WO2000057924A3 - Colloid for scintigraphy - Google Patents

Colloid for scintigraphy Download PDF

Info

Publication number
WO2000057924A3
WO2000057924A3 PCT/CA2000/000326 CA0000326W WO0057924A3 WO 2000057924 A3 WO2000057924 A3 WO 2000057924A3 CA 0000326 W CA0000326 W CA 0000326W WO 0057924 A3 WO0057924 A3 WO 0057924A3
Authority
WO
WIPO (PCT)
Prior art keywords
colloid
new
sulfur
formulation
rhenium
Prior art date
Application number
PCT/CA2000/000326
Other languages
French (fr)
Other versions
WO2000057924A2 (en
Inventor
Pamela Louise Zabel
Kent Dunn
Original Assignee
London Health Sciences Ct
Pamela Louise Zabel
Kent Dunn
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by London Health Sciences Ct, Pamela Louise Zabel, Kent Dunn filed Critical London Health Sciences Ct
Priority to CA002370409A priority Critical patent/CA2370409C/en
Priority to US09/926,219 priority patent/US6706251B1/en
Priority to EP00912305A priority patent/EP1163013A2/en
Priority to AU34130/00A priority patent/AU3413000A/en
Publication of WO2000057924A2 publication Critical patent/WO2000057924A2/en
Publication of WO2000057924A3 publication Critical patent/WO2000057924A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/12—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by a special physical form, e.g. emulsion, microcapsules, liposomes, characterized by a special physical form, e.g. emulsions, dispersions, microcapsules
    • A61K51/1217—Dispersions, suspensions, colloids, emulsions, e.g. perfluorinated emulsion, sols

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • Optics & Photonics (AREA)
  • Dispersion Chemistry (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Colloid Chemistry (AREA)

Abstract

A new formulation of Tc-99m colloid is described. The new colloid contains a high ratio of perrhenate to thiosulphate, cysteine, and a prepared higher final pH than found previously. In preparing the colloid preferred rhenium sulfide is not used as an ingredient. The pH of the final formulation and can be between about 5.5 an about 8.0, and the ratio of rhenium to sulfur is from about 0.05 to about 1.2. In addition, the new colloid has excellent radiochemical purity, and a much smaller particle size distribution than has generally been previously available for sulfur colloid preparations.
PCT/CA2000/000326 1999-03-26 2000-03-24 Colloid for scintigraphy WO2000057924A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
CA002370409A CA2370409C (en) 1999-03-26 2000-03-24 Colloid for scintigraphy
US09/926,219 US6706251B1 (en) 1999-03-26 2000-03-24 Colloid for scintigraphy
EP00912305A EP1163013A2 (en) 1999-03-26 2000-03-24 Colloid for scintigraphy
AU34130/00A AU3413000A (en) 1999-03-26 2000-03-24 Colloid for scintigraphy

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US12637999P 1999-03-26 1999-03-26
US60/126,379 1999-03-26

Publications (2)

Publication Number Publication Date
WO2000057924A2 WO2000057924A2 (en) 2000-10-05
WO2000057924A3 true WO2000057924A3 (en) 2001-03-22

Family

ID=22424517

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/CA2000/000326 WO2000057924A2 (en) 1999-03-26 2000-03-24 Colloid for scintigraphy

Country Status (4)

Country Link
EP (1) EP1163013A2 (en)
AU (1) AU3413000A (en)
CA (1) CA2370409C (en)
WO (1) WO2000057924A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3860576A4 (en) * 2018-10-06 2022-07-20 Jubilant Generics Limited Pharmaceutical compositions of sulfur colloid and processes thereof

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2088139A1 (en) * 1970-05-22 1972-01-07 Philips France
FR2107902A1 (en) * 1970-09-23 1972-05-12 Squibb & Sons Inc Technetium 99m co-pptd sulphur-albumin prepn - - for lung scanning
US3810976A (en) * 1970-05-20 1974-05-14 Univ Oklahoma Foundation Inc Lung scanning 99m technetium macroaggregate and method of preparation
US3845202A (en) * 1972-10-24 1974-10-29 Administrator Of Veterans Affa Lung scanning protein macroaggregate of indium 113m in a sulfide-sulfur composition
BE883114A (en) * 1980-05-05 1980-11-05 New England Nuclear Corp ALBUMIN MICROAGGREGATES FOR RADIO-ACTIVE EXPLORATION OF RETICULO-ENDOTHELIAL SYSTEMS AND THEIR PREPARATION.

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3810976A (en) * 1970-05-20 1974-05-14 Univ Oklahoma Foundation Inc Lung scanning 99m technetium macroaggregate and method of preparation
FR2088139A1 (en) * 1970-05-22 1972-01-07 Philips France
FR2107902A1 (en) * 1970-09-23 1972-05-12 Squibb & Sons Inc Technetium 99m co-pptd sulphur-albumin prepn - - for lung scanning
US3845202A (en) * 1972-10-24 1974-10-29 Administrator Of Veterans Affa Lung scanning protein macroaggregate of indium 113m in a sulfide-sulfur composition
BE883114A (en) * 1980-05-05 1980-11-05 New England Nuclear Corp ALBUMIN MICROAGGREGATES FOR RADIO-ACTIVE EXPLORATION OF RETICULO-ENDOTHELIAL SYSTEMS AND THEIR PREPARATION.

Non-Patent Citations (7)

* Cited by examiner, † Cited by third party
Title
BOYD R E: "The Gel Generator: a Viable Alternative Source of Tc for Nuclear Medicine", APPLIED RADIATION AND ISOTOPES,GB,PERGAMON PRESS LTD., EXETER, vol. 48, no. 8, 1 August 1997 (1997-08-01), pages 1027 - 1033, XP004094760, ISSN: 0969-8043 *
COHEN, MARVIN B. ET AL: "Rhenium and Technetium Heptasulfide", J. NUCL. MED., 1972, VOL. 13, NO. 4, PAGE(S) 287, XP002156944 *
NAKAJIMA, KENICHI ET AL: "Biodistribution of technetium -99m- rhenium colloid in rats: a comparison with technetium -99m- sulfur colloid", KAKU IGAKU, 1981, VOL. 18, NO. 7, PAGE(S) 967-71, XP002156946 *
SAMOCHOCKA, KRYSTYNA ET AL: "Preparation of colloidal sulfides labeled with technetium -99m and indium-113m and used in clinical scanning", NUCLEAR-MEDIZIN, 1971, VOL. 10, NO. 3, PAGE(S) 252-255, XP000971990 *
SANTOS A C ET AL: "Cardiac lymphatic dynamics after ischemia and reperfusion-experimental model - Basic concepts for optimal uptake of radiocolloids in the parasternal lymph nodes of rabbits", NUCLEAR MEDICINE AND BIOLOGY,US,ELSEVIER SCIENCE PUBLISHERS, NEW YORK, NY, vol. 25, no. 7, October 1998 (1998-10-01), pages 685 - 688, XP004149439, ISSN: 0969-8051 *
SZYMENDERA, J. ET AL: "Rhenium and Technetium Heptasulfide - the Author's Reply", J. NUCL. MED., 1972, VOL. 13, NO. 4, PAGE(S) 287-288, XP002156945 *
TAKAHASHI, KUNIBUMI: "Short half-lived radiocolloids for delineation of the reticuloendothelial system in the bone marrow", SCI. REP. RES. INST., TOHOKU UNIV., SER. C, 1974, VOL. 21, NO. 3-4, PAGE(S) 35-46, XP000971831 *

Also Published As

Publication number Publication date
AU3413000A (en) 2000-10-16
CA2370409C (en) 2009-02-03
CA2370409A1 (en) 2000-10-05
WO2000057924A2 (en) 2000-10-05
EP1163013A2 (en) 2001-12-19

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