WO2000063402A8 - Cassette de regulation de l'expression d'un acide nucleique heterologue dans une cellule eucaryote, en particulier musculaire - Google Patents

Cassette de regulation de l'expression d'un acide nucleique heterologue dans une cellule eucaryote, en particulier musculaire

Info

Publication number
WO2000063402A8
WO2000063402A8 PCT/FR2000/000972 FR0000972W WO0063402A8 WO 2000063402 A8 WO2000063402 A8 WO 2000063402A8 FR 0000972 W FR0000972 W FR 0000972W WO 0063402 A8 WO0063402 A8 WO 0063402A8
Authority
WO
WIPO (PCT)
Prior art keywords
cassette
cell
regulating
nucleic acid
expression
Prior art date
Application number
PCT/FR2000/000972
Other languages
English (en)
Other versions
WO2000063402A1 (fr
Inventor
Margaret Buckingham
Robert Kelly
Original Assignee
Pasteur Institut
Margaret Buckingham
Robert Kelly
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pasteur Institut, Margaret Buckingham, Robert Kelly filed Critical Pasteur Institut
Priority to CA002366125A priority Critical patent/CA2366125A1/fr
Priority to EP00920800A priority patent/EP1171622A1/fr
Publication of WO2000063402A1 publication Critical patent/WO2000063402A1/fr
Publication of WO2000063402A8 publication Critical patent/WO2000063402A8/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A61K48/005—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'active' part of the composition delivered, i.e. the nucleic acid delivered
    • A61K48/0058—Nucleic acids adapted for tissue specific expression, e.g. having tissue specific promoters as part of a contruct
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A61K48/005—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'active' part of the composition delivered, i.e. the nucleic acid delivered
    • A61K48/0066—Manipulation of the nucleic acid to modify its expression pattern, e.g. enhance its duration of expression, achieved by the presence of particular introns in the delivered nucleic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

La présente invention concerne une cassette de régulation de l'expression d'un acide nucléique hétérologue dans une cellule eucaryote, en particulier musculaire, un vecteur d'expression recombinant comprenant une telle cassette de régulation ainsi qu'un hôte cellulaire recombinant ou un animal transgénique contenant ladite cassette de régulation ou ledit vecteur recombinant. L'invention concerne aussi une composition, notamment une composition pharmaceutique, comprenant la cassette de régulation d'un acide nucléique hétérologue dans une cellule musculaire ou le vecteur recombinant ainsi que l'utilisation de la cassette de régulation ou du vecteur recombinant pour la fabrication d'un médicament.
PCT/FR2000/000972 1999-04-15 2000-04-14 Cassette de regulation de l'expression d'un acide nucleique heterologue dans une cellule eucaryote, en particulier musculaire WO2000063402A1 (fr)

Priority Applications (2)

Application Number Priority Date Filing Date Title
CA002366125A CA2366125A1 (fr) 1999-04-15 2000-04-14 Cassette de regulation de l'expression d'un acide nucleique heterologue dans une cellule eucaryote, en particulier musculaire
EP00920800A EP1171622A1 (fr) 1999-04-15 2000-04-14 Cassette de regulation de l'expression d'un acide nucleique heterologue dans une cellule eucaryote, en particulier musculaire

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR99/04730 1999-04-15
FR9904730A FR2792336B1 (fr) 1999-04-15 1999-04-15 Cassette de regulation de l'expression d'un acide nucleique heterologue dans une cellule eucaryote, en particulier musculaire

Publications (2)

Publication Number Publication Date
WO2000063402A1 WO2000063402A1 (fr) 2000-10-26
WO2000063402A8 true WO2000063402A8 (fr) 2000-12-07

Family

ID=9544440

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/FR2000/000972 WO2000063402A1 (fr) 1999-04-15 2000-04-14 Cassette de regulation de l'expression d'un acide nucleique heterologue dans une cellule eucaryote, en particulier musculaire

Country Status (4)

Country Link
EP (1) EP1171622A1 (fr)
CA (1) CA2366125A1 (fr)
FR (1) FR2792336B1 (fr)
WO (1) WO2000063402A1 (fr)

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9708526D0 (en) * 1997-04-25 1997-06-18 Royal Free Hosp School Med Eukaryotic gene expression cassette and uses thereof

Also Published As

Publication number Publication date
WO2000063402A1 (fr) 2000-10-26
EP1171622A1 (fr) 2002-01-16
FR2792336A1 (fr) 2000-10-20
FR2792336B1 (fr) 2003-07-11
CA2366125A1 (fr) 2000-10-26

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