental Lipids, Rapeseed Oil, Rice Bran Oil, Safflower Oil, Sesame Oil, Shark Liver Oil, Shea Butter, Soybean Oil, Sphingolipids, Sunflower Seed Oil, Sweet Almond Oil, Tall Oil, Tallow, Tribehenin, Tricaprin, Tricaprylin, Triheptanoin, Trihydroxymethoxystearin, Trihydroxystearin, Triisononanoin, Triisostearin, Trilaurin, 325 Trilinolein, Trilinolenin, Trimyristin, Trioctanoin, Triolein, Tripalmitin, Trisebacin, Tristearin, Triundecanoin, Vegetable Oil, Walnut Oil, Wheat Bran Lipids, Wheat Germ Oil, Zadoary Oil, and the like, as well as mixtures thereof.

Fatty Acids: Arachidic Acid, Arachidonic Acid, Behenic Acid, Capric Acid, Caproic Acid, 330 Caprylic Acid, Coconut Acid, Corn Acid, Cottonseed Acid, Hydrogenated Coconut Acid,

Hydrogenated Menhaden Acid, Hydrogenated Tallow Acid, Hydroxystearic Acid, Isostearic Acid, Laurie Acid, Linoleic Acid, Linolenic Acid, Linseed Acid, Myristic Acid, Oleic Acid, Palmitic Acid, Palm Kernel Acid, Pelargonic Acid, Ricinoleic Acid, Soy Acid, Stearic Acid, Tall Oil Acid, Tallow Acid, Undecanoic Acid, Undecylenic Acid, Wheat Germ Acid, and the like, as 335 well as mixtures thereof.

Fatty Alcohols: Behenyl Alcohol,

Figure imgf000013_0001
Alcohols, C12-C13 Alcohols, C12-C15 Alcohols, C12-C16 Alcohols, C14-C15 Alcohols, Caprylic Alcohol, Cetearyl Alcohol, Cetyl Alcohol, Coconut Alcohol, Decyl Alcohol, Hydrogenated Tallow Alcohol, Lanolin Alcohol, Lauryl Alcohol, 340 Myristyl Alcohol, Oleyl Alcohol, Palm Alcohol, Palm Kernel Alcohol, Stearyl Alcohol, Tallow Alcohol, Tridecyl Alcohol, and the like, as well as mixtures thereof.

Essential Oils: Anise Oil, Balm Mint Oil, Basil Oil, Bee Balm Oil, Bergamot Oil, Birch Oil, Bitter Almond Oil, Bitter Orange Oil, Calendula Oil, California Nutmeg Oil, Caraway Oil,

345 Cardamom Oil, Chamomile Oil, Cinnamon Oil, Clary Oil, Cloveleaf Oil, Clove Oil, Coriander Oil, Cypress Oil, Eucalyptus Oil, Fennel Oil, Gardenia Oil, Geranium Oil, Ginger Oil, Grapefruit Oil, Hops Oil, Hyptis Oil, Indigo Bush Oil, Jasmine Oil, Juniper Oil, Kiwi Oil, Laurel Oil, Lavender Oil, Lemongrass Oil, Lemon Oil, Linden Oil, Lovage Oil, Mandarin Orange Oil, Matricaria Oil, Musk Rose Oil, Nutmeg Oil, Olibanum, Orange Flower Oil, Orange Oil,

350 Patchouli Oil, Pennyroyal Oil, Peppermint Oil, Pine Oil, Pine Tar Oil, Rose Hips Oil,

Rosemary Oil, Rose Oil, Rue Oil, Sage Oil, Sambucus Oil, Sandalwood Oil, Sassafras Oil, Silver Fir Oil, Spearmint Oil, Sweet Marjoram Oil, Sweet Violet Oil, Tar Oil, Tea Tree Oil, Thyme Oil, Wild Mint Oil, Yarrow Oil, Ylang Ylang Oil, and the like, as well as mixtures thereof.

355 The preferred natural oils include, but not limited to: Avocado Oil, Apricot Oil, Babassu Oil, Borage Oil, Camellia oil, Canola oil, Castor Oil, Coconut oil, Corn Oil, Cottonseed Oil, Evening Primrose Oil, Hydrogenated Cottonseed Oil, Hydrogenated Palm Kernal Oil, Maleated Soybean Oil, Meadowfoam Oil, Palm Kernal Oil, Phospholipids,

360 Rapeseed Oil, Palmitic Acid, Stearic Acid, Linoleic Acid, Rose Hip Oil, Sunflower Oil,

Soybean Oil, PROLIPID 141 (proprietary blend of Glyceryl Stearate, Fatty Acids, Fattty Alcohols , and Phospholipids from International Specialty Products, Wayne, New Jersey), derivatives of natural fats or oils (such as Stearyl Alcohol, Lauryl Alcohol, Myristyl Alcohol, Benenyl Alcohol, and the like), and the like, as well as mixtures thereof.

365

The amount of a sterol or sterol derivative or mixture of sterols or sterol derivatives in the oil based-hydrophobic composition can be from about 0.1 to about 10 weight percent, more specifically from about 0.5 to about 5 weight percent, and still more specifically from about 0.8 to about 1 weight percent. As used herein, suitable sterols and sterol derivatives

370 include, but are not limited to, the following materials: β-sterols having a tail on the 17 position and having no polar groups, for example cholesterol, sitosterol, stigmasterol, and ergosterol, as well as C10-C30 cholesterol/lanosterol esters, cholecalciferol, cholesteryl hydroxystearate, cholesteryl isostearate, cholesteryl stearate, 7-dehydrocholesterol, dihydrocholesterol, dihydrocholesteryl octyldecanoate, dihydrolanosterol, dihydrolanosteryl

375 octyldecanoate, ergocalciferol, tall oil sterol, soy sterol acetate, lanasterol, soy sterol, avocado sterols, sterol esters, and the like, and sourced from natural extracts (such as avocadin and lanolin, and the like), as well as mixtures thereof.

The amount of water-in-oil emulsifying surfactant/surfactant combinations having an 380 HLB range from about 3 to about 6 in the oil based-hydrophobic composition can be from about 1 to about 20 weight percent, more specifically from about 2 to about 10 weight percent, and still more specifically from about 3 to about 8 weight percent. Emulsifying surfactants are employed typically in cosmetic preparations to form emulsions of various components. The immiscible phase, such as water and water soluble/dispersible materials, 385 is dispersed as droplets in the continuous phase, such as an oil. The preferred surfactants include, but are not limited to: Sorbitan monooleate, glyceryl stearate, sorbitan sequioleate, sorbitan trioleate, sorbitan stearate, sorbitan tristearate, and the like, as well as mixtures thereof.

390

The amount of humectant in the oil based-hydrophobic composition can be from about 0.5 to about 20 weight percent, more specifically from about 1 to about 15 weight percent, and still more specifically from about 3 to about 10 weight percent. Humectants are typically cosmetic ingredients used to increase the water content of the tip layers of the skin. This

395 group of materials includes primarily hydroscopic ingredients. As used herein, suitable humectants include, but are not limited to, the following materials: Acetamide MEA, Aloe Vera Gel, Arginine PCA, Chitosan PCA, Copper PCA, Corn Glycerides, Dimethyl Imidazolidinone, Fructose, Glucamine, Glucose, Glucose Glutamate, Glucuronic Acid, Glutamic Acid, Glycereth-7, Glycereth-12, Glycereth-20, Glycereth-26, Glycerin, Honey,

400 Hydrogenated Honey, Hydrogenated Starch Hydrolysate, Hydrolyzed Corn Starch, Lactamide MEA, Lactic Acid, Lactose Lysine PCA, Mannitol, Methyl Gluceth-10, Methyl Gluceth-20, PCA, PEG-2 Lactamide, PEG-10 Propylene Glycol, Polyamino Sugar Condensate, Potassium PCA, Propylene Glycol, Propylene Glycol Citrate, Saccharide Hydrolysate, Saccharide Isomerate, Sodium Aspartate, Socium Lactate, Sodium PCA, Sorbitol, TEA-

405 Lactate, TEA-PCA, Urea, Xylitol, and the like, as well as mixtures thereof.

The preferred humectants include, but are not limited to: Glycerin, Hydrogenated Starch Hydrolysate, Propylene glycol, Sodium PCA, Sodium Lactate, Sorbitol and the like, as well as mixtures thereof.

410 The amount of emollient in the oil based-hydrophobic composition may be from about

5 to about 95 weight percent, more specifically from about 15 to about 80 weight percent, and still more specifically from about 20 to about 65 weight percent. As used herein, suitable emollients include, but are not limited to, the following materials: mineral oil, mineral jelly, petrolatum, cosmetic esters (isoproyl palmitate, isopropyl myristate, isopropyl adipate, C12-C14

415 benzoate, stearyl benzoate, behenyl benzoate, octyl palmitate and the like), glyceryl esters, alkoxylated carboxylic acids, alkoxylated alcohols, fatty alcohols (lauryl alcohol, myristyl alcohol, cetyl alcohol, stearyl alcohol, ceateryl alcohol, behenyl alcohol, octyl dodecanol, and the like), lanolin and lanolin derivatives, natural oils, base oils, silicones, organofunctional silicones, hydrogenated vegetable oils, and the like, as well as mixtures thereof.

420

The preferred emollients include, but are not limited to: Mineral Oil, Petrolatum, cosmetic esters, fatty alcohols and the like, as well as mixtures thereof.

The amount of wax in the oil based-hydrophobic composition can be from about 5 to 425 about 95 weight percent, more specifically from about 10 to about 75 weight percent, and still more specifically from about 20 to about 60 weight percent. As used herein, suitable waxes include, but are not limited to, the following materials: natural and synthetic waxes, such as bayberry wax, beeswax, C30 alkyl dimethicone, candelilla wax, camuaba, ceresin, setyl esters, hydrogenated cottonseed oil, hydrogenated jojoba oil, hydrogenated jojoba wax, 430 hydrogenated microcrystalline wax, hydrogenated rice bran wax, japan wax, jojoba butter, jojoba esters, jojoba wax, lanolin wax, microcrystalline wax, mink wax, montan acid wax, montan wax, ouricury wax, ozokerite, paraffin, PEG-6 beeswax, PEG-8 beeswax, rice bran wax, shellac wax, spent grain wax, steryl dimethicone synthetic beeswax, synthetic candelilla wax, synthetic carnuba wax, synthetic japan wax, synthetic jojoba wax, synthetic wax, and 435 the like, as well as mixtures thereof.

The preferred waxes include but are not limited to: carnuba, cerasin, cetyl esters, microcrystalline wax, montan wax, ozokerite, synthetic wax, and the like, as well as mixtures thereof.

440

Optionally, the amount of viscosity enhancer in the oil based-hydrophobic composition can be from about 0 to about 25 weight percent, more specifically from about 5 to about 20 weight percent, and still more specifically from about 10 to about 15 weight percent. As used herein, suitable viscosity enhancers include, but are not limited to, the following materials: the

445 group consisting of polyolefins resins, polyolefin polymers, ethylene/vinyl acetate copolymers, polyethylene and the like, as well as mixtures thereof.

Resolidification of the melted oil based-hydrophobic composition can occur almost instantaneously, without the need for external cooling means such as chill rolls, if the 450 composition is heated to a temperature only slightly above or at the melting point of the composition. However, external means such as chill rolls, either before or after the application of melt, can be used if desired to accelerate resolidification. Such instantaneous resolidification tends to impede penetration of the composition into the tissue and retain it on the surface of the tissue, which is advantageous. For example, the temperature of the

455 melted composition can advantageously be above the melting point about 10 °C. or less, more specifically about 5 °C. or less and still more specifically about 2 °C. or less. As the temperature of the melted composition approaches the melting point, the viscosity of the melted composition generally increases, which further enhances the tendency of the melted composition to be retained on the surface.

460

For purposes herein, "melting point" is the temperature at which the majority of the melting occurs, it being recognized that melting actually occurs over a range of temperatures. The melting point of the compositions of this invention can be from about 30 °C. to about 100 °C, more specifically from about 40 °C. to about 90 °O, and still more specifically from about

465 50 °C. to about 70 °C.

In addition, for purposes herein, "penetration hardness" is the needle penetration in millimeters according to ASTM D 1321 , "Needle Penetration of Petroleum Waxes. Lower needle penetration hardness values correspond to harder materials. The penetration

470 hardness of the compositions of this invention can be from about 5 to 360 millimeters, more specifically from about 5 to about 200 millimeters, more specifically from about 5 to about 150 millimeters, and still more specifically from about 5 to about 00 millimeters. (Formulations having a needle penetration hardness greater than 360 millimeters cannot be measured using ASTM method D 1321).

475

The hardness of the formulations of this invention is important for two reasons. First, the softer the formulation the more mobile the formulation will be, making the formulation more likely to migrate to the inner plies of the tissue, which is not desirable. Secondly, softer formulations tend to be more greasy/oily to the touch, which is also less desirable. In

480 general, formulations having a needle penetration hardness of from about 200 to 360 millimeters feel creamy to slightly greasy with less smoothness (depending on additives). Formulations that have needle penetration hardness values of from about 5 to about 200 millimeters feel silky to creamy and very smooth (depending on additives). 485 The melt point viscosity and/or the process temperature viscosity of the formulations or compositions of this invention is important for two reasons: First, the higher the melt point viscosity or the process temperature viscosity as it is applied to the outside surface of the diaper liner, the formulation is less likely to penetrate through to the inner ply(s) of the tissue. The less formulation penetrates through the tissue, the more there is on the surface of the

490 tissue where it can readily transfer to the users skin surface. Secondly, the higher the viscosity of the formulation above or at the melting point of the formulation, the less likely the formulation will migrate at typical or adverse storage conditions.

In order to better enhance the benefits to consumers, additional ingredients can be

495 used. The classes of ingredients and their corresponding benefits include, without limitation: antiacne actives (a drug product used to reduce the number of acne blemishes, acne pimples, blackheads, and whiteheads); antifoaming agents (reduce the tendency of foaming during processing); antimicrobial actives; antifungal actives; antiseptic actives; antioxidants (product integrity to prevent oxidation of the natural oils or other formulation ingredients);

500 astringents - cosmetic (induce a tightening or tingling sensation on skin); astringent - drug (a drug product which checks oozing, discharge, or bleeding when applied to skin or mucous membrane and works by coagulating protein); biological additives (enhance the performance or consumer appeal of the product including vitamins); colorants (impart color to the product); deodorants (reduce or eliminate unpleasant odor and protect against the formation

505 of malodor on body surfaces); emollients (help to maintain the soft, smooth, and pliable appearance of the skin by their ability to remain on the skin surface or in the stratum corneum to act as lubricants, to reduce flaking, and to improve the skin's appearance); film formers (to hold active ingredients on the skin by producing a continuous film on skin upon drying); fragrances (consumer appeal); natural moisturizing agents (NMF) and other skin

510 moisturizing ingredients known in the art; skin conditioning agents; skin exfoliating agents (ingredients that increase the rate of skin cell turnover such as alpha hydroxy acids and beta hydroxyacids); skin protectants (a drug product which protects injured or exposed skin or mucous membrane surface from harmful or annoying stimuli); solvents (liquids employed to dissolve components found useful in the cosmetics or drugs); sunscreens (ingredients that

515 absorb at least 85 percent of the light in the UV range at wavelengths from 290 to 420 manometers, but transmit UV light at wavelengths longer than 420 manometers); and, surfactants (as cleansing agents, solubilizing agents, suspending agents, and wetting agents).

520 The total tissue add-on of the composition can be from about 0.5 to about 40 weight percent, more specifically from about 5 to about 30 weight percent, and more specifically from about 10 to about 15 weight percent, based on the weight of the tissue. The add-on amount will depend upon the desired effect of the composition on the product attributes and the specific composition. A preferred method to uniformly apply the heated composition to

525 the surface of the tissue web is rotogravure printing, either direct or indirect (offset), because it is a more precise exact printing process and offers maximum control of the composition distribution and transfer rate. However, other printing methods, but not limited to, flexographic printing or spraying such as WEKO, can be used.

530 As used herein, all recited ranges of amounts, temperatures, molecular weights and penetration hardnesses are intended to include all sub-ranges within the recited ranges, even though not specifically stated.

The compositions of the present invention may be applied to the entire outer 535 surface(s) of the tissue or towel product or portions thereof. The compositions of the present invention may be applied non-uniformly to the outer surface of the tissue or towel product. The term "non-uniformly", as used herein, refers to the amount, pattern of distribution, thickness of the application, areas of non-coverage, or the like, for which the composition can be varied over the outer surface(s) of the tissue or towel product. 540

Also as used herein, a "tissue product" can be a facial tissue, bath tissue, paper towel, dinner napkin or the like. The tissue products of this invention can be one-ply, two-ply, three- ply or more. In all cases, the composition is applied to one or both outer surfaces of the product after the product has been dried. The composition can be applied after the plies are 545 brought together or prior to bringing the plies together. The individual plies can be layered or blended (homogeneous) creped or uncreped, throughdried or wet-pressed. Examples

550

The following examples are presented to provide a more detailed understanding of the invention. The particular materials and parameters are exemplary and are not intended to limit the scope of the invention.

555 The following formulas are used in Examples 1-4.

Formula 1 weight percent

Petrolatum 93.7%

Glycerin 5%

560 PROLIPID 141 1.0%

(International Specialty Products, Wayne, NJ) Tocopherol acetate 0.3%

Formula 2 weight percent

565 Petrolatum 88.7%

Glycerin 5%

PROLIPID 141 1.0%

(International Specialty Products, Wayne, NJ)

Tocopherol acetate 0.3% 570 Avocadin (CRODA) 5.0%

Formula 3 weight percent

Petrolatum 83.7%

Glycerin 5%

575 Tocopherol acetate 0.3%

Sunflower oil 9.2%

Soy sterol 0.8%

PROLIPID 141 (ISP) 1.0%

(International Specialty Products, Wayne, NJ)

580

Formula 4 weight percent

Petrolatum 100%

Formula 5 weight percent

585 Petrolatum 85.4%

Glycerin 5%

Glyceryl monoleate 3%

Borage oil 3%

Soy sterol 3%

590 Aloe 0.3%

Tocopherol acetate 0.3% Formula 6 weight percent

Petrolatum 86.4

595 Glycerin 5%

Glyceryl monoleate 3%

Borage oil 3%

Soy sterol 1%

PROLIPID 141(ISP) 1.0%

600 (International Specialty Products, Wayne, NJ)

Aloe 0.3%

Tocopherol acetate 0.3%

Formula 7 weight percent

605 Petrolatum 44%

Mineral oil 10.8%

Cerasin 10%

Stearyl alcohol 25%

Isopropyl palmitate 3%

610 Sunflower oil 3%

Soy sterol 3%

Dimethicone 1%

Aloe Extract 0.1%

Vitamin E acetate 0.1%

615

Formula 8 weight percent

Petrolatum 36%

Mineral oil 10.8%

Cerasin 10%

620 Stearyl alcohol 25%

Glycerin 5%

Glyceryl mono-oleate 3%

Isopropyl palmitate 3%

Sunflower oil 3%

625 Soy sterol 3%

Dimethicone 1%

Aloe Extract 0.1%

Vitamin E acetate 0.1%

630

Example 1

Lipid-enriched formulations for treatment of absorbent tissue promote barrier repair as measured by TEWL..

635 All studies were conducted in a temperature and humidity controlled room (71° ± 5° F; 40% ± 5% relative humidity).

Transepidermal water loss (TEWL)

640

The volar forearm of 24 panelists was abraded by an emery cloth to increase TEWL levels to 18-20 g/m2h. After abrasion, fifteen microliters of a lipid-enriched formulation was topically applied to the volar forearm. TEWL measurements were obtained using a Dermalab evaporimeter instrument at 1 , 2, and 4 hours. Mean TEWL values are expressed in Table 1. 645 Repeated measures ANOVA was used to adjust for the repeated TEWL measures.

Table 1 : TEWL (g/m2/hr) Results- Lipid-enriched absorbent tissue formulations

PIR 1 Hour 2 Hour 4 Hour Mean Mean Mean Mean

Formula 1 19.8 6.6 * 6.6 * 7.9 Formula 2 18.3 6.4 * 6.6 * 7.3 Formula 3 19.2 6.5 * 6.5 * 7.1

Untreated 19.2 15.2 14.3 14.3

* denotes significantly different than untreated site.

650 The above data clearly demonstrates that the lipid-enriched formulations improve skin barrier repair.

Example 2

655 Lipid-enriched formulations for treatment of absorbent tissue enhance skin moisturization as measured by conductance.

All studies were conducted in a temperature and humidity controlled room (71 ° ± 5° F; 40% ± 5% relative humidity).

660

Conductance

Fifteen microliters of lipid-enriched formulation for an absorbent tissue was topically applied to the volar forearm. Conductance measurements were obtained using the Skicon 665 instrument at 1 , 2, 4, and 6 hours. Mean conductance values are expressed in Table 2. A pair-wise comparison for each time period using univariate ANOVAs was applied.

Table 2: Conductance- Lipid-enriched formulations for absorbent tissues

Baseline 1 Hour 2 Hour 4 Hour 6 Hour

Mean Mean Mean Mean Mean

Formula 1 202 370* 357* 335* 310*

Formula 2 220 344* 349* 333* 319*

Formula 3 220 342* 340* 333* 320*

Untreated 200 220 235 232 223

* denotes significantly different than untreated site. 670

The above data clearly demonstrates that the lipid-enriched formulations improve skin barrier moisturization.

675 Example 3

Lipid-enriched formulations for treatment of absorbent tissue enhance skin moisturization as measured by conductance.

680 All studies were conducted in a temperature and humidity controlled room (71° ± 5° F;

40% ± 5% relative humidity).

Conductance

685 Fifteen microliters of a lipid-enriched absorbent tissue formulation was topically applied to the volar forearm. Conductance measurements were obtained at 1 , 2, 4, and 6 hours. Mean conductance values for the baseline, 4, and 6 hour timepoints are expressed in Table 3. A pair-wise comparison for each time period using univariate ANOVAs was applied.

690 Table 3: Conductance- Absorbent tissue formulations

Baseline 4 Hour 6 Hour

Mean Mean Mean

Formula 4 187 243 247

Formula 5 179 281* 289*

Formula 6 195 295* 297*

Untreated 194 210 215

* denotes significantly different than untreated site.

The above data clearly demonstrates that the lipid-enriched formulations improve skin 695 barrier moisturization.

Example 4

700 Repetitive wiping with an absorbent tissue treated with a hydrophobic lipid-enriched formula reduces barrier damage compared to an untreated absorbent tissue

Absorbent tissue treated with a hydrophobic lipid-enriched formula was repetitively wiped on the side of the face to determine the extent of barrier damage as measured by

705 TEWL. The study consisted of repetitively wiping the face of 10 panelists with the absorbent tissues for a total of 15 wiping cycles. The wiping cycles were timed to be approximately 30 minutes apart with each wiping cycle consisting of 20 wipes. A baseline TEWL reading and TEWL readings after every two wiping cycles were obtained for each panelist using the Dermalab evaporimeter. The change in TEWL between wiping cycles was determined for

710 each treatment.

Treatment Estimated increase in TEWU wiping cycle

Absorbent tissue treated with formula 7 4.2* Absorbent tissue treated with formula 8 4.3* non-treated absorbent tissue 6.4

'denotes statistically different than non-treated absorbent tissue

Repetitive wiping with the absorbent tissues treated with the lipid-enriched 715 hydrophobic formulas resulted in less skin barrier damage compared to the untreated absorbent tissue. Thus, the Examples representatively illustrate that the lipid-enriched hydrophobic composition of the present invention may provide absorbent tissue products having improved

720 softness as well as providing improved protection of the skin barrier function. Accordingly, the different aspects of the present invention can advantageously provide absorbent tissue products which, when compared to conventional tissue products, are softer and have improved protection of skin barrier function. Such absorbent tissue products can advantageously be used for absorbent tissue products, such as facial tissue, bath tissue,

725 paper towels, and the like.

While the invention has been described in detail with respect to the specific aspects thereof, it will be appreciated that those skilled in the art, upon attaining an understanding of the foregoing, may readily conceive of alterations to, variations of, and equivalents to these 730 aspects. Accordingly, the scope of the present invention should be assessed as that of the appended claims and any equivalents thereto.

Claims

We claim:
1. A tissue or towel product having two outer surfaces, wherein one or both outer surfaces of said product have a composition that enhances skin barrier comprising: from about 0.1 to about 95 weight percent of natural fats or oils; from about 0.1 to about 10 weight percent of sterols or sterol derivatives; 735 from about 1 to about 20 weight percent of water-in-oil emulsifying surfactant having an HLB range from about 3 to about 6; from about 0.5 to about 20 weight percent of humectant; from about 5 to about 95 weight percent of emollient; from about 5 to about 95 weight percent of wax; and, 740 from about 0 to about 25 weight percent of viscosity enhancer.
2. The product of Claim 1 , wherein said composition has a melting point from about 30 °C to about 100 °C.
3. The product of Claim 1 , wherein said composition has a penetration hardness of from about 5 millimeters to about 360 millimeters.
4. The product of Claim 1 , wherein the add-on amount of said composition is from about 0.5 to about 30 weight percent based on the weight of said product.
5. The material of Claim 1, wherein the add-on amount of said composition is from about 0.1 grams per meter squared (g/m2) to about 30 g/m2 of said material.
6. The product of Claim 1 , wherein said natural fat or oil is sunflower oil.
7. The product of Claim 1 , wherein said natural fat or oil is borage oil.
8. The product of Claim 1 , wherein said natural fat or oil is avocado oil.
9. The product of Claim 1 , wherein said sterol or sterol derivative is soy sterol.
10. The product of Claim 1 , wherein said sterol or sterol derivative is cholesterol.
11. The product of Claim 1 , wherein said sterol or sterol derivative is lanasterol.
12. The product of Claim 1 , wherein said humectant is glycerin.
13. The product of Claim 1 , wherein said humectant is sorbitol.
14. The product of Claim 1 , wherein said humectant is hydrogenated starch hydrolysate.
15. The product of Claim 1, wherein said emulsifying surfactant is sorbitan oleate.
16. The product of Claim 1 , wherein said emulsifying surfactant is glyceryl stearate.
17. The product of Claim 1 , wherein said emulsifying surfactant is sorbitan stearate.
18. The product of Claim 1 , wherein said emollient is petrolatum.
19. The product of Claim 1 , wherein said emollient is mineral oil.
20. The product of Claim 1 , wherein said emollient is stearyl alcohol.
21. The product of Claim 1 , wherein said wax is cerasin.
22. The product of Claim 1 , wherein said wax is ozokerite.
23. The product of Claim 1 , wherein said wax is microcrystalline wax.
24. The product of Claim 1 , wherein said viscosity enhancer is ethylene/vinyl acetate copolymer.
25. The product of Claim 1 , wherein said viscosity enhancer is polyethylene.
26. A method of making a tissue or towel product having two outer surfaces comprising:
(a) heating a composition that enhances skin barrier comprising a natural fat or oil, sterol or sterol derivative, a humectant, an emulsifying surfactant having an HLB range from about 3 to about 6, an emollient, a wax, and viscosity enhancer, to a temperature above the melting point of said composition, causing said composition to melt; (b) applying said melted composition to one or both surfaces of a tissue or towel web; and, (c) resolidifying said melted composition.
27. The method of Claim 26, wherein said has a melting point of from about 30 °C to about 100 °C.
28. The method of Claim 26, wherein said resolidified composition has a penetration hardness of from about 5 to about 360 millimeters.
29. The method of Claim 26, wherein said melted composition is applied by printing.
30. A skin barrier enhancing composition comprising from about 0.1 to about 95 weight percent of natural fats or oils, from about 0.1 to about 10 weight percent of sterol or sterol derivative, from about 1 to about 20 weight percent of water-in-oii emulsifying surfactant with an HLB range from about 3 to about 6, from about 0.5 to about 20 weight percent of humectant, from about 5 to about 95 weight percent of emollient, from about 5 to about 95 weight percent of wax, and from about 0 to about 25 weight percent of viscosity enhancer.
31 . The composition of Claim 30, wherein said composition has a melting point from about 30 °C. to about 100 °C.
32. The composition of Claim 30, wherein said resolidified composition has a penetration hardness of from about 5 millimeters to about 360 millimeters.
33. The composition of Claim 30, wherein said natural fat or oil is selected from the group consisting of: avocado oil, apricot oil, babassu oil, borage oil, camellia oil, canola oil, castor oil, chamomile, coconut oil, corn oil, cottonseed oil, evening primrose oil, hemp seed, hydrogenated cottonseed oil, hydrogenated palm kernal oil, maleated soybean oil, meadowfoam oil, palm kernal oil, phospholipids, rapeseed oil, palmitic acid, stearic acid, linoleic acid, rose hip oil, safflower, sunflower oil, soybean oil, sweet almond, or derivatives of natural fats or oils such as stearyl alcohol, lauryl alcohol, myristyl alcohol, and benenyl alcohol, and mixtures thereof.
34. The composition of Claim 30, wherein said sterol or sterol derivative is selected from the group consisting of: cholesterol, sitosterol, stigmasterol, ergosterol, lanasterol, soy sterol, avocado sterols, sterol esters, and mixtures thereof.
35. The composition of Claim 30 wherein said sterol is selected from natural extracts that contain sterols or sterol derivatives selected from the group consisting of: lanolin, avocadin, and mixtures thereof.
36. The composition of Claim 30, wherein said emulsifying surfactant is selected from the group consisting of: sorbitan oleate, sorbitan sesquioleate, glyceryl stearate, sorbitan stearate, sorbitan tristerate, sorbitan trioleate, and mixtures thereof.
37. The composition of Claim 30, wherein said humectant is selected from the group consisting of: glycerin, hydrogenated starch hydrolysate, propylene glycol, sodium PCA, sodium lactate, sorbitol, and mixtures thereof.
38. The composition of Claim 30, wherein said emollient is selected from the group consisting of: mineral oil, petrolatum, stearyl alcohol, cetearyl alcohol, cetyl alcohol, behenyl alcohol, octyldodecanol, cosmetic esters, and mixtures thereof.
39. The composition of Claim 30, wherein said wax is selected from the group consisting of: carnuba, cerasin, cetyl esters, microcrystalline wax, montan wax, ozokerite, synthetic wax, and mixtures thereof.
40. The composition of Claim 30, wherein said viscosity enhancer is selected from the group consisting of: polyolefins resins, polyolefin polymers, ethylene/vinyl acetate copolymers, polyethylene, and mixtures thereof.
41. The composition of Claim 30, wherein the amount of said natural fats or oils is from about 0.1 to about 95 weight percent.
42. The composition of Claim 30, wherein the amount of said sterol or sterol derivative is from about 0.1 to about 10 percent.
43. The composition of Claim 30, wherein the amount of said emulsifying surfactant is from about 1 to about 20 weight percent.
44. The composition of Claim 30, wherein the amount of said humectant is from about 0.5 to about 20 weight percent.
45. The composition of Claim 30, wherein the amount of said emollient is from about 5 to about 95 weight percent.
46. The composition of Claim 30, wherein the amount of said wax is from about 5 to about 95 weight percent.
47. The composition of Claim 30, wherein the amount of said viscosity enhancer is from about 0 to about 25 weight percent.
48. A method for enhancing/restoring/maintaining skin barrier function skin of a user, comprising the steps of: a) contacting a tissue or towel product on said skin of said user wherein said product comprises a skin barrier enhancing/restoring/maintaining composition that provides a skin barrier enhancing/restoring/maintaining benefit upon transfer of said composition to said user's skin; b) transferring at least a portion of said composition during use of said tissue or towel product; and, c) repeating steps a) and b) with one or more additional tissue or towel product with sufficient frequency to enhance/restore/maintain said skin barrier in an area of skin contacted by said liner or tissue material, relative to skin contacted by an equivalent tissue or towel product that does not comprise said skin barrier enhancing/restoring/maintaining composition, wherein said skin barrier enhancing/restoring/maintaining composition comprises: from about 0.1 to about 95 weight percent of natural fats or oils, from about 0.1 to about 10 weight percent of sterols and sterol derivatives, from about 1 to about 20 weight percent of water-in- oil emulsifying surfactant having an HLB range from about 3 to about 6, from about 0.5 to about 10 weight percent of humectant, from about 5 to about 95 weight percent of emollient, from about 5 to about 95 weight percent of wax, and from about 0 to about 25 weight percent of viscosity enhancer.
49. The method of Claim 48, wherein said composition having a melting point from about 30°C. to about 100°C.
50. The method of Claim 48, wherein said resolidified composition has a process viscosity greater than about 50 centipoise.
51 . The method of Claim 48, wherein said resolidified composition has a penetration hardness of from about 5 to about 360 millimeters.
52. The method of Claim 48, wherein said tissue or towel product comprising said skin- barrier enhancing/restoring/maintaining composition are used by said user on each use occasion.
53. The method of Claim 48, wherein said tissue or towel product which do not comprise a skin-barrier enhancing/restoring/maintaining composition are used by said user intermittently.
54. The method of Claim 48, wherein said tissue or towel product comprising said skin- barrier enhancing/restoring/maintaining composition are used by a user whose skin is compromised and are used with sufficient frequency to improve skin-barrier function.
PCT/US2000/011089 1999-04-23 2000-04-20 Absorbent tissues providing skin barrier enhancement WO2000064407A1 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
US13090099P true 1999-04-23 1999-04-23
US60/130,900 1999-04-23
US37977799A true 1999-08-24 1999-08-24
US09/379,777 1999-08-24

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
BR0009348-3A BR0009348A (en) 1999-04-23 2000-04-20 paper tissue or towel product having two outer surfaces, a process for manufacturing the same, and enhancing skin barrier composition
DE2000184458 DE10084458T1 (en) 1999-04-23 2000-04-20 Absorbent tissue to improve the skin barrier
AU44896/00A AU4489600A (en) 1999-04-23 2000-04-20 Absorbent tissues providing skin barrier enhancement
GB0125796A GB2366203B (en) 1999-04-23 2000-04-20 Absorbent tissues providing skin barrier enhancement

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WO2000064407A1 true WO2000064407A1 (en) 2000-11-02

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AR (1) AR023933A1 (en)
AU (1) AU4489600A (en)
BR (1) BR0009348A (en)
CO (1) CO5160280A1 (en)
DE (1) DE10084458T1 (en)
GB (1) GB2366203B (en)
TW (1) TWI252110B (en)
WO (1) WO2000064407A1 (en)

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WO2002051456A2 (en) * 2000-12-22 2002-07-04 Kimberly-Clark Worldwide, Inc. Absorbent articles with non-aqueous compositions containing botanicals
US6475197B1 (en) 1999-08-24 2002-11-05 Kimberly-Clark Worldwide, Inc. Absorbent articles having skin health benefits
FR2829390A1 (en) * 2001-09-12 2003-03-14 Rocher Yves Biolog Vegetale Use of plant, yeast or fungal lipid extracts containing ergosterol in cosmetic compositions for enhancing the barrier function of the skin
US6534074B2 (en) 1999-08-24 2003-03-18 Kimberly-Clark Worldwide, Inc. Absorbent articles providing skin health benefits
US6756520B1 (en) 2000-10-20 2004-06-29 Kimberly-Clark Worldwide, Inc. Hydrophilic compositions for use on absorbent articles to enhance skin barrier
WO2004087092A1 (en) * 2003-03-28 2004-10-14 The Procter & Gamble Company Tacky skin care compositions and articles having tacky skin care compositions disposed thereon
WO2005034887A1 (en) * 2003-09-11 2005-04-21 Kimberly-Clark Worldwide, Inc. Lotioned tissue product with improved stability
WO2005110354A1 (en) * 2004-04-30 2005-11-24 Kimberly-Clark Worldwide, Inc. Pre-wipes for improving anal cleansing
EP1757261A2 (en) * 2001-07-13 2007-02-28 JOHNSON & JOHNSON GmbH Products comprising a sheet and a lipid and aqueous phase
KR100871521B1 (en) * 2001-08-02 2008-12-05 캠브리지 플랫 프로젝션 디스플레이스 리미티드 Flat-panel display using tapered waveguide and manufacturing method thereof
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US7771735B2 (en) 2000-12-22 2010-08-10 Kimberly-Clark Worldwide, Inc. Absorbent articles with compositions for reducing irritation response
US7998495B2 (en) 2004-06-04 2011-08-16 Kimberly-Clark Worldwide, Inc. Antimicrobial tissue products with reduced skin irritation potential

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Cited By (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6475197B1 (en) 1999-08-24 2002-11-05 Kimberly-Clark Worldwide, Inc. Absorbent articles having skin health benefits
US6534074B2 (en) 1999-08-24 2003-03-18 Kimberly-Clark Worldwide, Inc. Absorbent articles providing skin health benefits
US6756520B1 (en) 2000-10-20 2004-06-29 Kimberly-Clark Worldwide, Inc. Hydrophilic compositions for use on absorbent articles to enhance skin barrier
US7771735B2 (en) 2000-12-22 2010-08-10 Kimberly-Clark Worldwide, Inc. Absorbent articles with compositions for reducing irritation response
WO2002051456A3 (en) * 2000-12-22 2003-06-05 Kimberly Clark Co Absorbent articles with non-aqueous compositions containing botanicals
US6749860B2 (en) 2000-12-22 2004-06-15 Kimberly-Clark Worldwide, Inc. Absorbent articles with non-aqueous compositions containing botanicals
WO2002051456A2 (en) * 2000-12-22 2002-07-04 Kimberly-Clark Worldwide, Inc. Absorbent articles with non-aqueous compositions containing botanicals
EP1757261A3 (en) * 2001-07-13 2008-06-11 JOHNSON & JOHNSON GmbH Products comprising a sheet and a lipid and aqueous phase
EP1757261A2 (en) * 2001-07-13 2007-02-28 JOHNSON & JOHNSON GmbH Products comprising a sheet and a lipid and aqueous phase
KR100871521B1 (en) * 2001-08-02 2008-12-05 캠브리지 플랫 프로젝션 디스플레이스 리미티드 Flat-panel display using tapered waveguide and manufacturing method thereof
FR2829390A1 (en) * 2001-09-12 2003-03-14 Rocher Yves Biolog Vegetale Use of plant, yeast or fungal lipid extracts containing ergosterol in cosmetic compositions for enhancing the barrier function of the skin
WO2004087092A1 (en) * 2003-03-28 2004-10-14 The Procter & Gamble Company Tacky skin care compositions and articles having tacky skin care compositions disposed thereon
WO2005034887A1 (en) * 2003-09-11 2005-04-21 Kimberly-Clark Worldwide, Inc. Lotioned tissue product with improved stability
GB2420282B (en) * 2003-09-11 2007-08-15 Kimberly Clark Co Lotioned tissue product with improved stability
GB2420282A (en) * 2003-09-11 2006-05-24 Kimberly Clark Co Lotioned tissue product with improved stability
US7485373B2 (en) 2003-09-11 2009-02-03 Kimberly-Clark Worldwide, Inc. Lotioned tissue product with improved stability
US7547443B2 (en) 2003-09-11 2009-06-16 Kimberly-Clark Worldwide, Inc. Skin care topical ointment
WO2005110354A1 (en) * 2004-04-30 2005-11-24 Kimberly-Clark Worldwide, Inc. Pre-wipes for improving anal cleansing
US7998495B2 (en) 2004-06-04 2011-08-16 Kimberly-Clark Worldwide, Inc. Antimicrobial tissue products with reduced skin irritation potential

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GB2366203A (en) 2002-03-06
DE10084458T1 (en) 2002-04-25
CO5160280A1 (en) 2002-05-30
DE10084458T0 (en)
AU4489600A (en) 2000-11-10
GB2366203B (en) 2004-04-07
GB0125796D0 (en) 2001-12-19
AR023933A1 (en) 2002-09-04
BR0009348A (en) 2002-02-05
TWI252110B (en) 2006-04-01

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